Keck School Faculty

Reduced non-CpG methylation is a potential epigenetic target after spinal cord injury Neural Regen Res. 2023 Nov; 18(11):2489-2496. . View in PubMed

Enhanced brain entry of checkpoint-inhibitory therapeutic antibodies facilitated by intraarterial NEO100 in mouse models of brain-localized malignancies J Neurosurg. 2023 Sep 01; 139(3):822-830. . View in PubMed

Inhibition of autophagy and induction of glioblastoma cell death by NEO214, a perillyl alcohol-rolipram conjugate Autophagy. 2023 Aug 06; 1-20. . View in PubMed

From the groin to the brain: a transfemoral path to blood-brain barrier opening Oncotarget. 2023 05 04; 14:413-416. . View in PubMed

Intranasal Delivery of miR133b in a NEO100-Based Formulation Induces a Healing Response in Spinal Cord-Injured Mice Cells. 2023 03 18; 12(6). . View in PubMed

NEO212, a Perillyl Alcohol-Temozolomide Conjugate, Triggers Macrophage Differentiation of Acute Myeloid Leukemia Cells and Blocks Their Tumorigenicity Cancers (Basel). 2022 Dec 09; 14(24). . View in PubMed

Detection of perillyl alcohol and its metabolite perillic acid in postsurgical glioblastoma tissue after intranasal administration of NEO100: illustrative case J Neurosurg Case Lessons. 2022 Aug 22; 4(8). . View in PubMed

5-Aminolevulinic acid-enhanced fluorescence-guided treatment of high-grade glioma using angled endoscopic blue light visualization: technical case series with preliminary follow-up J Neurosurg. 2022 Mar 18; 1-9. . View in PubMed

Lumbar surgical drains do not increase the risk of infections in patients undergoing spine surgery Eur Spine J. 2022 07; 31(7):1775-1783. . View in PubMed

A Prospective, Cohort Study of SITOIGANAP to Treat Glioblastoma When Given in Combination With Granulocyte-Macrophage Colony-Stimulating Factor/Cyclophosphamide/Bevacizumab/Nivolumab or Granulocyte-Macrophage Colony-Stimulating Factor/Cyclophosphamide/Bevacizumab/Pembrolizumab in Patients Who Failed Prior Treatment With Surgical Resection, Radiation, and Temozolomide Front Oncol. 2022; 12:934638. . View in PubMed

The Monoterpenoid Perillyl Alcohol: Anticancer Agent and Medium to Overcome Biological Barriers Pharmaceutics. 2021 Dec 16; 13(12). . View in PubMed

Corrigendum to: Enhanced brain delivery and therapeutic activity of trastuzumab after blood-brain barrier opening by NEO100 in mouse models of brain-metastatic breast cancer Neuro Oncol. 2021 Dec 01; 23(12):2123. . View in PubMed

Surviving Over a Decade With Glioblastoma: A Clinical Course Characterized by Multiple Recurrences, Numerous Salvage Treatments, and Novel Use of Cesium-131 Tiles Cureus. 2021 Nov; 13(11):e19573. . View in PubMed

Medulloblastoma uses GABA transaminase to survive in the cerebrospinal fluid microenvironment and promote leptomeningeal dissemination Cell Rep. 2021 Jul 27; 36(4):109475. . View in PubMed

Potentially Curative Therapeutic Activity of NEO212, a Perillyl Alcohol-Temozolomide Conjugate, in Preclinical Cytarabine-Resistant Models of Acute Myeloid Leukemia Cancers (Basel). 2021 Jul 06; 13(14). . View in PubMed

Utilization of Discarded Surgical Tissue from Ultrasonic Aspirators to Establish Patient-Derived Metastatic Brain Tumor Cells: A Guide from the Operating Room to the Research Laboratory Curr Protoc. 2021 Jun; 1(6):e140. . View in PubMed

In vivo CRISPR screening for novel noncoding RNA functional targets in glioblastoma models J Neurosci Res. 2021 09; 99(9):2029-2045. . View in PubMed

Medulloblastoma uses GABA transaminase to survive in the cerebrospinal fluid microenvironment and promote leptomeningeal dissemination Cell Rep. 2021 06 29; 35(13):109302. . View in PubMed

Phase I trial of intranasal NEO100, highly purified perillyl alcohol, in adult patients with recurrent glioblastoma Neurooncol Adv. 2021 Jan-Dec; 3(1):vdab005. . View in PubMed

Neuro Oncol. 2021 01 30; 23(1):63-75. . View in PubMed

Enhanced brain delivery and therapeutic activity of trastuzumab after blood-brain barrier opening by NEO100 in mouse models of brain-metastatic breast cancer Neuro Oncol. 2021 10 01; 23(10):1656-1667. . View in PubMed

Association Between Outdoor Air Pollution and Risk of Malignant and Benign Brain Tumors: The Multiethnic Cohort Study JNCI Cancer Spectr. 2020 Apr; 4(2):pkz107. . View in PubMed

Efficient Prodrug Activator Gene Therapy by Retroviral Replicating Vectors Prolongs Survival in an Immune-Competent Intracerebral Glioma Model Int J Mol Sci. 2020 Feb 20; 21(4). . View in PubMed

Simultaneous measurement of perillyl alcohol and its metabolite perillic acid in plasma and lung after inhalational administration in Wistar rats Drug Test Anal. 2020 Feb; 12(2):268-279. . View in PubMed

Preclinical studies of a novel snake venom-derived recombinant disintegrin with antitumor activity: A review Biochem Pharmacol. 2020 11; 181:114149. . View in PubMed

Intravenous delivery of microRNA-133b along with Argonaute-2 enhances spinal cord recovery following cervical contusion in mice Spine J. 2020 07; 20(7):1138-1151. . View in PubMed

Developing a clinically relevant radiosensitizer for temozolomide-resistant gliomas PLoS One. 2020; 15(9):e0238238. . View in PubMed

Pharmacokinetic properties of the temozolomide perillyl alcohol conjugate (NEO212) in mice Neurooncol Adv. 2020 Jan-Dec; 2(1):vdaa160. . View in PubMed

miR-18a Inhibits BMP4 and HIF-1a Normalizing Brain Arteriovenous Malformations Circ Res. 2020 10 09; 127(9):e210-e231. . View in PubMed

Sodium Valproate Reduces Neuronal Apoptosis in Acute Pentylenetetrzole-Induced Seizures via Inhibiting ER Stress Neurochem Res. 2019 Nov; 44(11):2517-2526. . View in PubMed

Inhibition of motility by NEO100 through the calpain-1/RhoA pathway J Neurosurg. 2019 Aug 16; 1-12. . View in PubMed

NEO212 induces mitochondrial apoptosis and impairs autophagy flux in ovarian cancer J Exp Clin Cancer Res. 2019 Jun 07; 38(1):239. . View in PubMed

Efficient brain targeting and therapeutic intracranial activity of bortezomib through intranasal co-delivery with NEO100 in rodent glioblastoma models J Neurosurg. 2019 Mar 15; 132(3):959-967. . View in PubMed

Distribution of cancer stem cells in two human brain gliomas Oncol Lett. 2019 Feb; 17(2):2123-2130. . View in PubMed

The Rolipram-Perillyl Alcohol Conjugate (NEO214) Is A Mediator of Cell Death through the Death Receptor Pathway Mol Cancer Ther. 2019 03; 18(3):517-530. . View in PubMed

NEO212, a conjugate of temozolomide and perillyl alcohol, blocks the endothelial-to-mesenchymal transition in tumor-associated brain endothelial cells in glioblastoma Cancer Lett. 2019 02 01; 442:170-180. . View in PubMed

Cytotoxic impact of a perillyl alcohol-temozolomide conjugate, NEO212, on cutaneous T-cell lymphoma in vitro Ther Adv Med Oncol. 2019; 11:1758835919891567. . View in PubMed

NEO412: A temozolomide analog with transdermal activity in melanoma in vitro and in vivo Oncotarget. 2018 Dec 11; 9(97):37026-37041. . View in PubMed

Intranasal Perillyl Alcohol for Glioma Therapy: Molecular Mechanisms and Clinical Development Int J Mol Sci. 2018 Dec 06; 19(12). . View in PubMed

A Novel Venom-Derived Peptide for Brachytherapy of Glioblastoma: Preclinical Studies in Mice Molecules. 2018 Nov 08; 23(11). . View in PubMed

Temozolomide-Perillyl alcohol conjugate impairs Mitophagy flux by inducing lysosomal dysfunction in non-small cell lung Cancer cells and sensitizes them to irradiation J Exp Clin Cancer Res. 2018 Oct 16; 37(1):250. . View in PubMed

Rare Stochastic Expression of O6-Methylguanine- DNA Methyltransferase (MGMT) in MGMT-Negative Melanoma Cells Determines Immediate Emergence of Drug-Resistant Populations upon Treatment with Temozolomide In Vitro and In Vivo Cancers (Basel). 2018 Sep 28; 10(10). . View in PubMed

Therapeutic Immunization against Glioblastoma Int J Mol Sci. 2018 Aug 27; 19(9). . View in PubMed

NEO212: sub-cytotoxic doses capable of inhibiting glioma stem cell invasion Oncoscience. 2018 May; 5(5-6):148-149. . View in PubMed

Influence of Treatment With Tumor-Treating Fields on Health-Related Quality of Life of Patients With Newly Diagnosed Glioblastoma: A Secondary Analysis of a Randomized Clinical Trial JAMA Oncol. 2018 Apr 01; 4(4):495-504. . View in PubMed

Spine Surgery Complicated by an Engorged Lumbar Epidural Venous Plexus from Cerebrospinal Fluid Overshunting: A Case Report and Review of the Literature World Neurosurg. 2018 Mar; 111:68-72. . View in PubMed

Induction of Pro-Apoptotic Endoplasmic Reticulum Stress in Multiple Myeloma Cells by NEO214, Perillyl Alcohol Conjugated to Rolipram Int J Mol Sci. 2018 Jan 17; 19(1). . View in PubMed

NEO212 Inhibits Migration and Invasion of Glioma Stem Cells Mol Cancer Ther. 2018 03; 17(3):625-637. . View in PubMed

Intratumoral delivery of bortezomib: impact on survival in an intracranial glioma tumor model J Neurosurg. 2018 03; 128(3):695-700. . View in PubMed

Phase II study of ERC1671 plus bevacizumab versus bevacizumab plus placebo in recurrent glioblastoma: interim results and correlations with CD4+ T-lymphocyte counts CNS Oncol. 2018 07 01; 7(3):CNS22. . View in PubMed

Bioorthogonal Profiling of a Cancer Cell Proteome Identifies a Large Set of 3-Bromopyruvate Targets beyond Glycolysis ACS Chem Biol. 2018 11 16; 13(11):3054-3058. . View in PubMed

Temozolomide-perillyl alcohol conjugate downregulates O6-methylguanin DNA methltransferase via inducing ubiquitination-dependent proteolysis in non-small cell lung cancer Cell Death Dis. 2018 02 09; 9(2):202. . View in PubMed

Transpedicular Corpectomy and Cage Placement in the Treatment of Traumatic Lumbar Burst Fractures Clin Spine Surg. 2017 Oct; 30(8):360-366. . View in PubMed

A perillyl alcohol-conjugated analog of 3-bromopyruvate without cellular uptake dependency on monocarboxylate transporter 1 and with activity in 3-BP-resistant tumor cells Cancer Lett. 2017 08 01; 400:161-174. . View in PubMed

Perillyl Alcohol and Its Drug-Conjugated Derivatives as Potential Novel Methods of Treating Brain Metastases Int J Mol Sci. 2016 Sep 02; 17(9). . View in PubMed

Primary Intraosseous Meningioma Neurosurg Clin N Am. 2016 Apr; 27(2):189-93. . View in PubMed

Monoamine oxidase A (MAO A) inhibitors decrease glioma progression Oncotarget. 2016 Mar 22; 7(12):13842-53. . View in PubMed

Temozolomide-perillyl alcohol conjugate induced reactive oxygen species accumulation contributes to its cytotoxicity against non-small cell lung cancer Sci Rep. 2016 Mar 07; 6:22762. . View in PubMed

Effects of fusion and conservative treatment on disc degeneration and rates of subsequent surgery after thoracolumbar fracture J Neurosurg Spine. 2016 Mar; 24(3):476-82. . View in PubMed

A novel drug conjugate, NEO212, targeting proneural and mesenchymal subtypes of patient-derived glioma cancer stem cells Cancer Lett. 2016 Feb 28; 371(2):240-50. . View in PubMed

Therapeutic effect of TMZ-POH on human nasopharyngeal carcinoma depends on reactive oxygen species accumulation Oncotarget. 2016 Jan 12; 7(2):1651-62. . View in PubMed

Medulloblastoma initiation and spread: Where neurodevelopment, microenvironment and cancer cross pathways J Neurosci Res. 2016 12; 94(12):1511-1519. . View in PubMed

Heterocellular Contacts with Mouse Brain Endothelial Cells Via Laminin and a6ß1 Integrin Sustain Subventricular Zone (SVZ) Stem/Progenitor Cells Properties Front Cell Neurosci. 2016; 10:284. . View in PubMed

Targeting Notch enhances the efficacy of ERK inhibitors in BRAF-V600E melanoma Oncotarget. 2016 11 01; 7(44):71211-71222. . View in PubMed

Tumor vasculature and glioma stem cells: Contributions to glioma progression Cancer Lett. 2016 10 01; 380(2):545-551. . View in PubMed

Maintenance Therapy With Tumor-Treating Fields Plus Temozolomide vs Temozolomide Alone for Glioblastoma: A Randomized Clinical Trial JAMA. 2015 Dec 15; 314(23):2535-43. . View in PubMed

Nanoparticle biointerfacing by platelet membrane cloaking Nature. 2015 Oct 01; 526(7571):118-21. . View in PubMed

Chemotherapeutic effect of a novel temozolomide analog on nasopharyngeal carcinoma in vitro and in vivo J Biomed Sci. 2015 Aug 19; 22:71. . View in PubMed

Development of the Metronomic Biofeedback Pump for leptomeningeal carcinomatosis: technical note J Neurosurg. 2015 Aug; 123(2):362-72. . View in PubMed

First clinical results of a personalized immunotherapeutic vaccine against recurrent, incompletely resected, treatment-resistant glioblastoma multiforme (GBM) tumors, based on combined allo- and auto-immune tumor reactivity Vaccine. 2015 May 28; 33(23):2690-6. . View in PubMed

A novel temozolomide analog, NEO212, with enhanced activity against MGMT-positive melanoma in vitro and in vivo Cancer Lett. 2015 Mar 28; 358(2):144-151. . View in PubMed

Effects of convection-enhanced delivery of bevacizumab on survival of glioma-bearing animals Neurosurg Focus. 2015 Mar; 38(3):E8. . View in PubMed

Quinoline-based antimalarial drugs: a novel class of autophagy inhibitors Neurosurg Focus. 2015 Mar; 38(3):E12. . View in PubMed

IntroductionNeurooncology: update on therapeutic options. Neurosurg Focus. 2015 Mar; 38(3):E1. . View in PubMed

A Conserved Glycan in the C2 Domain of HIV-1 Envelope Acts as a Molecular Switch to Control X4 Utilization by Clonal Variants with Identical V3 Loops PLoS One. 2015; 10(6):e0128116. . View in PubMed

Stereotactic radiosurgery to the resection cavity for brain metastases: prognostic factors and outcomes J Radiosurg SBRT. 2015; 3(3):179-186. . View in PubMed

Use of ERC-1671 Vaccine in a Patient with Recurrent Glioblastoma Multiforme after Progression during Bevacizumab Therapy: First Published Report Perm J. 2015; 19(2):41-6. . View in PubMed

Preclinical development and clinical use of perillyl alcohol for chemoprevention and cancer therapy Am J Cancer Res. 2015; 5(5):1580-93. . View in PubMed

Chloroquine enhances temozolomide cytotoxicity in malignant gliomas by blocking autophagy Neurosurg Focus. 2014 Dec; 37(6):E12. . View in PubMed

Introduction: Glioblastoma: an update on pathophysiology and management strategies Neurosurg Focus. 2014 Dec; 37(6):Introduction. . View in PubMed

Diffusion restriction in a non-enhancing metastatic brain tumor treated with bevacizumab - recurrent tumor or atypical necrosis? Clin Imaging. 2014 Sep-Oct; 38(5):724-6.. View in PubMed

NEO212, temozolomide conjugated to perillyl alcohol, is a novel drug for effective treatment of a broad range of temozolomide-resistant gliomas Mol Cancer Ther. 2014 Aug; 13(8):2004-17. . View in PubMed

Argonaute-2 promotes miR-18a entry in human brain endothelial cells J Am Heart Assoc. 2014 May 16; 3(3):e000968. . View in PubMed

A novel temozolomide-perillyl alcohol conjugate exhibits superior activity against breast cancer cells in vitro and intracranial triple-negative tumor growth in vivo Mol Cancer Ther. 2014 May; 13(5):1181-93. . View in PubMed

A systematic review of inhaled intranasal therapy for central nervous system neoplasms: an emerging therapeutic option J Neurooncol. 2014 Feb; 116(3):437-46. . View in PubMed

MicroRNA-18a improves human cerebral arteriovenous malformation endothelial cell function Stroke. 2014 Jan; 45(1):293-7. . View in PubMed

Sequential administration of carbon nanotubes and near-infrared radiation for the treatment of gliomas Front Oncol. 2014; 4:180. . View in PubMed

Genomic and transcriptome analysis revealing an oncogenic functional module in meningiomas Neurosurg Focus. 2013 Dec; 35(6):E3. . View in PubMed

Lumbar facet joint and intervertebral disc loading during simulated pelvic obliquity Spine J. 2013 Nov; 13(11):1581-9. . View in PubMed

DNA methylation in the malignant transformation of meningiomas PLoS One. 2013; 8(1):e54114. . View in PubMed

Repositioning of Verrucosidin, a purported inhibitor of chaperone protein GRP78, as an inhibitor of mitochondrial electron transport chain complex I PLoS One. 2013; 8(6):e65695. . View in PubMed

Inhibition of autophagy and induction of breast cancer cell death by mefloquine, an antimalarial agent Cancer Lett. 2012 Dec 30; 326(2):143-54. . View in PubMed

Preferential killing of triple-negative breast cancer cells in vitro and in vivo when pharmacological aggravators of endoplasmic reticulum stress are combined with autophagy inhibitors Cancer Lett. 2012 Dec 01; 325(1):63-71. . View in PubMed

Perillyl alcohol for the treatment of temozolomide-resistant gliomas Mol Cancer Ther. 2012 Nov; 11(11):2462-72. . View in PubMed

Development of immune memory to glial brain tumors after tumor regression induced by immunotherapeutic Toll-like receptor 7/8 activation Oncoimmunology. 2012 May 01; 1(3):298-305. . View in PubMed

Fasting enhances the response of glioma to chemo- and radiotherapy PLoS One. 2012; 7(9):e44603. . View in PubMed

Exploring the Therapeutic Efficacy of Glioma Vaccines Based on Allo- and Syngeneic Antigens and Distinct Immunological Costimulation Activators J Clin Cell Immunol. 2012; Suppl 5:004. . View in PubMed

Noscapine inhibits tumor growth in TMZ-resistant gliomas Cancer Lett. 2011 Dec 22; 312(2):245-52. . View in PubMed

A phase 1/2 study of orally administered synthetic hypericin for treatment of recurrent malignant gliomas Cancer. 2011 Nov 01; 117(21):4905-15. . View in PubMed

Phase 1/pharmacology study of intraperitoneal topotecan alone and with cisplatin: potential for consolidation in ovarian cancer Cancer Chemother Pharmacol. 2011 Aug; 68(2):457-63. . View in PubMed

Molecular genetics of meningiomas: a systematic review of the current literature and potential basis for future treatment paradigms Neurosurg Focus. 2011 May; 30(5):E7. . View in PubMed

Green tea epigallocatechin gallate enhances therapeutic efficacy of temozolomide in orthotopic mouse glioblastoma models Cancer Lett. 2011 Mar 28; 302(2):100-8. . View in PubMed

Effective conversion of irinotecan to SN-38 after intratumoral drug delivery to an intracranial murine glioma model in vivoLaboratory investigation. J Neurosurg. 2011 Mar; 114(3):689-94. . View in PubMed

Preclinical development of novel anti-glioma drugs targeting the endoplasmic reticulum stress response Curr Pharm Des. 2011; 17(23):2428-38. . View in PubMed

GRP78/BiP modulation of GRP78/BiP in altering sensitivity to chemotherapy Methods Enzymol. 2011; 491:25-36. . View in PubMed

A technical description of the brain tumor window model: an in vivo model for the evaluation of intraoperative contrast agents Acta Neurochir Suppl. 2011; 109:259-63. . View in PubMed

A novel method for administering intrathecal chemotherapy in patients with leptomeningeal metastases and shunted hydrocephalus: case report Neurosurgery. 2010 Sep; 67(3 Suppl Operative):onsE306-7; discussion onsE307. . View in PubMed

A-Mode ultrasound guidance for pedicle screw advancement in ovine vertebral bodies Spine J. 2010 May; 10(5):422-32. . View in PubMed

The brain tumor window model: a combined cranial window and implanted glioma model for evaluating intraoperative contrast agents Neurosurgery. 2010 Apr; 66(4):736-43. . View in PubMed

Antiangiogenic activities of 2,5-dimethyl-celecoxib on the tumor vasculature Mol Cancer Ther. 2010 Mar; 9(3):631-41. . View in PubMed

An intensive, progressive exercise program reduces disability and improves functional performance in patients after single-level lumbar microdiskectomy Phys Ther. 2009 Nov; 89(11):1145-57. . View in PubMed

Glioma-associated endothelial cells are chemoresistant to temozolomide J Neurooncol. 2009 Oct; 95(1):13-22. . View in PubMed

Enhanced killing of chemo-resistant breast cancer cells via controlled aggravation of ER stress Cancer Lett. 2009 Sep 08; 282(1):87-97. . View in PubMed

Green tea polyphenols block the anticancer effects of bortezomib and other boronic acid-based proteasome inhibitors Blood. 2009 Jun 04; 113(23):5927-37. . View in PubMed

In vitro characterization of a targeted, dye-loaded nanodevice for intraoperative tumor delineation Neurosurgery. 2009 May; 64(5):965-71; discussion 971-2. . View in PubMed

Stress chaperone GRP78/BiP confers chemoresistance to tumor-associated endothelial cells Mol Cancer Res. 2008 Aug; 6(8):1268-75. . View in PubMed

Increased survivin expression confers chemoresistance to tumor-associated endothelial cells Am J Pathol. 2008 Aug; 173(2):575-85. . View in PubMed

Pharmacogenomics of brain cancer and personalized medicine in malignant gliomas Future Oncol. 2008 Aug; 4(4):525-34. . View in PubMed

Therapeutic vaccination against malignant gliomas based on allorecognition and syngeneic tumor antigens: proof of principle in two strains of rat Vaccine. 2008 Mar 25; 26(14):1764-72. . View in PubMed

Celecoxib analogs that lack COX-2 inhibitory function: preclinical development of novel anticancer drugs Expert Opin Investig Drugs. 2008 Feb; 17(2):197-208. . View in PubMed

Aggravated endoplasmic reticulum stress as a basis for enhanced glioblastoma cell killing by bortezomib in combination with celecoxib or its non-coxib analogue, 2,5-dimethyl-celecoxib Cancer Res. 2008 Feb 01; 68(3):843-51. . View in PubMed

HIV-1 protease inhibitors nelfinavir and atazanavir induce malignant glioma death by triggering endoplasmic reticulum stress Cancer Res. 2007 Nov 15; 67(22):10920-8. . View in PubMed

The unfolded protein response regulator GRP78/BiP as a novel target for increasing chemosensitivity in malignant gliomas Cancer Res. 2007 Oct 15; 67(20):9809-16. . View in PubMed

Glioma-associated endothelial cells show evidence of replicative senescence Exp Cell Res. 2007 Apr 01; 313(6):1192-202. . View in PubMed

Calcium-activated endoplasmic reticulum stress as a major component of tumor cell death induced by 2,5-dimethyl-celecoxib, a non-coxib analogue of celecoxib Mol Cancer Ther. 2007 Apr; 6(4):1262-75. . View in PubMed

Irinotecan: a potential new chemotherapeutic agent for atypical or malignant meningiomas J Neurosurg. 2007 Mar; 106(3):455-62. . View in PubMed

Adjuvant therapy for unresectable meningiomas: benign and malignant Neurosurg Focus. 2007; 23(4):1. . View in PubMed

Primary intraosseous meningioma Neurosurg Focus. 2007; 23(4):E13. . View in PubMed

Nelfinavir potentiation of imatinib cytotoxicity in meningioma cells via survivin inhibition Neurosurg Focus. 2007; 23(4):E9. . View in PubMed

Efficacy of celecoxib in the treatment of CNS lymphomas: an in vivo model Neurosurg Focus. 2006 Nov 15; 21(5):E14. . View in PubMed

Surgical interventions for primary central nervous system lymphoma Neurosurg Focus. 2006 Nov 15; 21(5):E13. . View in PubMed

Multiple signaling pathways are involved in endothelin-1-induced brain endothelial cell migration Am J Physiol Cell Physiol. 2006 Jul; 291(1):C155-64. . View in PubMed

Downregulation of survivin expression and concomitant induction of apoptosis by celecoxib and its non-cyclooxygenase-2-inhibitory analog, dimethyl-celecoxib (DMC), in tumor cells in vitro and in vivo Mol Cancer. 2006 May 18; 5:19. . View in PubMed

Fibroblast growth factor-2-retargeted adenoviral vector for selective transduction of primary glioblastoma multiforme endothelial cells Neurosurg Focus. 2006 Apr 15; 20(4):E26. . View in PubMed

Use of replication-competent retroviral vectors in an immunocompetent intracranial glioma model Neurosurg Focus. 2006 Apr 15; 20(4):E25. . View in PubMed

Enhancement of glioblastoma cell killing by combination treatment with temozolomide and tamoxifen or hypericin Neurosurg Focus. 2006 Apr 15; 20(4):E20. . View in PubMed

Characteristics of tumor-associated endothelial cells derived from glioblastoma multiforme Neurosurg Focus. 2006 Apr 15; 20(4):E22. . View in PubMed

Multitarget inhibition of drug-resistant multiple myeloma cell lines by dimethyl-celecoxib (DMC), a non-COX-2 inhibitory analog of celecoxib Blood. 2005 Dec 15; 106(13):4330-8. . View in PubMed

Retargeting of adenoviral vector using basic fibroblast growth factor ligand for malignant glioma gene therapy J Neurosurg. 2005 Dec; 103(6):1058-66. . View in PubMed

Interleukin-8 differentially regulates migration of tumor-associated and normal human brain endothelial cells Cancer Res. 2005 Nov 15; 65(22):10347-54. . View in PubMed

Single-shot, multicycle suicide gene therapy by replication-competent retrovirus vectors achieves long-term survival benefit in experimental glioma Mol Ther. 2005 Nov; 12(5):842-51. . View in PubMed

The role of contortrostatin, a snake venom disintegrin, in the inhibition of tumor progression and prolongation of survival in a rodent glioma model J Neurosurg. 2005 Sep; 103(3):526-37. . View in PubMed

Potent mimicry of fibronectin-induced intracellular signaling in glioma cells by the homodimeric snake venom disintegrin contortrostatin Neurosurgery. 2005 Jul; 57(1):141-53; discussion 141-53. . View in PubMed

Dimethyl-celecoxib (DMC), a derivative of celecoxib that lacks cyclooxygenase-2-inhibitory function, potently mimics the anti-tumor effects of celecoxib on Burkitt's lymphoma in vitro and in vivo Cancer Biol Ther. 2005 May; 4(5):571-82. . View in PubMed

Functional and phenotypic differences between glioblastoma multiforme-derived and normal human brain endothelial cells J Neurosurg. 2005 Apr; 102(4):699-705. . View in PubMed

Development of a novel recombinant disintegrin, contortrostatin, as an effective anti-tumor and anti-angiogenic agent Pathophysiol Haemost Thromb. 2005; 34(4-5):177-83. . View in PubMed

Differential effects of selective COX-2 inhibitors on cell cycle regulation and proliferation of glioblastoma cell lines Cancer Biol Ther. 2004 Jan; 3(1):55-62. . View in PubMed

Combination therapy with irinotecan and protein kinase C inhibitors in malignant glioma Cancer. 2003 May 01; 97(9 Suppl):2363-73. . View in PubMed

Highly efficient and tumor-restricted gene transfer to malignant gliomas by replication-competent retroviral vectors Hum Gene Ther. 2003 Jan 20; 14(2):117-27. . View in PubMed

Functional effect of contortrostatin, a snake venom disintegrin, on human glioma cell invasion in vitro Cell Commun Adhes. 2003 Jan-Feb; 10(1):1-16. . View in PubMed

Tamoxifen-induced growth arrest and apoptosis in pituitary tumor cells in vitro via a protein kinase C-independent pathway Cancer Lett. 2002 Nov 28; 185(2):131-8. . View in PubMed