Tobias S Ulmer
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Molecular basis of Q-length selectivity for the MW1 antibody-huntingtin interaction J Biol Chem. 2023 Mar 15; 104616. . View in PubMed
Phosphorylation and stabilization of EZH2 by DCAF1/VprBP trigger aberrant gene silencing in colon cancer Nat Commun. 2023 04 17; 14(1):2140. . View in PubMed
Isothermal Titration Calorimetry of Membrane Proteins Methods Mol Biol. 2021; 2302:69-79. . View in PubMed
Insight Into Pathological Integrin aIIbß3 Activation From Safeguarding The Inactive State J Mol Biol. 2021 04 02; 433(7):166832. . View in PubMed
Topological Adaptation of Transmembrane Domains to the Force-Modulated Lipid Bilayer Is a Basis of Sensing Mechanical Force Curr Biol. 2020 Jul 06; 30(13):2649. . View in PubMed
Topological Adaptation of Transmembrane Domains to the Force-Modulated Lipid Bilayer Is a Basis of Sensing Mechanical ForceCurr Biol. 2020 05 04; 30(9):1614-1625. e5. . View in PubMed
p32 is a negative regulator of p53 tetramerization and transactivation Mol Oncol. 2019 09; 13(9):1976-1992. . View in PubMed
Universal principles of membrane protein assembly, composition and evolution PLoS One. 2019; 14(8):e0221372. . View in PubMed
H3K27me1 is essential for MMP-9-dependent H3N-terminal tail proteolysis during osteoclastogenesis Epigenetics Chromatin. 2018 05 28; 11(1):23. . View in PubMed
The folding equilibrium of huntingtin exon 1 monomer depends on its polyglutamine tract J Biol Chem. 2018 12 21; 293(51):19613-19623. . View in PubMed
Regulation of Breast Cancer-Induced Osteoclastogenesis by MacroH2A12 Involving EZH2-Mediated H3K27me3. Cell Rep. 2018 07 03; 24(1):224-237. . View in PubMed
Membrane Anchoring of a-Helical Proteins: Role of Tryptophan J Phys Chem B. 2018 01 25; 122(3):1185-1194. . View in PubMed
Evolutionarily conserved dual lysine motif determines the non-chaperone function of secreted Hsp90alpha in tumour progression Oncogene. 2017 04; 36(15):2160-2171. . View in PubMed
Direct Evaluation of Protein-Lipid Contacts Reveals Protein Membrane Immersion and Isotropic Bicelle Structure J Phys Chem Lett. 2016 Nov 03; 7(21):4420-4426. . View in PubMed
MMP-9 facilitates selective proteolysis of the histone H3 tail at genes necessary for proficient osteoclastogenesis Genes Dev. 2016 Jan 15; 30(2):208-19. . View in PubMed
Structural and thermodynamic basis of proline-induced transmembrane complex stabilization Sci Rep. 2016 07 20; 6:29809. . View in PubMed
A Conserved Ectodomain-Transmembrane Domain Linker Motif Tunes the Allosteric Regulation of Cell Surface Receptors J Biol Chem. 2016 08 19; 291(34):17536-46. . View in PubMed
Linker histone H12 establishes chromatin compaction and gene silencing through recognition of H3K27me3. Sci Rep. 2015 Nov 19; 5:16714. . View in PubMed
Cooperation between SMYD3 and PC4 drives a distinct transcriptional program in cancer cells Nucleic Acids Res. 2015 Oct 15; 43(18):8868-83. . View in PubMed
Mutation in CPT1C Associated With Pure Autosomal Dominant Spastic Paraplegia JAMA Neurol. 2015 May; 72(5):561-70. . View in PubMed
Annular anionic lipids stabilize the integrin aIIbß3 transmembrane complex J Biol Chem. 2015 Mar 27; 290(13):8283-93. . View in PubMed
Characterization of membrane protein interactions by isothermal titration calorimetry J Mol Biol. 2014 Oct 23; 426(21):3670-80. . View in PubMed
Sequence and membrane determinants of the random coil-helix transition of a-synuclein J Mol Biol. 2014 May 15; 426(10):2130-44. . View in PubMed
Structural characterization of the regulatory domain of brain carnitine palmitoyltransferase 1 Biopolymers. 2014 Apr; 101(4):398-405. . View in PubMed
Insight into a-synuclein plasticity and misfolding from differential micelle binding J Phys Chem B. 2013 Oct 03; 117(39):11448-59. . View in PubMed
Construction of covalent membrane protein complexes and high-throughput selection of membrane mimics J Am Chem Soc. 2012 Jun 06; 134(22):9030-3. . View in PubMed
A potentially common peptide target in secreted heat shock protein-90a for hypoxia-inducible factor-1a-positive tumors Mol Biol Cell. 2012 Feb; 23(4):602-13. . View in PubMed
Basic amino-acid side chains regulate transmembrane integrin signalling Nature. 2011 Dec 18; 481(7380):209-13. . View in PubMed
An environment-dependent structural switch underlies the regulation of carnitine palmitoyltransferase 1A J Biol Chem. 2011 Dec 09; 286(49):42545-42554. . View in PubMed
Recognition of enhancer element-specific histone methylation by TIP60 in transcriptional activation Nat Struct Mol Biol. 2011 Nov 13; 18(12):1358-65. . View in PubMed
Alpha-synuclein populates both elongated and broken helix states on small unilamellar vesicles J Biol Chem. 2011 Jun 17; 286(24):21450-7. . View in PubMed
A combinatorial NMR and EPR approach for evaluating the structural ensemble of partially folded proteins J Am Chem Soc. 2010 Jun 30; 132(25):8657-68. . View in PubMed
Structural basis of transmembrane domain interactions in integrin signaling Cell Adh Migr. 2010 Apr-Jun; 4(2):243-8. . View in PubMed
The clustering and spatial arrangement of beta-sheet sequence, but not order, govern alpha-synuclein fibrillogenesis Biochemistry. 2010 Feb 23; 49(7):1533-40. . View in PubMed
Effect of pseudorepeat rearrangement on alpha-synuclein misfolding, vesicle binding, and micelle binding J Mol Biol. 2009 Jul 17; 390(3):516-29. . View in PubMed
Interactions of platelet integrin alphaIIb and beta3 transmembrane domains in mammalian cell membranes and their role in integrin activation Blood. 2009 May 07; 113(19):4747-53. . View in PubMed
The structure of the integrin alphaIIbbeta3 transmembrane complex explains integrin transmembrane signalling EMBO J. 2009 May 06; 28(9):1351-61. . View in PubMed
Structure of the integrin alphaIIb transmembrane segment J Biol Chem. 2008 Jun 06; 283(23):16162-8. . View in PubMed
Characterization of alpha-synuclein interactions with selected aggregation-inhibiting small molecules Biochemistry. 2008 Apr 22; 47(16):4651-6. . View in PubMed
Structure of the integrin beta3 transmembrane segment in phospholipid bicelles and detergent micelles Biochemistry. 2008 Apr 01; 47(13):4008-16. . View in PubMed
Insight into disulfide bond catalysis in Chlamydia from the structure and function of DsbH, a novel oxidoreductase J Biol Chem. 2008 Jan 11; 283(2):824-32. . View in PubMed
NMR assignment of the periplasmic oxidoreductase DsbH from Chlamydia Biomol NMR Assign. 2007 Dec; 1(2):195-6. . View in PubMed
Comparison of structure and dynamics of micelle-bound human alpha-synuclein and Parkinson disease variants J Biol Chem. 2005 Dec 30; 280(52):43179-87. . View in PubMed
Structure and dynamics of micelle-bound human alpha-synuclein J Biol Chem. 2005 Mar 11; 280(10):9595-603. . View in PubMed
Quantitative J correlation methods for the accurate measurement of 13C'-13Calpha dipolar couplings in proteins J Biomol NMR. 2004 Oct; 30(2):181-94. . View in PubMed
Amide proton relaxation measurements employing a highly deuterated protein J Magn Reson. 2004 Feb; 166(2):190-201. . View in PubMed
Calcium dependence of the interaction between calmodulin and anthrax edema factor J Biol Chem. 2003 Aug 01; 278(31):29261-6. . View in PubMed
Evaluation of backbone proton positions and dynamics in a small protein by liquid crystal NMR spectroscopy J Am Chem Soc. 2003 Jul 30; 125(30):9179-91. . View in PubMed
Domain-specific interactions of talin with the membrane-proximal region of the integrin beta3 subunit Biochemistry. 2003 Jul 15; 42(27):8307-12. . View in PubMed
Structural determinants of integrin recognition by talin Mol Cell. 2003 Jan; 11(1):49-58. . View in PubMed
SH3-SH2 domain orientation in Src kinases: NMR studies of Fyn Structure. 2002 Jul; 10(7):901-11. . View in PubMed
NMR analysis of structure and dynamics of the cytosolic tails of integrin alpha IIb beta 3 in aqueous solution Biochemistry. 2001 Jun 26; 40(25):7498-508. . View in PubMed
A membrane-distal segment of the integrin alpha IIb cytoplasmic domain regulates integrin activation J Biol Chem. 2001 Jun 22; 276(25):22514-21. . View in PubMed
The role of the Src homology 3-Src homology 2 interface in the regulation of Src kinases J Biol Chem. 2001 May 18; 276(20):17199-205. . View in PubMed
His research program centers on elucidating the molecular mechanism underlying physiological function and pathological dysfunction, respectively, of biological processes at atomic resolution. Specifically, the three-dimensional structure of proteins, their dynamics as well as protein-protein and protein-lipid interactions are determined. As a principal research tool, high-resolution, multidimensional solution-state nuclear magnetic resonance (NMR) spectroscopy is employed. His overarching interest is devoted to the structural biology of proteins that are either membrane embedded or membrane surface-bound.
Specifically, his laboratory focuses on understanding
(1) the structural basis of transmembrane signaling in cell surface receptors, and
(2) the mechanism of carnitine palmitoyltransferase 1 regulation.
