Unmesh Jadhav

Assistant Professor of Stem Cell Biology and Regenerative Medicine

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Research Funding

High resolution characterization of epigenetic dynamics in gastrointestinal cell plasticity
NIH · R03DK134799 · Feb 1, 2023 – Jan 31, 2025 · Role: Principal Investigator
Coordinate roles of histone H3K27me3 and DNA methylation in intestinal homeostasis and tumorigenesis
NIH · K01DK113067 · Jan 1, 2018 – Nov 30, 2022 · Role: Principal Investigator
Role of histone H3K27me3 mark in intestinal homeostasis
NIH · F32DK103453 · Jul 1, 2014 – Jun 30, 2017 · Role: Principal Investigator

Reversible, Sexually Dimorphic Sympathetic Aging: Distal Axon Withdrawal Shaped by Prepubertal Gonadal Influences. bioRxiv. 2026 Sep 07.. View in PubMed
Epigenetic Gatekeeping of Intestinal Stem Cell Transformation. bioRxiv. 2026 Feb 03.. View in PubMed
A niche-dependent redox rheostat regulates epithelial stem cell fate. Nat Commun. 2025 11 28; 16(1):11713.. View in PubMed
Motif distribution and DNA methylation underlie distinct Cdx2 binding during development and homeostasis. Nat Commun. 2025 Jan 22; 16(1):929.. View in PubMed
Crypt density and recruited enhancers underlie intestinal tumour initiation. Nature. 2025 04; 640(8057):231-239.. View in PubMed
DNA methylation-dependent and -independent binding of CDX2 directs activation of distinct developmental and homeostatic genes. bioRxiv. 2024 Mar 07.. View in PubMed
Ornithine aminotransferase supports polyamine synthesis in pancreatic cancer. Nature. 2023 04; 616(7956):339-347.. View in PubMed
Epigenetic Regulation of Intestinal Stem Cells and Disease: A Balancing Act of DNA and Histone Methylation. Gastroenterology. 2021 06; 160(7):2267-2282.. View in PubMed
Creb5 establishes the competence for Prg4 expression in articular cartilage. Commun Biol. 2021 03 12; 4(1):332.. View in PubMed
Adaptation of pancreatic cancer cells to nutrient deprivation is reversible and requires glutamine synthetase stabilization by mTORC1. Proc Natl Acad Sci U S A. 2021 03 09; 118(10).. View in PubMed