Keck School Faculty

William Gauderman

William Gauderman

Professor of Population and Public Health Sciences
Medicine
SSB 202K 2001 N. Soto Street Health Sciences Campus Los Angeles

Gene-lifestyle interactions in the genomics of human complex traits Eur J Hum Genet. 2022 Jun; 30(6):730-739. . View in PubMed

Genome-Wide Interaction Analysis of Genetic Variants With Menopausal Hormone Therapy for Colorectal Cancer Risk J Natl Cancer Inst. 2022 08 08; 114(8):1135-1148. . View in PubMed

Beyond GWAS of Colorectal Cancer: Evidence of Interaction with Alcohol Consumption and Putative Causal Variant for the 10q242 Region. Cancer Epidemiol Biomarkers Prev. 2022 05 04; 31(5):1077-1089. . View in PubMed

Two-step hypothesis testing to detect gene-environment interactions in a genome-wide scan with a survival endpoint Stat Med. 2022 04 30; 41(9):1644-1657. . View in PubMed

A two-step approach to testing overall effect of gene-environment interaction for multiple phenotypes Bioinformatics. 2021 Jan 16. . View in PubMed

Multi-Ancestry Genome-wide Association Study Accounting for Gene-Psychosocial Factor Interactions Identifies Novel Loci for Blood Pressure Traits HGG Adv. 2021 Jan 14; 2(1). . View in PubMed

Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure Mol Psychiatry. 2021 11; 26(11):6293-6304. . View in PubMed

Genetic architectures of proximal and distal colorectal cancer are partly distinct Gut. 2021 07; 70(7):1325-1334. . View in PubMed

Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci Mol Psychiatry. 2021 06; 26(6):2111-2125. . View in PubMed

Childhood traffic-related air pollution and adverse changes in subclinical atherosclerosis measures from childhood to adulthood Environ Health. 2021 04 14; 20(1):44. . View in PubMed

Mapping the 17q12-211 Locus for Variants Associated with Early-Onset Asthma in African Americans. Am J Respir Crit Care Med. 2021 02 15; 203(4):424-436. . View in PubMed

Increased burden of familial-associated early-onset cancer risk among minority Americans compared to non-Latino Whites Elife. 2021 06 22; 10. . View in PubMed

Hierarchical Bayesian estimation of covariate effects on airway and alveolar nitric oxide Sci Rep. 2021 08 25; 11(1):17180. . View in PubMed

A genome-wide association study on medulloblastoma J Neurooncol. 2020 Apr; 147(2):309-315. . View in PubMed

A Cross-Sectional Study Examining the Seroprevalence of Severe Acute Respiratory Syndrome Coronavirus 2 Antibodies in a University Student Population J Adolesc Health. 2020 12; 67(6):763-768. . View in PubMed

Functional informed genome-wide interaction analysis of body mass index, diabetes and colorectal cancer risk Cancer Med. 2020 05; 9(10):3563-3573. . View in PubMed

Asthma and its relationship to mitochondrial copy number: Results from the Asthma Translational Genomics Collaborative (ATGC) of the Trans-Omics for Precision Medicine (TOPMed) program PLoS One. 2020; 15(11):e0242364. . View in PubMed

Pediatric glioma and medulloblastoma risk and population demographics: a Poisson regression analysis Neurooncol Adv. 2020 Jan-Dec; 2(1):vdaa089. . View in PubMed

The Potential Effects of Policy-driven Air Pollution Interventions on Childhood Lung Development Am J Respir Crit Care Med. 2020 02 15; 201(4):438-444. . View in PubMed

Immune factors preceding diagnosis of glioma: a Prostate Lung Colorectal Ovarian Cancer Screening Trial nested case-control study Neurooncol Adv. 2019 May-Dec; 1(1):vdz031. . View in PubMed

Shift Work, Chronotype, and Melatonin Rhythm in Nurses Cancer Epidemiol Biomarkers Prev. 2019 07; 28(7):1177-1186. . View in PubMed

Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids Nat Genet. 2019 04; 51(4):636-648. . View in PubMed

Genet Epidemiol. 2019 03; 43(2):150-165. . View in PubMed

An admixture mapping meta-analysis implicates genetic variation at 18q21 with asthma susceptibility in Latinos J Allergy Clin Immunol. 2019 03; 143(3):957-969. . View in PubMed

Discovery of common and rare genetic risk variants for colorectal cancer Nat Genet. 2019 01; 51(1):76-87. . View in PubMed

Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity Nat Commun. 2019 01 22; 10(1):376. . View in PubMed

A Unified Model for the Analysis of Gene-Environment Interaction Am J Epidemiol. 2019 04 01; 188(4):760-767. . View in PubMed

A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure Hum Mol Genet. 2019 08 01; 28(15):2615-2633. . View in PubMed

Novel Common Genetic Susceptibility Loci for Colorectal Cancer J Natl Cancer Inst. 2019 02 01; 111(2):146-157. . View in PubMed

Multiancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions Am J Epidemiol. 2019 06 01; 188(6):1033-1054. . View in PubMed

A trans-ancestral meta-analysis of genome-wide association studies reveals loci associated with childhood obesity Hum Mol Genet. 2019 10 01; 28(19):3327-3338. . View in PubMed

Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration Nat Commun. 2019 11 12; 10(1):5121. . View in PubMed

Factors Associated with Prevalent Diabetic Retinopathy in Chinese Americans: The Chinese American Eye Study Ophthalmol Retina. 2018 Feb; 2(2):96-105. . View in PubMed

Gene Coexpression Networks in Whole Blood Implicate Multiple Interrelated Molecular Pathways in Obesity in People with Asthma Obesity (Silver Spring). 2018 12; 26(12):1938-1948. . View in PubMed

Author Correction: Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis Nat Genet. 2018 09; 50(9):1343. . View in PubMed

Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis Nat Genet. 2018 08; 50(8):1072-1080. . View in PubMed

Role of local CpG DNA methylation in mediating the 17q21 asthma susceptibility gasdermin B (GSDMB)/ORMDL sphingolipid biosynthesis regulator 3 (ORMDL3) expression quantitative trait locusJ Allergy Clin Immunol. 2018 06; 141(6):2282-2286. e6. . View in PubMed

Air pollution, weight loss and metabolic benefits of bariatric surgery: a potential model for study of metabolic effects of environmental exposures Pediatr Obes. 2018 05; 13(5):312-320. . View in PubMed

Factors Associated with Age-Related Macular Degeneration in Chinese American Adults: The Chinese American Eye Study (CHES) Ophthalmol Retina. 2018 03; 2(3):209-216. . View in PubMed

Dietary Nutrient Intake, Ethnicity, and Epigenetic Silencing of Lung Cancer Genes Detected in Sputum in New Mexican Smokers Cancer Prev Res (Phila). 2018 02; 11(2):93-102. . View in PubMed

Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries PLoS One. 2018; 13(6):e0198166. . View in PubMed

Traffic-Related Pollutants: Exposure and Health Effects Among Hispanic Children Am J Epidemiol. 2018 01 01; 187(1):45-52. . View in PubMed

A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure Am J Hum Genet. 2018 03 01; 102(3):375-400. . View in PubMed

Genetic-Epigenetic Interactions in Asthma Revealed by a Genome-Wide Gene-Centric Search Hum Hered. 2018; 83(3):130-152. . View in PubMed

Update on the State of the Science for Analytical Methods for Gene-Environment Interactions Am J Epidemiol. 2017 Oct 01; 186(7):762-770. . View in PubMed

Current Challenges and New Opportunities for Gene-Environment Interaction Studies of Complex Diseases Am J Epidemiol. 2017 Oct 01; 186(7):753-761. . View in PubMed

Lessons Learned From Past Gene-Environment Interaction Successes Am J Epidemiol. 2017 Oct 01; 186(7):778-786. . View in PubMed

Multiancestry Study of Gene-Lifestyle Interactions for Cardiovascular Traits in 610 475 Individuals From 124 Cohorts: Design and Rationale Circ Cardiovasc Genet. 2017 Jun; 10(3). . View in PubMed

Trends in childhood leukemia incidence over two decades from 1992 to 2013 Int J Cancer. 2017 Mar 01; 140(5):1000-1008. . View in PubMed

Gene Expression Profiling in Blood Provides Reproducible Molecular Insights into Asthma Control Am J Respir Crit Care Med. 2017 01 15; 195(2):179-188. . View in PubMed

Dietary nutrients associated with preservation of lung function in Hispanic and non-Hispanic white smokers from New Mexico Int J Chron Obstruct Pulmon Dis. 2017; 12:3171-3181. . View in PubMed

The Effects of Policy-Driven Air Quality Improvements on Children's Respiratory Health Res Rep Health Eff Inst. 2017 Jan; (190):1-75. . View in PubMed

Genome-Wide Interaction Analysis of Air Pollution Exposure and Childhood Asthma with Functional Follow-up Am J Respir Crit Care Med. 2017 05 15; 195(10):1373-1383. . View in PubMed

Association of Changes in Air Quality With Bronchitic Symptoms in Children in California, 1993-2012 JAMA. 2016 Apr 12; 315(14):1491-501. . View in PubMed

Increased yield of actionable mutations using multi-gene panels to assess hereditary cancer susceptibility in an ethnically diverse clinical cohort Cancer Genet. 2016 Apr; 209(4):130-7. . View in PubMed

Adaptive Set-Based Methods for Association Testing Genet Epidemiol. 2016 Feb; 40(2):113-22. . View in PubMed

E-cigarettes, Cigarettes, and the Prevalence of Adolescent Tobacco Use Pediatrics. 2016 08; 138(2). . View in PubMed

An Empirical Comparison of Joint and Stratified Frameworks for Studying G × E Interactions: Systolic Blood Pressure and Smoking in the CHARGE Gene-Lifestyle Interactions Working Group Genet Epidemiol. 2016 07; 40(5):404-15. . View in PubMed

Detecting Gene-Environment Interactions for a Quantitative Trait in a Genome-Wide Association Study Genet Epidemiol. 2016 07; 40(5):394-403. . View in PubMed

Genome-wide association study identifies WNT7B as a novel locus for central corneal thickness in Latinos Hum Mol Genet. 2016 11 15; 25(22):5035-5045. . View in PubMed

Age-Related Macular Degeneration and Quality of Life in Latinos: The Los Angeles Latino Eye Study JAMA Ophthalmol. 2016 06 01; 134(6):683-90. . View in PubMed

Correction: Inducible Nitric Oxide Synthase Promoter Haplotypes and Residential Traffic-Related Air Pollution Jointly Influence Exhaled Nitric Oxide Level in Children PLoS One. 2016; 11(5):e0155567. . View in PubMed

Air Pollution and Lung Function in Minority Youth with Asthma in the GALA II (Genes-Environments and Admixture in Latino Americans) and SAGE II (Study of African Americans, Asthma, Genes, and Environments) Studies Am J Respir Crit Care Med. 2016 06 01; 193(11):1271-80. . View in PubMed

Corrigendum: genome-wide association study of colorectal cancer identifies six new susceptibility loci Nat Commun. 2015 Oct 26; 6:8739. . View in PubMed

Genome-wide association study of colorectal cancer identifies six new susceptibility loci Nat Commun. 2015 Jul 07; 6:7138. . View in PubMed

Rising rates of acute lymphoblastic leukemia in Hispanic children: trends in incidence from 1992 to 2011 Blood. 2015 May 07; 125(19):3033-4. . View in PubMed

Association of aspirin and NSAID use with risk of colorectal cancer according to genetic variants JAMA. 2015 Mar 17; 313(11):1133-42. . View in PubMed

Association of improved air quality with lung development in children N Engl J Med. 2015 Mar 05; 372(10):905-13. . View in PubMed

15q12 variants, sputum gene promoter hypermethylation, and lung cancer risk: a GWAS in smokers J Natl Cancer Inst. 2015 Feb 23; 107(5). . View in PubMed

Ethnic-specific associations of rare and low-frequency DNA sequence variants with asthma Nat Commun. 2015 Jan 16; 6:5965. . View in PubMed

Genetic ancestry influences asthma susceptibility and lung function among Latinos J Allergy Clin Immunol. 2015 Jan; 135(1):228-35. . View in PubMed

Inducible Nitric Oxide Synthase Promoter Haplotypes and Residential Traffic-Related Air Pollution Jointly Influence Exhaled Nitric Oxide Level in Children PLoS One. 2015; 10(12):e0145363. . View in PubMed

No evidence of gene-calcium interactions from genome-wide analysis of colorectal cancer risk Cancer Epidemiol Biomarkers Prev. 2014 Dec; 23(12):2971-6. . View in PubMed

Genome-wide interaction studies reveal sex-specific asthma risk alleles Hum Mol Genet. 2014 Oct 01; 23(19):5251-9. . View in PubMed

Native American ancestry is associated with severe diabetic retinopathy in Latinos Invest Ophthalmol Vis Sci. 2014 Aug 21; 55(9):6041-5. . View in PubMed

Integrated genome-wide association, coexpression network, and expression single nucleotide polymorphism analysis identifies novel pathway in allergic rhinitis BMC Med Genomics. 2014 Aug 02; 7:48. . View in PubMed

Fraction of exhaled nitric oxide values in childhood are associated with 17q112-q12 and 17q12-q21 variants. J Allergy Clin Immunol. 2014 Jul; 134(1):46-55. . View in PubMed

Associations of children's lung function with ambient air pollution: joint effects of regional and near-roadway pollutants Thorax. 2014 Jun; 69(6):540-7. . View in PubMed

NOS1 methylation and carotid artery intima-media thickness in children Circ Cardiovasc Genet. 2014 Apr; 7(2):116-22. . View in PubMed

Genome-wide diet-gene interaction analyses for risk of colorectal cancer PLoS Genet. 2014 Apr; 10(4):e1004228. . View in PubMed

Native American ancestry affects the risk for gene methylation in the lungs of Hispanic smokers from New Mexico Am J Respir Crit Care Med. 2013 Nov 01; 188(9):1110-6. . View in PubMed

Finding novel genes by testing G × E interactions in a genome-wide association study Genet Epidemiol. 2013 Sep; 37(6):603-13. . View in PubMed

Childhood infections and adult height in monozygotic twin pairs Am J Epidemiol. 2013 Aug 15; 178(4):551-8. . View in PubMed

Efficient two-step testing of gene-gene interactions in genome-wide association studies Genet Epidemiol. 2013 Jul; 37(5):440-51. . View in PubMed

A genome-wide association study of central corneal thickness in Latinos Invest Ophthalmol Vis Sci. 2013 Apr 01; 54(4):2435-43. . View in PubMed

A meta-analysis of genome-wide association studies for serum total IgE in diverse study populations J Allergy Clin Immunol. 2013 Apr; 131(4):1176-84. . View in PubMed

Confounding and heterogeneity in genetic association studies with admixed populations Am J Epidemiol. 2013 Feb 15; 177(4):351-60. . View in PubMed

Integration of mouse and human genome-wide association data identifies KCNIP4 as an asthma gene PLoS One. 2013; 8(2):e56179. . View in PubMed

Parental smoking and risk of childhood brain tumors by functional polymorphisms in polycyclic aromatic hydrocarbon metabolism genes PLoS One. 2013; 8(11):e79110. . View in PubMed

Further replication studies of the EVE Consortium meta-analysis identifies 2 asthma risk loci in European Americans J Allergy Clin Immunol. 2012 Dec; 130(6):1294-301. . View in PubMed

Accuracy of a new time-resolved step counter in children Pediatr Exerc Sci. 2012 Nov; 24(4):622-33. . View in PubMed

A genome-wide association meta-analysis identifies new childhood obesity loci Nat Genet. 2012 May; 44(5):526-31. . View in PubMed

Predictors of intra-community variation in air quality J Expo Sci Environ Epidemiol. 2012 Mar-Apr; 22(2):135-47. . View in PubMed

Invited commentary: GE-Whiz! Ratcheting gene-environment studies up to the whole genome and the whole exposome Am J Epidemiol. 2012 Feb 01; 175(3):203-7; discussion 208-9. . View in PubMed

Genotype Imputation for Latinos Using the HapMap and 1000 Genomes Project Reference Panels Front Genet. 2012; 3:117. . View in PubMed

Using extreme phenotype sampling to identify the rare causal variants of quantitative traits in association studies Genet Epidemiol. 2011 Dec; 35(8):790-9. . View in PubMed

Parental stress increases the detrimental effect of traffic exposure on children's lung function Am J Respir Crit Care Med. 2011 Oct 01; 184(7):822-7. . View in PubMed

Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations Nat Genet. 2011 Jul 31; 43(9):887-92. . View in PubMed

Association of the calcyon neuron-specific vesicular protein gene (CALY) with adolescent smoking initiation in China and California Am J Epidemiol. 2011 May 01; 173(9):1039-48. . View in PubMed

Sample size requirements to detect gene-environment interactions in genome-wide association studies Genet Epidemiol. 2011 Apr; 35(3):201-10. . View in PubMed

Genetic variations in nitric oxide synthase and arginase influence exhaled nitric oxide levels in children Allergy. 2011 Mar; 66(3):412-9. . View in PubMed

Genetic variation in the glutathione synthesis pathway, air pollution, and children's lung function growth Am J Respir Crit Care Med. 2011 Jan 15; 183(2):243-8. . View in PubMed

TSLP polymorphisms are associated with asthma in a sex-specific fashion Allergy. 2010 Dec; 65(12):1566-75. . View in PubMed

PDE11A associations with asthma: results of a genome-wide association scanJ Allergy Clin Immunol. 2010 Oct; 126(4):871-873. e9. . View in PubMed

Discovery of complex pathways from observational data Stat Med. 2010 Aug 30; 29(19):1998-2011. . View in PubMed

Efficient genome-wide association testing of gene-environment interaction in case-parent trios Am J Epidemiol. 2010 Jul 01; 172(1):116-22. . View in PubMed

Role of inducible nitric oxide synthase in asthma risk and lung function growth during adolescence Thorax. 2010 Feb; 65(2):139-45. . View in PubMed

Functional variants in the catalase and myeloperoxidase genes, ambient air pollution, and respiratory-related school absences: an example of epistasis in gene-environment interactions Am J Epidemiol. 2009 Dec 15; 170(12):1494-501. . View in PubMed

Genetic Analysis Workshop 16: Strategies for genome-wide association study analyses BMC Proc. 2009 Dec 15; 3 Suppl 7:S1. . View in PubMed

Respiratory symptoms following wildfire smoke exposure: airway size as a susceptibility factor Epidemiology. 2009 May; 20(3):451-9. . View in PubMed

Genome-wide association analysis identifies PDE4D as an asthma-susceptibility gene Am J Hum Genet. 2009 May; 84(5):581-93. . View in PubMed

In utero smoke exposure, glutathione S-transferase P1 haplotypes, and respiratory illness-related absence among schoolchildren Pediatrics. 2009 May; 123(5):1344-51. . View in PubMed

Variation in the GST mu locus and tobacco smoke exposure as determinants of childhood lung function Am J Respir Crit Care Med. 2009 Apr 01; 179(7):601-7. . View in PubMed

Glutathione-S-transferase (GST) P1, GSTM1, exercise, ozone and asthma incidence in school children Thorax. 2009 Mar; 64(3):197-202. . View in PubMed

Roles of arginase variants, atopy, and ozone in childhood asthmaJ Allergy Clin Immunol. 2009 Mar; 123(3):596-602602. e1-8. . View in PubMed

Gene-environment interaction in genome-wide association studies Am J Epidemiol. 2009 Jan 15; 169(2):219-26. . View in PubMed

Detecting gene-environment interactions in genome-wide association data Genet Epidemiol. 2009; 33 Suppl 1:S68-73. . View in PubMed

Traffic-related air pollution and asthma onset in children: a prospective cohort study with individual exposure measurement Environ Health Perspect. 2008 Oct; 116(10):1433-8. . View in PubMed

Effects of in utero and childhood tobacco smoke exposure and beta2-adrenergic receptor genotype on childhood asthma and wheezing Pediatrics. 2008 Jul; 122(1):e107-14. . View in PubMed

Interleukin-2, interleukin-12, and interferon-gamma levels and risk of young adult Hodgkin lymphoma Blood. 2008 Apr 01; 111(7):3377-82. . View in PubMed

Use of an electrostatic dust cloth for self-administered home allergen collection Twin Res Hum Genet. 2008 Apr; 11(2):150-5. . View in PubMed

Glutathione S-transferase P1, maternal smoking, and asthma in children: a haplotype-based analysis Environ Health Perspect. 2008 Mar; 116(3):409-15. . View in PubMed

Ozone, oxidant defense genes, and risk of asthma during adolescence Am J Respir Crit Care Med. 2008 Feb 15; 177(4):388-95. . View in PubMed

Transforming growth factor- 1 C-509T polymorphism, oxidant stress, and early-onset childhood asthma Am J Respir Crit Care Med. 2007 Dec 15; 176(12):1192-9. . View in PubMed

Microsomal epoxide hydrolase, glutathione S-transferase P1, traffic and childhood asthma Thorax. 2007 Dec; 62(12):1050-7. . View in PubMed

Relationship between air pollution, lung function and asthma in adolescents Thorax. 2007 Nov; 62(11):957-63. . View in PubMed

Childhood sun exposure influences risk of multiple sclerosis in monozygotic twins Neurology. 2007 Jul 24; 69(4):381-8. . View in PubMed

Testing association between disease and multiple SNPs in a candidate gene Genet Epidemiol. 2007 Jul; 31(5):383-95. . View in PubMed

The ADRB3 Trp64Arg variant and obesity in African-American breast cancer cases Int J Obes (Lond). 2007 Jul; 31(7):1110-8. . View in PubMed

Indoor time-microenvironment-activity patterns in seven regions of Europe J Expo Sci Environ Epidemiol. 2007 Mar; 17(2):170-81. . View in PubMed

Effect of exposure to traffic on lung development from 10 to 18 years of age: a cohort study Lancet. 2007 Feb 17; 369(9561):571-7. . View in PubMed

Exploiting gene-environment interaction to detect genetic associations Hum Hered. 2007; 63(2):111-9. . View in PubMed

Dog ownership enhances symptomatic responses to air pollution in children with asthma Environ Health Perspect. 2006 Dec; 114(12):1910-5. . View in PubMed

Health effects of the 2003 Southern California wildfires on children Am J Respir Crit Care Med. 2006 Dec 01; 174(11):1221-8. . View in PubMed

Regular smoking and asthma incidence in adolescents Am J Respir Crit Care Med. 2006 Nov 15; 174(10):1094-100. . View in PubMed

Air pollution and children--an unhealthy mix N Engl J Med. 2006 Jul 06; 355(1):78-9. . View in PubMed

Differential twin concordance for multiple sclerosis by latitude of birthplace Ann Neurol. 2006 Jul; 60(1):56-64. . View in PubMed

Associations of tumor necrosis factor G-308A with childhood asthma and wheezing Am J Respir Crit Care Med. 2006 May 01; 173(9):970-6. . View in PubMed

A testing framework for identifying susceptibility genes in the presence of epistasis Am J Hum Genet. 2006 Jan; 78(1):15-27. . View in PubMed

Identifying susceptibility genes by using joint tests of association and linkage and accounting for epistasis BMC Genet. 2005 Dec 30; 6 Suppl 1:S147. . View in PubMed

TNF-308 modifies the effect of second-hand smoke on respiratory illness-related school absences Am J Respir Crit Care Med. 2005 Dec 15; 172(12):1563-8. . View in PubMed

Testing association and linkage using affected-sib-parent study designs Genet Epidemiol. 2005 Nov; 29(3):225-33. . View in PubMed

Childhood asthma and exposure to traffic and nitrogen dioxide Epidemiology. 2005 Nov; 16(6):737-43. . View in PubMed

Intercellular adhesion molecule-1 and childhood asthma Hum Genet. 2005 Sep; 117(5):476-84. . View in PubMed

SNPs, haplotypes, and model selection in a candidate gene region: the SIMPle analysis for multilocus data Genet Epidemiol. 2004 Dec; 27(4):429-41. . View in PubMed

Effects of ambient air pollutants on asthma medication use and wheezing among fourth-grade school children from 12 Southern California communities enrolled in The Children's Health Study Arch Environ Health. 2004 Oct; 59(10):505-14. . View in PubMed

The effect of air pollution on lung development from 10 to 18 years of age N Engl J Med. 2004 Sep 09; 351(11):1057-67. . View in PubMed

IL-6 levels and genotype are associated with risk of young adult Hodgkin lymphoma Blood. 2004 Apr 15; 103(8):3216-21. . View in PubMed

Polymorphism in the androgen receptor and mammographic density in women taking and not taking estrogen and progestin therapy Cancer Res. 2004 Feb 15; 64(4):1237-41. . View in PubMed

Does mammographic density reflect ethnic differences in breast cancer incidence rates? Am J Epidemiol. 2004 Jan 15; 159(2):140-7.. View in PubMed

Multiple imputation methods for longitudinal blood pressure measurements from the Framingham Heart Study BMC Genet. 2003 Dec 31; 4 Suppl 1:S43. . View in PubMed

Segregation and linkage analysis for longitudinal measurements of a quantitative trait BMC Genet. 2003 Dec 31; 4 Suppl 1:S21. . View in PubMed

Candidate gene association analysis for a quantitative trait, using parent-offspring trios Genet Epidemiol. 2003 Dec; 25(4):327-38. . View in PubMed

Prospective study of air pollution and bronchitic symptoms in children with asthma Am J Respir Crit Care Med. 2003 Oct 01; 168(7):790-7. . View in PubMed

Children's lung function and antioxidant vitamin, fruit, juice, and vegetable intake Am J Epidemiol. 2003 Sep 15; 158(6):576-84. . View in PubMed

Obesity and the risk of newly diagnosed asthma in school-age children Am J Epidemiol. 2003 Sep 01; 158(5):406-15. . View in PubMed

Environmental tobacco smoke and absenteeism related to respiratory illness in schoolchildren Am J Epidemiol. 2003 May 15; 157(10):861-9. . View in PubMed

Regression models for linkage: issues of traits, covariates, heterogeneity, and interaction Hum Hered. 2003; 55(2-3):86-96. . View in PubMed

Longitudinal data analysis in pedigree studies Genet Epidemiol. 2003; 25 Suppl 1:S18-28. . View in PubMed

Effects of glutathione-S-transferase M1, T1, and P1 on childhood lung function growth Am J Respir Crit Care Med. 2002 Sep 01; 166(5):710-6. . View in PubMed

Effects of glutathione S-transferase M1, maternal smoking during pregnancy, and environmental tobacco smoke on asthma and wheezing in children Am J Respir Crit Care Med. 2002 Aug 15; 166(4):457-63. . View in PubMed

Impact of respiratory illness on expiratory flow rates in normal, asthmatic, and allergic children Pediatr Pulmonol. 2002 Aug; 34(2):112-21. . View in PubMed

Effects of glutathione S-transferase P1, M1, and T1 on acute respiratory illness in school children Am J Respir Crit Care Med. 2002 Aug 01; 166(3):346-51. . View in PubMed

Association between air pollution and lung function growth in southern California children: results from a second cohort Am J Respir Crit Care Med. 2002 Jul 01; 166(1):76-84. . View in PubMed

Indoor risk factors for asthma in a prospective study of adolescents Epidemiology. 2002 May; 13(3):288-95. . View in PubMed

Sample size requirements for association studies of gene-gene interaction Am J Epidemiol. 2002 Mar 01; 155(5):478-84. . View in PubMed

Asthma in exercising children exposed to ozone: a cohort study Lancet. 2002 Feb 02; 359(9304):386-91. . View in PubMed

Sample size requirements for matched case-control studies of gene-environment interaction Stat Med. 2002 Jan 15; 21(1):35-50. . View in PubMed

Respiratory effects of relocating to areas of differing air pollution levels Am J Respir Crit Care Med. 2001 Dec 01; 164(11):2067-72. . View in PubMed

Should we consider gene x environment interaction in the hunt for quantitative trait loci? Genet Epidemiol. 2001; 21 Suppl 1:S831-6.. View in PubMed

The effects of ambient air pollution on school absenteeism due to respiratory illnesses Epidemiology. 2001 Jan; 12(1):43-54. . View in PubMed

The role of interacting determinants in the localization of genes Adv Genet. 2001; 42:393-412. . View in PubMed

Gene-environment interaction and affected sib pair linkage analysis Hum Hered. 2001; 52(1):34-46. . View in PubMed

Association tests in nuclear families Hum Hered. 2001; 52(2):66-76. . View in PubMed

Combined linkage and association analysis in pedigrees Genet Epidemiol. 2001; 21 Suppl 1:S358-63. . View in PubMed

Effects of in utero and environmental tobacco smoke exposure on lung function in boys and girls with and without asthma Am J Respir Crit Care Med. 2000 Dec; 162(6):2097-104. . View in PubMed

Sex-specific effects of asthma on pulmonary function in children Am J Respir Crit Care Med. 2000 Nov; 162(5):1723-30. . View in PubMed

Association between air pollution and lung function growth in southern California children Am J Respir Crit Care Med. 2000 Oct; 162(4 Pt 1):1383-90. . View in PubMed

Maternal smoking during pregnancy, environmental tobacco smoke exposure and childhood lung function Thorax. 2000 Apr; 55(4):271-6. . View in PubMed

The role of restricted motility in determining outcomes for vertical strabismus surgery in Graves' ophthalmology Ophthalmology. 2000 Mar; 107(3):545-9. . View in PubMed

Evidence for age-specific genetic relative risks in lung cancer Am J Epidemiol. 2000 Jan 01; 151(1):41-9. . View in PubMed

Air pollution and bronchitic symptoms in Southern California children with asthma Environ Health Perspect. 1999 Sep; 107(9):757-60. . View in PubMed

Asymptotic bias and efficiency in case-control studies of candidate genes and gene-environment interactions: basic family designs Am J Epidemiol. 1999 Apr 15; 149(8):693-705. . View in PubMed

Genome-wide screen for systemic lupus erythematosus susceptibility genes in multiplex families Hum Mol Genet. 1999 Apr; 8(4):639-44. . View in PubMed

A study of twelve Southern California communities with differing levels and types of air pollutionII. Effects on pulmonary function. Am J Respir Crit Care Med. 1999 Mar; 159(3):768-75. . View in PubMed

A study of twelve Southern California communities with differing levels and types of air pollutionI. Prevalence of respiratory morbidity. Am J Respir Crit Care Med. 1999 Mar; 159(3):760-7. . View in PubMed

Association tests using unaffected-sibling versus pseudo-sibling controls Genet Epidemiol. 1999; 17 Suppl 1:S731-6. . View in PubMed

Study-design issues in the development of the University of Southern California Consortium's Colorectal Cancer Family Registry J Natl Cancer Inst Monogr. 1999; (26):89-93. . View in PubMed

A generalized estimating equations approach to linkage analysis in sibships in relation to multiple markers and exposure factors Genet Epidemiol. 1999; 17 Suppl 1:S737-42. . View in PubMed

Family-based association studies J Natl Cancer Inst Monogr. 1999; (26):31-7. . View in PubMed

A joint test of linkage and gene x environment interaction, with affected sib pairs Genet Epidemiol. 1999; 17 Suppl 1:S563-8. . View in PubMed

Synergistic effect between IL-10 and bcl-2 genotypes in determining susceptibility to systemic lupus erythematosus Arthritis Rheum. 1998 Apr; 41(4):596-602. . View in PubMed

Detection of gene-environment interactions in joint segregation and linkage analysis Am J Hum Genet. 1997 Nov; 61(5):1189-99. . View in PubMed

Analysis of gene-smoking interaction in lung cancer Genet Epidemiol. 1997; 14(2):199-214. . View in PubMed

Joint segregation and linkage analysis of a quantitative trait compared to separate analyses Genet Epidemiol. 1997; 14(6):993-8. . View in PubMed

Association between the Rfp-Y haplotype and the incidence of Marek's disease in chickens Immunogenetics. 1996; 44(4):242-5. . View in PubMed

Ocular infections West J Med. 1995 Mar; 162(3):277. . View in PubMed

Genetic epidemiologic analysis of quantitative phenotypes using Gibbs sampling Genet Epidemiol. 1995; 12(6):753-8. . View in PubMed

Censored survival models for genetic epidemiology: a Gibbs sampling approach Genet Epidemiol. 1994; 11(2):171-88. . View in PubMed

A bivariate genetic analysis of HDL- and LDL-cholesterol incorporating measured covariates: a Gibbs sampling application Genet Epidemiol. 1993; 10(6):623-8. . View in PubMed

Combined segregation and linkage analysis of late-onset Alzheimer's disease in Duke families using Gibbs sampling Genet Epidemiol. 1993; 10(6):489-94. . View in PubMed

Community care of corneal ulcers Am J Ophthalmol. 1992 Nov 15; 114(5):531-8. . View in PubMed

Anti-inflammatory therapy and outcome in a guinea pig model of Pseudomonas keratitis Cornea. 1992 Sep; 11(5):398-403. . View in PubMed

Sample size calculations for ophthalmologic studies Arch Ophthalmol. 1992 May; 110(5):690-2. . View in PubMed

Intravitreal penetration of oral ciprofloxacin in humans Ophthalmology. 1992 Apr; 99(4):483-6. . View in PubMed

Diurnal variation of corneal topography after radial keratotomy Arch Ophthalmol. 1992 Mar; 110(3):351-6. . View in PubMed

Anti-inflammatory effects of vitamin E on experimental lens-induced uveitis Int Ophthalmol. 1992 Jan; 16(1):27-32. . View in PubMed

Computer-assisted study of diurnal variation in corneal topography after penetrating keratoplasty Ophthalmic Surg. 1992 Jan; 23(1):10-6. . View in PubMed

Pituitary tumor volume as a predictor of postoperative visual field recoveryQuantitative analysis using automated static perimetry and computed tomography morphometry. J Clin Neuroophthalmol. 1991 Dec; 11(4):280-3. . View in PubMed

Pars plana vitrectomy for acute retinal detachment in penetrating ocular injuries Arch Ophthalmol. 1990 Dec; 108(12):1724-8. . View in PubMed

Clearance rate of macrophages from the vitreous in rabbits Curr Eye Res. 1990 Jul; 9(7):683-6. . View in PubMed

Dr. Gauderman's research falls into two distinct areas:

1) developing statistical methods for genetic-epidemiologic analysis of pedigree data; 2) design and analysis of studies relating health outcomes to environmental exposures. In the field of genetic-epidemiology, he has developed models and methods of estimation for complex traits that depend on both genetic and environment causes, possibly interacting. He has evaluated a technique known as joint segregation and linkage analysis and has found it to be an efficient strategy both for detecting linkage and for estimating gene-environment interactions when the disease gene has not yet been identified. He has also compared various case-control designs for studying measured genes (e.g. candidate genes). In the field of environmental health, he works with the Children's Health Study, a multi-community study of lung function and respiratory health in school-aged children in the Southern California area. The ultimate goal of this research is to determine whether air pollution, or particular components of air pollution such as ozone, is associated with reduced lung growth and increased incidence of asthma, bronchitis, and other respiratory illnesses. He is also the principal investigator of the biostatistics core of the NIEHS Center, and thus is available for statistical consultation for projects involving environmental health.
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