William Gauderman, PhD

Professor of Population and Public Health Sciences

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Overview

Dr. Gauderman’s research falls into two distinct areas:

1) developing statistical methods for genetic-epidemiologic analysis of pedigree data; 2) design and analysis of studies relating health outcomes to environmental exposures. In the field of genetic-epidemiology, he has developed models and methods of estimation for complex traits that depend on both genetic and environment causes, possibly interacting. He has evaluated a technique known as joint segregation and linkage analysis and has found it to be an efficient strategy both for detecting linkage and for estimating gene-environment interactions when the disease gene has not yet been identified. He has also compared various case-control designs for studying measured genes (e.g. candidate genes). In the field of environmental health, he works with the Children’s Health Study, a multi-community study of lung function and respiratory health in school-aged children in the Southern California area. The ultimate goal of this research is to determine whether air pollution, or particular components of air pollution such as ozone, is associated with reduced lung growth and increased incidence of asthma, bronchitis, and other respiratory illnesses. He is also the principal investigator of the biostatistics core of the NIEHS Center, and thus is available for statistical consultation for projects involving environmental health.

Publications

  • Genome-wide interaction study of dietary intake of fibre, fruits, and vegetables with risk of colorectal cancer EBioMedicine. 2024 Jun; 104:105146. . View in PubMed
  • Two genome-wide interaction loci modify the association of nonsteroidal anti-inflammatory drugs with colorectal cancer Sci Adv. 2024 May 31; 10(22):eadk3121. . View in PubMed
  • Author Correction: Trans-ancestral genome-wide association study of longitudinal pubertal height growth and shared heritability with adult health outcomes Genome Biol. 2024 May 21; 25(1):129. . View in PubMed
  • J Expo Sci Environ Epidemiol. 2024 May 07. . View in PubMed
  • Fine-mapping analysis including over 254,000 East Asian and European descendants identifies 136 putative colorectal cancer susceptibility genes Nat Commun. 2024 Apr 26; 15(1):3557. . View in PubMed
  • An approach to identify gene-environment interactions and reveal new biological insight in complex traits Nat Commun. 2024 Apr 22; 15(1):3385. . View in PubMed
  • Genetic risk impacts the association of menopausal hormone therapy with colorectal cancer risk Br J Cancer. 2024 Apr 01. . View in PubMed
  • Genome-Wide Interaction Analysis With DASH Diet Score Identified Novel Loci for Systolic Blood Pressure Hypertension. 2024 Mar; 81(3):552-560. . View in PubMed
  • Perceived Stress From Childhood to Adulthood and Cardiometabolic End Points in Young Adulthood: An 18-Year Prospective Study J Am Heart Assoc. 2024 Feb 06; 13(3):e030741. . View in PubMed
  • Trans-ancestral genome-wide association study of longitudinal pubertal height growth and shared heritability with adult health outcomes Genome Biol. 2024 Jan 16; 25(1):22. . View in PubMed
  • Air pollution and age-dependent changes in emotional behavior across early adolescence in the US. Environ Res. 2024 Jan 01; 240(Pt 1):117390. . View in PubMed
  • Genome-Wide Gene-Environment Interaction Analyses to Understand the Relationship between Red Meat and Processed Meat Intake and Colorectal Cancer Risk Cancer Epidemiol Biomarkers Prev. 2024 03 01; 33(3):400-410. . View in PubMed
  • Genome-Wide Interaction Analysis with DASH Diet Score Identified Novel Loci for Systolic Blood Pressure medRxiv. 2023 Nov 11. . View in PubMed
  • A new Approach to Identify Gene-Environment Interactions and Reveal New Biological Insight in Complex traits Res Sq. 2023 Oct 05. . View in PubMed
  • Author Correction: Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk Nat Genet. 2023 Oct; 55(10):1778-1779. . View in PubMed
  • Sex-specific effects in how childhood exposures to multiple ambient air pollutants affect white matter microstructure development across early adolescence Res Sq. 2023 Aug 17. . View in PubMed
  • A note on p-value multiple-testing adjustment for two-step genome-wide gene-environment interactions scans medRxiv. 2023 Jun 28. . View in PubMed
  • Ambient temperature and air pollution associations with suicide and homicide mortality in California: A statewide case-crossover study Sci Total Environ. 2023 May 20; 874:162462. . View in PubMed
  • Air pollution and emotional behavior in adolescents across the US. medRxiv. 2023 Apr 25. . View in PubMed
  • Author Correction: Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries Nat Genet. 2023 Mar; 55(3):519-520. . View in PubMed
  • Genome-wide interaction analysis of folate for colorectal cancer risk Am J Clin Nutr. 2023 11; 118(5):881-891. . View in PubMed
  • Probing the diabetes and colorectal cancer relationship using gene – environment interaction analyses Br J Cancer. 2023 08; 129(3):511-520. . View in PubMed
  • Differences in Self-Reported Food Allergy and Food-Associated Anaphylaxis by Race and Ethnicity Among SAPPHIRE Cohort ParticipantsJ Allergy Clin Immunol Pract. 2023 04; 11(4):1123-1133. e11. . View in PubMed
  • Improved two-step testing of genome-wide gene-environment interactions Genet Epidemiol. 2023 03; 47(2):152-166. . View in PubMed
  • Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk Nat Genet. 2023 03; 55(3):410-422. . View in PubMed
  • Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries Nat Genet. 2023 01; 55(1):89-99. . View in PubMed
  • Longitudinal hierarchical Bayesian models of covariate effects on airway and alveolar nitric oxide Sci Rep. 2023 04 01; 13(1):5346. . View in PubMed
  • Genome-wide Interaction Study with Smoking for Colorectal Cancer Risk Identifies Novel Genetic Loci Related to Tumor Suppression, Inflammation, and Immune Response Cancer Epidemiol Biomarkers Prev. 2023 03 06; 32(3):315-328. . View in PubMed
  • The genetic determinants of recurrent somatic mutations in 43,693 blood genomes Sci Adv. 2023 04 28; 9(17):eabm4945. . View in PubMed
  • A Genetic Locus within the FMN1/GREM1 Gene Region Interacts with Body Mass Index in Colorectal Cancer Risk Cancer Res. 2023 08 01; 83(15):2572-2583. . View in PubMed
  • Prenatal ambient air pollution exposure and child weight trajectories from the 3rd trimester of pregnancy to 2 years of age: a cohort study BMC Med. 2023 09 07; 21(1):341. . View in PubMed
  • Investigating the impact of London’s ultra low emission zone on children’s health: children’s health in London and Luton (CHILL) protocol for a prospective parallel cohort study BMC Pediatr. 2023 11 04; 23(1):556. . View in PubMed
  • Gene-Environment Analyses Reveal Novel Genetic Candidates with Prenatal Tobacco Exposure in Relation to Risk for Childhood Acute Lymphoblastic Leukemia Cancer Epidemiol Biomarkers Prev. 2023 12 01; 32(12):1707-1715. . View in PubMed
  • Correction: Childhood traffic-related air pollution and adverse changes in subclinical atherosclerosis measures from childhood to adulthood Environ Health. 2022 Nov 16; 21(1):110. . View in PubMed
  • Gene-lifestyle interactions in the genomics of human complex traits Eur J Hum Genet. 2022 06; 30(6):730-739. . View in PubMed
  • Interactions between folate intake and genetic predictors of gene expression levels associated with colorectal cancer risk Sci Rep. 2022 11 07; 12(1):18852. . View in PubMed
  • Transcriptomic Response to Calcium in Normal Colon Organoids is Impacted by Colon Location and Sex Cancer Prev Res (Phila). 2022 10 04; 15(10):679-688. . View in PubMed
  • Beyond GWAS of Colorectal Cancer: Evidence of Interaction with Alcohol Consumption and Putative Causal Variant for the 10q242 Region. Cancer Epidemiol Biomarkers Prev. 2022 05 04; 31(5):1077-1089. . View in PubMed
  • Genome-Wide Interaction Analysis of Genetic Variants With Menopausal Hormone Therapy for Colorectal Cancer Risk J Natl Cancer Inst. 2022 08 08; 114(8):1135-1148. . View in PubMed
  • Multi-omics insights into the biological mechanisms underlying statistical gene-by-lifestyle interactions with smoking and alcohol consumption Front Genet. 2022; 13:954713. . View in PubMed
  • Two-step hypothesis testing to detect gene-environment interactions in a genome-wide scan with a survival endpoint Stat Med. 2022 04 30; 41(9):1644-1657. . View in PubMed
  • A scalable hierarchical lasso for gene-environment interactions J Comput Graph Stat. 2022; 31(4):1091-1103. . View in PubMed
  • A two-step approach to testing overall effect of gene-environment interaction for multiple phenotypes Bioinformatics. 2021 Apr 05; 36(24):5640-5648. . View in PubMed
  • Multi-Ancestry Genome-wide Association Study Accounting for Gene-Psychosocial Factor Interactions Identifies Novel Loci for Blood Pressure Traits HGG Adv. 2021 Jan 14; 2(1). . View in PubMed
  • Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure Mol Psychiatry. 2021 11; 26(11):6293-6304. . View in PubMed
  • Genetic architectures of proximal and distal colorectal cancer are partly distinct Gut. 2021 07; 70(7):1325-1334. . View in PubMed
  • Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci Mol Psychiatry. 2021 06; 26(6):2111-2125. . View in PubMed
  • Increased burden of familial-associated early-onset cancer risk among minority Americans compared to non-Latino Whites Elife. 2021 06 22; 10. . View in PubMed
  • Childhood traffic-related air pollution and adverse changes in subclinical atherosclerosis measures from childhood to adulthood Environ Health. 2021 04 14; 20(1):44. . View in PubMed
  • Hierarchical Bayesian estimation of covariate effects on airway and alveolar nitric oxide Sci Rep. 2021 08 25; 11(1):17180. . View in PubMed
  • Mapping the 17q12-211 Locus for Variants Associated with Early-Onset Asthma in African Americans. Am J Respir Crit Care Med. 2021 02 15; 203(4):424-436. . View in PubMed
  • A genome-wide association study on medulloblastoma J Neurooncol. 2020 Apr; 147(2):309-315. . View in PubMed
  • A Cross-Sectional Study Examining the Seroprevalence of Severe Acute Respiratory Syndrome Coronavirus 2 Antibodies in a University Student Population J Adolesc Health. 2020 12; 67(6):763-768. . View in PubMed
  • Functional informed genome-wide interaction analysis of body mass index, diabetes and colorectal cancer risk Cancer Med. 2020 05; 9(10):3563-3573. . View in PubMed
  • Asthma and its relationship to mitochondrial copy number: Results from the Asthma Translational Genomics Collaborative (ATGC) of the Trans-Omics for Precision Medicine (TOPMed) program PLoS One. 2020; 15(11):e0242364. . View in PubMed
  • Pediatric glioma and medulloblastoma risk and population demographics: a Poisson regression analysis Neurooncol Adv. 2020 Jan-Dec; 2(1):vdaa089. . View in PubMed
  • The Potential Effects of Policy-driven Air Pollution Interventions on Childhood Lung Development Am J Respir Crit Care Med. 2020 02 15; 201(4):438-444. . View in PubMed
  • Immune factors preceding diagnosis of glioma: a Prostate Lung Colorectal Ovarian Cancer Screening Trial nested case-control study Neurooncol Adv. 2019 May-Dec; 1(1):vdz031. . View in PubMed
  • Shift Work, Chronotype, and Melatonin Rhythm in Nurses Cancer Epidemiol Biomarkers Prev. 2019 07; 28(7):1177-1186. . View in PubMed
  • Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids Nat Genet. 2019 04; 51(4):636-648. . View in PubMed
  • An admixture mapping meta-analysis implicates genetic variation at 18q21 with asthma susceptibility in Latinos J Allergy Clin Immunol. 2019 03; 143(3):957-969. . View in PubMed
  • Genet Epidemiol. 2019 03; 43(2):150-165. . View in PubMed
  • Discovery of common and rare genetic risk variants for colorectal cancer Nat Genet. 2019 01; 51(1):76-87. . View in PubMed
  • Novel Common Genetic Susceptibility Loci for Colorectal Cancer J Natl Cancer Inst. 2019 02 01; 111(2):146-157. . View in PubMed
  • A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure Hum Mol Genet. 2019 08 01; 28(15):2615-2633. . View in PubMed
  • Multiancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions Am J Epidemiol. 2019 06 01; 188(6):1033-1054. . View in PubMed
  • A trans-ancestral meta-analysis of genome-wide association studies reveals loci associated with childhood obesity Hum Mol Genet. 2019 10 01; 28(19):3327-3338. . View in PubMed
  • Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration Nat Commun. 2019 11 12; 10(1):5121. . View in PubMed
  • A Unified Model for the Analysis of Gene-Environment Interaction Am J Epidemiol. 2019 04 01; 188(4):760-767. . View in PubMed
  • Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity Nat Commun. 2019 01 22; 10(1):376. . View in PubMed
  • Factors Associated with Prevalent Diabetic Retinopathy in Chinese Americans: The Chinese American Eye Study Ophthalmol Retina. 2018 Feb; 2(2):96-105. . View in PubMed
  • Gene Coexpression Networks in Whole Blood Implicate Multiple Interrelated Molecular Pathways in Obesity in People with Asthma Obesity (Silver Spring). 2018 12; 26(12):1938-1948. . View in PubMed
  • Author Correction: Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis Nat Genet. 2018 09; 50(9):1343. . View in PubMed
  • Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis Nat Genet. 2018 08; 50(8):1072-1080. . View in PubMed
  • Role of local CpG DNA methylation in mediating the 17q21 asthma susceptibility gasdermin B (GSDMB)/ORMDL sphingolipid biosynthesis regulator 3 (ORMDL3) expression quantitative trait locusJ Allergy Clin Immunol. 2018 06; 141(6):2282-2286. e6. . View in PubMed
  • Air pollution, weight loss and metabolic benefits of bariatric surgery: a potential model for study of metabolic effects of environmental exposures Pediatr Obes. 2018 05; 13(5):312-320. . View in PubMed
  • Factors Associated with Age-Related Macular Degeneration in Chinese American Adults: The Chinese American Eye Study (CHES) Ophthalmol Retina. 2018 03; 2(3):209-216. . View in PubMed
  • Dietary Nutrient Intake, Ethnicity, and Epigenetic Silencing of Lung Cancer Genes Detected in Sputum in New Mexican Smokers Cancer Prev Res (Phila). 2018 02; 11(2):93-102. . View in PubMed
  • Genetic-Epigenetic Interactions in Asthma Revealed by a Genome-Wide Gene-Centric Search Hum Hered. 2018; 83(3):130-152. . View in PubMed
  • A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure Am J Hum Genet. 2018 03 01; 102(3):375-400. . View in PubMed
  • Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries PLoS One. 2018; 13(6):e0198166. . View in PubMed
  • Traffic-Related Pollutants: Exposure and Health Effects Among Hispanic Children Am J Epidemiol. 2018 01 01; 187(1):45-52. . View in PubMed
  • Lessons Learned From Past Gene-Environment Interaction Successes Am J Epidemiol. 2017 Oct 01; 186(7):778-786. . View in PubMed
  • Current Challenges and New Opportunities for Gene-Environment Interaction Studies of Complex Diseases Am J Epidemiol. 2017 Oct 01; 186(7):753-761. . View in PubMed
  • Update on the State of the Science for Analytical Methods for Gene-Environment Interactions Am J Epidemiol. 2017 Oct 01; 186(7):762-770. . View in PubMed
  • Multiancestry Study of Gene-Lifestyle Interactions for Cardiovascular Traits in 610 475 Individuals From 124 Cohorts: Design and Rationale Circ Cardiovasc Genet. 2017 Jun; 10(3). . View in PubMed
  • Trends in childhood leukemia incidence over two decades from 1992 to 2013 Int J Cancer. 2017 Mar 01; 140(5):1000-1008. . View in PubMed
  • Genome-Wide Interaction Analysis of Air Pollution Exposure and Childhood Asthma with Functional Follow-up Am J Respir Crit Care Med. 2017 05 15; 195(10):1373-1383. . View in PubMed
  • Dietary nutrients associated with preservation of lung function in Hispanic and non-Hispanic white smokers from New Mexico Int J Chron Obstruct Pulmon Dis. 2017; 12:3171-3181. . View in PubMed
  • Gene Expression Profiling in Blood Provides Reproducible Molecular Insights into Asthma Control Am J Respir Crit Care Med. 2017 01 15; 195(2):179-188. . View in PubMed
  • The Effects of Policy-Driven Air Quality Improvements on Children’s Respiratory Health Res Rep Health Eff Inst. 2017 Jan; (190):1-75. . View in PubMed
  • Association of Changes in Air Quality With Bronchitic Symptoms in Children in California, 1993-2012 JAMA. 2016 Apr 12; 315(14):1491-501. . View in PubMed
  • Increased yield of actionable mutations using multi-gene panels to assess hereditary cancer susceptibility in an ethnically diverse clinical cohort Cancer Genet. 2016 Apr; 209(4):130-7. . View in PubMed
  • Adaptive Set-Based Methods for Association Testing Genet Epidemiol. 2016 Feb; 40(2):113-22. . View in PubMed
  • E-cigarettes, Cigarettes, and the Prevalence of Adolescent Tobacco Use Pediatrics. 2016 08; 138(2). . View in PubMed
  • Detecting Gene-Environment Interactions for a Quantitative Trait in a Genome-Wide Association Study Genet Epidemiol. 2016 07; 40(5):394-403. . View in PubMed
  • An Empirical Comparison of Joint and Stratified Frameworks for Studying G × E Interactions: Systolic Blood Pressure and Smoking in the CHARGE Gene-Lifestyle Interactions Working Group Genet Epidemiol. 2016 07; 40(5):404-15. . View in PubMed
  • Air Pollution and Lung Function in Minority Youth with Asthma in the GALA II (Genes-Environments and Admixture in Latino Americans) and SAGE II (Study of African Americans, Asthma, Genes, and Environments) Studies Am J Respir Crit Care Med. 2016 06 01; 193(11):1271-80. . View in PubMed
  • Correction: Inducible Nitric Oxide Synthase Promoter Haplotypes and Residential Traffic-Related Air Pollution Jointly Influence Exhaled Nitric Oxide Level in Children PLoS One. 2016; 11(5):e0155567. . View in PubMed
  • Genome-wide association study identifies WNT7B as a novel locus for central corneal thickness in Latinos Hum Mol Genet. 2016 11 15; 25(22):5035-5045. . View in PubMed
  • Age-Related Macular Degeneration and Quality of Life in Latinos: The Los Angeles Latino Eye Study JAMA Ophthalmol. 2016 06 01; 134(6):683-90. . View in PubMed
  • Corrigendum: genome-wide association study of colorectal cancer identifies six new susceptibility loci Nat Commun. 2015 Oct 26; 6:8739. . View in PubMed
  • Genome-wide association study of colorectal cancer identifies six new susceptibility loci Nat Commun. 2015 Jul 07; 6:7138. . View in PubMed
  • Rising rates of acute lymphoblastic leukemia in Hispanic children: trends in incidence from 1992 to 2011 Blood. 2015 May 07; 125(19):3033-4. . View in PubMed
  • Association of aspirin and NSAID use with risk of colorectal cancer according to genetic variants JAMA. 2015 Mar 17; 313(11):1133-42. . View in PubMed
  • Association of improved air quality with lung development in children N Engl J Med. 2015 Mar 05; 372(10):905-13. . View in PubMed
  • 15q12 variants, sputum gene promoter hypermethylation, and lung cancer risk: a GWAS in smokers J Natl Cancer Inst. 2015 Feb 23; 107(5). . View in PubMed
  • Ethnic-specific associations of rare and low-frequency DNA sequence variants with asthma Nat Commun. 2015 Jan 16; 6:5965. . View in PubMed
  • Genetic ancestry influences asthma susceptibility and lung function among Latinos J Allergy Clin Immunol. 2015 Jan; 135(1):228-35. . View in PubMed
  • Inducible Nitric Oxide Synthase Promoter Haplotypes and Residential Traffic-Related Air Pollution Jointly Influence Exhaled Nitric Oxide Level in Children PLoS One. 2015; 10(12):e0145363. . View in PubMed
  • No evidence of gene-calcium interactions from genome-wide analysis of colorectal cancer risk Cancer Epidemiol Biomarkers Prev. 2014 Dec; 23(12):2971-6. . View in PubMed
  • Genome-wide interaction studies reveal sex-specific asthma risk alleles Hum Mol Genet. 2014 Oct 01; 23(19):5251-9. . View in PubMed
  • Native American ancestry is associated with severe diabetic retinopathy in Latinos Invest Ophthalmol Vis Sci. 2014 Aug 21; 55(9):6041-5. . View in PubMed
  • Integrated genome-wide association, coexpression network, and expression single nucleotide polymorphism analysis identifies novel pathway in allergic rhinitis BMC Med Genomics. 2014 Aug 02; 7:48. . View in PubMed
  • Fraction of exhaled nitric oxide values in childhood are associated with 17q112-q12 and 17q12-q21 variants. J Allergy Clin Immunol. 2014 Jul; 134(1):46-55. . View in PubMed
  • Associations of children’s lung function with ambient air pollution: joint effects of regional and near-roadway pollutants Thorax. 2014 Jun; 69(6):540-7. . View in PubMed
  • NOS1 methylation and carotid artery intima-media thickness in children Circ Cardiovasc Genet. 2014 Apr; 7(2):116-22. . View in PubMed
  • Genome-wide diet-gene interaction analyses for risk of colorectal cancer PLoS Genet. 2014 Apr; 10(4):e1004228. . View in PubMed
  • Native American ancestry affects the risk for gene methylation in the lungs of Hispanic smokers from New Mexico Am J Respir Crit Care Med. 2013 Nov 01; 188(9):1110-6. . View in PubMed
  • High-resolution MODIS aerosol retrieval during wildfire events in California for use in exposure assessment J Geophys Res Atmos. 2013 Oct 16; 118(19):11242-11255. . View in PubMed
  • Finding novel genes by testing G × E interactions in a genome-wide association study Genet Epidemiol. 2013 Sep; 37(6):603-13. . View in PubMed
  • Childhood infections and adult height in monozygotic twin pairs Am J Epidemiol. 2013 Aug 15; 178(4):551-8. . View in PubMed
  • Efficient two-step testing of gene-gene interactions in genome-wide association studies Genet Epidemiol. 2013 Jul; 37(5):440-51. . View in PubMed
  • A meta-analysis of genome-wide association studies for serum total IgE in diverse study populations J Allergy Clin Immunol. 2013 Apr; 131(4):1176-84. . View in PubMed
  • A genome-wide association study of central corneal thickness in Latinos Invest Ophthalmol Vis Sci. 2013 Apr 01; 54(4):2435-43. . View in PubMed
  • Confounding and heterogeneity in genetic association studies with admixed populations Am J Epidemiol. 2013 Feb 15; 177(4):351-60. . View in PubMed
  • Parental smoking and risk of childhood brain tumors by functional polymorphisms in polycyclic aromatic hydrocarbon metabolism genes PLoS One. 2013; 8(11):e79110. . View in PubMed
  • Integration of mouse and human genome-wide association data identifies KCNIP4 as an asthma gene PLoS One. 2013; 8(2):e56179. . View in PubMed
  • Further replication studies of the EVE Consortium meta-analysis identifies 2 asthma risk loci in European Americans J Allergy Clin Immunol. 2012 Dec; 130(6):1294-301. . View in PubMed
  • Accuracy of a new time-resolved step counter in children Pediatr Exerc Sci. 2012 Nov; 24(4):622-33. . View in PubMed
  • A genome-wide association meta-analysis identifies new childhood obesity loci Nat Genet. 2012 May; 44(5):526-31. . View in PubMed
  • Predictors of intra-community variation in air quality J Expo Sci Environ Epidemiol. 2012 Mar-Apr; 22(2):135-47. . View in PubMed
  • Invited commentary: GE-Whiz! Ratcheting gene-environment studies up to the whole genome and the whole exposome Am J Epidemiol. 2012 Feb 01; 175(3):203-7; discussion 208-9. . View in PubMed
  • Genotype Imputation for Latinos Using the HapMap and 1000 Genomes Project Reference Panels Front Genet. 2012; 3:117. . View in PubMed
  • Using extreme phenotype sampling to identify the rare causal variants of quantitative traits in association studies Genet Epidemiol. 2011 Dec; 35(8):790-9. . View in PubMed
  • Parental stress increases the detrimental effect of traffic exposure on children’s lung function Am J Respir Crit Care Med. 2011 Oct 01; 184(7):822-7. . View in PubMed
  • Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations Nat Genet. 2011 Jul 31; 43(9):887-92. . View in PubMed
  • Association of the calcyon neuron-specific vesicular protein gene (CALY) with adolescent smoking initiation in China and California Am J Epidemiol. 2011 May 01; 173(9):1039-48. . View in PubMed
  • Sample size requirements to detect gene-environment interactions in genome-wide association studies Genet Epidemiol. 2011 Apr; 35(3):201-10. . View in PubMed
  • Genetic variations in nitric oxide synthase and arginase influence exhaled nitric oxide levels in children Allergy. 2011 Mar; 66(3):412-9. . View in PubMed
  • Genetic variation in the glutathione synthesis pathway, air pollution, and children’s lung function growth Am J Respir Crit Care Med. 2011 Jan 15; 183(2):243-8. . View in PubMed
  • TSLP polymorphisms are associated with asthma in a sex-specific fashion Allergy. 2010 Dec; 65(12):1566-75. . View in PubMed
  • PDE11A associations with asthma: results of a genome-wide association scanJ Allergy Clin Immunol. 2010 Oct; 126(4):871-873. e9. . View in PubMed
  • Discovery of complex pathways from observational data Stat Med. 2010 Aug 30; 29(19):1998-2011. . View in PubMed
  • Efficient genome-wide association testing of gene-environment interaction in case-parent trios Am J Epidemiol. 2010 Jul 01; 172(1):116-22. . View in PubMed
  • Role of inducible nitric oxide synthase in asthma risk and lung function growth during adolescence Thorax. 2010 Feb; 65(2):139-45. . View in PubMed
  • Functional variants in the catalase and myeloperoxidase genes, ambient air pollution, and respiratory-related school absences: an example of epistasis in gene-environment interactions Am J Epidemiol. 2009 Dec 15; 170(12):1494-501. . View in PubMed
  • Genetic Analysis Workshop 16: Strategies for genome-wide association study analyses BMC Proc. 2009 Dec 15; 3 Suppl 7:S1. . View in PubMed
  • Genome-wide association analysis identifies PDE4D as an asthma-susceptibility gene Am J Hum Genet. 2009 May; 84(5):581-93. . View in PubMed
  • Respiratory symptoms following wildfire smoke exposure: airway size as a susceptibility factor Epidemiology. 2009 May; 20(3):451-9. . View in PubMed
  • In utero smoke exposure, glutathione S-transferase P1 haplotypes, and respiratory illness-related absence among schoolchildren Pediatrics. 2009 May; 123(5):1344-51. . View in PubMed
  • Variation in the GST mu locus and tobacco smoke exposure as determinants of childhood lung function Am J Respir Crit Care Med. 2009 Apr 01; 179(7):601-7. . View in PubMed
  • Roles of arginase variants, atopy, and ozone in childhood asthmaJ Allergy Clin Immunol. 2009 Mar; 123(3):596-602602. e1-8. . View in PubMed
  • Glutathione-S-transferase (GST) P1, GSTM1, exercise, ozone and asthma incidence in school children Thorax. 2009 Mar; 64(3):197-202. . View in PubMed
  • Gene-environment interaction in genome-wide association studies Am J Epidemiol. 2009 Jan 15; 169(2):219-26. . View in PubMed
  • Detecting gene-environment interactions in genome-wide association data Genet Epidemiol. 2009; 33 Suppl 1:S68-73. . View in PubMed
  • Traffic-related air pollution and asthma onset in children: a prospective cohort study with individual exposure measurement Environ Health Perspect. 2008 Oct; 116(10):1433-8. . View in PubMed
  • Effects of in utero and childhood tobacco smoke exposure and beta2-adrenergic receptor genotype on childhood asthma and wheezing Pediatrics. 2008 Jul; 122(1):e107-14. . View in PubMed
  • Use of an electrostatic dust cloth for self-administered home allergen collection Twin Res Hum Genet. 2008 Apr; 11(2):150-5. . View in PubMed
  • Interleukin-2, interleukin-12, and interferon-gamma levels and risk of young adult Hodgkin lymphoma Blood. 2008 Apr 01; 111(7):3377-82. . View in PubMed
  • Glutathione S-transferase P1, maternal smoking, and asthma in children: a haplotype-based analysis Environ Health Perspect. 2008 Mar; 116(3):409-15. . View in PubMed
  • Ozone, oxidant defense genes, and risk of asthma during adolescence Am J Respir Crit Care Med. 2008 Feb 15; 177(4):388-95. . View in PubMed
  • Transforming growth factor- 1 C-509T polymorphism, oxidant stress, and early-onset childhood asthma Am J Respir Crit Care Med. 2007 Dec 15; 176(12):1192-9. . View in PubMed
  • Microsomal epoxide hydrolase, glutathione S-transferase P1, traffic and childhood asthma Thorax. 2007 Dec; 62(12):1050-7. . View in PubMed
  • Relationship between air pollution, lung function and asthma in adolescents Thorax. 2007 Nov; 62(11):957-63. . View in PubMed
  • Childhood sun exposure influences risk of multiple sclerosis in monozygotic twins Neurology. 2007 Jul 24; 69(4):381-8. . View in PubMed
  • The ADRB3 Trp64Arg variant and obesity in African-American breast cancer cases Int J Obes (Lond). 2007 Jul; 31(7):1110-8. . View in PubMed
  • Testing association between disease and multiple SNPs in a candidate gene Genet Epidemiol. 2007 Jul; 31(5):383-95. . View in PubMed
  • Indoor time-microenvironment-activity patterns in seven regions of Europe J Expo Sci Environ Epidemiol. 2007 Mar; 17(2):170-81. . View in PubMed
  • Effect of exposure to traffic on lung development from 10 to 18 years of age: a cohort study Lancet. 2007 Feb 17; 369(9561):571-7. . View in PubMed
  • Exploiting gene-environment interaction to detect genetic associations Hum Hered. 2007; 63(2):111-9. . View in PubMed
  • Dog ownership enhances symptomatic responses to air pollution in children with asthma Environ Health Perspect. 2006 Dec; 114(12):1910-5. . View in PubMed
  • Health effects of the 2003 Southern California wildfires on children Am J Respir Crit Care Med. 2006 Dec 01; 174(11):1221-8. . View in PubMed
  • Regular smoking and asthma incidence in adolescents Am J Respir Crit Care Med. 2006 Nov 15; 174(10):1094-100. . View in PubMed
  • Air pollution and children–an unhealthy mix N Engl J Med. 2006 Jul 06; 355(1):78-9. . View in PubMed
  • Differential twin concordance for multiple sclerosis by latitude of birthplace Ann Neurol. 2006 Jul; 60(1):56-64. . View in PubMed
  • Associations of tumor necrosis factor G-308A with childhood asthma and wheezing Am J Respir Crit Care Med. 2006 May 01; 173(9):970-6. . View in PubMed
  • A testing framework for identifying susceptibility genes in the presence of epistasis Am J Hum Genet. 2006 Jan; 78(1):15-27. . View in PubMed
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