Xuejuan Jiang, PhD

Associate Professor of Research Ophthalmology

Director of Biostatistics

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Overview

As a seasoned epidemiologist, Dr. Xuejuan Jiang possesses expertise in designing, managing, and analyzing epidemiological studies. Currently, she is at the forefront of an international endeavor aimed at consolidating all existing population-based studies of eye diseases in preschool children, with the goal of creating the largest repository of population-based survey data on vision health among this age group. Additionally, she serves as the Principal Investigator for a study investigating the relationship between intrauterine exposure to smoking, DNA methylation, and ocular disorders in multiethnic children.

Dr. Jiang’s research interests extend to evaluating the impact of race/ethnicity, various environmental factors, and genetic risk factors in various eye-related conditions, including neurodevelopmental (e.g., amblyopia), neurodegenerative (e.g., glaucoma), and microvascular diseases (e.g., retinopathy). She has contributed as a co-investigator in pivotal studies such as the Los Angeles Latino Eye Study (LALES), the Chinese American Eye Study (CHES), and the African American Eye Disease Study (AFEDS). Notably, she has led investigations employing Spectral-Domain Optic Coherence Tomography (OCT) images obtained from African Americans, Chinese Americans, and Latinos, assessing racial/ethnic disparities and identifying genetic and biological determinants of imaging biomarkers associated with neurodegeneration. Presently, she spearheads projects examining retinal vascular complications linked to sickle cell trait in African Americans and the impact of sickle cell trait on innovative neuroimaging markers of cerebral small vascular disease (CSVD).

Dr. Jiang has also collaborated on the MarkVCID consortium, which aims to identify and validate biomarkers for brain small vessel diseases contributing to cognitive impairment and dementia (VCID). She also leads a project to systematically evaluate metrics of small vessel morphology/density and perfusion as imaging biomarkers of VCID in a multiethnic longitudinal cohort.

Publications

  • Prevalence of Comprehensive Eye Examination in Preschool Children With Eye Conditions AJPM Focus. 2024 Apr; 3(2):100184. . View in PubMed
  • Retinal perfusion is linked to cognition and brain MRI biomarkers in Black Americans Alzheimers Dement. 2024 Feb; 20(2):858-868. . View in PubMed
  • Age-Related Decline in BBB Function is More Pronounced in Males than Females bioRxiv. 2024 Jan 15. . View in PubMed
  • Inner retinal oxygen delivery and metabolism in progressive stages of diabetic retinopathy Sci Rep. 2024 02 22; 14(1):4414. . View in PubMed
  • Optimal number and orientation of anterior segment OCT images to measure ocular biometric parameters in angle closure eyes: the Chinese American Eye Study Br J Ophthalmol. 2023 06; 107(6):795-801. . View in PubMed
  • Classification of Angle Closure Severity by Hierarchical Cluster Analysis of Ocular Biometrics in the Dark and Light Transl Vis Sci Technol. 2023 09 01; 12(9):4. . View in PubMed
  • Refractive Error and Anterior Chamber Depth as Risk Factors in Primary Angle Closure Disease: The Chinese American Eye Study J Glaucoma. 2023 04 01; 32(4):257-264. . View in PubMed
  • Racial and Ethnic Differences in the Roles of Myopia and Ocular Biometrics as Risk Factors for Primary Open-Angle Glaucoma Invest Ophthalmol Vis Sci. 2023 06 01; 64(7):4. . View in PubMed
  • Ocular Biometric Determinants of Dark-to-Light Change in Angle Width: The Chinese American Eye Study Am J Ophthalmol. 2022 05; 237:183-192. . View in PubMed
  • Visual Outcomes in Eyes With Neovascular Glaucoma and Anterior Segment Neovascularization Without Glaucoma Am J Ophthalmol. 2022 04; 236:1-11. . View in PubMed
  • Hemiretinal Asymmetry in Peripapillary Vessel Density in Healthy, Glaucoma Suspect, and Glaucoma Eyes Am J Ophthalmol. 2021 10; 230:156-165. . View in PubMed
  • Retinal Nerve Fiber Layer Thickness in Healthy Eyes of Black, Chinese, and Latino Americans: A Population-Based Multiethnic Study Ophthalmology. 2021 07; 128(7):1005-1015. . View in PubMed
  • Abnormal retinal capillary blood flow in autosomal dominant Alzheimer’s disease Alzheimers Dement (Amst). 2021; 13(1):e12162. . View in PubMed
  • Longer Axial Length Potentiates Relationship of Intraocular Pressure and Peripapillary Vessel Density in Glaucoma Patients Invest Ophthalmol Vis Sci. 2021 07 01; 62(9):37. . View in PubMed
  • Optical Coherence Tomography Angiography-Derived Flux As a Measure of Physiological Changes in Retinal Capillary Blood Flow Transl Vis Sci Technol. 2021 08 02; 10(9):5. . View in PubMed
  • Ocular Biometric Determinants of Anterior Chamber Angle Width in Chinese Americans: The Chinese American Eye Study Am J Ophthalmol. 2020 12; 220:19-26. . View in PubMed
  • A Mitochondrial Genome-Wide Association Study of Cataract in a Latino Population Transl Vis Sci Technol. 2020 05; 9(6):25. . View in PubMed
  • Lower retinal capillary density in minimal cognitive impairment among older Latinx adults Alzheimers Dement (Amst). 2020; 12(1):e12071. . View in PubMed
  • Association of Parental Myopia With Higher Risk of Myopia Among Multiethnic Children Before School Age JAMA Ophthalmol. 2020 05 01; 138(5):501-509. . View in PubMed
  • Machine Learning Models for Diagnosing Glaucoma from Retinal Nerve Fiber Layer Thickness Maps Ophthalmol Glaucoma. 2019 Nov – Dec; 2(6):422-428. . View in PubMed
  • Prevalence, Characteristics, and Risk Factors of Moderate or High Hyperopia among Multiethnic Children 6 to 72 Months of Age: A Pooled Analysis of Individual Participant Data Ophthalmology. 2019 07; 126(7):989-999. . View in PubMed
  • Correlation between Intraocular Pressure and Angle Configuration Measured by OCT: The Chinese American Eye Study Ophthalmol Glaucoma. 2018 Nov-Dec; 1(3):158-166. . View in PubMed
  • Factors Associated with Prevalent Diabetic Retinopathy in Chinese Americans: The Chinese American Eye Study Ophthalmol Retina. 2018 Feb; 2(2):96-105. . View in PubMed
  • The African American Eye Disease Study: Design and Methods Ophthalmic Epidemiol. 2018 08; 25(4):306-314. . View in PubMed
  • Variation in Intraocular Pressure and the Risk of Developing Open-Angle Glaucoma: The Los Angeles Latino Eye Study Am J Ophthalmol. 2018 04; 188:51-59. . View in PubMed
  • Prevalence and Characteristics of Myopic Degeneration in an Adult Chinese American Population: The Chinese American Eye Study Am J Ophthalmol. 2018 03; 187:34-42. . View in PubMed
  • Factors Associated with Age-Related Macular Degeneration in Chinese American Adults: The Chinese American Eye Study (CHES) Ophthalmol Retina. 2018 03; 2(3):209-216. . View in PubMed
  • The “Curse” of the Fellow Eye in Glaucoma JAMA Ophthalmol. 2018 10 01; 136(10):1156-1157. . View in PubMed
  • Self-reported Use of Eye Care Among Adult Chinese Americans: The Chinese American Eye Study Am J Ophthalmol. 2017 Apr; 176:183-193. . View in PubMed
  • Prevalence and Risk Factors for Refractive Error in Adult Chinese Americans: The Chinese American Eye Study Am J Ophthalmol. 2017 Mar; 175:201-212. . View in PubMed
  • Visual Impairment in Preschool Children in the United States: Demographic and Geographic Variations From 2015 to 2060 JAMA Ophthalmol. 2017 06 01; 135(6):610-616. . View in PubMed
  • Ocular Determinants of Refractive Error and Its Age- and Sex-Related Variations in the Chinese American Eye Study JAMA Ophthalmol. 2017 07 01; 135(7):724-732. . View in PubMed
  • Use of Structural End Points in Glaucoma: Beyond Visual Field Loss JAMA Ophthalmol. 2017 07 01; 135(7):789-790. . View in PubMed
  • Quantifying Retinal Microvascular Changes in Uveitis Using Spectral-Domain Optical Coherence Tomography Angiography Am J Ophthalmol. 2016 Nov; 171:101-112. . View in PubMed
  • Prevalence of Diabetic Retinopathy in Adult Chinese American Individuals: The Chinese American Eye Study JAMA Ophthalmol. 2016 May 01; 134(5):563-569. . View in PubMed
  • The Role of Contextual Factors in Racial/Ethnic Disparities in Eye Care Use JAMA Ophthalmol. 2016 10 01; 134(10):1167-1168. . View in PubMed
  • Benefit of Measuring Anterior Segment Structures Using an Increased Number of Optical Coherence Tomography Images: The Chinese American Eye Study Invest Ophthalmol Vis Sci. 2016 11 01; 57(14):6313-6319. . View in PubMed
  • Combination of molecular alterations and smoking intensity predicts bladder cancer outcome: a report from the Los Angeles Cancer Surveillance Program Cancer. 2013 Feb 15; 119(4):756-65. . View in PubMed
  • Genetic variations in SMAD7 are associated with colorectal cancer risk in the colon cancer family registry PLoS One. 2013; 8(4):e60464. . View in PubMed
  • Baseline risk factors that predict the development of open-angle glaucoma in a population: the Los Angeles Latino Eye Study Ophthalmology. 2012 Nov; 119(11):2245-53. . View in PubMed
  • Diabetes and risk of esophageal and gastric adenocarcinomas Int J Cancer. 2012 Sep 15; 131(6):1417-22. . View in PubMed
  • Cigarette smoking and subtypes of bladder cancer Int J Cancer. 2012 Feb 15; 130(4):896-901. . View in PubMed
  • Family history and breast cancer hormone receptor status in a Spanish cohort PLoS One. 2012; 7(1):e29459. . View in PubMed
  • Association of the calcyon neuron-specific vesicular protein gene (CALY) with adolescent smoking initiation in China and California Am J Epidemiol. 2011 May 01; 173(9):1039-48. . View in PubMed
  • Genetic variations on chromosomes 5p15 and 15q25 and bladder cancer risk: findings from the Los Angeles-Shanghai bladder case-control study Carcinogenesis. 2011 Feb; 32(2):197-202. . View in PubMed
  • Risk of urinary bladder cancer is associated with 8q24 variant rs9642880[T] in multiple racial/ethnic groups: results from the Los Angeles-Shanghai case-control study Cancer Epidemiol Biomarkers Prev. 2010 Dec; 19(12):3150-6. . View in PubMed
  • Hypertension, diuretics and antihypertensives in relation to bladder cancer Carcinogenesis. 2010 Nov; 31(11):1964-71. . View in PubMed
  • Urinary tract infections and reduced risk of bladder cancer in Los Angeles Br J Cancer. 2009 Mar 10; 100(5):834-9. . View in PubMed
  • Water intake and bladder cancer risk in Los Angeles County Int J Cancer. 2008 Oct 01; 123(7):1649-56. . View in PubMed
  • Alcohol consumption and risk of bladder cancer in Los Angeles County Int J Cancer. 2007 Aug 15; 121(4):839-45. . View in PubMed
  • Environmental tobacco smoke and bladder cancer risk in never smokers of Los Angeles County Cancer Res. 2007 Aug 01; 67(15):7540-5. . View in PubMed
  • Lipid peroxidation, oxidative stress genes and dietary factors in breast cancer protection: a hypothesis Breast Cancer Res. 2007; 9(1):201. . View in PubMed
  • Lipid peroxidation and the protective effect of physical exercise on breast cancer Med Hypotheses. 2007; 68(5):1138-43. . View in PubMed