Ya-Chen Liang, PhD

Assistant Professor Of Research Pathology

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Overview

Dr. Liang’s long-term research goal seeks to decompose how genomes and sub-nuclear structures are functionally organized in cell nuclei while maintaining their flexibility to respond to biological cues during development and disease pathogenesis. She focuses on studying spatial regulations of gene clusters, which are widespread in genomes, but little is known about their inter-cluster and subnuclear organizations. Her research integrates state-of-the-art functional genomic, computational, and proteomic approaches to address long-standing questions at the intersection of topological chromatin states and spatial subnuclear protein scaffolds.

*Dr. Liang’s lab is actively recruiting graduate students and postdoctoral fellows. Please email your C.V. to [email protected].

Research Funding

  • Intra- and Inter-cluster Regulations of Multiplex Gene Clusters
    NIH/NIGMS · 1R35GM150714-01 · Sep 1, 2023 – Jul 31, 2028 · Role: Principle Investigator

Publications

  • Sexually dimorphic sail feathers in the Mandarin duck as a model for lifelong developmental modulation. Sci Rep. 2025 Oct 21; 15(1):36593.. View in PubMed
  • Roles of Msx2 in exogen control: modulating the stem cell niche during the transition from hair shedding to regeneration. J Adv Res. 2026 06; 84:345-359.. View in PubMed
  • Fibroblast bioelectric signaling drives hair growth. Cell. 2025 Sep 18; 188(19):5175-5193.e21.. View in PubMed
  • Molecular insights into region-specific sexual dichromatism: Comparative transcriptome analysis of red cheek pigmentation in zebra finches. PLoS Genet. 2025 May; 21(5):e1011693.. View in PubMed
  • Skin regional specification and higher-order HoxC regulation. Sci Adv. 2025 Mar 21; 11(12):eado2223.. View in PubMed
  • Organizational principles of integumentary organs: Maximizing variations for effective adaptation. Dev Biol. 2025 06; 522:171-195.. View in PubMed
  • Regional Specific Differentiation of Integumentary Organs: Regulation of Gene Clusters within the Avian Epidermal Differentiation Complex and Impacts of SATB2 Overexpression. Genes (Basel). 2021 08 23; 12(8).. View in PubMed
  • Regional specific differentiation of integumentary organs: SATB2 is involved in α- and β-keratin gene cluster switching in the chicken. Dev Dyn. 2022 09; 251(9):1490-1508.. View in PubMed
  • Symmetry breaking of tissue mechanics in wound induced hair follicle regeneration of laboratory and spiny mice. Nat Commun. 2021 05 10; 12(1):2595.. View in PubMed
  • Making region-specific integumentary organs in birds: evolution and modifications. Curr Opin Genet Dev. 2021 08; 69:103-111.. View in PubMed