Zhengzheng Xu, PhD

Assistant Professor of Clinical Radiation Oncology

Lead, Medical Physics LINAC Machine QA and QA Audits

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Dr. Zhengzheng Xu is an Assistant Professor of Clinical Radiation Oncology-Medical Physics at USC Norris Cancer Hospital and USC + Los Angeles County Medical Center. Dr. Xu joined USC in February 2021.

Dr. Xu graduated from Zhejiang University in Zhejiang, China with a Bachelor of Science degree in Biomedical Engineering. He received his Master degree in Medical Physics from Duke University and the doctorate degree in Medical Physics from University at Buffalo. Dr. Xu completed his residency in medical physics at University Hospitals Seidman Cancer Center in 2018. After completing the residency, Dr. Xu became a clinical staff at UH Seidman Cancer Center specializing in medical physics. He was focused and dedicated in image guided radiotherapy (IGRT) for GI cancer and advanced HDR brachytherapy for GYN cancer.

Dr. Xu has presented and published in multiple areas including HDR brachytherapy, stereotactic body radiation therapy(SBRT)/stereotactic radiosurgery(SRS), and FMEA for RadOnc. His research interests include image guided adaptive brachytherapy, SBRT/SRS and small field dosimetry.


  • AAPM Penn-Ohio Chapter: AAPM Annual Meeting Travel Award of Penn-Ohio Chapter Meeting, 2018
  • AAPM Upstate New York Chapter: Young Investigator Competition -2nd, 2016
  • Duke University: Master Thesis Project Scholarship, 2011
  • Zhejiang University: First-Class of National Scholarship Award, 2009-2010
  • Zhejiang University: Top Student Dissertation Award, 2009


  • Comparison of 125I and 103Pd isotopes in
    escalating dose to intraprostatic lesions for low dose rate prostate brachytherapy: dosimetry and acute
    toxicity Journal of Oncology Research. 1(3):109. . View in PubMed
  • Hippocampal sparing radiation therapy for brain metastases: treatment techniques and clinical implementation Chin Clin Oncol. 2023 Oct; 12(5):56. . View in PubMed
  • Automatic segmentation of high-risk clinical target volume for tandem-and-ovoids brachytherapy patients using an asymmetric dual-path convolutional neural network Med Phys. 2022 Mar; 49(3):1712-1722. . View in PubMed
  • Feasibility of improving patient’s safety with in vivo dose tracking in intracavitary and interstitial HDR brachytherapy Brachytherapy. 2021 Mar-Apr; 20(2):353-360. . View in PubMed
  • Permanent Interstitial Cesium-131 Brachytherapy in Treating High-Risk Recurrent Head and Neck Cancer: A Prospective Pilot Study Front Oncol. 2021; 11:639480. . View in PubMed
  • Appropriate Methodology for EBRT and HDR Intracavitary/Interstitial Brachytherapy Dose Composite and Clinical Plan Evaluation for Patients With Cervical Cancer Pract Radiat Oncol. 2019 Nov; 9(6):e559-e571. . View in PubMed
  • Evaluating radiotherapy treatment delay using Failure Mode and Effects Analysis (FMEA) Radiother Oncol. 2019 08; 137:102-109. . View in PubMed
  • Assessment of beam-matched linacs quality/accuracy for interchanging SBRT or SRT patient using VMAT without replanning J Appl Clin Med Phys. 2019 Jan; 20(1):68-75. . View in PubMed
  • Effects of collimator angle, couch angle, and starting phase on motion-tracking dynamic conformal arc therapy (4D DCAT) J Appl Clin Med Phys. 2017 Sep; 18(5):54-63. . View in PubMed
  • Evaluation of dosimetric effect caused by slowing with multi-leaf collimator (MLC) leaves for volumetric modulated arc therapy (VMAT) Radiol Oncol. 2016 Feb 16; 50(1):121-128. . View in PubMed
  • Evaluation of fluence-based dose delivery incorporating the spatial variation of dosimetric leaf gap (DLG) J Appl Clin Med Phys. 2016 01 08; 17(1):12-21. . View in PubMed
  • Spatial Variation of Dosimetric Leaf Gap and its Impact on Dose Delivery Medical Physics. 2014; 11(41):111711. . View in PubMed