Helena Chang Chui, MD

Chair and Professor of Neurology

Raymond and Betty McCarron Chair in Neurology

Websites

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Overview

Dr. Chui is internationally recognized for her research in Alzheimer disease and vascular cognitive impairment. She is the principal investigator for the NIA-funded Alzheimer Disease Research Center, as well as a multi-institutional program project on vascular dementia.

Dr. Chui is the author of over 120 publications and has served on the editorial board for Stroke, Alzheimer Disease and Associated Disorders, and Archives of Neurology. She holds the Raymond and Betty McCarron endowed Chair at the Keck School of Medicine and serves as the Chair of the Department of Neurology.

Awards

Pasadena Magazine: Top Doctor, 2011

Publications

20-year depressive symptoms, dementia, and structural neuropathology in older women Alzheimers Dement. 2024 Apr 09. . View in PubMed
Assessment of arterial pulsatility of cerebral perforating arteries using 7T high-resolution dual-VENC phase-contrast MRI Magn Reson Med. 2024 Mar 05. . View in PubMed
Asian Cohort for Alzheimer’s Disease (ACAD) pilot study on genetic and non-genetic risk factors for Alzheimer’s disease among Asian Americans and Canadians Alzheimers Dement. 2024 Mar; 20(3):2058-2071. . View in PubMed
Association Between Self- and Proxy-Reported Depression and Quality of Life in Mild-Moderate Alzheimer’s Disease Am J Geriatr Psychiatry. 2024 01; 32(1):58-67. . View in PubMed
White matter hyperintensity volume modifies the association between CSF vascular inflammatory biomarkers and regional FDG-PET along the Alzheimer’s disease continuum Neurobiol Aging. 2023 Dec; 132:1-12. . View in PubMed
Etiology of White Matter Hyperintensities in Autosomal Dominant and Sporadic Alzheimer Disease JAMA Neurol. 2023 Dec 01; 80(12):1353-1363. . View in PubMed
Alzheimer’s Related Neurodegeneration Mediates Air Pollution Effects on Medial Temporal Lobe Atrophy medRxiv. 2023 Nov 29. . View in PubMed
Association between late-life air pollution exposure and medial temporal lobe atrophy in older women medRxiv. 2023 Nov 29. . View in PubMed
Use of the Spanish English Neuropsychological Assessment Scale in older adult Latines and those at risk for autosomal dominant Alzheimer’s disease J Clin Exp Neuropsychol. 2023 Aug; 45(6):553-569. . View in PubMed
Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies LRRC4C, LHX5-AS1 and nominates ancestry-specific loci PTPRK , GRB14 , and KIAA0825 as novel risk loci for Alzheimer’s disease: the Alzheimer’s Disease Genetics Consortium medRxiv. 2023 Jul 08. . View in PubMed
Decreased functional connectivity is associated with increased levels of Cerebral Spinal Fluid soluble-PDGFRß, a marker of blood brain barrier breakdown, in older adults Res Sq. 2023 Mar 07. . View in PubMed
Location of pathogenic variants in PSEN1 impacts progression of cognitive, clinical, and neurodegenerative measures in autosomal-dominant Alzheimer’s disease Aging Cell. 2023 08; 22(8):e13871. . View in PubMed
Metabolomic and lipidomic signatures in autosomal dominant and late-onset Alzheimer’s disease brains Alzheimers Dement. 2023 05; 19(5):1785-1799. . View in PubMed
The small HDL particle hypothesis of Alzheimer’s disease Alzheimers Dement. 2023 02; 19(2):391-404. . View in PubMed
Prevalence of dementia and mild cognitive impairment in indigenous Bolivian forager-horticulturalists Alzheimers Dement. 2023 01; 19(1):44-55. . View in PubMed
Microstructural mapping of dentate gyrus pathology in Alzheimer’s disease: A 164 Tesla MRI study. Neuroimage Clin. 2023; 37:103318. . View in PubMed
Baseline Findings of PreventE4: A Double-Blind Placebo Controlled Clinical Trial Testing High Dose DHA in APOE4 Carriers before the Onset of Dementia J Prev Alzheimers Dis. 2023; 10(4):810-820. . View in PubMed
The association between white matter hyperintensities and amyloid and tau deposition Neuroimage Clin. 2023; 38:103383. . View in PubMed
Characterization of spastic paraplegia in a family with a novel PSEN1 mutation Brain Commun. 2023; 5(2):fcad030. . View in PubMed
Proteomics of brain, CSF, and plasma identifies molecular signatures for distinguishing sporadic and genetic Alzheimer’s disease Sci Transl Med. 2023 07 05; 15(703):eabq5923. . View in PubMed
Brain volume, energy balance, and cardiovascular health in two nonindustrial South American populations Proc Natl Acad Sci U S A. 2023 03 28; 120(13):e2205448120. . View in PubMed
The relationship of history of psychiatric and substance use disorders on risk of dementia among racial and ethnic groups in the United States Front Psychiatry. 2023; 14:1165262. . View in PubMed
B vitamin intakes modify the association between particulate air pollutants and incidence of all-cause dementia: Findings from the Women’s Health Initiative Memory Study Alzheimers Dement. 2022 Nov; 18(11):2188-2198. . View in PubMed
Brain age estimation reveals older adults’ accelerated senescence after traumatic brain injury Geroscience. 2022 Jul 06. . View in PubMed
Ambient air pollution exposure and increasing depressive symptoms in older women: The mediating role of the prefrontal cortex and insula Sci Total Environ. 2022 Jun 01; 823:153642. . View in PubMed
White matter degradation near cerebral microbleeds is associated with cognitive change after mild traumatic brain injury Neurobiol Aging. 2022 12; 120:68-80. . View in PubMed
Locus coeruleus integrity is related to tau burden and memory loss in autosomal-dominant Alzheimer’s disease Neurobiol Aging. 2022 04; 112:39-54. . View in PubMed
Brain energy failure in dementia syndromes: Opportunities and challenges for glucagon-like peptide-1 receptor agonists Alzheimers Dement. 2022 03; 18(3):478-497. . View in PubMed
Air quality improvement and cognitive decline in community-dwelling older women in the United States: A longitudinal cohort study PLoS Med. 2022 02; 19(2):e1003893. . View in PubMed
Older age, male sex, and cerebral microbleeds predict white matter loss after traumatic brain injury Geroscience. 2022 02; 44(1):83-102. . View in PubMed
Calcium-dependent cytosolic phospholipase A2 activation is implicated in neuroinflammation and oxidative stress associated with ApoE4 Mol Neurodegener. 2022 06 15; 17(1):42. . View in PubMed
Retraction Note: Calcium-dependent cytosolic phospholipase A2 activation is implicated in neuroinflammation and oxidative stress associated with ApoE4 Mol Neurodegener. 2022 02 04; 17(1):14. . View in PubMed
Racial/Ethnic Disparities in Alzheimer’s Disease Risk: Role of Exposure to Ambient Fine Particles J Gerontol A Biol Sci Med Sci. 2022 05 05; 77(5):977-985. . View in PubMed
Association of improved air quality with lower dementia risk in older women Proc Natl Acad Sci U S A. 2022 01 11; 119(2). . View in PubMed
Circular RNA detection identifies circPSEN1 alterations in brain specific to autosomal dominant Alzheimer’s disease Acta Neuropathol Commun. 2022 03 04; 10(1):29. . View in PubMed
Autosomal dominant and sporadic late onset Alzheimer’s disease share a common in vivo pathophysiology Brain. 2022 10 21; 145(10):3594-3607. . View in PubMed
Alzheimer’s disease after mild traumatic brain injury Aging (Albany NY). 2022 07 12; 14(13):5292-5293. . View in PubMed
Cerebral Amyloid Angiopathy-related Inflammation Presenting With a Cystic Lesion in Young-onset Alzheimer Disease Alzheimer Dis Assoc Disord. 2021 Jul-Sep 01; 35(3):265-268. . View in PubMed
PM25 Associated With Gray Matter Atrophy Reflecting Increased Alzheimer Risk in Older Women. Neurology. 2021 Feb 22; 96(8):e1190-e1201. . View in PubMed
Outdoor air pollution exposure and inter-relation of global cognitive performance and emotional distress in older women Environ Pollut. 2021 Feb 15; 271:116282. . View in PubMed
Adherence to a MIND-Like Dietary Pattern, Long-Term Exposure to Fine Particulate Matter Air Pollution, and MRI-Based Measures of Brain Volume: The Women’s Health Initiative Memory Study-MRI Environ Health Perspect. 2021 12; 129(12):127008. . View in PubMed
Ambient Air Pollution and Long-Term Trajectories of Episodic Memory Decline among Older Women in the WHIMS-ECHO Cohort Environ Health Perspect. 2021 09; 129(9):97009. . View in PubMed
Past, present and future role of retinal imaging in neurodegenerative disease Prog Retin Eye Res. 2021 07; 83:100938. . View in PubMed
Assessment of carotid stiffness by measuring carotid pulse wave velocity using a single-slice oblique-sagittal phase-contrast MRI Magn Reson Med. 2021 07; 86(1):442-455. . View in PubMed
Early neuroinflammation is associated with lower amyloid and tau levels in cognitively normal older adults Brain Behav Immun. 2021 05; 94:299-307. . View in PubMed
Volumetric distribution of perivascular space in relation to mild cognitive impairment Neurobiol Aging. 2021 03; 99:28-43. . View in PubMed
Cerebroarterial pulsatility and resistivity indices are associated with cognitive impairment and white matter hyperintensity in elderly subjects: A phase-contrast MRI study J Cereb Blood Flow Metab. 2021 03; 41(3):670-683. . View in PubMed
Reaction time and response inhibition in autosomal dominant Alzheimer’s disease Brain Cogn. 2021 02; 147:105656. . View in PubMed
Air Pollution and the Dynamic Association Between Depressive Symptoms and Memory in Oldest-Old Women J Am Geriatr Soc. 2021 02; 69(2):474-484. . View in PubMed
Novel Alzheimer Disease Risk Loci and Pathways in African American Individuals Using the African Genome Resources Panel: A Meta-analysis JAMA Neurol. 2021 01 01; 78(1):102-113. . View in PubMed
Longitudinal Accumulation of Cerebral Microhemorrhages in Dominantly Inherited Alzheimer Disease Neurology. 2021 03 23; 96(12):e1632-e1645. . View in PubMed
Segregation of functional networks is associated with cognitive resilience in Alzheimer’s disease Brain. 2021 08 17; 144(7):2176-2185. . View in PubMed
Associations Between Air Pollution Exposure and Empirically Derived Profiles of Cognitive Performance in Older Women J Alzheimers Dis. 2021; 84(4):1691-1707. . View in PubMed
Calcium-dependent cytosolic phospholipase A2 activation is implicated in neuroinflammation and oxidative stress associated with ApoE4 Mol Neurodegener. 2021 04 16; 16(1):26. . View in PubMed
Brain delivery of supplemental docosahexaenoic acid (DHA): A randomized placebo-controlled clinical trial EBioMedicine. 2020 Sep; 59:102883. . View in PubMed
Emotional detachment, gait ataxia, and cerebellar dysconnectivity associated with compound heterozygous mutations in the SPG7 gene Neurocase. 2020 10; 26(5):299-304. . View in PubMed
A novel sensitive assay for detection of a biomarker of pericyte injury in cerebrospinal fluid Alzheimers Dement. 2020 06; 16(6):821-830. . View in PubMed
APOE4 leads to blood-brain barrier dysfunction predicting cognitive decline Nature. 2020 05; 581(7806):71-76. . View in PubMed
Exposure to fine particulate matter and temporal dynamics of episodic memory and depressive symptoms in older women Environ Int. 2020 02; 135:105196. . View in PubMed
Erythrocyte omega-3 index, ambient fine particle exposure, and brain aging Neurology. 2020 08 25; 95(8):e995-e1007. . View in PubMed
Correction: Retinal nerve fiber layer thickness predicts CSF amyloid/tau before cognitive decline PLoS One. 2020; 15(7):e0236379. . View in PubMed
Associations between Vascular Function and Tau PET Are Associated with Global Cognition and Amyloid J Neurosci. 2020 10 28; 40(44):8573-8586. . View in PubMed
Retinal nerve fiber layer thickness predicts CSF amyloid/tau before cognitive decline PLoS One. 2020; 15(5):e0232785. . View in PubMed
Urine dicarboxylic acids change in pre-symptomatic Alzheimer’s disease and reflect loss of energy capacity and hippocampal volume PLoS One. 2020; 15(4):e0231765. . View in PubMed
Particulate matter and episodic memory decline mediated by early neuroanatomic biomarkers of Alzheimer’s disease Brain. 2020 01 01; 143(1):289-302. . View in PubMed
Frequency of the TREM2 R47H Variant in Various Neurodegenerative Disorders Alzheimer Dis Assoc Disord. 2019 Oct-Dec; 33(4):327-330. . View in PubMed
Author Correction: Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aß, tau, immunity and lipid processing Nat Genet. 2019 Sep; 51(9):1423-1424. . View in PubMed
Undetectable gadolinium brain retention in individuals with an age-dependent blood-brain barrier breakdown in the hippocampus and mild cognitive impairment Alzheimers Dement. 2019 12; 15(12):1568-1575. . View in PubMed
Particulate Air Pollutants and Trajectories of Depressive Symptoms in Older Women Am J Geriatr Psychiatry. 2019 10; 27(10):1083-1096. . View in PubMed
Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aß, tau, immunity and lipid processing Nat Genet. 2019 03; 51(3):414-430. . View in PubMed
Blood-brain barrier breakdown is an early biomarker of human cognitive dysfunction Nat Med. 2019 02; 25(2):270-276. . View in PubMed
Vascular dysfunction-The disregarded partner of Alzheimer’s disease Alzheimers Dement. 2019 01; 15(1):158-167. . View in PubMed
Psychometric Characteristics of Cognitive Reserve: How High Education Might Improve Certain Cognitive Abilities in Aging Dement Geriatr Cogn Disord. 2019; 47(4-6):335-344. . View in PubMed
Limbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report Brain. 2019 06 01; 142(6):1503-1527. . View in PubMed
Low-Density Lipoprotein Particle Size Subfractions and Cerebral Amyloidosis J Alzheimers Dis. 2019; 68(3):983-990. . View in PubMed
ApoE4 Alters ABCA1 Membrane Trafficking in Astrocytes J Neurosci. 2019 11 27; 39(48):9611-9622. . View in PubMed
General and domain-specific cognitive reserve, mild cognitive impairment, and dementia risk in older women Alzheimers Dement (N Y). 2019; 5:118-128. . View in PubMed
Version 3 of the National Alzheimer’s Coordinating Center’s Uniform Data Set Alzheimer Dis Assoc Disord. 2018 Oct-Dec; 32(4):351-358. . View in PubMed
Review: Vascular dementia: clinicopathologic and genetic considerations Neuropathol Appl Neurobiol. 2018 04; 44(3):247-266. . View in PubMed
Triglycerides are negatively correlated with cognitive function in nondemented aging adults Neuropsychology. 2017 Sep; 31(6):682-688. . View in PubMed
Association of Docosahexaenoic Acid Supplementation With Alzheimer Disease Stage in Apolipoprotein E e4 Carriers: A Review JAMA Neurol. 2017 Mar 01; 74(3):339-347. . View in PubMed
Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer’s disease Nat Genet. 2017 09; 49(9):1373-1384. . View in PubMed
Vascular Contributions to Cognitive Impairment in Late Life Neurol Clin. 2017 05; 35(2):295-323. . View in PubMed
Two Novel Mutations in the First Transmembrane Domain of Presenilin1 Cause Young-Onset Alzheimer’s Disease J Alzheimers Dis. 2017; 58(4):1035-1041. . View in PubMed
A T1 and DTI fused 3D corpus callosum analysis in MCI subjects with high and low cardiovascular risk profile Neuroimage Clin. 2017; 14:298-307. . View in PubMed
Neuropsychological Profiles Differentiate Alzheimer Disease from Subcortical Ischemic Vascular Dementia in an Autopsy-Defined Cohort Dement Geriatr Cogn Disord. 2017; 44(1-2):1-11. . View in PubMed
Particulate air pollutants, APOE alleles and their contributions to cognitive impairment in older women and to amyloidogenesis in experimental models Transl Psychiatry. 2017 01 31; 7(1):e1022. . View in PubMed
Late-Life Vascular Risk Factors and Alzheimer Disease Neuropathology in Individuals with Normal Cognition J Neuropathol Exp Neurol. 2016 Oct; 75(10):955-962. . View in PubMed
Association of Serum Docosahexaenoic Acid With Cerebral Amyloidosis JAMA Neurol. 2016 Oct 01; 73(10):1208-1216. . View in PubMed
ABCA1-Mediated Cholesterol Efflux Capacity to Cerebrospinal Fluid Is Reduced in Patients With Mild Cognitive Impairment and Alzheimer’s Disease J Am Heart Assoc. 2016 Feb 12; 5(2). . View in PubMed
Melanopsin retinal ganglion cell loss in Alzheimer disease Ann Neurol. 2016 Jan; 79(1):90-109. . View in PubMed
The effect of APOE genotype on the delivery of DHA to cerebrospinal fluid in Alzheimer’s disease Alzheimers Res Ther. 2016 06 30; 8:25. . View in PubMed
A Voxel-Based Morphometry Study Reveals Local Brain Structural Alterations Associated with Ambient Fine Particles in Older Women Front Hum Neurosci. 2016; 10:495. . View in PubMed
A Multidisciplinary Model of Dementia Care in an Underserved Retirement Community, Made Possible by Telemedicine Front Neurol. 2016; 7:225. . View in PubMed
Differential effects of ischemic vascular disease and Alzheimer’s disease on brain atrophy and cognition J Cereb Blood Flow Metab. 2016 Jan; 36(1):204-15. . View in PubMed
Consensus statement for diagnosis of subcortical small vessel disease J Cereb Blood Flow Metab. 2016 Jan; 36(1):6-25. . View in PubMed
Trajectories of depressive symptoms in old age: Integrating age-, pathology-, and mortality-related changes Psychol Aging. 2015 Dec; 30(4):940-51. . View in PubMed
Ambient air pollution and neurotoxicity on brain structure: Evidence from women’s health initiative memory study Ann Neurol. 2015 Sep; 78(3):466-76. . View in PubMed
A multiancestral genome-wide exome array study of Alzheimer disease, frontotemporal dementia, and progressive supranuclear palsy JAMA Neurol. 2015 Apr; 72(4):414-22. . View in PubMed
Rarity of the Alzheimer disease-protective APP A673T variant in the United States JAMA Neurol. 2015 Feb; 72(2):209-16. . View in PubMed
Blood-brain barrier breakdown in the aging human hippocampus Neuron. 2015 Jan 21; 85(2):296-302. . View in PubMed
Clinical and imaging features of mixed Alzheimer and vascular pathologies Alzheimers Res Ther. 2015; 7(1):21. . View in PubMed
Measuring future time perspective across adulthood: development and evaluation of a brief multidimensional questionnaire Gerontologist. 2014 Dec; 54(6):1075-88. . View in PubMed
Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study JAMA Neurol. 2014 Nov; 71(11):1394-404. . View in PubMed
Vascular risk and Aß interact to reduce cortical thickness in AD vulnerable brain regions Neurology. 2014 Jul 01; 83(1):40-7. . View in PubMed
Diagnostic criteria for vascular cognitive disorders: a VASCOG statement Alzheimer Dis Assoc Disord. 2014 Jul-Sep; 28(3):206-18. . View in PubMed
Mapping of ApoE4 Related White Matter Damage using Diffusion MRI Proc SPIE Int Soc Opt Eng. 2014 Apr 09; 9039:90390H. . View in PubMed
The Power of Hybrid/Fusion Imaging Metrics in Future PACS Systems: A Case Study into the White Matter Hyperintensity Prenumbra using FLAIR and Diffusion MR Proc SPIE Int Soc Opt Eng. 2014 Apr 09; 9039:90390I. . View in PubMed
Cortical thickness mediates the effect of ß-amyloid on episodic memory Neurology. 2014 Mar 04; 82(9):761-7. . View in PubMed
Social partners and momentary affect in the oldest-old: the presence of others benefits affect depending on who we are and who we are with Dev Psychol. 2014 Mar; 50(3):728-40. . View in PubMed
APOE associations with severe CAA-associated vasculopathic changes: collaborative meta-analysis J Neurol Neurosurg Psychiatry. 2014 Mar; 85(3):300-5. . View in PubMed
Change in coping and defense mechanisms across adulthood: longitudinal findings in a European American sample Dev Psychol. 2014 Feb; 50(2):634-48. . View in PubMed
Associations between serum cholesterol levels and cerebral amyloidosis JAMA Neurol. 2014 Feb; 71(2):195-200. . View in PubMed
The role of carotid intima-media thickness in predicting longitudinal cognitive function in an older adult cohort Cerebrovasc Dis. 2014; 38(6):441-7. . View in PubMed
10-minute delayed recall from the modified mini-mental state test predicts Alzheimer’s disease pathology J Alzheimers Dis. 2014; 39(3):575-82. . View in PubMed
Differences in prefrontal, limbic, and white matter lesion volumes according to cognitive status in elderly patients with first-onset subsyndromal depression PLoS One. 2014; 9(1):e87747. . View in PubMed
Assessment of cerebrovascular reactivity during resting state breathing and its correlation with cognitive function in hypertension Cerebrovasc Dis. 2014; 38(1):10-6. . View in PubMed
Cerebral atherosclerosis is associated with cystic infarcts and microinfarcts but not Alzheimer pathologic changes Stroke. 2013 Oct; 44(10):2835-41. . View in PubMed
The aging brain and cognition: contribution of vascular injury and aß to mild cognitive dysfunction JAMA Neurol. 2013 Apr; 70(4):488-95. . View in PubMed
Alzheimer pathology and angiotension receptor blockers JAMA Neurol. 2013 Mar 01; 70(3):414. . View in PubMed
Associations between white matter hyperintensities and ß amyloid on integrity of projection, association, and limbic fiber tracts measured with diffusion tensor MRI PLoS One. 2013; 8(6):e65175. . View in PubMed
Walking stabilizes cognitive functioning in Alzheimer’s disease (AD) across one year Arch Gerontol Geriatr. 2013 Jan-Feb; 56(1):96-103. . View in PubMed
Impact of Angiotensin receptor blockers on Alzheimer disease neuropathology in a large brain autopsy series Arch Neurol. 2012 Dec; 69(12):1632-8. . View in PubMed
Associations among vascular risk factors, carotid atherosclerosis, and cortical volume and thickness in older adults Stroke. 2012 Nov; 43(11):2865-70. . View in PubMed
Coronary risk correlates with cerebral amyloid deposition Neurobiol Aging. 2012 Sep; 33(9):1979-87. . View in PubMed
Different associations of white matter lesions with depression and cognition BMC Neurol. 2012 Aug 25; 12:83. . View in PubMed
Evidence for a role of the rare pA152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimer’s diseases. Hum Mol Genet. 2012 Aug 01; 21(15):3500-12. . View in PubMed
Novel late-onset Alzheimer disease loci variants associate with brain gene expression Neurology. 2012 Jul 17; 79(3):221-8. . View in PubMed
Prevalence, laterality, and comorbidity of hippocampal sclerosis in an autopsy sample Brain Behav. 2012 Jul; 2(4):435-42. . View in PubMed
Preservation of neurons of the nucleus basalis in subcortical ischemic vascular disease Arch Neurol. 2012 Jul; 69(7):879-86. . View in PubMed
Cerebrovascular disease, ß-amyloid, and cognition in agingNeurobiol Aging. 2012 May; 33(5):1006. e25-36. . View in PubMed
Effect of antihypertensive therapy on cognitive function in early executive cognitive impairment: a double-blind randomized clinical trial Arch Intern Med. 2012 Mar 12; 172(5):442-4. . View in PubMed
Coronary artery disease is associated with cognitive decline independent of changes on magnetic resonance imaging in cognitively normal elderly adults J Am Geriatr Soc. 2012 Mar; 60(3):499-504. . View in PubMed
Alzheimers Res Ther. 2012 Jan 04; 4(1):1. . View in PubMed
Chinese-language montreal cognitive assessment for cantonese or mandarin speakers: age, education, and gender effects Int J Alzheimers Dis. 2012; 2012:204623. . View in PubMed
Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the american heart association/american stroke association Stroke. 2011 Sep; 42(9):2672-713. . View in PubMed
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer’s disease Nat Genet. 2011 May; 43(5):436-41. . View in PubMed
MRI shows more severe hippocampal atrophy and shape deformation in hippocampal sclerosis than in Alzheimer’s disease Int J Alzheimers Dis. 2011 Apr 11; 2011:483972. . View in PubMed
Operationalizing diagnostic criteria for Alzheimer’s disease and other age-related cognitive impairment-Part 2 Alzheimers Dement. 2011 Jan; 7(1):35-52. . View in PubMed
Association of depressed mood and mortality in older adults with and without cognitive impairment in a prospective naturalistic study Am J Psychiatry. 2010 May; 167(5):589-97. . View in PubMed
Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions Nat Genet. 2010 Mar; 42(3):234-9. . View in PubMed
Influences of lobar gray matter and white matter lesion load on cognition and mood Psychiatry Res. 2010 Feb 28; 181(2):90-6. . View in PubMed
White matter integrity and cortical metabolic associations in aging and dementia Alzheimers Dement. 2010 Jan; 6(1):54-62. . View in PubMed
Cerebral blood flow in ischemic vascular dementia and Alzheimer’s disease, measured by arterial spin-labeling magnetic resonance imaging Alzheimers Dement. 2009 Nov; 5(6):454-62. . View in PubMed
The Alzheimer’s Disease Centers’ Uniform Data Set (UDS): the neuropsychologic test battery Alzheimer Dis Assoc Disord. 2009 Apr-Jun; 23(2):91-101. . View in PubMed
Longitudinal changes in memory and executive functioning are associated with longitudinal change in instrumental activities of daily living in older adults Clin Neuropsychol. 2009 Apr; 23(3):446-61. . View in PubMed
An inverse association of cardiovascular risk and frontal lobe glucose metabolism Neurology. 2009 Feb 24; 72(8):738-43. . View in PubMed
Association of distinct variants in SORL1 with cerebrovascular and neurodegenerative changes related to Alzheimer disease Arch Neurol. 2008 Dec; 65(12):1640-8. . View in PubMed
The MRI brain correlates of depressed mood, anhedonia, apathy, and anergia in older adults with and without cognitive impairment or dementia Int J Geriatr Psychiatry. 2008 Oct; 23(10):1040-50. . View in PubMed
Understanding hippocampal sclerosis in the elderly: epidemiology, characterization, and diagnostic issues Curr Neurol Neurosci Rep. 2008 Sep; 8(5):363-70. . View in PubMed
Cognitive and anatomic contributions of metabolic decline in Alzheimer disease and cerebrovascular disease Arch Neurol. 2008 May; 65(5):650-5. . View in PubMed
Incidence of dementia in long-term hormone users Am J Epidemiol. 2008 Mar 15; 167(6):692-700. . View in PubMed
Subcortical lacunes are associated with executive dysfunction in cognitively normal elderly Stroke. 2008 Feb; 39(2):397-402. . View in PubMed
Co-registration of In-Vivo Human MRI Brain Images to Postmortem Histological Microscopic Images Int J Imaging Syst Technol. 2008; 18(5-6):325-335. . View in PubMed
Neuropathological basis of magnetic resonance images in aging and dementia Ann Neurol. 2008 Jan; 63(1):72-80. . View in PubMed
Cognitive and neuroimaging predictors of instrumental activities of daily living J Int Neuropsychol Soc. 2007 Sep; 13(5):747-57. . View in PubMed
Subcortical ischemic vascular dementia Neurol Clin. 2007 Aug; 25(3):717-40vi. . View in PubMed
A community epidemiological survey of generalized anxiety disorder in Hong Kong Community Ment Health J. 2007 Aug; 43(4):305-19. . View in PubMed
Amyloid imaging in distinguishing atypical prion disease from Alzheimer disease Neurology. 2007 Jul 17; 69(3):283-90. . View in PubMed
Longitudinal MRI and cognitive change in healthy elderly Neuropsychology. 2007 Jul; 21(4):412-8. . View in PubMed
Profiles of neuropsychological impairment in autopsy-defined Alzheimer’s disease and cerebrovascular disease Brain. 2007 Mar; 130(Pt 3):731-9. . View in PubMed
Diffusion tensor imaging of cingulum fibers in mild cognitive impairment and Alzheimer disease Neurology. 2007 Jan 02; 68(1):13-9. . View in PubMed
Memory in the aging brain: doubly dissociating the contribution of the hippocampus and entorhinal cortex Hippocampus. 2007; 17(11):1134-40. . View in PubMed
Cognitive impact of subcortical vascular and Alzheimer’s disease pathology Ann Neurol. 2006 Dec; 60(6):677-87. . View in PubMed
Performance of Spanish speakers on the Mattis dementia rating scale (MDRS) Arch Clin Neuropsychol. 2006 Dec; 21(8):827-36. . View in PubMed
The A431E mutation in PSEN1 causing familial Alzheimer’s disease originating in Jalisco State, Mexico: an additional fifteen families Neurogenetics. 2006 Nov; 7(4):277-9. . View in PubMed
The Uniform Data Set (UDS): clinical and cognitive variables and descriptive data from Alzheimer Disease Centers Alzheimer Dis Assoc Disord. 2006 Oct-Dec; 20(4):210-6. . View in PubMed
Vascular cognitive impairment: today and tomorrow Alzheimers Dement. 2006 Jul; 2(3):185-94. . View in PubMed
Age effects on atrophy rates of entorhinal cortex and hippocampus Neurobiol Aging. 2006 May; 27(5):733-40. . View in PubMed
Pulse pressure correlates with leukoaraiosis in Alzheimer disease Arch Gerontol Geriatr. 2006 Mar-Apr; 42(2):157-66. . View in PubMed
Advances in vascular cognitive impairment 2005 Stroke. 2006 Feb; 37(2):323-5. . View in PubMed
Cultural diversity in Alzheimer disease: the interface between biology, belief, and behavior Alzheimer Dis Assoc Disord. 2005 Oct-Dec; 19(4):250-5. . View in PubMed
Longitudinal volumetric MRI change and rate of cognitive decline Neurology. 2005 Aug 23; 65(4):565-71. . View in PubMed
Category fluency in a latino sample: associations with age, education, gender, and language J Clin Exp Neuropsychol. 2005 Jul; 27(5):591-8. . View in PubMed
Correlates of hippocampal neuron number in Alzheimer’s disease and ischemic vascular dementia Ann Neurol. 2005 Jun; 57(6):896-903. . View in PubMed
Validation of multi-stage telephone-based identification of cognitive impairment and dementia BMC Neurol. 2005 Apr 13; 5(1):8. . View in PubMed
White matter lesions are associated with cortical atrophy more than entorhinal and hippocampal atrophy Neurobiol Aging. 2005 Apr; 26(4):553-9. . View in PubMed
Pattern of cerebral hypoperfusion in Alzheimer disease and mild cognitive impairment measured with arterial spin-labeling MR imaging: initial experience Radiology. 2005 Mar; 234(3):851-9. . View in PubMed
Reduced medial temporal lobe N-acetylaspartate in cognitively impaired but nondemented patients Neurology. 2005 Jan 25; 64(2):282-9. . View in PubMed
Neuropathology lessons in vascular dementia Alzheimer Dis Assoc Disord. 2005 Jan-Mar; 19(1):45-52. . View in PubMed
A standardized method for brain-cutting suitable for both stereology and MRI-brain co-registration J Neurosci Methods. 2004 Oct 30; 139(2):209-15. . View in PubMed
Comparisons between global and focal brain atrophy rates in normal aging and Alzheimer disease: Boundary Shift Integral versus tracing of the entorhinal cortex and hippocampus Alzheimer Dis Assoc Disord. 2004 Oct-Dec; 18(4):196-201. . View in PubMed
White matter lesions impair frontal lobe function regardless of their location Neurology. 2004 Jul 27; 63(2):246-53. . View in PubMed
Memory impairment, but not cerebrovascular disease, predicts progression of MCI to dementia Neurology. 2004 Jul 27; 63(2):220-7. . View in PubMed
Hippocampal volume and retention in Alzheimer’s disease J Int Neuropsychol Soc. 2004 Jul; 10(4):639-43. . View in PubMed
A randomized controlled comparison of upper-extremity rehabilitation strategies in acute stroke: A pilot study of immediate and long-term outcomes Arch Phys Med Rehabil. 2004 Apr; 85(4):620-8. . View in PubMed
Higher atrophy rate of entorhinal cortex than hippocampus in AD Neurology. 2004 Feb 10; 62(3):422-7. . View in PubMed
Forgetting in dementia with and without subcortical lacunes Clin Neuropsychol. 2004 Feb; 18(1):32-40. . View in PubMed
Clinical and neuropsychological features in autopsy-defined vascular dementia Clin Neuropsychol. 2004 Feb; 18(1):63-74. . View in PubMed
Different patterns of N-acetylaspartate loss in subcortical ischemic vascular dementia and AD Neurology. 2003 Aug 12; 61(3):358-64. . View in PubMed
Comparison of methods for measuring longitudinal brain change in cognitive impairment and dementia Neurobiol Aging. 2003 Jul-Aug; 24(4):537-44. . View in PubMed
Depression as a risk factor for Alzheimer disease: the MIRAGE Study Arch Neurol. 2003 May; 60(5):753-9. . View in PubMed
Neuronal loss is greater in the locus coeruleus than nucleus basalis and substantia nigra in Alzheimer and Parkinson diseases Arch Neurol. 2003 Mar; 60(3):337-41. . View in PubMed
Atrophy rates of entorhinal cortex in AD and normal aging Neurology. 2003 Feb 11; 60(3):481-6. . View in PubMed
Neuron loss in key cholinergic and aminergic nuclei in Alzheimer disease: a meta-analysis Neurobiol Aging. 2003 Jan-Feb; 24(1):1-23. . View in PubMed
Subcortical ischaemic vascular dementia Lancet Neurol. 2002 Nov; 1(7):426-36. . View in PubMed
Volumetric MRI predicts rate of cognitive decline related to AD and cerebrovascular disease Neurology. 2002 Sep 24; 59(6):867-73. . View in PubMed
Effects of subcortical ischemic vascular dementia and AD on entorhinal cortex and hippocampus Neurology. 2002 Jun 11; 58(11):1635-41. . View in PubMed
Quantitative magnetic resonance imaging differences between Alzheimer disease with and without subcortical lacunes Alzheimer Dis Assoc Disord. 2002 Apr-Jun; 16(2):58-64. . View in PubMed
Executive dysfunction in subcortical ischaemic vascular disease J Neurol Neurosurg Psychiatry. 2002 Feb; 72(2):217-20. . View in PubMed
MRI predictors of cognition in subcortical ischemic vascular disease and Alzheimer’s disease Neurology. 2001 Dec 26; 57(12):2229-35. . View in PubMed
Magnetic resonance imaging of the entorhinal cortex and hippocampus in mild cognitive impairment and Alzheimer’s disease J Neurol Neurosurg Psychiatry. 2001 Oct; 71(4):441-7. . View in PubMed
Practice parameter: diagnosis of dementia (an evidence-based review)Report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology. 2001 May 08; 56(9):1143-53. . View in PubMed
Dementia due to subcortical ischemic vascular disease Clin Cornerstone. 2001; 3(4):40-51. . View in PubMed
Hippocampal and cortical atrophy predict dementia in subcortical ischemic vascular disease Neurology. 2000 Dec 12; 55(11):1626-35. . View in PubMed
Neuropathologic substrates of ischemic vascular dementia J Neuropathol Exp Neurol. 2000 Nov; 59(11):931-45. . View in PubMed
Vascular dementia, a new beginning: shifting focus from clinical phenotype to ischemic brain injury Neurol Clin. 2000 Nov; 18(4):951-78. . View in PubMed
Subcortical ischemic vascular dementia: assessment with quantitative MR imaging and 1H MR spectroscopy AJNR Am J Neuroradiol. 2000 Apr; 21(4):621-30. . View in PubMed
Head injury and the risk of AD in the MIRAGE study Neurology. 2000 Mar 28; 54(6):1316-23. . View in PubMed
Clinical criteria for the diagnosis of vascular dementia: a multicenter study of comparability and interrater reliability Arch Neurol. 2000 Feb; 57(2):191-6. . View in PubMed
Research criteria for subcortical vascular dementia in clinical trials J Neural Transm Suppl. 2000; 59:23-30. . View in PubMed
Natural history of vascular dementia Alzheimer Dis Assoc Disord. 1999 Oct-Dec; 13 Suppl 3:S124-30. . View in PubMed
Magnetization transfer ratio of white matter hyperintensities in subcortical ischemic vascular dementia AJNR Am J Neuroradiol. 1999 May; 20(5):839-44. . View in PubMed
Cerebral amyloid angiopathy in Alzheimer disease is associated with apolipoprotein E4 and cortical neuron loss Alzheimer Dis Assoc Disord. 1999 Jan; 13(1):1-8. . View in PubMed
Ideomotor apraxia in early Alzheimer’s disease: time and accuracy measures Brain Cogn. 1998 Nov; 38(2):220-33. . View in PubMed
[Advances in the molecular biological study of hereditary antithrombin III deficiency] Zhonghua Xue Ye Xue Za Zhi. 1998 Mar; 19(3):162-4. . View in PubMed
Potent alpha 4 beta 1 peptide antagonists as potential anti-inflammatory agents J Med Chem. 1997 Oct 10; 40(21):3359-68. . View in PubMed
Evaluation of dementia: a systematic study of the usefulness of the American Academy of Neurology’s practice parameters Neurology. 1997 Oct; 49(4):925-35. . View in PubMed
Vascular basement membrane pathology and Alzheimer’s disease Ann N Y Acad Sci. 1997 Sep 26; 826:147-60. . View in PubMed
Eligibility of Alzheimer’s disease clinic patients for clinical trials J Am Geriatr Soc. 1997 Aug; 45(8):923-8. . View in PubMed
Elevated risk of Alzheimer’s disease among workers with likely electromagnetic field exposure Neurology. 1996 Dec; 47(6):1477-81. . View in PubMed
Evidence for major gene inheritance of Alzheimer disease in families of patients with and without apolipoprotein E epsilon 4 Am J Hum Genet. 1996 Sep; 59(3):664-75. . View in PubMed
Physical aggression is associated with preservation of substantia nigra pars compacta in Alzheimer disease Arch Neurol. 1996 May; 53(5):428-34. . View in PubMed
Risk of dementia among relatives of Alzheimer’s disease patients in the MIRAGE study: What is in store for the oldest old? Neurology. 1996 Mar; 46(3):641-50.. View in PubMed
Multicenter clinicopathological correlation in dementia Am J Psychiatry. 1995 Oct; 152(10):1476-84. . View in PubMed
Localization of amyloid P component in human brain: vascular staining patterns and association with Alzheimer’s disease lesions J Comp Neurol. 1995 Jan 30; 352(1):92-105. . View in PubMed
A method to improve interrater reliability of visual inspection of brain MRI scans in dementia Neurology. 1994 Dec; 44(12):2267-76. . View in PubMed
Re: A scoring error in the Mini-Mental State Test Can J Psychiatry. 1994 Aug; 39(6):383-4; author reply 384-5. . View in PubMed
Extrapyramidal signs and psychiatric symptoms predict faster cognitive decline in Alzheimer’s disease Arch Neurol. 1994 Jul; 51(7):676-81. . View in PubMed
Reliability and usefulness of a new immunochemical assay for Alzheimer’s disease Arch Neurol. 1993 Jan; 50(1):57-63. . View in PubMed
Studies of the enteric nervous system in Alzheimer disease and other dementias of the elderly: enteric neurons in Alzheimer disease Mod Pathol. 1993 Jan; 6(1):10-4. . View in PubMed
Neuropathologic diagnosis of Alzheimer disease: interrater reliability in the assessment of senile plaques and neurofibrillary tangles Alzheimer Dis Assoc Disord. 1993; 7(1):48-54. . View in PubMed
MHC class II-positive microglia in human brain: association with Alzheimer lesions J Neurosci Res. 1992 Dec; 33(4):549-58. . View in PubMed
Cortical biopsy in Alzheimer’s disease: diagnostic accuracy and neurochemical, neuropathological, and cognitive correlationsIntraventricular Bethanecol Study Group. Ann Neurol. 1992 Nov; 32(5):625-32. . View in PubMed
Criteria for the diagnosis of ischemic vascular dementia proposed by the State of California Alzheimer’s Disease Diagnostic and Treatment Centers Neurology. 1992 Mar; 42(3 Pt 1):473-80. . View in PubMed
Association between vascular basement membrane components and the lesions of Alzheimer’s disease J Neurosci Res. 1991 Dec; 30(4):673-81. . View in PubMed
Temporal and hippocampal metabolic rate during an olfactory memory task assessed by positron emission tomography in patients with dementia of the Alzheimer type and controlsPreliminary studies. Arch Gen Psychiatry. 1991 Sep; 48(9):840-7. . View in PubMed
Morphologic association between microglia and senile plaque amyloid in Alzheimer’s disease Neurosci Lett. 1990 Oct 30; 119(1):32-6. . View in PubMed
Microangiopathy, the vascular basement membrane and Alzheimer’s disease: a review Brain Res Bull. 1990 May; 24(5):677-86. . View in PubMed
Microangiopathy and the colocalization of heparan sulfate proteoglycan with amyloid in senile plaques of Alzheimer’s disease Brain Res. 1990 Jan 29; 508(1):13-9. . View in PubMed
Alzheimer’s dementia: performance on parallel forms of the dementia assessment battery J Clin Exp Neuropsychol. 1989 Dec; 11(6):899-912. . View in PubMed
Intracerebroventricular bethanechol chloride infusion in Alzheimer’s diseaseResults of a collaborative double-blind study. J Neurosurg. 1989 Oct; 71(4):481-6. . View in PubMed
DementiaA review emphasizing clinicopathologic correlation and brain-behavior relationships. Arch Neurol. 1989 Jul; 46(7):806-14. . View in PubMed
Visual evoked potentials in dementia: a meta-analysis and empirical study of Alzheimer’s disease patients Biol Psychiatry. 1989 Apr 15; 25(8):1003-13. . View in PubMed
Progressive supranuclear palsy with agitation: response to trazodone but not to thiothixine or carbamazepine J Geriatr Psychiatry Neurol. 1989 Apr-Jun; 2(2):109-12. . View in PubMed
Multicenter trial of naloxone in Alzheimer’s disease Ann Neurol. 1989 Apr; 25(4):404-6. . View in PubMed
Phenotypic heterogeneity in familial Alzheimer’s disease: a study of 24 kindreds Ann Neurol. 1989 Jan; 25(1):12-25. . View in PubMed
Platelet tritiated imipramine binding and MAO activity in Alzheimer’s disease patients with agitation and delusions Psychiatry Res. 1988 Sep; 25(3):311-22. . View in PubMed
Decreased platelet 3H-imipramine binding in Parkinson’s disease Biol Psychiatry. 1988 Jul; 24(3):348-51. . View in PubMed
Olfactory tests as possible probes for detecting and monitoring Alzheimer’s disease Neurobiol Aging. 1988 Jul-Aug; 9(4):399-403. . View in PubMed
Functional recoveryA major risk factor for the development of postpoliomyelitis muscular atrophy. Arch Neurol. 1988 Jun; 45(6):645-7. . View in PubMed
The Modified Mini-Mental State (3MS) examination J Clin Psychiatry. 1987 Aug; 48(8):314-8. . View in PubMed
Alzheimer’s dementia: performance on the Mini-Mental State Examination J Consult Clin Psychol. 1987 Feb; 55(1):96-100. . View in PubMed
The significance of clinically defined subgroups of Alzheimer’s disease J Neural Transm Suppl. 1987; 24:57-68. . View in PubMed
Pathologic correlates of dementia in Parkinson’s disease Arch Neurol. 1986 Oct; 43(10):991-5. . View in PubMed
Progressive supranuclear palsy manifesting with depressive features J Am Geriatr Soc. 1986 Sep; 34(9):663-5. . View in PubMed
Plasticity of hippocampal circuitry in Alzheimer’s disease Science. 1985 Dec 06; 230(4730):1179-81. . View in PubMed
Clinical subtypes of dementia of the Alzheimer type Neurology. 1985 Nov; 35(11):1544-50. . View in PubMed
CT criteria of hemisphere asymmetry fail to predict language laterality Neurology. 1984 Aug; 34(8):1086-9. . View in PubMed
Stability of neuronal number in the human nucleus basalis of Meynert with age Neurobiol Aging. 1984; 5(2):83-8. . View in PubMed
Brachial plexus involvement in familial pressure-sensitive neuropathy: electrophysiological and morphological findings Ann Neurol. 1980 Dec; 8(6):620-4. . View in PubMed
Computerized tomographic scan findings in patients with autistic behavior Arch Neurol. 1980 Aug; 37(8):504-10. . View in PubMed
Posterior callosal section in a non-epileptic patient J Neurol Neurosurg Psychiatry. 1980 Apr; 43(4):351-6. . View in PubMed
Progressive dialysis encephalopathy (“dialysis dementia”) J Neurol. 1980 Jan; 222(3):145-57. . View in PubMed
Neglect following damage to frontal lobe or basal ganglia Neuropsychologia. 1980; 18(2):123-32. . View in PubMed

Helena Chang Chui, MD

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