Jonathan Katz, PhD

Dr. Katz earned his B.S. in Microbiology & Molecular Genetics and Cognitive Science. He then went on to earn his PhD in Biochemistry and Molecular Biology from University of California, Los Angeles.

Dr. Katz’s research interests include mass spectrometry, proteomics and elucidation of novel clinical prognostic markers.

• Integration of Patient-Derived Organoids and Organ-on-Chip Systems: Investigating Colorectal Cancer Invasion within the Mechanical and GABAergic Tumor Microenvironment bioRxiv. 2023 Sep 17. . View in PubMed
• Synthesis and anti-cancer potential of potent peripheral MAOA inhibitors designed to limit blood:brain penetration Bioorg Med Chem. 2023 09 07; 92:117425. . View in PubMed
• Human colorectal cancer-on-chip model to study the microenvironmental influence on early metastatic spread iScience. 2021 May 21; 24(5):102509. . View in PubMed
• Deploying Mass Spectrometric Data Analysis in the Amazon AWS Cloud Computing Environment Methods Mol Biol. 2021; 2271:375-397. . View in PubMed
• ARID1A prevents squamous cell carcinoma initiation and chemoresistance by antagonizing pRb/E2F1/c-Myc-mediated cancer stemness Cell Death Differ. 2020 06; 27(6):1981-1997. . View in PubMed
• Pharmacokinetic properties of the temozolomide perillyl alcohol conjugate (NEO212) in mice Neurooncol Adv. 2020 Jan-Dec; 2(1):vdaa160. . View in PubMed
• Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis Oncogene. 2019 04; 38(16):3003-3018. . View in PubMed
• Identification, characterization and application of a new peptide against anterior gradient homolog 2 (AGR2) Oncotarget. 2018 Jun 08; 9(44):27363-27379. . View in PubMed
• JUN-Mediated Downregulation of EGFR Signaling Is Associated with Resistance to Gefitinib in EGFR-mutant NSCLC Cell Lines Mol Cancer Ther. 2017 08; 16(8):1645-1657. . View in PubMed
• Virtualization of Legacy Instrumentation Control Computers for Improved Reliability, Operational Life, and Management Methods Mol Biol. 2017; 1550:309-324. . View in PubMed
• Krüppel-like factors in cancer Nat Rev Cancer. 2013 Oct; 13(10):701-13. . View in PubMed
• A physical sciences network characterization of non-tumorigenic and metastatic cells Sci Rep. 2013; 3:1449. . View in PubMed
• A cross-platform toolkit for mass spectrometry and proteomics Nat Biotechnol. 2012 Oct; 30(10):918-20. . View in PubMed
• Quantitative proteomic profiling identifies protein correlates to EGFR kinase inhibition Mol Cancer Ther. 2012 May; 11(5):1071-81. . View in PubMed
• A high-confidence human plasma proteome reference set with estimated concentrations in PeptideAtlasMol Cell Proteomics. 2011 Sep; 10(9):M110. 006353. . View in PubMed
• Model-based discovery of circulating biomarkers Methods Mol Biol. 2011; 728:87-107. . View in PubMed
• Peptide identification from mixture tandem mass spectra Mol Cell Proteomics. 2010 Jul; 9(7):1476-85. . View in PubMed
• Precursor-ion mass re-estimation improves peptide identification on hybrid instruments J Proteome Res. 2008 Sep; 7(9):4031-9. . View in PubMed
• The standard protein mix database: a diverse data set to assist in the production of improved Peptide and protein identification software tools J Proteome Res. 2008 Jan; 7(1):96-103. . View in PubMed
• Clinical proteomics: the promises and challenges of mass spectrometry-based biomarker discovery Clin Adv Hematol Oncol. 2006 Jul; 4(7):541-9. . View in PubMed
• Yeast Hsl7 (histone synthetic lethal 7) catalyses the in vitro formation of omega-N(G)-monomethylarginine in calf thymus histone H2A Biochem J. 2006 May 01; 395(3):563-70. . View in PubMed
• A perspective on protein profiling of blood BJU Int. 2005 Sep; 96(4):477-82. . View in PubMed
• Subtle modification of isotope ratio proteomics; an integrated strategy for expression proteomics Phytochemistry. 2004 Jun; 65(11):1507-15. . View in PubMed
• 3-Isopropylmalate is the major endogenous substrate of the Saccharomyces cerevisiae trans-aconitate methyltransferase Biochemistry. 2004 May 25; 43(20):5976-86. . View in PubMed
• A new technique (COMSPARI) to facilitate the identification of minor compounds in complex mixtures by GC/MS and LC/MS: tools for the visualization of matched datasets J Am Soc Mass Spectrom. 2004 Apr; 15(4):580-4. . View in PubMed
• Automated identification of putative methyltransferases from genomic open reading frames Mol Cell Proteomics. 2003 Aug; 2(8):525-40. . View in PubMed
• Structure and function of an archaeal homolog of survival protein E (SurEalpha): an acid phosphatase with purine nucleotide specificity J Mol Biol. 2003 Mar 07; 326(5):1559-75. . View in PubMed

• Lenz, Heinz-Josef
• Schilling, Birgit