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Karen Ting Chang, PhD
Associate Professor of Physiology and Neuroscience
Zilkha Neurogenetic Institute
ZNI 219, 1501 San Pablo Street Health Sciences Campus Los Angeles
+1 323 442 1871


. Validation of maternal reports for low birthweight and preterm birth indicators in rural Nepal J Glob Health. 2018 Jun; 8(1):010604. View in: PubMed

. Activity-Induced Synaptic Structural Modifications by an Activator of Integrin Signaling at the Drosophila Neuromuscular Junction J Neurosci. 2017 Mar 22; 37(12):3246-3263. View in: PubMed

. Maintenance of Stem Cell Niche Integrity by a Novel Activator of Integrin Signaling PLoS Genet. 2016 May; 12(5):e1006043. View in: PubMed

. DSCR1 is required for both axonal growth cone extension and steering J Cell Biol. 2016 05 23; 213(4):451-62. View in: PubMed

. Phosphorylation of Synaptojanin Differentially Regulates Endocytosis of Functionally Distinct Synaptic Vesicle Pools J Neurosci. 2016 08 24; 36(34):8882-94. View in: PubMed

. Dynamics of Mitochondrial Transport in Axons Front Cell Neurosci. 2016; 10:123. View in: PubMed

. Bidirectional Regulation of Amyloid Precursor Protein-Induced Memory Defects by Nebula/DSCR1: A Protein Upregulated in Alzheimer's Disease and Down Syndrome J Neurosci. 2015 Aug 12; 35(32):11374-83. View in: PubMed

. Activity-dependent facilitation of Synaptojanin and synaptic vesicle recycling by the Minibrain kinase Nat Commun. 2014 Jun 30; 5:4246. View in: PubMed

. Meeting at the crossroads: common mechanisms in Fragile X and Down syndrome Trends Neurosci. 2013 Dec; 36(12):685-94. View in: PubMed

. Miro, MCU, and calcium: bridging our understanding of mitochondrial movement in axons Front Cell Neurosci. 2013 Sep 10; 7:148. View in: PubMed

. Nebula/DSCR1 upregulation delays neurodegeneration and protects against APP-induced axonal transport defects by restoring calcineurin and GSK-3ß signaling PLoS Genet. 2013; 9(9):e1003792. View in: PubMed

. DSCR1 interacts with FMRP and is required for spine morphogenesis and local protein synthesis EMBO J. 2012 Sep 12; 31(18):3655-66. View in: PubMed

. Mitochondrial matrix Ca2+ as an intrinsic signal regulating mitochondrial motility in axons Proc Natl Acad Sci U S A. 2011 Sep 13; 108(37):15456-61. View in: PubMed

. Progress in molecular biology and translational scienceAnimal models of human disease. Preface. Prog Mol Biol Transl Sci. 2011; 100:xv. View in: PubMed

. Upregulation of three Drosophila homologs of human chromosome 21 genes alters synaptic function: implications for Down syndrome Proc Natl Acad Sci U S A. 2009 Oct 06; 106(40):17117-22. View in: PubMed

. Sir2 mediates apoptosis through JNK-dependent pathways in Drosophila Proc Natl Acad Sci U S A. 2008 Jun 24; 105(25):8673-8. View in: PubMed

. Drosophila melanogaster homolog of Down syndrome critical region 1 is critical for mitochondrial function Nat Neurosci. 2005 Nov; 8(11):1577-85. View in: PubMed

. The Drosophila homolog of Down's syndrome critical region 1 gene regulates learning: implications for mental retardation Proc Natl Acad Sci U S A. 2003 Dec 23; 100(26):15794-9. View in: PubMed

. Nicotinic regulation of CREB activation in hippocampal neurons by glutamatergic and nonglutamatergic pathways Mol Cell Neurosci. 2002 Dec; 21(4):616-25. View in: PubMed

. Regulation of lifespan by histone deacetylase Ageing Res Rev. 2002 Jun; 1(3):313-26. View in: PubMed

. Voltage-gated channels block nicotinic regulation of CREB phosphorylation and gene expression in neurons Neuron. 2001 Dec 06; 32(5):855-65. View in: PubMed

. Synaptically driven calcium transients via nicotinic receptors on somatic spines J Neurosci. 2001 Feb 01; 21(3):771-81. View in: PubMed

. Nicotinic acetylcholine receptors containing alpha7 subunits are required for reliable synaptic transmission in situ J Neurosci. 1999 May 15; 19(10):3701-10. View in: PubMed

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