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Rex A. Moats, PhD

Scientific Director of Small Animal Research

Associate Professor of Research Pathology and Radiology

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Phone +1 323 361 8503
Email rmoats@chla.usc.edu
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Publications

  • Quantitative noninvasive measurement of cerebrospinal fluid flow in shunted hydrocephalus J Neurosurg. 2024 Apr 01; 140(4):1117-1128. . View in PubMed
  • Episodic live imaging of cone photoreceptor maturation in GNAT2-EGFP retinal organoids Dis Model Mech. 2023 Nov 01; 16(11). . View in PubMed
  • Episodic live imaging of cone photoreceptor maturation in GNAT2-EGFP retinal organoids bioRxiv. 2023 Mar 01. . View in PubMed
  • Development of an ultrafast brain MR neuronavigation protocol for ventricular shunt placement J Neurosurg. 2023 02 01; 138(2):367-373. . View in PubMed
  • Imaging Pulmonary Blood Vessels and Ventilation-Perfusion Mismatch in COVID-19 Mol Imaging Biol. 2022 08; 24(4):526-536. . View in PubMed
  • Distribution of 14C-Latanoprost Following a Single Intracameral Administration Versus Repeated Topical Administration Ophthalmol Ther. 2020 Dec; 9(4):929-940. . View in PubMed
  • Mesenchymal folliculin is required for alveolar development: implications for cystic lung disease in Birt-Hogg-Dubé syndrome Thorax. 2020 06; 75(6):486-493. . View in PubMed
  • MEASUREMENT OF THE HYDRAULIC CONDUCTIVITY OF THE VITREOUS HUMOR J Porous Media. 2020; 23(2):195-206. . View in PubMed
  • Diffusive Transport in the Vitreous Humor: Experimental and Analytical Studies J Heat Transfer. 2019 May; 141(5):050801. . View in PubMed
  • Continuous and bolus intraventricular topotecan prolong survival in a mouse model of leptomeningeal medulloblastoma PLoS One. 2019; 14(1):e0206394. . View in PubMed
  • Alteration of cystic airway mesenchyme in congenital pulmonary airway malformation Sci Rep. 2019 03 28; 9(1):5296. . View in PubMed
  • Spatial and temporal changes in extracellular elastin and laminin distribution during lung alveolar development Sci Rep. 2018 05 29; 8(1):8334. . View in PubMed
  • Discs large 1 controls daughter-cell polarity after cytokinesis in vertebrate morphogenesis Proc Natl Acad Sci U S A. 2018 11 13; 115(46):E10859-E10868. . View in PubMed
  • Optimization of a Neural Stem-Cell-Mediated Carboxylesterase/Irinotecan Gene Therapy for Metastatic Neuroblastoma Mol Ther Oncolytics. 2017 Mar 17; 4:67-76. . View in PubMed
  • Human Neural Stem Cell Biodistribution and Predicted Tumor Coverage by a Diffusible Therapeutic in a Mouse Glioma Model Stem Cells Transl Med. 2017 06; 6(6):1522-1532. . View in PubMed
  • Intestinal adaptation in proximal and distal segments: Two epithelial responses diverge after intestinal separation Surgery. 2017 04; 161(4):1016-1027. . View in PubMed
  • Structural and Functional Characterization of Human Stem-Cell-Derived Retinal Organoids by Live Imaging Invest Ophthalmol Vis Sci. 2017 07 01; 58(9):3311-3318. . View in PubMed
  • PID1 increases chemotherapy-induced apoptosis in medulloblastoma and glioblastoma cells in a manner that involves NF? B. Sci Rep. 2017 04 11; 7(1):835.. View in PubMed
  • An allograft mouse model for the study of hearing loss secondary to vestibular schwannoma growth J Neurooncol. 2016 08; 129(1):47-56. . View in PubMed
  • BarTeL, a Genetically Versatile, Bioluminescent and Granule Neuron Precursor-Targeted Mouse Model for Medulloblastoma PLoS One. 2016; 11(6):e0156907. . View in PubMed
  • A corrole nanobiologic elicits tissue-activated MRI contrast enhancement and tumor-targeted toxicity J Control Release. 2015 Nov 10; 217:92-101. . View in PubMed
  • Increased alveolar soluble annexin V promotes lung inflammation and fibrosis Eur Respir J. 2015 Nov; 46(5):1417-29. . View in PubMed
  • Adult zebrafish intestine resection: a novel model of short bowel syndrome, adaptation, and intestinal stem cell regeneration Am J Physiol Gastrointest Liver Physiol. 2015 Aug 01; 309(3):G135-45. . View in PubMed
  • Dynamic imaging of the growth plate cartilage reveals multiple contributors to skeletal morphogenesis Nat Commun. 2015 Apr 13; 6:6798. . View in PubMed
  • Juvenile skeletogenesis in anciently diverged sea urchin clades Dev Biol. 2015 Apr 01; 400(1):148-58. . View in PubMed
  • Analysis of glioblastoma tumor coverage by oncolytic virus-loaded neural stem cells using MRI-based tracking and histological reconstruction Cancer Gene Ther. 2015 Jan; 22(1):55-61. . View in PubMed
  • Cellular uptake and cytotoxicity of a near-IR fluorescent corrole-TiO2 nanoconjugate J Inorg Biochem. 2014 Nov; 140:39-44. . View in PubMed
  • Integrin a2ß1 targeted GdVO4:Eu ultrathin nanosheet for multimodal PET/MR imaging Biomaterials. 2014 Oct; 35(30):8649-58. . View in PubMed
  • The synthesis of lanthanide-doped GdVO4 ultrathin nanosheets with great optical and paramagnetic properties for FRET biodetection and in vivo MR imaging J Mater Chem B. 2014 Jul 07; 2(25):3998-4007. . View in PubMed
  • Magnetic resonance imaging tracking of ferumoxytol-labeled human neural stem cells: studies leading to clinical use Stem Cells Transl Med. 2013 Oct; 2(10):766-75. . View in PubMed
  • Functionalized magnetonanoparticles in visualization of intracranial tumors on MRI Mol Imaging Biol. 2013 Jun; 15(3):299-306. . View in PubMed
  • Neural stem cell-mediated enzyme/prodrug therapy for glioma: preclinical studies Sci Transl Med. 2013 May 08; 5(184):184ra59. . View in PubMed
  • Decorating metal oxide surfaces with fluorescent chlorosulfonated corroles Inorg Chem. 2013 May 06; 52(9):4774-6. . View in PubMed
  • Neural stem cell-mediated CE/CPT-11 enzyme/prodrug therapy in transgenic mouse model of intracerebellar medulloblastoma Gene Ther. 2013 Feb; 20(2):143-50. . View in PubMed
  • Imaging brain neuronal activity using functionalized magnetonanoparticles and MRI Brain Topogr. 2012 Oct; 25(4):374-88. . View in PubMed
  • Novel cell lines established from pediatric brain tumors J Neurooncol. 2012 Apr; 107(2):269-80. . View in PubMed
  • Automatic abdominal fat assessment in obese mice using a segmental shape model J Magn Reson Imaging. 2011 Oct; 34(4):866-73. . View in PubMed
  • Adipose segmentation in small animals at 7T: a preliminary study BMC Genomics. 2010 Dec 01; 11 Suppl 3:S9. . View in PubMed
  • Iron labeling and pre-clinical MRI visualization of therapeutic human neural stem cells in a murine glioma model PLoS One. 2009 Sep 29; 4(9):e7218. . View in PubMed
  • S-adenosylmethionine in the chemoprevention and treatment of hepatocellular carcinoma in a rat model Hepatology. 2009 Aug; 50(2):462-71. . View in PubMed
  • Shape-aided kidney extraction in MR urography Annu Int Conf IEEE Eng Med Biol Soc. 2009; 2009:5781-4. . View in PubMed
  • Biglycan overexpression on tooth enamel formation in transgenic mice Anat Rec (Hoboken). 2008 Oct; 291(10):1246-53. . View in PubMed
  • Corticotomy-/osteotomy-assisted tooth movement microCTs differ J Dent Res. 2008 Sep; 87(9):861-7. . View in PubMed
  • Functionalized magnetonanoparticles for MRI diagnosis and localization in epilepsy Epilepsia. 2008 Aug; 49(8):1419-30. . View in PubMed
  • Influence of iron chelation on R1 and R2 calibration curves in gerbil liver and heart Magn Reson Med. 2008 Jul; 60(1):82-9. . View in PubMed
  • The activity of zoledronic Acid on neuroblastoma bone metastasis involves inhibition of osteoclasts and tumor cell survival and proliferation Cancer Res. 2007 Oct 01; 67(19):9346-55. . View in PubMed
  • Mouse models of prostate adenocarcinoma with the capacity to monitor spontaneous carcinogenesis by bioluminescence or fluorescence Cancer Res. 2007 Aug 01; 67(15):7525-33. . View in PubMed
  • Comparison of twice-daily vs once-daily deferasirox dosing in a gerbil model of iron cardiomyopathy Exp Hematol. 2007 Jul; 35(7):1069-73. . View in PubMed
  • Antioxidant-mediated effects in a gerbil model of iron overload Acta Haematol. 2007; 118(4):193-9. . View in PubMed
  • Deferasirox and deferiprone remove cardiac iron in the iron-overloaded gerbil Transl Res. 2006 Nov; 148(5):272-80. . View in PubMed
  • Smad3 deficiency promotes tumorigenesis in the distal colon of ApcMin/+ mice Cancer Res. 2006 Sep 01; 66(17):8430-8. . View in PubMed
  • Multimodal imaging analysis of tumor progression and bone resorption in a murine cancer model J Comput Assist Tomogr. 2006 May-Jun; 30(3):525-34. . View in PubMed
  • Longitudinal microPET imaging of brain tumor growth with F-18-labeled RGD peptide Mol Imaging Biol. 2006 Jan-Feb; 8(1):9-15. . View in PubMed
  • Hyperspectral and multispectral bioluminescence optical tomography for small animal imaging Phys Med Biol. 2005 Dec 07; 50(23):5421-41. . View in PubMed
  • Inter-individual variation in brain phenylalanine concentration in patients with PKU is not caused by genetic variation in the 4F2hc/LAT1 complex Mol Genet Metab. 2005 Dec; 86 Suppl 1:S119-23. . View in PubMed
  • Cardiac iron determines cardiac T2*, T2, and T1 in the gerbil model of iron cardiomyopathy Circulation. 2005 Jul 26; 112(4):535-43. . View in PubMed
  • Neonatal gene therapy of MPS I mice by intravenous injection of a lentiviral vector Mol Ther. 2005 May; 11(5):776-89. . View in PubMed
  • Assessing growth and response to therapy in murine tumor models Methods Mol Med. 2005; 111:335-50. . View in PubMed
  • Physiology and pathophysiology of iron cardiomyopathy in thalassemia Ann N Y Acad Sci. 2005; 1054:386-95. . View in PubMed
  • In vivo near-infrared fluorescence imaging of integrin alphavbeta3 in brain tumor xenografts Cancer Res. 2004 Nov 01; 64(21):8009-14. . View in PubMed
  • 18F-labeled RGD peptide: initial evaluation for imaging brain tumor angiogenesis Nucl Med Biol. 2004 Feb; 31(2):179-89. . View in PubMed
  • Neuropsychological outcome of subjects participating in the PKU adult collaborative study: a preliminary review J Inherit Metab Dis. 2004; 27(5):549-66. . View in PubMed
  • Brain phenylalanine concentrations in phenylketonuria: research and treatment of adults Pediatrics. 2003 Dec; 112(6 Pt 2):1575-9. . View in PubMed
  • Micro-MRI at 117 T of a murine brain tumor model using delayed contrast enhancement. Mol Imaging. 2003 Jul; 2(3):150-8. . View in PubMed
  • Time course of bioluminescent signal in orthotopic and heterotopic brain tumors in nude mice Biotechniques. 2003 Jun; 34(6):1184-8. . View in PubMed
  • Large neutral amino acid therapy and phenylketonuria: a promising approach to treatment Mol Genet Metab. 2003 Jun; 79(2):110-3. . View in PubMed
  • Danger of high-protein dietary supplements to persons with hyperphenylalaninaemia J Inherit Metab Dis. 2003; 26(4):339-42. . View in PubMed
  • Craniosynostosis in transgenic mice overexpressing Nell-1 J Clin Invest. 2002 Sep; 110(6):861-70. . View in PubMed
  • Blood-brain phenylalanine relationships in persons with phenylketonuria Pediatrics. 2000 Nov; 106(5):1093-6. . View in PubMed
  • High resolution magnetic resonance imaging of the brain in the dy/dy mouse with merosin-deficient congenital muscular dystrophy Neuromuscul Disord. 2000 Jun; 10(4-5):292-8. . View in PubMed
  • In vivo visualization of gene expression using magnetic resonance imaging Nat Biotechnol. 2000 Mar; 18(3):321-5. . View in PubMed
  • Brain phenylalanine concentration in the management of adults with phenylketonuria J Inherit Metab Dis. 2000 Feb; 23(1):7-14. . View in PubMed
  • Quantitative proton-decoupled 31P MRS and 1H MRS in the evaluation of Huntington’s and Parkinson’s diseases Neurology. 1998 Apr; 50(4):1033-40. . View in PubMed
  • Evaluation of automated MR spectroscopy: application in Alzheimer disease AJNR Am J Neuroradiol. 1995 Oct; 16(9):1779-82. . View in PubMed
  • Added value of automated clinical proton MR spectroscopy of the brain J Comput Assist Tomogr. 1995 May-Jun; 19(3):480-91. . View in PubMed
  • Probable Alzheimer disease: diagnosis with proton MR spectroscopy Radiology. 1995 Apr; 195(1):65-72. . View in PubMed
  • Subclinical hepatic encephalopathy: proton MR spectroscopic abnormalities Radiology. 1994 Nov; 193(2):457-63. . View in PubMed
  • Abnormal cerebral metabolite concentrations in patients with probable Alzheimer disease Magn Reson Med. 1994 Jul; 32(1):110-5. . View in PubMed
  • Automated single-voxel proton MRS: technical development and multisite verification Magn Reson Med. 1994 Apr; 31(4):365-73. . View in PubMed
  • Scyllo-inositol depletion in hepatic encephalopathy Life Sci. 1994; 54(20):1507-12. . View in PubMed
  • Decrease in cerebral inositols in rats and humans Biochem J. 1993 Oct 01; 295 ( Pt 1):15-8. . View in PubMed
  • Alzheimer disease: depiction of increased cerebral myo-inositol with proton MR spectroscopy Radiology. 1993 May; 187(2):433-7. . View in PubMed
  • Ester and ketone components of aggregation pheromone ofDrosophila hydei (Diptera: Drosophilidae) J Chem Ecol. 1987 Mar; 13(3):451-62. . View in PubMed

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