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Hui Li, MD

Assistant Professor of Research Medicine

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Phone +1 323 442 1039
Email hli772@usc.edu
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Overview

Dr. Li’s main research interests are in epithelial ion transport physiology and the coupling of membrane transport processes to cellular metabolism via the metabolic sensor AMP-activated protein kinase (AMPK). His current research involves mechanisms and relevance of sodium transport regulation by AMPK, and the role of modulating AMPK and other signaling mediators in autosomal dominant polycystic kidney disease and acute kidney injury.

Dr. Li earned his medical degree from Shenyang Medical College. Prior to joining USC, Dr. Li served as a Research Assistant Professor in the Renal-Electrolyte Division at The University of Pittsburgh.

Publications

  • ß1Pix exchange factor stabilizes the ubiquitin ligase Nedd4-2 and plays a critical role in ENaC regulation by AMPK in kidney epithelial cells J Biol Chem. 2018 07 20; 293(29):11612-11624. . View in PubMed
  • Using Ex Vivo Kidney Slices to Study AMPK Effects on Kidney Proteins Methods Mol Biol. 2018; 1732:449-464. . View in PubMed
  • Lack of Effects of Metformin and AICAR Chronic Infusion on the Development of Hypertension in Dahl Salt-Sensitive Rats Front Physiol. 2017; 8:227. . View in PubMed
  • Renoprotective Effects of Metformin are Independent of Organic Cation Transporters 1 &2 and AMP-activated Protein Kinase in the Kidney Sci Rep. 2016 10 26; 6:35952. . View in PubMed
  • Aurora kinase A activates the vacuolar H+-ATPase (V-ATPase) in kidney carcinoma cells Am J Physiol Renal Physiol. 2016 06 01; 310(11):F1216-28. . View in PubMed
  • Activation of the metabolic sensor AMP-activated protein kinase inhibits aquaporin-2 function in kidney principal cells Am J Physiol Renal Physiol. 2016 11 01; 311(5):F890-F900. . View in PubMed
  • Interactions between HIF-1a and AMPK in the regulation of cellular hypoxia adaptation in chronic kidney disease Am J Physiol Renal Physiol. 2015 Sep 01; 309(5):F414-28. . View in PubMed
  • Epithelial morphological reversion drives Profilin-1-induced elevation of p27(kip1) in mesenchymal triple-negative human breast cancer cells through AMP-activated protein kinase activation Cell Cycle. 2015; 14(18):2914-23. . View in PubMed
  • Akt recruits Dab2 to albumin endocytosis in the proximal tubule Am J Physiol Renal Physiol. 2014 Dec 15; 307(12):F1380-9. . View in PubMed
  • A1 adenosine receptor-stimulated exocytosis in bladder umbrella cells requires phosphorylation of ADAM17 Ser-811 and EGF receptor transactivation Mol Biol Cell. 2014 Nov 15; 25(23):3798-812. . View in PubMed
  • AMP-activated protein kinase regulates the vacuolar H+-ATPase via direct phosphorylation of the A subunit (ATP6V1A) in the kidney Am J Physiol Renal Physiol. 2013 Oct 01; 305(7):F943-56. . View in PubMed
  • Resveratrol inhibits the epithelial sodium channel via phopshoinositides and AMP-activated protein kinase in kidney collecting duct cells PLoS One. 2013; 8(10):e78019. . View in PubMed
  • AMPK couples plasma renin to cellular metabolism by phosphorylation of ACC1 Am J Physiol Renal Physiol. 2013; 305(5):F679-90. . View in PubMed
  • Activating AMP-activated protein kinase (AMPK) slows renal cystogenesis Proc Natl Acad Sci U S A. 2011; 108:2462-7. . View in PubMed
  • Nedd4-2 Regulation by 14-3-3 Binding at Canonical SGK1 Phosphorylation Sites J Biol Chem. 2011; 286:37830-40. . View in PubMed
  • Galectin-7 modulates the length of the primary cilia and wound repair in polarized kidney epithelial cells Am J Physiol Renal Physiol. 2011; 301:F622-33. . View in PubMed
  • PKA regulates vacuolar H+-ATPase localization and activity via direct phosphorylation of the A subunit in kidney cells J Biol Chem. 2010; 285:24676-85. . View in PubMed
  • Vacuolar H+-ATPase apical accumulation in kidney intercalated cells is regulated by PKA and AMP-activated protein kinase Am J Physiol Renal Physiol. 2010; 298(5):F1162-9. . View in PubMed
  • Phosphopeptide screen uncovers novel Nedd4-2 phosphorylation sites that potentiate its inhibition of the epithelial Na+ channel J Biol Chem. 2010; 285:21671-8. . View in PubMed
  • Regulation of the creatine transporter by AMP-activated protein kinase in kidney epithelial cells Am J Physiol Renal Physiol. 2010; 299(1):F167-77. . View in PubMed
  • AMP-activated protein kinase inhibits alkaline pH- and PKA-induced apical vacuolar H+-ATPase accumulation in epididymal clear cells Am J Physiol Cell Physiol. 2009; 296:C672-81. . View in PubMed
  • Regulation of epithelial Na+ transport by soluble adenylyl cyclase in kidney collecting duct cells J Biol Chem. 2009; 284:5774-83. . View in PubMed
  • Specific and slow inhibition of the kir21 K+ channel by gambogic acid. J Biol Chem. 2009; 284:15432-8. . . View in PubMed
  • Functional regulation of the epithelial Na+ channel by IkappaB kinase-beta occurs via phosphorylation of the ubiquitin ligase Nedd4-2 J Biol Chem. 2008; 284:150-7. . View in PubMed
  • Identification of GRIF-1 (TRAK2) as a trafficking factor for the K+ channel Kir21. J Biol Chem. 2006; 281:30104-11. . View in PubMed
  • Attenuation of apoptosis in enterocytes by blockade of potassium channels Am J Physiol Gastrointest Liver Physiol. 2005; 289:G815-21. . View in PubMed

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