Faculty

Liya Xu

Liya Xu

Assistant Professor
Ophthalmology
4640 West Sunset Blvd Off Campus Los Angeles

Contact

Knight Templar Eye Foundation (KTEF): Pediatric Ophthalmology Career-Starter Research Grant, 2021

Identification of epithelial and mesenchymal circulating tumor cells in clonal lineage of an aggressive prostate cancer case NPJ Precis Oncol. 2022 Jun 21; 6(1):41. . View in PubMed

Disease characterization in liquid biopsy from HER2-mutated, non-amplified metastatic breast cancer patients treated with neratinib NPJ Breast Cancer. 2022 Feb 18; 8(1):22. . View in PubMed

Aqueous Humor as a Liquid Biopsy for Retinoblastoma: Clear Corneal Paracentesis and Genomic Analysis J Vis Exp. 2021 09 07; (175). . View in PubMed

Author Correction: SMURF-seq: efficient copy number profiling on long-read sequencers Genome Biol. 2020 Aug 25; 21(1):214. . View in PubMed

Treatment response and tumor evolution: lessons from an extended series of multianalyte liquid biopsies in a metastatic breast cancer patient Cold Spring Harb Mol Case Stud. 2020 12; 6(6). . View in PubMed

Aqueous Humor Is Superior to Blood as a Liquid Biopsy for Retinoblastoma Ophthalmology. 2020 04; 127(4):552-554. . View in PubMed

Preanalytical Variables for the Genomic Assessment of the Cellular and Acellular Fractions of the Liquid Biopsy in a Cohort of Breast Cancer Patients J Mol Diagn. 2020 03; 22(3):319-337. . View in PubMed

SMURF-seq: efficient copy number profiling on long-read sequencers Genome Biol. 2019 07 08; 20(1):134. . View in PubMed

Genomic cfDNA Analysis of Aqueous Humor in Retinoblastoma Predicts Eye Salvage: The Surrogate Tumor Biopsy for Retinoblastoma Mol Cancer Res. 2018 11; 16(11):1701-1712. . View in PubMed

Functional role of the intracellular loop linking transmembrane domains 6 and 7 of the human dipeptide transporter hPEPT1 J Membr Biol. 2010 Dec; 238(1-3):43-9. . View in PubMed

Mutagenesis and cysteine scanning of transmembrane domain 10 of the human dipeptide transporter Pharm Res. 2009 Oct; 26(10):2358-66. . View in PubMed

Ethanol inhibits functional activity of the human intestinal dipeptide transporter hPepT1 expressed in Xenopus oocytes Alcohol Clin Exp Res. 2008 May; 32(5):777-84. . View in PubMed

Liya Xu received her PhD in Neuroscience from University of Southern California 2010. Subsequently, she joined Biomedical Pioneering Innovation Center (BIOPIC) of Peking University to lead the development of one-step next generation sequencing (NGS) based Preimplantation Genetic Diagnosis (PGD) for simultaneous avoidance of monogenic disease and chromosome abnormality. Since 2017, her collaboration with Dr. Jesse Berry has been focusing on developing aqueous humor (AH) as a surrogate tumor biopsy for retinoblastoma (RB). It holds the potential to unlock a new era of precision medicine that will transform the way to detect RB, guide the management and prognosis for RB and lead to alternative treatment regimens that offer a personalized approach to medicine for these children with a greater chance of saving the eye.

Dr. Xu’s research concentrates on integrating patient, model system, and high-content single particle data to translate clinically observed correlations into a mechanistic understanding of the physical and biological underpinning of the dynamics of ocular cancers, specifically retinoblastoma. Two complementary research projects address the laboratory’s aims of 1) developing the clinical utility of aqueous humors (AH) as liquid biopsy platform for ocular cancer management; and 2) characterizing the tumor circulome of aqueous humor from RB eyes with multi-omics approaches.
sc ctsi logoPowered by SC CTSI

Affiliated Faculty at UPC