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Rayudu Gopalakrishna, PhD

Professor of Integrative Anatomical Sciences

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Phone +1 323 442 1770
Email rgopalak@usc.edu
CTSI Profile

Awards

  • Keck School of Medicine of USC: Outstanding Teaching Award (Year II med), 2014
  • Keck School of Medicine of USC: Outstanding Teaching Award (Year I med), 2014
  • Keck School of Medicine of USC: Outstanding Teaching Award (Year I med), 2011
  • Alpha Omega Alpha: Membership, 2010
  • Keck School of Medicine of USC: Outstanding Teaching Award (Year II med), 2008
  • Keck School of Medicine of USC: Master Teacher, 2008
  • Keck School of Medicine of USC: Outstanding Teaching Award (Year I med), 2006
  • Keck School of Medicine of USC: Outstanding teaching Award (year II med), 2004
  • Keck School of Medicine of USC: Outstanding Teaching Award (year I med), 2003
  • Keck School of Medicine of USC: Outstanding Teaching Award (year II med), 2000
  • Keck School of Medicine of USC: Outstanding Teaching Award (year II med)), 1996
  • Keck School of Medicine of USC: Excellence in Teaching Certificate, 1995
  • National Cancer Institute, NIH: FIRST Award, 1988-1993

Publications

  • Neuroprotection by resveratrol-glucuronide and quercetin-glucuronide via binding to polyphenol- and glycosaminoglycan-binding sites in the laminin receptor. Neural Regen Res. 2025 Mar 01; 20(3):819-820.. View in PubMed
  • Resveratrol and its metabolites elicit neuroprotection via high-affinity binding to the laminin receptor at low nanomolar concentrations. FEBS Lett. 2024 May; 598(9):995-1007.. View in PubMed
  • Cyclic adenosine monophosphate-elevating agents inhibit amyloid-beta internalization and neurotoxicity: their action in Alzheimer’s disease prevention. Neural Regen Res. 2023 Dec; 18(12):2675-2676.. View in PubMed
  • Flavonoid quercetin and its glucuronide and sulfate conjugates bind to 67-kDa laminin receptor and prevent neuronal cell death induced by serum starvation. Biochem Biophys Res Commun. 2023 09 03; 671:116-123.. View in PubMed
  • cAMP-induced decrease in cell-surface laminin receptor and cellular prion protein attenuates amyloid-β uptake and amyloid-β-induced neuronal cell death. FEBS Lett. 2022 11; 596(22):2914-2927.. View in PubMed
  • Nogo-A receptor internalization by cyclic adenosine monophosphate in overcoming axonal growth inhibitors after stroke. Neural Regen Res. 2022 Jan; 17(1):91-92.. View in PubMed
  • Cyclic-AMP induces Nogo-A receptor NgR1 internalization and inhibits Nogo-A-mediated collapse of growth cone. Biochem Biophys Res Commun. 2020 03 12; 523(3):678-684.. View in PubMed
  • Cell signaling associated with internalization of 67 kDa laminin receptor (67LR) by soluble laminin and its implication for protection against neurodegenerative diseases. Neural Regen Res. 2019 Sep; 14(9):1513-1514.. View in PubMed
  • Redox regulation of protein kinase C by selenometabolites and selenoprotein thioredoxin reductase limits cancer prevention by selenium. Free Radic Biol Med. 2018 11 01; 127:55-61.. View in PubMed
  • Lowering side effects of NSAID usage in osteoarthritis: recent attempts at minimizing dosage. Expert Opin Pharmacother. 2018 02; 19(2):93-102.. View in PubMed
  • Laminin-1 induces endocytosis of 67KDa laminin receptor and protects Neuroscreen-1 cells against death induced by serum withdrawal. Biochem Biophys Res Commun. 2018 01 01; 495(1):230-237.. View in PubMed
  • Counteraction of Nogo-A and axonal growth inhibitors by green tea polyphenols and other natural products. Neural Regen Res. 2016 Apr; 11(4):545-6.. View in PubMed
  • Imbalance in Protein Thiol Redox Regulation and Cancer-Preventive Efficacy of Selenium. React Oxyg Species (Apex). 2016; 2(4):272-289.. View in PubMed
  • Polyphenols from green tea prevent antineuritogenic action of Nogo-A via 67-kDa laminin receptor and hydrogen peroxide. J Neurochem. 2015 Jan; 132(1):70-84.. View in PubMed
  • Green tea catechins potentiate the neuritogenic action of brain-derived neurotrophic factor: role of 67-kDa laminin receptor and hydrogen peroxide. Biochem Biophys Res Commun. 2014 Feb 28; 445(1):218-24.. View in PubMed
  • Methods for studying oxidative regulation of protein kinase C. Methods Enzymol. 2013; 528:79-98.. View in PubMed
  • Green tea polyphenols precondition against cell death induced by oxygen-glucose deprivation via stimulation of laminin receptor, generation of reactive oxygen species, and activation of protein kinase Cε. J Biol Chem. 2012 Oct 05; 287(41):34694-708.. View in PubMed
  • Green tea polyphenols potentiate the action of nerve growth factor to induce neuritogenesis: possible role of reactive oxygen species. J Neurosci Res. 2010 Dec; 88(16):3644-55.. View in PubMed
  • Negation of the cancer-preventive actions of selenium by over-expression of protein kinase Cepsilon and selenoprotein thioredoxin reductase. Carcinogenesis. 2009 Sep; 30(9):1553-61.. View in PubMed
  • Locally generated methylseleninic acid induces specific inactivation of protein kinase C isoenzymes: relevance to selenium-induced apoptosis in prostate cancer cells. J Biol Chem. 2008 Dec 12; 283(50):34519-31.. View in PubMed
  • A direct redox regulation of protein kinase C isoenzymes mediates oxidant-induced neuritogenesis in PC12 cells. J Biol Chem. 2008 May 23; 283(21):14430-44.. View in PubMed
  • The synthetic estrogen 4-estren-3 alpha,17 beta-diol (estren) induces estrogen-like neuroprotection. Neurobiol Dis. 2005 Jun-Jul; 19(1-2):331-9.. View in PubMed
  • Estrogen activates protein kinase C in neurons: role in neuroprotection. J Neurochem. 2003 Mar; 84(6):1340-8.. View in PubMed
  • Antioxidant regulation of protein kinase C in cancer prevention. J Nutr. 2002 Dec; 132(12):3819S-3823S.. View in PubMed
  • Protein kinase C as a molecular target for cancer prevention by selenocompounds. Nutr Cancer. 2001; 40(1):55-63.. View in PubMed
  • Protein kinase C signaling and oxidative stress. Free Radic Biol Med. 2000 May 01; 28(9):1349-61.. View in PubMed
  • Tumor promoter benzoyl peroxide induces sulfhydryl oxidation in protein kinase C: its reversibility is related to the cellular resistance to peroxide-induced cytotoxicity. Arch Biochem Biophys. 1999 Mar 15; 363(2):246-58.. View in PubMed
  • Differential distribution of protein phosphatase 2A in human breast carcinoma cell lines and its relation to estrogen receptor status. Cancer Lett. 1999 Mar 01; 136(2):143-51.. View in PubMed
  • Role of protein kinase C in basal and hydrogen peroxide-stimulated NF-kappa B activation in the murine macrophage J774A.1 cell line. Arch Biochem Biophys. 1998 Feb 01; 350(1):79-86.. View in PubMed
  • Cancer-preventive selenocompounds induce a specific redox modification of cysteine-rich regions in Ca(2+)-dependent isoenzymes of protein kinase C. Arch Biochem Biophys. 1997 Dec 01; 348(1):25-36.. View in PubMed
  • Selenocompounds induce a redox modulation of protein kinase C in the cell, compartmentally independent from cytosolic glutathione: its role in inhibition of tumor promotion. Arch Biochem Biophys. 1997 Dec 01; 348(1):37-48.. View in PubMed
  • Hypericin inhibits choroidal endothelial cell proliferation and cord formation in vitro. Curr Eye Res. 1997 Oct; 16(10):967-72.. View in PubMed
  • Inhibition of cellular growth and induction of apoptosis in pituitary adenoma cell lines by the protein kinase C inhibitor hypericin: potential therapeutic application. J Neurosurg. 1996 Aug; 85(2):329-34.. View in PubMed
  • Tamoxifen modulates protein kinase C via oxidative stress in estrogen receptor-negative breast cancer cells. J Biol Chem. 1996 Jun 07; 271(23):13504-14.. View in PubMed
  • Enhancement of radiosensitivity in human malignant glioma cells by hypericin in vitro. Clin Cancer Res. 1996 May; 2(5):843-6.. View in PubMed
  • Induction of intercellular adhesion molecule-1 by tumor necrosis factor-alpha through the 55-kDa receptor is dependent on protein kinase C in human retinal pigment epithelial cells. Invest Ophthalmol Vis Sci. 1996 Mar; 37(4):597-606.. View in PubMed
  • Protein kinase C and growth regulation of pituitary adenomas. Acta Neurochir Suppl. 1996; 65:22-6.. View in PubMed
  • Effect of linoleic acid hydroperoxide on endothelial cell calcium homeostasis and phospholipid hydrolysis. Arch Biochem Biophys. 1995 Oct 20; 323(1):97-107.. View in PubMed
  • Modifications of cysteine-rich regions in protein kinase C induced by oxidant tumor promoters and enzyme-specific inhibitors. Methods Enzymol. 1995; 252:132-46.. View in PubMed
  • Tobacco smoke tumor promoters, catechol and hydroquinone, induce oxidative regulation of protein kinase C and influence invasion and metastasis of lung carcinoma cells. Proc Natl Acad Sci U S A. 1994 Dec 06; 91(25):12233-7.. View in PubMed
  • Transforming growth factor-beta regulates human retinal pigment epithelial cell phagocytosis by influencing a protein kinase C-dependent pathway. Graefes Arch Clin Exp Ophthalmol. 1994 Nov; 232(11):695-701.. View in PubMed
  • Hypericin: a potential antiglioma therapy. Neurosurgery. 1994 Oct; 35(4):705-9; discussion 709-10.. View in PubMed
  • Nitric oxide and nitric oxide-generating agents induce a reversible inactivation of protein kinase C activity and phorbol ester binding. J Biol Chem. 1993 Dec 25; 268(36):27180-5.. View in PubMed
  • Multiwell filtration assay for rapid determination of protein phosphatase activity. Anal Biochem. 1993 Jul; 212(1):296-9.. View in PubMed
  • Retinoids inhibit the oxidative modification of protein kinase C induced by oxidant tumor promoters. Arch Biochem Biophys. 1993 Jan; 300(1):526-30.. View in PubMed
  • Nonphorbol tumor promoters okadaic acid and calyculin-A induce membrane translocation of protein kinase C. Biochem Biophys Res Commun. 1992 Dec 15; 189(2):950-7.. View in PubMed
  • Irreversible oxidative inactivation of protein kinase C by photosensitive inhibitor calphostin C. FEBS Lett. 1992 Dec 14; 314(2):149-54.. View in PubMed
  • Rapid filtration assays for protein kinase C activity and phorbol ester binding using multiwell plates with fitted filtration discs. Anal Biochem. 1992 Oct; 206(1):24-35.. View in PubMed
  • Reversible oxidative activation and inactivation of protein kinase C by the mitogen/tumor promoter periodate. Arch Biochem Biophys. 1991 Mar; 285(2):382-7.. View in PubMed

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