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Mary Samplaski, MD

Associate Professor of Clinical Urology

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Phone +1 323 865 3700
Email mary.samplaski@med.usc.edu
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Overview

Dr. Samplaski is a specialist in in Male Reproductive Medicine, Microsurgery and Andrology. She completed her medical school at the George Washington University School of Medicine, urology residency at the Cleveland Clinic, and specialty fellowship at the University of Toronto. Dr. Samplaski is an expert in all aspects of male reproductive health, including fertility preservation counseling and treatment, vasectomies and vasectomy reversals, low testosterone, erectile dysfunction, sexual dysfunction, Peyronie’s disease and testicular pain. She specializes in the management of male infertility with the aim of improving natural conception or improved outcomes from assisted reproduction. She also specializes in fertility for spinal cord injury patients. Surgical techniques that she is skilled in for the treatment of these conditions include the minimally invasive vasectomy and microsurgical vasectomy reversals, advanced sperm retrieval techniques, microscopic varicocele repair, penile vibratory stimulation, electroejaculation and spermatic cord denervations. For erectile dysfunction she also specializes in correction of penile curvature and penile prostheses for erectile dysfunction. Dr. Samplaski has a strong record demonstrating a commitment to educational excellence and advancing the field of male fertility. She consistently presents at major national and international meetings and is a reviewer for several scientific journals. At present, the cause of 60% of male factor infertility is completely unknown. She believes that this represents a major opportunity for scientific advancement in order to make parenthood possible for everyone desiring it.

Publications

  • Gender disparities among publications within international sexual medicine urology journals and the impact of blinding in the review process J Sex Med. 2024 Jan 30; 21(2):117-121. . View in PubMed
  • Untreated hypogonadism and testosterone replacement therapy in hypogonadal men are associated with a decreased risk of subsequent prostate cancer: a population-based study Int J Impot Res. 2024 Jan 05. . View in PubMed
  • The effect of testicular trauma on male infertility Hum Fertil (Camb). 2023 Dec; 26(5):1093-1098. . View in PubMed
  • Does male fertility-related quality of life differ when undergoing evaluation by reproductive urologist versus reproductive endocrinologist? Hum Fertil (Camb). 2023 Dec; 26(2):276-283.. View in PubMed
  • Uncovering the Association Between Complete AZFc Microduplications and Spermatogenic Ability: The First Reported Series Cureus. 2023 Dec; 15(12):e51140. . View in PubMed
  • Deafening Silence of Male Infertility Urology. 2023 Dec; 182:111-124. . View in PubMed
  • Evaluating the Effectiveness of Artificial Intelligence-powered Large Language Models Application in Disseminating Appropriate and Readable Health Information in Urology J Urol. 2023 10; 210(4):688-694. . View in PubMed
  • Reflections on Diversity, Equity, and Inclusion in Medical Publishing: The Journal of Urology® HEAD Table J Urol. 2023 05; 209(5):830-832. . View in PubMed
  • Andrologia. 2022 Nov; 54(10):e14551. . View in PubMed
  • Global online interest in finasteride sexual side effects Int J Impot Res. 2022 Sep 13. . View in PubMed
  • The impact of male infertility faculty on urology residency training Andrologia. 2022 Sep; 54(8):e14457. . View in PubMed
  • Sperm granulomas: Predictive factors and impacts on patency post vasectomy reversal Andrologia. 2022 Aug; 54(7):e14439. . View in PubMed
  • Complete testicular-epididymal dissociation presenting as adult chronic orchialgia Urol Case Rep. 2022 May; 42:102032. . View in PubMed
  • Science and Politics J Urol. 2022 10; 208(4):771-772. . View in PubMed
  • Systematic Review: The Neovaginal Microbiome Urology. 2022 09; 167:3-12. . View in PubMed
  • The Impact of Race and Gender on 30-Day Urologic Surgery Complications Urology. 2022 04; 162:77-83. . View in PubMed
  • Factors Influencing the Decision for Fresh vs Cryopreserved Microdissection Testicular Sperm Extraction for Non-Obstructive Azoospermia Urology. 2021 11; 157:131-137. . View in PubMed
  • One size does not fit all: variations by ethnicity in demographic characteristics of men seeking fertility treatment across North America Fertil Steril. 2021 11; 116(5):1287-1294. . View in PubMed
  • The Impact of Physician Productivity Models on Access to Subspecialty Care: A White Paper From the Society for the Study of Male Reproduction and the Society for Male Reproduction and Urology Urology. 2021 07; 153:28-34. . View in PubMed
  • Development and validation of a novel mail-in semen analysis system and the correlation between one hour and delayed semen analysis testing Fertil Steril. 2021 04; 115(4):922-929. . View in PubMed
  • Why does COVID-19 kill more elderly men than women? Andrology. 2021 01; 9(1):65-72.. View in PubMed
  • Male Infertility Websites: What are Our Patients Reading? Urol Pract. 2021 Jan; 8(1):137-142.. View in PubMed
  • The Effect of Loss of Anonymity from Direct-to-Consumer DNA Databases on Sperm Donation Attitudes and Practices of American Sperm Donors J Urol. 2020 Dec; 204(6):1125-1126. . View in PubMed
  • The effect of trainee involvement on surgical outcomes and complications of male infertility surgical procedures Andrologia. 2020 Oct; 52(9):e13719. . View in PubMed
  • Empirical medical therapy for idiopathic male infertility F S Rep. 2020 Jun; 1(1):15-20. . View in PubMed
  • National opioid prescription patterns and patient usage after routine vasectomy Andrologia. 2020 Jun; 52(5):e13563. . View in PubMed
  • AUTHOR REPLY Urology. 2020 11; 145:139-140. . View in PubMed
  • The Effect of Male Age Over 50 Years on Vasectomy Reversal Outcomes Urology. 2020 11; 145:134-140. . View in PubMed
  • Editorial Comment J Urol. 2020 02; 203(2):403. . View in PubMed
  • ‘Testosterone Boosting’ Supplements Composition and Claims Are not Supported by the Academic Literature World J Mens Health. 2020 Jan; 38(1):115-122. . View in PubMed
  • Effect of antidepressant medications on semen parameters and male fertility Int J Urol. 2020 Jan; 27(1):39-46. . View in PubMed
  • Fertility in Adolescents With Klinefelter Syndrome: A Survey of Current Clinical Practice J Clin Endocrinol Metab. 2020 04 01; 105(4). . View in PubMed
  • Analysis of online discussion boards for male infertility Andrologia. 2019 Dec; 51(11):e13422. . View in PubMed
  • Reproductive Urologist and Gynecologist Involvement in Postvasectomy Sperm Retrieval Procedures at American Fertility Clinics Urology. 2019 Nov; 133:116-120. . View in PubMed
  • Sperm Morphology: History, Challenges, and Impact on Natural and Assisted Fertility Curr Urol Rep. 2019 Jun 15; 20(8):43. . View in PubMed
  • Reproductive endocrinologists are the gatekeepers for male infertility care in North America: results of a North American survey on the referral patterns and characteristics of men presenting to male infertility specialists for infertility investigations Fertil Steril. 2019 10; 112(4):657-662. . View in PubMed
  • Editorial Commentary Urol Pract. 2019 Jan; 6(1):44. . View in PubMed
  • Discrepancies between the internet and academic literature regarding vitamin use for male infertility Transl Androl Urol. 2018 May; 7(Suppl 2):S193-S197. . View in PubMed
  • EDITORIAL COMMENT Urology. 2018 11; 121:49. . View in PubMed
  • Editorial Comment J Urol. 2018 04; 199(4):1022. . View in PubMed
  • Author Reply Urology. 2018 01; 111:38. . View in PubMed
  • A Thematic Analysis of Online Discussion Boards for Vasectomy Urology. 2018 01; 111:32-38. . View in PubMed
  • A few more fragments: putting sperm DNA integrity testing into clinical practice Transl Androl Urol. 2017 Sep; 6(Suppl 4):S473-S475. . View in PubMed
  • Editorial Comment J Urol. 2017 11; 198(5):1174. . View in PubMed
  • Varicocelectomy to “upgrade” semen quality to allow couples to use less invasive forms of assisted reproductive technology Fertil Steril. 2017 10; 108(4):609-612. . View in PubMed
  • Urinary mycobacterium avium presenting as sterile pyuria Can Urol Assoc J. 2016 May-Jun; 10(5-6):E186-E188. . View in PubMed
  • Prognostic factors for a favorable outcome after varicocele repair in adolescents and adults Asian J Androl. 2016 Mar-Apr; 18(2):217-21. . View in PubMed
  • Anatomical Targeting Improves Delivery of Unconjugated Nanoparticles to the Testicle J Urol. 2015 Oct; 194(4):1155-61. . View in PubMed
  • Human Fetal Testicular Tissue Xenotransplantation: A Platform to Study the Effect of Gonadotropins on Human Germ Cell Development In Utero J Urol. 2015 Aug; 194(2):585-91. . View in PubMed
  • Adverse effects of common medications on male fertility Nat Rev Urol. 2015 Jul; 12(7):401-13. . View in PubMed
  • The relationship between sperm viability and DNA fragmentation rates Reprod Biol Endocrinol. 2015 May 14; 13:42. . View in PubMed
  • Cocaine Use in the Infertile Male Population: A Marker for Conditions Resulting in Subfertility Curr Urol. 2015 May; 8(1):38-42. . View in PubMed
  • Nomograms for predicting changes in semen parameters in infertile men after varicocele repair Fertil Steril. 2014 Jul; 102(1):68-74. . View in PubMed
  • Editorial comment J Urol. 2014 May; 191(5):1415. . View in PubMed
  • Vasectomy as a reversible form of contraception for select patients Can J Urol. 2014 Apr; 21(2):7234-40. . View in PubMed
  • Genetic and Epigenetic Changes After Spermatogonial Stem Cell Culture and Transplantation EJIFCC. 2014 Apr; 25(1):27-41. . View in PubMed
  • Phenotypic differences in mosaic Klinefelter patients as compared with non-mosaic Klinefelter patients Fertil Steril. 2014 Apr; 101(4):950-5. . View in PubMed
  • Superoxide dismutase-loaded biodegradable nanoparticles targeted with a follicle-stimulating hormone peptide protect Sertoli cells from oxidative stress Fertil Steril. 2014 Feb; 101(2):560-7. . View in PubMed
  • Testosterone use in the male infertility population: prescribing patterns and effects on semen and hormonal parameters Fertil Steril. 2014 Jan; 101(1):64-9. . View in PubMed
  • Finasteride use in the male infertility population: effects on semen and hormone parameters Fertil Steril. 2013 Dec; 100(6):1542-6. . View in PubMed
  • Clustering of UPOINT domains and subdomains in men with chronic prostatitis/chronic pelvic pain syndrome and contribution to symptom severity J Urol. 2012 Nov; 188(5):1788-93. . View in PubMed
  • Folate hydrolase (prostate-specific membrane [corrected] antigen) 1 expression in bladder cancer subtypes and associated tumor neovasculature Mod Pathol. 2011 Nov; 24(11):1521-9. . View in PubMed
  • Drug delivery to the testis: current status and potential pathways for the development of novel therapeutics Drug Deliv Transl Res. 2011 Oct; 1(5):351-60. . View in PubMed
  • Inclusion of erectile domain to UPOINT phenotype does not improve correlation with symptom severity in men with chronic prostatitis/chronic pelvic pain syndrome Urology. 2011 Sep; 78(3):653-8. . View in PubMed
  • Functional and quality-of-life outcomes in patients undergoing transperineal repair with gracilis muscle interposition for complex rectourethral fistula Urology. 2011 Mar; 77(3):736-41. . View in PubMed
  • Renal mass sampling: an enlightened perspective Int J Urol. 2011 Jan; 18(1):5-19. . View in PubMed
  • C-index is associated with functional outcomes after laparoscopic partial nephrectomy J Urol. 2010 Dec; 184(6):2259-63. . View in PubMed
  • New generation of diagnostic tests for infertility: review of specialized semen tests Int J Urol. 2010 Oct; 17(10):839-47. . View in PubMed
  • Kidney tumor location measurement using the C index method J Urol. 2010 May; 183(5):1708-13. . View in PubMed
  • Post-transplantation lymphoproliferative disorder in the renal transplant ureter Urology. 2010 Mar; 75(3):516-9. . View in PubMed
  • Less-invasive ways to remove stones from the kidneys and ureters Cleve Clin J Med. 2009 Oct; 76(10):592-8. . View in PubMed
  • Apocrine hidrocystoma on glans penis of a child Urology. 2009 Apr; 73(4):800-1. . View in PubMed
  • Two centuries of cystoscopy: the development of imaging, instrumentation and synergistic technologies BJU Int. 2009 Jan; 103(2):154-8. . View in PubMed
  • Malignant melanoma of the gallbladder: a report of two cases and review of the literature J Gastrointest Surg. 2008 Jun; 12(6):1123-6. . View in PubMed
  • Renal mass biopsy–a renaissance? J Urol. 2008 Jan; 179(1):20-7.. View in PubMed
  • Time course of neuroanatomical and functional recovery after bilateral pudendal nerve injury in female rats Am J Physiol Renal Physiol. 2007 Nov; 293(5):F1614-21. . View in PubMed
  • Activation of human eosinophils through leukocyte immunoglobulin-like receptor 7 Proc Natl Acad Sci U S A. 2003 Feb 04; 100(3):1174-9. . View in PubMed

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