William Gauderman, PhD

Professor of Population and Public Health Sciences

Websites

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Overview

Dr. Gauderman’s research falls into two distinct areas: 1) developing statistical methods for genetic-epidemiologic analysis of pedigree data; 2) design and analysis of studies relating health outcomes to environmental exposures. In the field of genetic-epidemiology, he has developed models and methods of estimation for complex traits that depend on both genetic and environment causes, possibly interacting. He has evaluated a technique known as joint segregation and linkage analysis and has found it to be an efficient strategy both for detecting linkage and for estimating gene-environment interactions when the disease gene has not yet been identified. He has also compared various case-control designs for studying measured genes (e.g. candidate genes). In the field of environmental health, he works with the Children’s Health Study, a multi-community study of lung function and respiratory health in school-aged children in the Southern California area. The ultimate goal of this research is to determine whether air pollution, or particular components of air pollution such as ozone, is associated with reduced lung growth and increased incidence of asthma, bronchitis, and other respiratory illnesses. He is also the principal investigator of the biostatistics core of the NIEHS Center, and thus is available for statistical consultation for projects involving environmental health.

Publications

Pathway-specific polygenic scores substantially increase the discovery of gene-adiposity interactions impacting liver biomarkers. HGG Adv. 2026 Jan 15; 7(1):100515.. View in PubMed
Genetic risk factors modulate the association between physical activity and colorectal cancer. Res Sq. 2025 Sep 02.. View in PubMed
Correction: Children’s Health in London and Luton (CHILL) cohort: a 12-month natural experimental study of the effects of the Ultra Low Emission Zone on children’s travel to school. Int J Behav Nutr Phys Act. 2025 Aug 05; 22(1):107.. View in PubMed
Pathway polygenic risk scores (pPRS) for the analysis of gene-environment interaction. PLoS Genet. 2025 Aug; 21(8):e1011543.. View in PubMed
Fine particulate matter air pollution and longitudinal gray matter development changes during early adolescence: variation by neighborhood disadvantage level. Environ Int. 2025 Jul; 201:109561.. View in PubMed
Red meat intake interacts with a TGF-β-pathway-based polygenic risk score to impact colorectal cancer risk: Application of a novel approach for polygenic risk score construction. medRxiv. 2025 Jun 16.. View in PubMed
Pathway-specific polygenic scores substantially increase the discovery of gene-adiposity interactions impacting liver biomarkers. medRxiv. 2025 May 21.. View in PubMed
Effects of depression genetic risk and household socioeconomic status on emotional behavior and brain development in early adolescence. medRxiv. 2025 May 18.. View in PubMed
Cohort Profile: The Children’s Health in London and Luton (CHILL) cohort. Int J Epidemiol. 2025 Apr 12; 54(3).. View in PubMed
Childhood Exposure to Air Pollution, Body Mass Index Trajectories, and Insulin Resistance Among Young Adults. JAMA Netw Open. 2025 04 01; 8(4):e256431.. View in PubMed
Does socioeconomic and environmental burden affect vulnerability to extreme air pollution and heat? A case-crossover study of mortality in California. J Expo Sci Environ Epidemiol. 2025 Apr; 35(2):294-302.. View in PubMed
Air Pollution Exposure, Prefrontal Connectivity, and Emotional Behavior in Early Adolescence. Res Rep Health Eff Inst. 2025 Mar; (225):1-56.. View in PubMed
A Large-Scale Genome-wide Association Study of Blood Pressure Accounting for Gene-Depressive Symptomatology Interactions in 564,680 Individuals from Diverse Populations. Res Sq. 2025 Feb 17.. View in PubMed
The Influence of DNA Repair Genes and Prenatal Tobacco Exposure on Risk of Childhood Acute Lymphoblastic Leukemia: A Gene-Environment Interaction Study. Cancer Epidemiol Biomarkers Prev. 2025 Jan 09; 34(1):100-107.. View in PubMed
Characterization of Additive Gene-environment Interactions For Colorectal Cancer Risk. Epidemiology. 2025 Jan 01; 36(1):126-138.. View in PubMed
Pathway Polygenic Risk Scores (pPRS) for the Analysis of Gene-environment Interaction. bioRxiv. 2024 Dec 19.. View in PubMed
Impact of childhood exposure to traffic related air pollution on adult cardiometabolic health: Exploring the role of perceived stress. Environ Res. 2024 Dec 15; 263(Pt 2):120130.. View in PubMed
Genetic Variation and Regulation of MICA Alters Natural Killer Cell-Mediated Immunosurveillance in Early-Onset Colorectal Cancer. medRxiv. 2024 Sep 26.. View in PubMed
Children’s Health in London and Luton (CHILL) cohort: a 12-month natural experimental study of the effects of the Ultra Low Emission Zone on children’s travel to school. Int J Behav Nutr Phys Act. 2024 Sep 05; 21(1):89.. View in PubMed
A Large-Scale Genome-Wide Gene-Sleep Interaction Study in 732,564 Participants Identifies Lipid Loci Explaining Sleep-Associated Lipid Disturbances. medRxiv. 2024 Sep 04.. View in PubMed
Genome-Wide Interaction Analyses of Serum Calcium on Ventricular Repolarization Time in 125 393 Participants. J Am Heart Assoc. 2024 Sep 03; 13(17):e034760.. View in PubMed
Carotid Artery Wall Echogenicity Measured by Gray Scale Median of the Intima-Media Complex From Childhood to Young Adulthood. J Am Heart Assoc. 2024 Aug 06; 13(15):e034821.. View in PubMed
Association Between Cardiovascular Health and Subclinical Atherosclerosis Among Young Adults Using the American Heart Association’s “Life’s Essential 8” Metrics. J Am Heart Assoc. 2024 Aug 06; 13(15):e033990.. View in PubMed
Exposure to multiple ambient air pollutants changes white matter microstructure during early adolescence with sex-specific differences. Commun Med (Lond). 2024 Aug 01; 4(1):155.. View in PubMed
A Large-Scale Genome-Wide Study of Gene-Sleep Duration Interactions for Blood Pressure in 811,405 Individuals from Diverse Populations. Res Sq. 2024 Jul 17.. View in PubMed
Genome-wide interaction study of dietary intake of fibre, fruits, and vegetables with risk of colorectal cancer. EBioMedicine. 2024 Jun; 104:105146.. View in PubMed
Genetic risk impacts the association of menopausal hormone therapy with colorectal cancer risk. Br J Cancer. 2024 Jun; 130(10):1687-1696.. View in PubMed
Two genome-wide interaction loci modify the association of nonsteroidal anti-inflammatory drugs with colorectal cancer. Sci Adv. 2024 05 31; 10(22):eadk3121.. View in PubMed
Author Correction: Trans-ancestral genome-wide association study of longitudinal pubertal height growth and shared heritability with adult health outcomes. Genome Biol. 2024 May 21; 25(1):129.. View in PubMed
Fine-mapping analysis including over 254,000 East Asian and European descendants identifies 136 putative colorectal cancer susceptibility genes. Nat Commun. 2024 Apr 26; 15(1):3557.. View in PubMed
An approach to identify gene-environment interactions and reveal new biological insight in complex traits. Nat Commun. 2024 Apr 22; 15(1):3385.. View in PubMed
Genome-Wide Interaction Analysis With DASH Diet Score Identified Novel Loci for Systolic Blood Pressure. Hypertension. 2024 Mar; 81(3):552-560.. View in PubMed
Genome-Wide Gene-Environment Interaction Analyses to Understand the Relationship between Red Meat and Processed Meat Intake and Colorectal Cancer Risk. Cancer Epidemiol Biomarkers Prev. 2024 03 01; 33(3):400-410.. View in PubMed
Perceived Stress From Childhood to Adulthood and Cardiometabolic End Points in Young Adulthood: An 18-Year Prospective Study. J Am Heart Assoc. 2024 Feb 06; 13(3):e030741.. View in PubMed
Trans-ancestral genome-wide association study of longitudinal pubertal height growth and shared heritability with adult health outcomes. Genome Biol. 2024 01 16; 25(1):22.. View in PubMed
Air pollution and age-dependent changes in emotional behavior across early adolescence in the U.S. Environ Res. 2024 Jan 01; 240(Pt 1):117390.. View in PubMed
Calcium intake and genetic variants in the calcium sensing receptor in relation to colorectal cancer mortality: an international consortium study of 18,952 patients. BJC Rep. 2024; 2(1):63.. View in PubMed
Gene-Environment Analyses Reveal Novel Genetic Candidates with Prenatal Tobacco Exposure in Relation to Risk for Childhood Acute Lymphoblastic Leukemia. Cancer Epidemiol Biomarkers Prev. 2023 12 01; 32(12):1707-1715.. View in PubMed
Genome-Wide Interaction Analysis with DASH Diet Score Identified Novel Loci for Systolic Blood Pressure. medRxiv. 2023 Nov 11.. View in PubMed
Investigating the impact of London’s ultra low emission zone on children’s health: children’s health in London and Luton (CHILL) protocol for a prospective parallel cohort study. BMC Pediatr. 2023 11 04; 23(1):556.. View in PubMed
Genome-wide interaction analysis of folate for colorectal cancer risk. Am J Clin Nutr. 2023 11; 118(5):881-891.. View in PubMed
A new Approach to Identify Gene-Environment Interactions and Reveal New Biological Insight in Complex traits. Res Sq. 2023 Oct 05.. View in PubMed
Author Correction: Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk. Nat Genet. 2023 Oct; 55(10):1778-1779.. View in PubMed
Prenatal ambient air pollution exposure and child weight trajectories from the 3rd trimester of pregnancy to 2 years of age: a cohort study. BMC Med. 2023 09 07; 21(1):341.. View in PubMed
Sex-specific effects in how childhood exposures to multiple ambient air pollutants affect white matter microstructure development across early adolescence. Res Sq. 2023 Aug 17.. View in PubMed
A Genetic Locus within the FMN1/GREM1 Gene Region Interacts with Body Mass Index in Colorectal Cancer Risk. Cancer Res. 2023 08 01; 83(15):2572-2583.. View in PubMed
Probing the diabetes and colorectal cancer relationship using gene – environment interaction analyses. Br J Cancer. 2023 08; 129(3):511-520.. View in PubMed
A note on p-value multiple-testing adjustment for two-step genome-wide gene-environment interactions scans. medRxiv. 2023 Jun 28.. View in PubMed
Ambient temperature and air pollution associations with suicide and homicide mortality in California: A statewide case-crossover study. Sci Total Environ. 2023 May 20; 874:162462.. View in PubMed
The genetic determinants of recurrent somatic mutations in 43,693 blood genomes. Sci Adv. 2023 04 28; 9(17):eabm4945.. View in PubMed
Air pollution and emotional behavior in adolescents across the U.S. medRxiv. 2023 Apr 25.. View in PubMed
Longitudinal hierarchical Bayesian models of covariate effects on airway and alveolar nitric oxide. Sci Rep. 2023 04 01; 13(1):5346.. View in PubMed
Differences in Self-Reported Food Allergy and Food-Associated Anaphylaxis by Race and Ethnicity Among SAPPHIRE Cohort Participants. J Allergy Clin Immunol Pract. 2023 04; 11(4):1123-1133.e11.. View in PubMed
Genome-wide Interaction Study with Smoking for Colorectal Cancer Risk Identifies Novel Genetic Loci Related to Tumor Suppression, Inflammation, and Immune Response. Cancer Epidemiol Biomarkers Prev. 2023 03 06; 32(3):315-328.. View in PubMed
Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk. Nat Genet. 2023 03; 55(3):410-422.. View in PubMed
Improved two-step testing of genome-wide gene-environment interactions. Genet Epidemiol. 2023 03; 47(2):152-166.. View in PubMed
Author Correction: Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries. Nat Genet. 2023 Mar; 55(3):519-520.. View in PubMed
Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries. Nat Genet. 2023 01; 55(1):89-99.. View in PubMed
Correction: Childhood traffic-related air pollution and adverse changes in subclinical atherosclerosis measures from childhood to adulthood. Environ Health. 2022 Nov 16; 21(1):110.. View in PubMed
Interactions between folate intake and genetic predictors of gene expression levels associated with colorectal cancer risk. Sci Rep. 2022 11 07; 12(1):18852.. View in PubMed
Transcriptomic Response to Calcium in Normal Colon Organoids is Impacted by Colon Location and Sex. Cancer Prev Res (Phila). 2022 10 04; 15(10):679-688.. View in PubMed
Genome-Wide Interaction Analysis of Genetic Variants With Menopausal Hormone Therapy for Colorectal Cancer Risk. J Natl Cancer Inst. 2022 08 08; 114(8):1135-1148.. View in PubMed
Gene-lifestyle interactions in the genomics of human complex traits. Eur J Hum Genet. 2022 06; 30(6):730-739.. View in PubMed
Beyond GWAS of Colorectal Cancer: Evidence of Interaction with Alcohol Consumption and Putative Causal Variant for the 10q24.2 Region. Cancer Epidemiol Biomarkers Prev. 2022 05 04; 31(5):1077-1089.. View in PubMed
Two-step hypothesis testing to detect gene-environment interactions in a genome-wide scan with a survival endpoint. Stat Med. 2022 04 30; 41(9):1644-1657.. View in PubMed
Multi-omics insights into the biological mechanisms underlying statistical gene-by-lifestyle interactions with smoking and alcohol consumption. Front Genet. 2022; 13:954713.. View in PubMed
A scalable hierarchical lasso for gene-environment interactions. J Comput Graph Stat. 2022; 31(4):1091-1103.. View in PubMed
Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure. Mol Psychiatry. 2021 11; 26(11):6293-6304.. View in PubMed
Hierarchical Bayesian estimation of covariate effects on airway and alveolar nitric oxide. Sci Rep. 2021 08 25; 11(1):17180.. View in PubMed
Genetic architectures of proximal and distal colorectal cancer are partly distinct. Gut. 2021 07; 70(7):1325-1334.. View in PubMed
Increased burden of familial-associated early-onset cancer risk among minority Americans compared to non-Latino Whites. Elife. 2021 06 22; 10.. View in PubMed
Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci. Mol Psychiatry. 2021 Jun; 26(6):2111-2125.. View in PubMed
Childhood traffic-related air pollution and adverse changes in subclinical atherosclerosis measures from childhood to adulthood. Environ Health. 2021 04 14; 20(1):44.. View in PubMed
A two-step approach to testing overall effect of gene-environment interaction for multiple phenotypes. Bioinformatics. 2021 Apr 05; 36(24):5640-5648.. View in PubMed
Mapping the 17q12-21.1 Locus for Variants Associated with Early-Onset Asthma in African Americans. Am J Respir Crit Care Med. 2021 02 15; 203(4):424-436.. View in PubMed
Multi-Ancestry Genome-wide Association Study Accounting for Gene-Psychosocial Factor Interactions Identifies Novel Loci for Blood Pressure Traits. HGG Adv. 2021 Jan 14; 2(1).. View in PubMed
A Cross-Sectional Study Examining the Seroprevalence of Severe Acute Respiratory Syndrome Coronavirus 2 Antibodies in a University Student Population. J Adolesc Health. 2020 12; 67(6):763-768.. View in PubMed
Functional informed genome-wide interaction analysis of body mass index, diabetes and colorectal cancer risk. Cancer Med. 2020 05; 9(10):3563-3573.. View in PubMed
A genome-wide association study on medulloblastoma. J Neurooncol. 2020 Apr; 147(2):309-315.. View in PubMed
The Potential Effects of Policy-driven Air Pollution Interventions on Childhood Lung Development. Am J Respir Crit Care Med. 2020 02 15; 201(4):438-444.. View in PubMed
Pediatric glioma and medulloblastoma risk and population demographics: a Poisson regression analysis. Neurooncol Adv. 2020 Jan-Dec; 2(1):vdaa089.. View in PubMed
Asthma and its relationship to mitochondrial copy number: Results from the Asthma Translational Genomics Collaborative (ATGC) of the Trans-Omics for Precision Medicine (TOPMed) program. PLoS One. 2020; 15(11):e0242364.. View in PubMed
Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration. Nat Commun. 2019 Nov 12; 10(1):5121.. View in PubMed
A trans-ancestral meta-analysis of genome-wide association studies reveals loci associated with childhood obesity. Hum Mol Genet. 2019 10 01; 28(19):3327-3338.. View in PubMed
A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure. Hum Mol Genet. 2019 Aug 01; 28(15):2615-2633.. View in PubMed
Shift Work, Chronotype, and Melatonin Rhythm in Nurses. Cancer Epidemiol Biomarkers Prev. 2019 07; 28(7):1177-1186.. View in PubMed
Multiancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions. Am J Epidemiol. 2019 Jun 01; 188(6):1033-1054.. View in PubMed
Immune factors preceding diagnosis of glioma: a Prostate Lung Colorectal Ovarian Cancer Screening Trial nested case-control study. Neurooncol Adv. 2019 May-Dec; 1(1):vdz031.. View in PubMed
Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids. Nat Genet. 2019 Apr; 51(4):636-648.. View in PubMed
A Unified Model for the Analysis of Gene-Environment Interaction. Am J Epidemiol. 2019 04 01; 188(4):760-767.. View in PubMed
An admixture mapping meta-analysis implicates genetic variation at 18q21 with asthma susceptibility in Latinos. J Allergy Clin Immunol. 2019 03; 143(3):957-969.. View in PubMed
Using Bayes model averaging to leverage both gene main effects and G × E interactions to identify genomic regions in genome-wide association studies. Genet Epidemiol. 2019 03; 43(2):150-165.. View in PubMed
Novel Common Genetic Susceptibility Loci for Colorectal Cancer. J Natl Cancer Inst. 2019 02 01; 111(2):146-157.. View in PubMed
Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity. Nat Commun. 2019 Jan 22; 10(1):376.. View in PubMed
Discovery of common and rare genetic risk variants for colorectal cancer. Nat Genet. 2019 01; 51(1):76-87.. View in PubMed
Gene Coexpression Networks in Whole Blood Implicate Multiple Interrelated Molecular Pathways in Obesity in People with Asthma. Obesity (Silver Spring). 2018 12; 26(12):1938-1948.. View in PubMed
Author Correction: Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis. Nat Genet. 2018 09; 50(9):1343.. View in PubMed
Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis. Nat Genet. 2018 08; 50(8):1072-1080.. View in PubMed
Role of local CpG DNA methylation in mediating the 17q21 asthma susceptibility gasdermin B (GSDMB)/ORMDL sphingolipid biosynthesis regulator 3 (ORMDL3) expression quantitative trait locus. J Allergy Clin Immunol. 2018 06; 141(6):2282-2286.e6.. View in PubMed
Air pollution, weight loss and metabolic benefits of bariatric surgery: a potential model for study of metabolic effects of environmental exposures. Pediatr Obes. 2018 05; 13(5):312-320.. View in PubMed
Factors Associated with Age-Related Macular Degeneration in Chinese American Adults: The Chinese American Eye Study (CHES). Ophthalmol Retina. 2018 03; 2(3):209-216.. View in PubMed
A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Am J Hum Genet. 2018 Mar 01; 102(3):375-400.. View in PubMed
Dietary Nutrient Intake, Ethnicity, and Epigenetic Silencing of Lung Cancer Genes Detected in Sputum in New Mexican Smokers. Cancer Prev Res (Phila). 2018 02; 11(2):93-102.. View in PubMed
Factors Associated with Prevalent Diabetic Retinopathy in Chinese Americans: The Chinese American Eye Study. Ophthalmol Retina. 2018 Feb; 2(2):96-105.. View in PubMed
Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries. PLoS One. 2018; 13(6):e0198166.. View in PubMed
Traffic-Related Pollutants: Exposure and Health Effects Among Hispanic Children. Am J Epidemiol. 2018 01 01; 187(1):45-52.. View in PubMed
Genetic-Epigenetic Interactions in Asthma Revealed by a Genome-Wide Gene-Centric Search. Hum Hered. 2018; 83(3):130-152.. View in PubMed
Update on the State of the Science for Analytical Methods for Gene-Environment Interactions. Am J Epidemiol. 2017 Oct 01; 186(7):762-770.. View in PubMed
Current Challenges and New Opportunities for Gene-Environment Interaction Studies of Complex Diseases. Am J Epidemiol. 2017 Oct 01; 186(7):753-761.. View in PubMed
Lessons Learned From Past Gene-Environment Interaction Successes. Am J Epidemiol. 2017 Oct 01; 186(7):778-786.. View in PubMed
Multiancestry Study of Gene-Lifestyle Interactions for Cardiovascular Traits in 610 475 Individuals From 124 Cohorts: Design and Rationale. Circ Cardiovasc Genet. 2017 Jun; 10(3).. View in PubMed
Genome-Wide Interaction Analysis of Air Pollution Exposure and Childhood Asthma with Functional Follow-up. Am J Respir Crit Care Med. 2017 05 15; 195(10):1373-1383.. View in PubMed
Trends in childhood leukemia incidence over two decades from 1992 to 2013. Int J Cancer. 2017 Mar 01; 140(5):1000-1008.. View in PubMed
Gene Expression Profiling in Blood Provides Reproducible Molecular Insights into Asthma Control. Am J Respir Crit Care Med. 2017 01 15; 195(2):179-188.. View in PubMed
Dietary nutrients associated with preservation of lung function in Hispanic and non-Hispanic white smokers from New Mexico. Int J Chron Obstruct Pulmon Dis. 2017; 12:3171-3181.. View in PubMed
The Effects of Policy-Driven Air Quality Improvements on Children’s Respiratory Health. Res Rep Health Eff Inst. 2017 Jan; (190):1-75.. View in PubMed
Genome-wide association study identifies WNT7B as a novel locus for central corneal thickness in Latinos. Hum Mol Genet. 2016 11 15; 25(22):5035-5045.. View in PubMed
E-cigarettes, Cigarettes, and the Prevalence of Adolescent Tobacco Use. Pediatrics. 2016 08; 138(2).. View in PubMed
Detecting Gene-Environment Interactions for a Quantitative Trait in a Genome-Wide Association Study. Genet Epidemiol. 2016 07; 40(5):394-403.. View in PubMed
An Empirical Comparison of Joint and Stratified Frameworks for Studying G × E Interactions: Systolic Blood Pressure and Smoking in the CHARGE Gene-Lifestyle Interactions Working Group. Genet Epidemiol. 2016 07; 40(5):404-15.. View in PubMed
Air Pollution and Lung Function in Minority Youth with Asthma in the GALA II (Genes-Environments and Admixture in Latino Americans) and SAGE II (Study of African Americans, Asthma, Genes, and Environments) Studies. Am J Respir Crit Care Med. 2016 06 01; 193(11):1271-80.. View in PubMed
Age-Related Macular Degeneration and Quality of Life in Latinos: The Los Angeles Latino Eye Study. JAMA Ophthalmol. 2016 06 01; 134(6):683-90.. View in PubMed
Association of Changes in Air Quality With Bronchitic Symptoms in Children in California, 1993-2012. JAMA. 2016 Apr 12; 315(14):1491-501.. View in PubMed
Increased yield of actionable mutations using multi-gene panels to assess hereditary cancer susceptibility in an ethnically diverse clinical cohort. Cancer Genet. 2016 Apr; 209(4):130-7.. View in PubMed
Adaptive Set-Based Methods for Association Testing. Genet Epidemiol. 2016 Feb; 40(2):113-22.. View in PubMed
Correction: Inducible Nitric Oxide Synthase Promoter Haplotypes and Residential Traffic-Related Air Pollution Jointly Influence Exhaled Nitric Oxide Level in Children. PLoS One. 2016; 11(5):e0155567.. View in PubMed
Corrigendum: genome-wide association study of colorectal cancer identifies six new susceptibility loci. Nat Commun. 2015 Oct 26; 6:8739.. View in PubMed
Genome-wide association study of colorectal cancer identifies six new susceptibility loci. Nat Commun. 2015 Jul 07; 6:7138.. View in PubMed
Rising rates of acute lymphoblastic leukemia in Hispanic children: trends in incidence from 1992 to 2011. Blood. 2015 May 07; 125(19):3033-4.. View in PubMed
Association of aspirin and NSAID use with risk of colorectal cancer according to genetic variants. JAMA. 2015 Mar 17; 313(11):1133-42.. View in PubMed
Association of improved air quality with lung development in children. N Engl J Med. 2015 Mar 05; 372(10):905-13.. View in PubMed
15q12 variants, sputum gene promoter hypermethylation, and lung cancer risk: a GWAS in smokers. J Natl Cancer Inst. 2015 Feb 23; 107(5).. View in PubMed
Ethnic-specific associations of rare and low-frequency DNA sequence variants with asthma. Nat Commun. 2015 Jan 16; 6:5965.. View in PubMed
Inducible Nitric Oxide Synthase Promoter Haplotypes and Residential Traffic-Related Air Pollution Jointly Influence Exhaled Nitric Oxide Level in Children. PLoS One. 2015; 10(12):e0145363.. View in PubMed
Genetic ancestry influences asthma susceptibility and lung function among Latinos. J Allergy Clin Immunol. 2015 Jan; 135(1):228-35.. View in PubMed
No evidence of gene-calcium interactions from genome-wide analysis of colorectal cancer risk. Cancer Epidemiol Biomarkers Prev. 2014 Dec; 23(12):2971-6.. View in PubMed
Genome-wide interaction studies reveal sex-specific asthma risk alleles. Hum Mol Genet. 2014 Oct 01; 23(19):5251-9.. View in PubMed
Native American ancestry is associated with severe diabetic retinopathy in Latinos. Invest Ophthalmol Vis Sci. 2014 Aug 21; 55(9):6041-5.. View in PubMed
Integrated genome-wide association, coexpression network, and expression single nucleotide polymorphism analysis identifies novel pathway in allergic rhinitis. BMC Med Genomics. 2014 Aug 02; 7:48.. View in PubMed
Fraction of exhaled nitric oxide values in childhood are associated with 17q11.2-q12 and 17q12-q21 variants. J Allergy Clin Immunol. 2014 Jul; 134(1):46-55.. View in PubMed
Associations of children’s lung function with ambient air pollution: joint effects of regional and near-roadway pollutants. Thorax. 2014 Jun; 69(6):540-7.. View in PubMed
NOS1 methylation and carotid artery intima-media thickness in children. Circ Cardiovasc Genet. 2014 Apr; 7(2):116-22.. View in PubMed
Genome-wide diet-gene interaction analyses for risk of colorectal cancer. PLoS Genet. 2014 Apr; 10(4):e1004228.. View in PubMed
Native American ancestry affects the risk for gene methylation in the lungs of Hispanic smokers from New Mexico. Am J Respir Crit Care Med. 2013 Nov 01; 188(9):1110-6.. View in PubMed
High-resolution MODIS aerosol retrieval during wildfire events in California for use in exposure assessment. J Geophys Res Atmos. 2013 Oct 16; 118(19):11242-11255.. View in PubMed
Finding novel genes by testing G × E interactions in a genome-wide association study. Genet Epidemiol. 2013 Sep; 37(6):603-13.. View in PubMed
Childhood infections and adult height in monozygotic twin pairs. Am J Epidemiol. 2013 Aug 15; 178(4):551-8.. View in PubMed
Efficient two-step testing of gene-gene interactions in genome-wide association studies. Genet Epidemiol. 2013 Jul; 37(5):440-51.. View in PubMed
A meta-analysis of genome-wide association studies for serum total IgE in diverse study populations. J Allergy Clin Immunol. 2013 Apr; 131(4):1176-84.. View in PubMed
A genome-wide association study of central corneal thickness in Latinos. Invest Ophthalmol Vis Sci. 2013 Apr 01; 54(4):2435-43.. View in PubMed
Confounding and heterogeneity in genetic association studies with admixed populations. Am J Epidemiol. 2013 Feb 15; 177(4):351-60.. View in PubMed
Parental smoking and risk of childhood brain tumors by functional polymorphisms in polycyclic aromatic hydrocarbon metabolism genes. PLoS One. 2013; 8(11):e79110.. View in PubMed
Integration of mouse and human genome-wide association data identifies KCNIP4 as an asthma gene. PLoS One. 2013; 8(2):e56179.. View in PubMed
Further replication studies of the EVE Consortium meta-analysis identifies 2 asthma risk loci in European Americans. J Allergy Clin Immunol. 2012 Dec; 130(6):1294-301.. View in PubMed
Accuracy of a new time-resolved step counter in children. Pediatr Exerc Sci. 2012 Nov; 24(4):622-33.. View in PubMed
A genome-wide association meta-analysis identifies new childhood obesity loci. Nat Genet. 2012 May; 44(5):526-31.. View in PubMed
Predictors of intra-community variation in air quality. J Expo Sci Environ Epidemiol. 2012 Mar-Apr; 22(2):135-47.. View in PubMed
Invited commentary: GE-Whiz! Ratcheting gene-environment studies up to the whole genome and the whole exposome. Am J Epidemiol. 2012 Feb 01; 175(3):203-7; discussion 208-9.. View in PubMed
Genotype Imputation for Latinos Using the HapMap and 1000 Genomes Project Reference Panels. Front Genet. 2012; 3:117.. View in PubMed
Using extreme phenotype sampling to identify the rare causal variants of quantitative traits in association studies. Genet Epidemiol. 2011 Dec; 35(8):790-9.. View in PubMed
Parental stress increases the detrimental effect of traffic exposure on children’s lung function. Am J Respir Crit Care Med. 2011 Oct 01; 184(7):822-7.. View in PubMed
Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations. Nat Genet. 2011 Jul 31; 43(9):887-92.. View in PubMed
Association of the calcyon neuron-specific vesicular protein gene (CALY) with adolescent smoking initiation in China and California. Am J Epidemiol. 2011 May 01; 173(9):1039-48.. View in PubMed
Sample size requirements to detect gene-environment interactions in genome-wide association studies. Genet Epidemiol. 2011 Apr; 35(3):201-10.. View in PubMed
Genetic variations in nitric oxide synthase and arginase influence exhaled nitric oxide levels in children. Allergy. 2011 Mar; 66(3):412-9.. View in PubMed
Genetic variation in the glutathione synthesis pathway, air pollution, and children’s lung function growth. Am J Respir Crit Care Med. 2011 Jan 15; 183(2):243-8.. View in PubMed
TSLP polymorphisms are associated with asthma in a sex-specific fashion. Allergy. 2010 Dec; 65(12):1566-75.. View in PubMed
PDE11A associations with asthma: results of a genome-wide association scan. J Allergy Clin Immunol. 2010 Oct; 126(4):871-873.e9.. View in PubMed
Discovery of complex pathways from observational data. Stat Med. 2010 Aug 30; 29(19):1998-2011.. View in PubMed
Efficient genome-wide association testing of gene-environment interaction in case-parent trios. Am J Epidemiol. 2010 Jul 01; 172(1):116-22.. View in PubMed
Role of inducible nitric oxide synthase in asthma risk and lung function growth during adolescence. Thorax. 2010 Feb; 65(2):139-45.. View in PubMed
Genetic Analysis Workshop 16: Strategies for genome-wide association study analyses. BMC Proc. 2009 Dec 15; 3 Suppl 7:S1.. View in PubMed
Functional variants in the catalase and myeloperoxidase genes, ambient air pollution, and respiratory-related school absences: an example of epistasis in gene-environment interactions. Am J Epidemiol. 2009 Dec 15; 170(12):1494-501.. View in PubMed
Genome-wide association analysis identifies PDE4D as an asthma-susceptibility gene. Am J Hum Genet. 2009 May; 84(5):581-93.. View in PubMed
Respiratory symptoms following wildfire smoke exposure: airway size as a susceptibility factor. Epidemiology. 2009 May; 20(3):451-9.. View in PubMed
In utero smoke exposure, glutathione S-transferase P1 haplotypes, and respiratory illness-related absence among schoolchildren. Pediatrics. 2009 May; 123(5):1344-51.. View in PubMed
Variation in the GST mu locus and tobacco smoke exposure as determinants of childhood lung function. Am J Respir Crit Care Med. 2009 Apr 01; 179(7):601-7.. View in PubMed
Roles of arginase variants, atopy, and ozone in childhood asthma. J Allergy Clin Immunol. 2009 Mar; 123(3):596-602, 602.e1-8.. View in PubMed
Glutathione-S-transferase (GST) P1, GSTM1, exercise, ozone and asthma incidence in school children. Thorax. 2009 Mar; 64(3):197-202.. View in PubMed
Gene-environment interaction in genome-wide association studies. Am J Epidemiol. 2009 Jan 15; 169(2):219-26.. View in PubMed
Detecting gene-environment interactions in genome-wide association data. Genet Epidemiol. 2009; 33 Suppl 1:S68-73.. View in PubMed
Traffic-related air pollution and asthma onset in children: a prospective cohort study with individual exposure measurement. Environ Health Perspect. 2008 Oct; 116(10):1433-8.. View in PubMed
Effects of in utero and childhood tobacco smoke exposure and beta2-adrenergic receptor genotype on childhood asthma and wheezing. Pediatrics. 2008 Jul; 122(1):e107-14.. View in PubMed
Use of an electrostatic dust cloth for self-administered home allergen collection. Twin Res Hum Genet. 2008 Apr; 11(2):150-5.. View in PubMed
Interleukin-2, interleukin-12, and interferon-gamma levels and risk of young adult Hodgkin lymphoma. Blood. 2008 Apr 01; 111(7):3377-82.. View in PubMed
Glutathione S-transferase P1, maternal smoking, and asthma in children: a haplotype-based analysis. Environ Health Perspect. 2008 Mar; 116(3):409-15.. View in PubMed
Ozone, oxidant defense genes, and risk of asthma during adolescence. Am J Respir Crit Care Med. 2008 Feb 15; 177(4):388-95.. View in PubMed
Transforming growth factor- 1 C-509T polymorphism, oxidant stress, and early-onset childhood asthma. Am J Respir Crit Care Med. 2007 Dec 15; 176(12):1192-9.. View in PubMed
Microsomal epoxide hydrolase, glutathione S-transferase P1, traffic and childhood asthma. Thorax. 2007 Dec; 62(12):1050-7.. View in PubMed
Relationship between air pollution, lung function and asthma in adolescents. Thorax. 2007 Nov; 62(11):957-63.. View in PubMed
Childhood sun exposure influences risk of multiple sclerosis in monozygotic twins. Neurology. 2007 Jul 24; 69(4):381-8.. View in PubMed
Testing association between disease and multiple SNPs in a candidate gene. Genet Epidemiol. 2007 Jul; 31(5):383-95.. View in PubMed
The ADRB3 Trp64Arg variant and obesity in African-American breast cancer cases. Int J Obes (Lond). 2007 Jul; 31(7):1110-8.. View in PubMed
Indoor time-microenvironment-activity patterns in seven regions of Europe. J Expo Sci Environ Epidemiol. 2007 Mar; 17(2):170-81.. View in PubMed
Effect of exposure to traffic on lung development from 10 to 18 years of age: a cohort study. Lancet. 2007 Feb 17; 369(9561):571-7.. View in PubMed
Exploiting gene-environment interaction to detect genetic associations. Hum Hered. 2007; 63(2):111-9.. View in PubMed
Dog ownership enhances symptomatic responses to air pollution in children with asthma. Environ Health Perspect. 2006 Dec; 114(12):1910-5.. View in PubMed
Health effects of the 2003 Southern California wildfires on children. Am J Respir Crit Care Med. 2006 Dec 01; 174(11):1221-8.. View in PubMed
Regular smoking and asthma incidence in adolescents. Am J Respir Crit Care Med. 2006 Nov 15; 174(10):1094-100.. View in PubMed
Air pollution and children–an unhealthy mix. N Engl J Med. 2006 Jul 06; 355(1):78-9.. View in PubMed
Differential twin concordance for multiple sclerosis by latitude of birthplace. Ann Neurol. 2006 Jul; 60(1):56-64.. View in PubMed
Associations of tumor necrosis factor G-308A with childhood asthma and wheezing. Am J Respir Crit Care Med. 2006 May 01; 173(9):970-6.. View in PubMed
A testing framework for identifying susceptibility genes in the presence of epistasis. Am J Hum Genet. 2006 Jan; 78(1):15-27.. View in PubMed
Identifying susceptibility genes by using joint tests of association and linkage and accounting for epistasis. BMC Genet. 2005 Dec 30; 6 Suppl 1:S147.. View in PubMed
TNF-308 modifies the effect of second-hand smoke on respiratory illness-related school absences. Am J Respir Crit Care Med. 2005 Dec 15; 172(12):1563-8.. View in PubMed
Testing association and linkage using affected-sib-parent study designs. Genet Epidemiol. 2005 Nov; 29(3):225-33.. View in PubMed
Childhood asthma and exposure to traffic and nitrogen dioxide. Epidemiology. 2005 Nov; 16(6):737-43.. View in PubMed
Intercellular adhesion molecule-1 and childhood asthma. Hum Genet. 2005 Sep; 117(5):476-84.. View in PubMed
SNPs, haplotypes, and model selection in a candidate gene region: the SIMPle analysis for multilocus data. Genet Epidemiol. 2004 Dec; 27(4):429-41.. View in PubMed
Effects of ambient air pollutants on asthma medication use and wheezing among fourth-grade school children from 12 Southern California communities enrolled in The Children’s Health Study. Arch Environ Health. 2004 Oct; 59(10):505-14.. View in PubMed
The effect of air pollution on lung development from 10 to 18 years of age. N Engl J Med. 2004 Sep 09; 351(11):1057-67.. View in PubMed
IL-6 levels and genotype are associated with risk of young adult Hodgkin lymphoma. Blood. 2004 Apr 15; 103(8):3216-21.. View in PubMed
Polymorphism in the androgen receptor and mammographic density in women taking and not taking estrogen and progestin therapy. Cancer Res. 2004 Feb 15; 64(4):1237-41.. View in PubMed
Does mammographic density reflect ethnic differences in breast cancer incidence rates? Am J Epidemiol. 2004 Jan 15; 159(2):140-7.. View in PubMed
Multiple imputation methods for longitudinal blood pressure measurements from the Framingham Heart Study. BMC Genet. 2003 Dec 31; 4 Suppl 1:S43.. View in PubMed
Segregation and linkage analysis for longitudinal measurements of a quantitative trait. BMC Genet. 2003 Dec 31; 4 Suppl 1:S21.. View in PubMed
Candidate gene association analysis for a quantitative trait, using parent-offspring trios. Genet Epidemiol. 2003 Dec; 25(4):327-38.. View in PubMed
Prospective study of air pollution and bronchitic symptoms in children with asthma. Am J Respir Crit Care Med. 2003 Oct 01; 168(7):790-7.. View in PubMed
Children’s lung function and antioxidant vitamin, fruit, juice, and vegetable intake. Am J Epidemiol. 2003 Sep 15; 158(6):576-84.. View in PubMed
Obesity and the risk of newly diagnosed asthma in school-age children. Am J Epidemiol. 2003 Sep 01; 158(5):406-15.. View in PubMed
Environmental tobacco smoke and absenteeism related to respiratory illness in schoolchildren. Am J Epidemiol. 2003 May 15; 157(10):861-9.. View in PubMed
Longitudinal data analysis in pedigree studies. Genet Epidemiol. 2003; 25 Suppl 1:S18-28.. View in PubMed
Regression models for linkage: issues of traits, covariates, heterogeneity, and interaction. Hum Hered. 2003; 55(2-3):86-96.. View in PubMed
Effects of glutathione-S-transferase M1, T1, and P1 on childhood lung function growth. Am J Respir Crit Care Med. 2002 Sep 01; 166(5):710-6.. View in PubMed
Effects of glutathione S-transferase M1, maternal smoking during pregnancy, and environmental tobacco smoke on asthma and wheezing in children. Am J Respir Crit Care Med. 2002 Aug 15; 166(4):457-63.. View in PubMed
Effects of glutathione S-transferase P1, M1, and T1 on acute respiratory illness in school children. Am J Respir Crit Care Med. 2002 Aug 01; 166(3):346-51.. View in PubMed
Impact of respiratory illness on expiratory flow rates in normal, asthmatic, and allergic children. Pediatr Pulmonol. 2002 Aug; 34(2):112-21.. View in PubMed
Association between air pollution and lung function growth in southern California children: results from a second cohort. Am J Respir Crit Care Med. 2002 Jul 01; 166(1):76-84.. View in PubMed
Indoor risk factors for asthma in a prospective study of adolescents. Epidemiology. 2002 May; 13(3):288-95.. View in PubMed
Sample size requirements for association studies of gene-gene interaction. Am J Epidemiol. 2002 Mar 01; 155(5):478-84.. View in PubMed
Asthma in exercising children exposed to ozone: a cohort study. Lancet. 2002 Feb 02; 359(9304):386-91.. View in PubMed
Sample size requirements for matched case-control studies of gene-environment interaction. Stat Med. 2002 Jan 15; 21(1):35-50.. View in PubMed
Respiratory effects of relocating to areas of differing air pollution levels. Am J Respir Crit Care Med. 2001 Dec 01; 164(11):2067-72.. View in PubMed
The role of interacting determinants in the localization of genes. Adv Genet. 2001; 42:393-412.. View in PubMed
Combined linkage and association analysis in pedigrees. Genet Epidemiol. 2001; 21 Suppl 1:S358-63.. View in PubMed
Association tests in nuclear families. Hum Hered. 2001; 52(2):66-76.. View in PubMed
The effects of ambient air pollution on school absenteeism due to respiratory illnesses. Epidemiology. 2001 Jan; 12(1):43-54.. View in PubMed
Should we consider gene x environment interaction in the hunt for quantitative trait loci? Genet Epidemiol. 2001; 21 Suppl 1:S831-6.. View in PubMed
Gene-environment interaction and affected sib pair linkage analysis. Hum Hered. 2001; 52(1):34-46.. View in PubMed
Effects of in utero and environmental tobacco smoke exposure on lung function in boys and girls with and without asthma. Am J Respir Crit Care Med. 2000 Dec; 162(6):2097-104.. View in PubMed
Sex-specific effects of asthma on pulmonary function in children. Am J Respir Crit Care Med. 2000 Nov; 162(5):1723-30.. View in PubMed
Association between air pollution and lung function growth in southern California children. Am J Respir Crit Care Med. 2000 Oct; 162(4 Pt 1):1383-90.. View in PubMed
Maternal smoking during pregnancy, environmental tobacco smoke exposure and childhood lung function. Thorax. 2000 Apr; 55(4):271-6.. View in PubMed
The role of restricted motility in determining outcomes for vertical strabismus surgery in Graves’ ophthalmology. Ophthalmology. 2000 Mar; 107(3):545-9.. View in PubMed
Evidence for age-specific genetic relative risks in lung cancer. Am J Epidemiol. 2000 Jan 01; 151(1):41-9.. View in PubMed
Air pollution and bronchitic symptoms in Southern California children with asthma. Environ Health Perspect. 1999 Sep; 107(9):757-60.. View in PubMed
Asymptotic bias and efficiency in case-control studies of candidate genes and gene-environment interactions: basic family designs. Am J Epidemiol. 1999 Apr 15; 149(8):693-705.. View in PubMed
Genome-wide screen for systemic lupus erythematosus susceptibility genes in multiplex families. Hum Mol Genet. 1999 Apr; 8(4):639-44.. View in PubMed
A study of twelve Southern California communities with differing levels and types of air pollution. I. Prevalence of respiratory morbidity. Am J Respir Crit Care Med. 1999 Mar; 159(3):760-7.. View in PubMed
A study of twelve Southern California communities with differing levels and types of air pollution. II. Effects on pulmonary function. Am J Respir Crit Care Med. 1999 Mar; 159(3):768-75.. View in PubMed
A joint test of linkage and gene x environment interaction, with affected sib pairs. Genet Epidemiol. 1999; 17 Suppl 1:S563-8.. View in PubMed
Family-based association studies. J Natl Cancer Inst Monogr. 1999; (26):31-7.. View in PubMed
A generalized estimating equations approach to linkage analysis in sibships in relation to multiple markers and exposure factors. Genet Epidemiol. 1999; 17 Suppl 1:S737-42.. View in PubMed
Association tests using unaffected-sibling versus pseudo-sibling controls. Genet Epidemiol. 1999; 17 Suppl 1:S731-6.. View in PubMed
Study-design issues in the development of the University of Southern California Consortium’s Colorectal Cancer Family Registry. J Natl Cancer Inst Monogr. 1999; (26):89-93.. View in PubMed
Synergistic effect between IL-10 and bcl-2 genotypes in determining susceptibility to systemic lupus erythematosus. Arthritis Rheum. 1998 Apr; 41(4):596-602.. View in PubMed
Detection of gene-environment interactions in joint segregation and linkage analysis. Am J Hum Genet. 1997 Nov; 61(5):1189-99.. View in PubMed
Joint segregation and linkage analysis of a quantitative trait compared to separate analyses. Genet Epidemiol. 1997; 14(6):993-8.. View in PubMed
Analysis of gene-smoking interaction in lung cancer. Genet Epidemiol. 1997; 14(2):199-214.. View in PubMed
Association between the Rfp-Y haplotype and the incidence of Marek’s disease in chickens. Immunogenetics. 1996; 44(4):242-5.. View in PubMed
Ocular infections. West J Med. 1995 Mar; 162(3):277.. View in PubMed
Genetic epidemiologic analysis of quantitative phenotypes using Gibbs sampling. Genet Epidemiol. 1995; 12(6):753-8.. View in PubMed
Censored survival models for genetic epidemiology: a Gibbs sampling approach. Genet Epidemiol. 1994; 11(2):171-88.. View in PubMed
A bivariate genetic analysis of HDL- and LDL-cholesterol incorporating measured covariates: a Gibbs sampling application. Genet Epidemiol. 1993; 10(6):623-8.. View in PubMed
Combined segregation and linkage analysis of late-onset Alzheimer’s disease in Duke families using Gibbs sampling. Genet Epidemiol. 1993; 10(6):489-94.. View in PubMed
Community care of corneal ulcers. Am J Ophthalmol. 1992 Nov 15; 114(5):531-8.. View in PubMed
Anti-inflammatory therapy and outcome in a guinea pig model of Pseudomonas keratitis. Cornea. 1992 Sep; 11(5):398-403.. View in PubMed
Sample size calculations for ophthalmologic studies. Arch Ophthalmol. 1992 May; 110(5):690-2.. View in PubMed
Intravitreal penetration of oral ciprofloxacin in humans. Ophthalmology. 1992 Apr; 99(4):483-6.. View in PubMed
Diurnal variation of corneal topography after radial keratotomy. Arch Ophthalmol. 1992 Mar; 110(3):351-6.. View in PubMed
Anti-inflammatory effects of vitamin E on experimental lens-induced uveitis. Int Ophthalmol. 1992 Jan; 16(1):27-32.. View in PubMed
Computer-assisted study of diurnal variation in corneal topography after penetrating keratoplasty. Ophthalmic Surg. 1992 Jan; 23(1):10-6.. View in PubMed
Pituitary tumor volume as a predictor of postoperative visual field recovery. Quantitative analysis using automated static perimetry and computed tomography morphometry. J Clin Neuroophthalmol. 1991 Dec; 11(4):280-3.. View in PubMed
Pars plana vitrectomy for acute retinal detachment in penetrating ocular injuries. Arch Ophthalmol. 1990 Dec; 108(12):1724-8.. View in PubMed
Clearance rate of macrophages from the vitreous in rabbits. Curr Eye Res. 1990 Jul; 9(7):683-6.. View in PubMed

William Gauderman, PhD

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