Sanda Win, MBBS, PhD

Assistant Professor of Research Medicine

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Overview

Dr. Win’s major areas of research interest are signal transduction in drug-induced hepatotoxicity, regulation of mitochondrial bioenergetic signaling in hepatotoxicity, metabolic dysfunction-associated steatotic liver disease (MASLD), and alcoholic hepatitis, oxidative stress, and identification of therapeutic targets to prevent drug-induced hepatotoxicity and metabolic dysfunction-associated steatotic liver disease (MASLD) (previous term: nonalcoholic fatty liver disease, NAFLD). Her current research includes cellular mechanisms of hepatotoxicity.

Dr. Win earned her medical degree from University of Yangon Institute of Medicine. She then went on to perform her Medicine and Surgery Internship and Residency at University of Yangon General Hospital, followed by her PhD in Immunology & Molecular Biology from Okayama University Graduate School of Medicine and Dentistry.

Awards

  • American Association for the Study of Liver Disease: Presidential Poster of Distinction, 2020
  • American Association for the Study of Liver Disease: Presidential Poster of Distinction, 2020
  • Baxter Foundation: Donald E. and Delia B. Baxter Foundation Faculty Fellowship Award, 2018
  • NIH: Research Center for Liver Diseases, Keck School of Medicine of USC Research Pilot Award, 2016
  • American Association for the Study of Liver Disease: Presidential Poster of Distinction, 2014
  • Sagawa Scholarship Foundation, Japan: Award for Doctoral Program, 2001

Publications

  • Chronic Liver-Specific LRP1 Silencing Drives Progressive Brain Amyloidosis, Neuroinflammation, and Behavioral Deficits in APP/PS1 Mice. Res Sq. 2026 Sep 03.. View in PubMed
  • Hepatic LRP-1 plays an important role in amyloidosis in Alzheimer’s disease mice: Potential role in chronic heavy alcohol feeding. Neurobiol Dis. 2024 09; 199:106570.. View in PubMed
  • Mitochondrial P-JNK target, SAB (SH3BP5), in regulation of cell death. Front Cell Dev Biol. 2024; 12:1359152.. View in PubMed
  • Oral magnesium prevents acetaminophen-induced acute liver injury by modulating microbial metabolism. Cell Host Microbe. 2024 01 10; 32(1):48-62.e9.. View in PubMed
  • c-Jun-N Terminal Kinase-Mediated Degradation of γ-Glutamylcysteine Ligase Catalytic Subunit Inhibits GSH Recovery After Acetaminophen Treatment: Role in Sustaining JNK Activation and Liver Injury. Antioxid Redox Signal. 2023 06; 38(16-18):1071-1081.. View in PubMed
  • Mechanism and Therapeutic Targets of c-Jun-N-Terminal Kinases Activation in Nonalcoholic Fatty Liver Disease. Biomedicines. 2022 Aug 20; 10(8).. View in PubMed
  • Hepatic Mitochondrial SAB Deletion or Knockdown Alleviates Diet-Induced Metabolic Syndrome, Steatohepatitis, and Hepatic Fibrosis. Hepatology. 2021 12; 74(6):3127-3145.. View in PubMed
  • Risk factors for lymphatic filariasis and mass drug administration non-participation in Mandalay Region, Myanmar. Parasit Vectors. 2021 Jan 22; 14(1):72.. View in PubMed
  • Acetaminophen Hepatotoxicity: Strong Offense and Weakened Defense. Hepatology. 2020 05; 71(5):1530-1532.. View in PubMed
  • Gut Microbiota and Liver Injury (I)-Acute Liver Injury. Adv Exp Med Biol. 2020; 1238:23-37.. View in PubMed