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Jing-Hsiung James Ou, PhD

Professor of Immunology and Immune Therapeutics

Fletcher Jones Foundation Chair in Molecular Microbiology and Immunology

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Phone +1 323 442 1720
Email [email protected]
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Overview

The research of our laboratory is centered on hepatitis B virus (HBV), hepatitis C virus (HCV), and liver cancer. We are particularly interested in understanding how these two viruses interact with their host cells, how they invaded host immunity to establish persistent infection, and how they cause liver diseases including hepatocellular carcinoma.

Education and Training

  • National Taiwan University, Taiwan — B.S. — 06/1976 — Zoology
  • California Institute of Technology, Pasadena, California — Ph.D. — 06/1982 — Molecular Virology

Research Keywords

  • Hepatitis B Virus
  • Hepatitis C Virus
  • Hepatocellular Carcinoma
  • Autophagy
  • Mitophagy
  • Viral Persistence

Publications

  • Retraction: C-Jun mediates hepatitis C virus hepatocarcinogenesis through signal transducer and activator of transcription 3 and nitric oxide-dependent impairment of oxidative DNA repair. Hepatology. 2025 06 01; 81(6):E181.. View in PubMed
  • Effects of cellular membranes and the precore protein on hepatitis B virus core particle assembly and DNA replication. mBio. 2025 04 09; 16(4):e0397224.. View in PubMed
  • Hepatitis B virus entry, assembly, and egress. Microbiol Mol Biol Rev. 2024 Dec 18; 88(4):e0001424.. View in PubMed
  • Hepatitis B virus e antigen induces atypical metabolism and differentially regulates programmed cell deaths of macrophages. PLoS Pathog. 2024 03; 20(3):e1012079.. View in PubMed
  • Regulation of Mitochondrial Metabolism by Hepatitis B Virus. Viruses. 2023 11 30; 15(12).. View in PubMed
  • β-CATENIN stabilizes HIF2 through lncRNA and inhibits intravenous immunoglobulin immunotherapy. Front Immunol. 2023; 14:1204907.. View in PubMed
  • Enhancing autophagy in CD11c+ antigen-presenting cells as a therapeutic strategy for acute respiratory distress syndrome. Cell Rep. 2023 08 29; 42(8):112990.. View in PubMed
  • Pathogenicity and virulence of Hepatitis B virus. Virulence. 2022 12; 13(1):258-296.. View in PubMed
  • Regulation of hepatitis B virus replication by autophagic membranes. Autophagy. 2023 04; 19(4):1357-1358.. View in PubMed
  • Autophagic membranes participate in hepatitis B virus nucleocapsid assembly, precore and core protein trafficking, and viral release. Proc Natl Acad Sci U S A. 2022 07 26; 119(30):e2201927119.. View in PubMed

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