Research

NCT01042379
NIH / Quantum Leap Healthcare Collaborative
I SPY 2 Trial (Investigation of Serial Studies to Predict Your Therapeutic Response with Imaging and Molecular Analysis): Neoadjuvant and Personalized Adaptive Novel Agents to Treat Breast Cancer.
The major goal of this multi-center study is to test new agents added to standard chemotherapy in their effectiveness to induce pathological responses in patients receiving neoadjuvant therapy.

NCT03257839
Delphinus Medical Technologies, Inc.
A Prospective, Multicenter, Multi-arm, Clinical Case Collection Program for SoftVue.
The major goal is to acquire breast image data and establish an image library of exams for use in future research studies, training, and product development efforts.

ECOG-ACRIN TMIST EA1151
NIH / NCI
Tomosynthesis Mammographic Imaging Screening Trial (TMIST).
The major goal of this multicenter study is to compare the proportions of participants in the Tomosynthesis (TM) and Digital Mammography (DM) study arms experiencing the occurrence of an “advanced” breast cancer at any time during a period of 4.5 years from randomization, including the period of active screening and a period of clinical follow-up after the last screen.

HS-20-00103
Koios Medical
Triple Negative Cancer versus Cyst.
The major goal of this multicenter study is to improve ultrasound-CAD (Computer Aided Detection) recognition of triple negative invasive breast cancer as suspicious and distinct from benign simple cysts and benign complicated cysts, with the ultimate goal of helping the radiologist triage suspicious cyst-like lesions on breast ultrasound.

HS-16-00483
Wright Foundation
Characterizing Breast Masses Using an Integrative Framework of Machine Learning and Radiomics.
The major role is to characterize breast cancer using a combination of machine learning and radiomics and evaluate its role in clinical diagnosis and treatment response assessment.

HS-16-00874
Wright Foundation Pilot/Norris Endowment funds
Emerging Tools in the Detection of Breast Cancer: Comparison of Contrast Enhanced Spectral Mammography (CESM) with Digital Breast Tomosynthesis (DBT) to Conventional Imaging Techniques Including Contrast Enhanced Magnetic Resonance Imaging and 2D Mammography with or without Targeted Ultrasound.
The major goal is to conduct preoperative evaluation of CESM with DBT in improving the accuracy of identifying and determining the extent of newly diagnosed breast cancer (primary and additional lesions) when used as an adjunct to standard of care mammography.

NIH UH2EB019889
Dr Susan Love Research Foundation
PHASE 2:Validation Study of Low-Cost Portable Computer-Aided Diagnosis (CAD) Ultrasound System for Breast Cancer Triage in Low to Middle-Income Countries (LMIC) Environments.
The major goal is to validate software using portable ultrasound to triage palpable breast lumps between those that need further workup (typically biopsy) and those that are benign, so that it is ready for use in a Clinical Trial in Mexico for patients with little access to medical care.

ACRIN 6666; NCT00072501
NCI and Avon Foundation
Screening Breast Ultrasound Breast in High Risk Women.
The major goal of this project is to compare the use of whole-breast ultrasound as an adjunct to mammography in women with dense breasts and with an additional high risk of breast cancer.

P30CA14089
Keck Medicine of USC
Colocalization of Mammographic Breast Density and Breast Cancer.
The major role is to determine whether DCIS occurs in a dense area on the mammogram.

T32 EB00438
NIH / NBIB / USC- Dept of Radiology and Biomedical Engineering
Biomedical Imaging Informatics Training Program.
The major role is to designate program faculty and mentors for the radiology residency-training program.

BC044808
Department of Defense
Evaluating Post-pregnancy Changes in Breast Epithelium.
The major role is to compare breast tissue from core biopsy in women pre and post pregnancy.

BC044808
Department of Defense
Elite: Evaluating the effect of intravaginal progesterone on breast epithelial cell proliferation in healthy postmenopausal women.
The major goal is to evaluate core biopsy as a method of following breast epithelial proliferation in healthy postmenopausal women during hormone replacement therapy.

BC044808
Department of Defense
Molecular characterization of normal breast tissue from healthy premenopausal and postmenopausal women.
The major role is to compare normal breast tissue from breast biopsies in premenopausal and postmenopausal women volunteers.

BC044808
Department of Defense
Evaluating the Effect of High Levels of Estrogen on Gene Expression Patterns in Breast Tissue (Egg Donors).
The major role is to evaluate effects of high levels of estrogen on breast tissue from core biopsies in egg donors.

BC044808
Department of Defense
Oral Contraceptive Take 2.
The major role is to identify the effects of oral contraceptives on breast tissue from core biopsy.

BCTR 0600577
Susan G Komen Foundation
Sonography Compared with MRI in Pre-operative Work-up of Women Diagnosed with Breast Cancer to Determine Extent of Breast Disease.
The major goal of this project is to compare standard-of-care, whole breast ultrasound, and bilateral CE-MRI in terms of accurately measuring the size of the index cancer and the number and location of tumor foci (using surgical pathology as gold standard).

NCT00484614
Naviscan PET Systems, Inc. and Certus International Inc.
Prospective Multicenter Study of the Role of Positron Emission Mammography (PEM) in Pre-Surgical Planning for Breast Cancer.
The major goal is to determine changes in surgical management resulting from PEM or MRI compared to conventional imaging with mammography and ultrasound.

NCT00716482
SuperSonicImagine
Assessment of clinical value of SuperSonic shear wave elastography in ultrasonic evaluation of breast lesions.
The major goal is to evaluate the sensitivity and specificity of elastography in breast lesions using the supersonic protocol.

ACRIN 6688 / NCT00572728
NCI / ACRIN (American College of Radiology Imaging Network)
Phase II Study: 3’-Deoxy-3’-18F Fluorothymidine PET/CT in Predicting Response to Chemotherapy Before Surgery in Patients with Locally Advanced Breast Cancer.
The major goal is to evaluate the relationship between [18F] FLT uptake parameters and pathologic complete response to neoadjuvant therapy of the primary tumor in patients with locally advanced breast cancer.

NCT01007890
Precision Therapeutics, Inc. / United States Department of Defense
Prediction of Response to Neoadjuvant Chemotherapy in Women with Operable Breast Cancer.
The major goal is to develop a biomarker to predict pathological complete response in women treated with neoadjuvant chemotherapy for breast cancer.

NCT01104584
Bayer Corporation
An open label, multi-center, phase 3 study with corresponding blinded image reading to determine the efficacy and safety of a single intravenous injection of 0.1 mmol/kg body weight of gadobutrol 1.0 molar (Gadovist(r)) in patients with newly diagnosed breast cancer referred for contrast-enhanced breast MRI.
The major role is to look at the efficacy and safety of gadbutrol when used for MR imaging of both breasts.

HS-10-06500
Keck Medicine of USC
MRI Characteristics and Pathology of Women Undergoing BRCA Testing at LAC Medical Center: Review
The major role is to compare MRI findings in women who are BRCA positive with those who are not.

CDR0000636131
Southwest Oncology Group / NCI
(SWOG S0800) trial- A Randomized Phase II Study of Weekly Nab Paclitaxel With or Without Bevacizumab, Either Preceded or Followed by Q2 Week Doxorubicin, Cyclophosphamide Plus Pegfilgrastim as Neoadjuvant Therapy for Inflammatory or Locally Advanced HER2/NEU Negative Breast Cancer.
The major goal is to assess the impact or the complete pathological rate from the addition of becavizumab to neoadjuvant nab-paclitaxel, doxorubicin, cyclophosphamide, and pegfilgrastim for inflammatory breast cancer.

NCT01219075
USC / California Breast Cancer Research Program / NCI
Soy Isoflavones Supplementation in Treating High Risk Women and DCIS patients.
The major goal of this project is to the effects of soy on breast tissue by evaluating the core biopsy samples obtained following treatment with soy.

HS1300687
Whittier Foundation
Real Time Contrast Enhanced Ultrasound and Ultrasound-Based Elastography: Novel Techniques in Assessment of Treatment Response to Neoadjuvant Chemotherapy for Breast Cancer.
The major goal of this project is to establish a quantitative prediction rule for accurate and early prediction of pathologic tumor response to neoadjuvant chemotherapy (NAC), using the change of contrast enhanced ultrasound assessments of tumor size and perfusion characteristics before and 2-3 weeks post NAC initiation.

HS-13-00743
Keck Medicine of USC
Ex Vivo High Frequency Ultrasound Imaging of Breast Cancer Specimens.
The major goal of this project is to determine the effectiveness of high frequency ultrasound imaging in characterizing breast tissue by differentiating benign and malignant tissue in ex-vivo breast tissue.

HS1500337
Dr Susan Love Research Foundation and NIH
Phase 1: Low Cost Automated Ultrasound for Breast Cancer Detection and Diagnosis.
The major goal of this project is to determine the sensitivity and specificity of CAD ultrasound system to triage benign lumps and to determine the acceptability and feasibility of ultrasound for breast cancer in low and middle-income environments.

HS1600483
Wright Foundation Pilot
Qualitative and Quantitative Analysis of Cystic Breast Masses by Contrast Enhanced Ultrasound: Is Biopsy Necessary?
The major goal is to evaluate whether qualitative and quantitative parameters in real time contrast enhanced ultrasound can aid in assessing suspicious indeterminate cystic appearing breast masses and ultimately determine whether or not an ultrasound-guided biopsy is necessary.

NIH NCT02888366
Menssana Research, Inc.
A Prospective Validation Study of a Rapid Point-of-Care Breath Test for Breast Cancer.
The major goal of this study is to investigate the Breath Link test to determine if breath testing combined with a mammogram is more accurate than mammogram alone for identifying breast cancer.