Denis Evseenko, MD, PhD

Professor of Orthopaedic Surgery and Stem Cell Biology and Regenerative Medicine

J. Harold and Edna La Briola Chair in Genetic Orthopaedic Research

Director of Skeletel Regeneration

Vice Chair for Research in Orthopaedic Surgery

Executive Director of PARRIS Longevity Accelerator

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Overview

Dr. Denis Evseenko is currently a Professor of Orthopaedic Surgery, Stem Cell Research and Regenerative Medicine at USC. He holds the J. Harold and Edna La Briola Chair in Genetic Orthopaedic Research and is Director of Skeletal Regeneration, as well as Vice Chair for Research in Orthopaedic Surgery. Dr Evseenko was trained in both medicine and molecular pharmacology. His research focuses on the development of novel translational stem cell and small molecule-based approaches for prevention of arthritis and restoration of damaged articular cartilage. Dr Evseenko has been involved in translational research for over 10 years and is the author of numerous peer-reviewed research articles, presentations, and patents.

Awards

  • Arthritis National Research Foundation: James Klinenberg Award, 2015
  • USC: USC Stevens Technology Advancement Grant, 2016
  • Wright Foundation: Wright Foundation Award, 2016

Research Funding

  • Pre-clinical development of a small molecule therapeutic for the systemic treatment of idiopathic pulmonary fibrosis
    NIH · UG3AG097137 · Sep 15, 2025 – Aug 31, 2027 · Role: Principal Investigator
  • Cellular origins and molecular mechanisms of arthrofibrosis
    NIH · R01AR085642 · May 2, 2025 – Mar 31, 2030 · Role: Principal Investigator
  • Preclinical assessment of a novel systemic drug candidate for osteoarthritic pain
    NIH · R61NS131307 · Jun 1, 2023 – May 31, 2025 · Role: Principal Investigator

Publications

  • A universal 6iL/E4 culture system for deriving and maintaining embryonic stem cells across mammalian species. Cell Res. 2026 Jul 13.. View in PubMed
  • GP130 Y814 SIGNALING IS REQUIRED FOR THE DYNAMIN-MEDIATED ENDOCYTOSIS, MAPK/P38 ACTIVATION AND PERSISTENCE OF CHRONIC SYSTEMIC INFLAMMATION INDUCED BY HIGH FAT DIET. bioRxiv. 2026 Feb 09.. View in PubMed
  • A Universal 6iL/E4 Culture System for Deriving and Maintaining Embryonic Stem Cells Across Mammalian Species. bioRxiv. 2025 May 21.. View in PubMed
  • Repurposing of a gill gene regulatory program for outer-ear evolution. Nature. 2025 03; 639(8055):682-690.. View in PubMed
  • Ex Vivo Regional Gene Therapy Compared to Recombinant BMP-2 for the Treatment of Critical-Size Bone Defects: An In Vivo Single-Cell RNA-Sequencing Study. Bioengineering (Basel). 2025 Jan 01; 12(1).. View in PubMed
  • Pharmacological inactivation of a non-canonical gp130 signaling arm attenuates chronic systemic inflammation and multimorbidity induced by a high-fat diet. Sci Rep. 2024 12 28; 14(1):31151.. View in PubMed
  • Inactivation of a non-canonical gp130 signaling arm attenuates chronic systemic inflammation and multimorbidity induced by a high-fat diet. bioRxiv. 2024 Apr 11.. View in PubMed
  • Distinct human skeletal muscle-derived CD90 progenitor subsets for myo-fibro-adipogenic disease modeling and treatment in multiplexed conditions. Front Cell Dev Biol. 2023; 11:1173794.. View in PubMed
  • Inhibition of a signaling modality within the gp130 receptor enhances tissue regeneration and mitigates osteoarthritis. Sci Transl Med. 2023 03 22; 15(688):eabq2395.. View in PubMed
  • STAT3 promotes a youthful epigenetic state in articular chondrocytes. Aging Cell. 2023 02; 22(2):e13773.. View in PubMed