Duke Han, PhD

Professor of Psychology and Family Medicine

Image of Duke Han, PhD
Is this your profile? Click to edit


Duke Han, PhD, is a Diplomate of the American Board of Professional Psychology in Clinical Neuropsychology, a Fellow of the American Psychological Association and the National Academy of Neuropsychology, Director of the Neuropsychology Division in Family Medicine, and a tenured Professor of Family Medicine, Neurology, Psychology, and Gerontology at the Keck School of Medicine of the University of Southern California. He received his Bachelor of Science degree in Psychology with a specialization in Neuroscience from Duke University, and his PhD Doctorate Degree in Clinical Psychology from the University of Massachusetts Boston. He received training in clinical neuropsychology and experimental neuroimaging techniques through various programs of Harvard Medical School’s Brigham and Women’s Hospital. He continued his clinical neuropsychology and neuroimaging activities during his clinical internship and postdoctoral fellowship years at the University of California San Diego (UCSD) and the San Diego VA Healthcare System. He maintains an active research collaboration with the Rush Alzheimer’s Disease Center (RADC) in Chicago where he was formerly a tenured faculty member. Dr. Han is interested in the factors that affect cognition and decision making in aging. He also has special interests in leveraging novel empirical approaches to better understand these factors, and in the advocacy of justice, equity, diversity, and inclusion considerations in aging and neuroscience research. He was the recipient of the prestigious Paul B. Beeson fellowship, which is considered the premiere career development award of the National Institute on Aging (NIA). He is the primary investigator or co-investigator on multiple research grants extramurally funded by the National Institutes of Health (NIH) and private foundations. He is actively involved in the peer-review of aging and Alzheimer’s Disease research grants, and has previously served as the Chair of the NIA Clinical and Translational Research of Aging review committee (NIA-T) and the Neuroscience of Aging review committee (NIA-N). Dr. Han is a founding governance committee member of the Global Council on Brain Health, an international independent science collaborative convened by AARP that is tasked with offering the aging public the best advice about brain health. He is also a member of the Scientific Advisory Board for the Alzheimer’s Disease Neuroimaging Initiative (ADNI) and the American Psychological Association (APA) Presidential Task Force on Neuropsychological Test Norming in Diverse Populations. Dr. Han has served as an oral examiner for the clinical neuropsychology board certification process for the American Board of Clinical Neuropsychology (ABCN), and he currently holds multiple service or mentorship roles in the International Neuropsychological Society (INS), the National Academy of Neuropsychology (NAN), the American Academy of Clinical Neuropsychology (AACN), and the Society for Clinical Neuropsychology (Division 40) of the APA. His work has been featured in multiple media outlets, including Reuters, CBS, PBS, Forbes, Fox Business News, and U.S. News and World Report.


  • AARP and AgeUK: Global Council on Brain Health Governance Member, 2015-2018
  • National Institutes of Aging/AFAR: Paul B. Beason Award for Aging Research, 2012-2017
  • American Psychological Association: Division 40 Blue Ribbon Award, 2012
  • International Neuropsychological Society: Nelson Butters Award, 2006


  • Self-reported experiences of discrimination in older black adults are associated with insula functional connectivity Brain Imaging Behav. 2021 Aug; 15(4):1718-1727. . View in PubMed
  • Neuropsychological case report of MCI reversion at one-year follow-up Appl Neuropsychol Adult. 2020 May-Jun; 27(3):284-293. . View in PubMed
  • The search for meaning in preclinical Alzheimer disease clinical trials Neurology. 2019 07 23; 93(4):139-140. . View in PubMed
  • White matter correlates of temporal discounting in older adults Brain Struct Funct. 2018 Nov; 223(8):3653-3663. . View in PubMed
  • Correction to: Detectable Neuropsychological Differences in Early Preclinical Alzheimer’s Disease: a Meta-Analysis Neuropsychol Rev. 2017 12; 27(4):326-327. . View in PubMed
  • Detectable Neuropsychological Differences in Early Preclinical Alzheimer’s Disease: A Meta-Analysis Neuropsychol Rev. 2017 12; 27(4):305-325. . View in PubMed
  • Financial literacy is associated with white matter integrity in old age Neuroimage. 2016 Apr 15; 130:223-229. . View in PubMed
  • Discrepancies between cognition and decision making in older adults Aging Clin Exp Res. 2016 Feb; 28(1):99-108. . View in PubMed
  • Grey matter correlates of susceptibility to scams in community-dwelling older adults Brain Imaging Behav. 2016 06; 10(2):524-32. . View in PubMed
  • Mild Cognitive Impairment and Susceptibility to Scams in Old Age J Alzheimers Dis. 2016; 49(3):845-51. . View in PubMed
  • Age-Associated Financial Vulnerability: An Emerging Public Health Issue Ann Intern Med. 2015 Dec 01; 163(11):877-8. . View in PubMed
  • Poorer Financial and Health Literacy Among Community-Dwelling Older Adults With Mild Cognitive Impairment J Aging Health. 2015 Sep; 27(6):1105-17. . View in PubMed
  • Pulse pressure in relation to tau-mediated neurodegeneration, cerebral amyloidosis, and progression to dementia in very old adults JAMA Neurol. 2015 May; 72(5):546-53. . View in PubMed
  • Mild cognitive impairment is associated with poorer decision-making in community-based older persons J Am Geriatr Soc. 2015 Apr; 63(4):676-83. . View in PubMed
  • Cognitive decline is associated with risk aversion and temporal discounting in older adults without dementia PLoS One. 2015; 10(4):e0121900. . View in PubMed
  • Gray-matter macrostructure in cognitively healthy older persons: associations with age and cognition Brain Struct Funct. 2014 Nov; 219(6):2029-49. . View in PubMed
  • Financial literacy is associated with medial brain region functional connectivity in old age Arch Gerontol Geriatr. 2014 Sep-Oct; 59(2):429-38. . View in PubMed
  • Ventromedial PFC, parahippocampal, and cerebellar connectivity are associated with temporal discounting in old age Exp Gerontol. 2013 Dec; 48(12):1489-98. . View in PubMed
  • Functional connectivity networks associated with chronic musculoskeletal pain in old age Int J Geriatr Psychiatry. 2013 Aug; 28(8):858-67. . View in PubMed
  • Faster cognitive decline in the years prior to MR imaging is associated with smaller hippocampal volumes in cognitively healthy older persons Front Aging Neurosci. 2013; 5:21. . View in PubMed
  • Executive functions, depressive symptoms, and college adjustment in women Appl Neuropsychol Adult. 2013; 20(2):136-44. . View in PubMed
  • Beta amyloid, tau, neuroimaging, and cognition: sequence modeling of biomarkers for Alzheimer’s Disease Brain Imaging Behav. 2012 Dec; 6(4):610-20. . View in PubMed
  • CSF biomarker associations with change in hippocampal volume and precuneus thickness: implications for the Alzheimer’s pathological cascade Brain Imaging Behav. 2012 Dec; 6(4):599-609. . View in PubMed
  • Neural intrinsic connectivity networks associated with risk aversion in old age Behav Brain Res. 2012 Feb 01; 227(1):233-40. . View in PubMed
  • Functional neuroimaging studies in normal aging Curr Top Behav Neurosci. 2012; 10:91-111. . View in PubMed
  • Functional connectivity variations in mild cognitive impairment: associations with cognitive function J Int Neuropsychol Soc. 2012 Jan; 18(1):39-48. . View in PubMed
  • Neuropsychological assessment in a case of adult-onset hemophagocytic lymphohistiocytosis (HLH) Clin Neuropsychol. 2012; 26(6):1038-52. . View in PubMed
  • Are self-reported symptoms of executive dysfunction associated with objective executive function performance following mild to moderate traumatic brain injury? J Clin Exp Neuropsychol. 2011 Jul; 33(6):704-14.. View in PubMed
  • The apolipoprotein e antagonistic pleiotropy hypothesis: review and recommendations Int J Alzheimers Dis. 2011 Feb 24; 2011:726197. . View in PubMed
  • Increased 5-HT1B receptor density in the basolateral amygdala of passive observer rats exposed to aggression Brain Res Bull. 2010 Aug 30; 83(1-2):38-43. . View in PubMed
  • Complex activities of daily living vary by mild cognitive impairment subtype J Int Neuropsychol Soc. 2010 Jul; 16(4):630-9. . View in PubMed
  • Hierarchical cognitive and psychosocial predictors of amnestic mild cognitive impairment J Int Neuropsychol Soc. 2010 Jul; 16(4):721-9. . View in PubMed
  • Chronic passive exposure to aggression decreases D2 and 5-HT 1B receptor densities Physiol Behav. 2010 Apr 19; 99(5):562-70. . View in PubMed
  • Neuroimaging of semantic processing in schizophrenia: a parametric priming approach Int J Psychophysiol. 2010 Feb; 75(2):100-6. . View in PubMed
  • Predictors of health status in nondepressed and nondemented individuals with Parkinson’s disease Arch Clin Neuropsychol. 2009 Nov; 24(7):699-709. . View in PubMed
  • Development of set-shifting ability from late childhood through early adulthood Arch Clin Neuropsychol. 2009 Sep; 24(6):565-74. . View in PubMed
  • Functional magnetic resonance imaging of compensatory neural recruitment in aging and risk for Alzheimer’s disease: review and recommendations Dement Geriatr Cogn Disord. 2009; 27(1):1-10. . View in PubMed
  • Clinical, cognitive, and genetic predictors of change in job status following traumatic brain injury in a military population J Head Trauma Rehabil. 2009 Jan-Feb; 24(1):57-64. . View in PubMed
  • Revision of the apolipoprotein E compensatory mechanism recruitment hypothesis Alzheimers Dement. 2008 Jul; 4(4):251-4. . View in PubMed
  • Apolipoprotein E and traumatic brain injury in a military population: evidence of a neuropsychological compensatory mechanism? J Neurol Neurosurg Psychiatry. 2007 Oct; 78(10):1103-8.. View in PubMed
  • Functional neuroimaging of word priming in males with chronic schizophrenia Neuroimage. 2007 Mar; 35(1):273-82. . View in PubMed
  • Verbal paired-associate learning by APOE genotype in non-demented older adults: fMRI evidence of a right hemispheric compensatory response Neurobiol Aging. 2007 Feb; 28(2):238-47. . View in PubMed
  • Creativity Lost: The Importance of Testing Higher-Level Executive Functions in School-Age Children and Adolescents Journal of Psychoeducational Assessment. 2007; 25:29-40. . View in PubMed
  • Journal of NeurologyNeurosurgeryand Psychiatry. 2007; 78(10):1103-1108. . View in PubMed
  • Connectivity among semantic associates: an fMRI study of semantic priming Brain Lang. 2006 Jun; 97(3):294-305. . View in PubMed
  • fMRI of lexical-semantic priming in a chronic schizophrenia patient Appl Neuropsychol. 2006; 13(1):51-7. . View in PubMed
  • Associative memory in chronic schizophrenia: a computational model Schizophr Res. 2003 Jun 01; 61(2-3):255-63. . View in PubMed
  • Semantic disturbance in schizophrenia and its relationship to the cognitive neuroscience of attention Biol Psychol. 2001 Jul-Aug; 57(1-3):23-46. . View in PubMed