Peggy Farnham, PhD

Professor of Cancer Biology

Vice Dean for Health and Biomedical Sciences Education

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Overview

Dr. Farnham is the William M. Keck Professor of Biochemistry, Professor of Cancer Biology, and the former Chair of the Department of Biochemistry and Molecular Biology at the Keck School of Medicine at the University of Southern California in Los Angeles, California. Dr. Farnham received her bachelor’s degree from Rice University, her Ph.D. from Yale University, and performed her post-doctoral training at Stanford University. Dr. Farnham previously held Professorships at the McArdle Laboratory for Cancer Research at the University of Wisconsin-Madison and at the University of California-Davis where she was the Associate Director of the UC Davis Genome Center. Dr. Farnham is an international leader in the study of chromatin regulation and its control of transcription factor binding and function. She is a member of an international consortia of genomic scientists working on the ENCODE (Encyclopedia of DNA elements) Project and a member of an NIH Roadmap Reference Epigenome Mapping Center. Based on her contributions to biomedical research, she was elected as a fellow of AAAS in 2010 and in 2012 she received the ASBMB Herbert A Sober Award, which recognizes outstanding biochemical and molecular biological research with particular emphasis on the development of methods and techniques to aid in research.

Research Interests: transcriptional genomics, genomic technologies
Diseases Models: cancer cells and tissues, cultured neuroepithelial cells
Consortia: ENCODE, Roadmap Epigenome Mapping Centers, PsychENCODE

Awards

  • AAAS Fellow, 2010
  • ASBMB Herbert A. Sober Award, 2012

Education and Training

  • Rice University, Houston, Texas — BA — 1978 — Biochemistry
  • Yale University, New Haven, CT — PhD — 1982 — Molecular Biochemistry
  • Stanford University, Palo Alto, CA — Postdoc — 1986 — Molecular Biology

Research Funding

  • Characterization of a novel family of human transcription factors that bind at +240 downstream of the transcription start site.
    NIH · R01GM133450 · Apr 1, 2020 – Mar 31, 2024 · Role: Principal Investigator
  • Development of a novel promoter tagging technology to identify enhancer targets
    NIH · R21HG009742 · Sep 1, 2017 – Jun 30, 2019 · Role: Principal Investigator
  • The USC PsychENCODE Project
    NIH · U01MH103346 · Jun 15, 2014 – May 31, 2018 · Role: Co-Principal Investigator
  • Development of a nuclease-mediated technology to validate chromatin hubs
    NIH · R21HG006761 · Apr 24, 2012 – Mar 31, 2015 · Role: Principal Investigator
  • Mechanisms of Transcriptional Regulation in Stem Cells
    NIH · R56DK067889 · Sep 21, 2009 – Jul 31, 2010 · Role: Principal Investigator
  • Prostate Cancer Risk Enhancers
    NIH · R01CA136924 · Dec 1, 2008 – Jan 31, 2021 · Role: Principal Investigator
  • Scaling the ChIP-chip assay to improve analysis of clinical biospecimens
    NIH · R21CA128471 · Jul 1, 2007 – Jun 30, 2010 · Role: Principal Investigator
  • Mechanisms of Transcriptional Regulation in Stem Cells
    NIH · R01DK067889 · Jul 1, 2005 – May 31, 2010 · Role: Principal Investigator
  • THE ROLE OF FAF KINASE IN CELL PROLIFERATION
    NIH · R01CA059524 · Mar 15, 1994 – Jan 31, 1997 · Role: Principal Investigator
  • Transcriptional Regulation of Growth Related Genes
    NIH · R01CA045240 · Apr 1, 1987 – May 31, 2013 · Role: Principal Investigator
  • TRANSCRIPTIONAL REGULATION OF GROWTH-RELATED GENES
    NIH · R29CA045240 · Apr 1, 1987 – Mar 31, 1992 · Role: Principal Investigator
  • CELL CYCLE REGULATION OF THE DIHYDROFOLATE REDUCTASE GEN
    NIH · F32GM008853 · Jun 30, 1985 · Role: Principal Investigator
  • University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG)
    NIH · P30CA014089 · Apr 1, 1980 – Nov 30, 2026 · Role: Principal Investigator

Publications

  • Reduction of ZFX levels decreases histone H4 acetylation and increases Pol2 pausing at target promoters. Nucleic Acids Res. 2024 07 08; 52(12):6850-6865.. View in PubMed
  • Variants in ZFX are associated with an X-linked neurodevelopmental disorder with recurrent facial gestalt. Am J Hum Genet. 2024 03 07; 111(3):487-508.. View in PubMed
  • m6A epitranscriptome analysis reveals differentially methylated transcripts that drive early chemoresistance in bladder cancer. NAR Cancer. 2023 Dec; 5(4):zcad054.. View in PubMed
  • Large-scale manipulation of promoter DNA methylation reveals context-specific transcriptional responses and stability. Genome Biol. 2022 07 26; 23(1):163.. View in PubMed
  • Author Correction: Expanded encyclopaedias of DNA elements in the human and mouse genomes. Nature. 2022 May; 605(7909):E3.. View in PubMed
  • FOXC1 Binds Enhancers and Promotes Cisplatin Resistance in Bladder Cancer. Cancers (Basel). 2022 Mar 28; 14(7).. View in PubMed
  • TENET 2.0: Identification of key transcriptional regulators and enhancers in lung adenocarcinoma. PLoS Genet. 2020 09; 16(9):e1009023.. View in PubMed
  • Expanded encyclopaedias of DNA elements in the human and mouse genomes. Nature. 2020 07; 583(7818):699-710.. View in PubMed
  • Characterization of the ZFX family of transcription factors that bind downstream of the start site of CpG island promoters. Nucleic Acids Res. 2020 06 19; 48(11):5986-6000.. View in PubMed
  • Genome-wide analysis of HOXC4 and HOXC6 regulated genes and binding sites in prostate cancer cells. PLoS One. 2020; 15(2):e0228590.. View in PubMed