Alan S. Wayne, MD

Alan S. Wayne, MD serves as Chair of the Department of Pediatrics at the Keck School of Medicine of USC and Senior Vice President of Academic Affairs and Pediatrician-in-Chief at Children’s Hospital Los Angeles (CHLA). Dr. Wayne is Professor of Pediatrics and Medicine at the Keck School of Medicine of USC. In these roles, Dr. Wayne oversees the Department’s clinical care delivery, medical education, and research programs, and leads the departmental strategy, faculty affairs, and budget management in the context of the missions of USC and CHLA.

Dr. Wayne’s primary research efforts are directed toward the development of new treatment approaches for leukemias and lymphomas, with a focus on targeted, immune-based, and cellular therapies. He is the Medical Director of the Therapeutic Advances in Childhood Leukemia/Lymphoma (TACL) Consortium, a multinational clinical trials group headquartered at CHLA. He has an ongoing leadership role in the development of genetically modified chimeric antigen receptor (CAR) T-cells for childhood hematologic malignancies. Additionally, he plays a leadership role in international efforts in the area of post-transplant relapse of hematologic malignancies, the primary aim of which is to study the biology, prevention, and treatment of relapse after hematopoietic stem cell transplantation.

Board-certified in pediatric hematology-oncology, Dr. Wayne attended the Honors Program in Medical Education obtaining his BS and MD degrees from Northwestern University. He conducted internship, residency, and chief residency in pediatrics at Boston Children’s Hospital followed by pediatric hematology-oncology fellowship at Boston Children’s Hospital and the Dana-Farber Cancer Institute.

• Randomized study of low versus moderate dose busulfan in transplant for severe combined immunodeficiency
  NIH · U01AI126612 · Aug 24, 2017 – Jul 31, 2024 · Role: Principal Investigator
• University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG)
  NIH · P30CA014089 · Apr 1, 1980 – Nov 30, 2026 · Role: Principal Investigator
• Pediatric Graft-vs-Host Disease
  NIH · Z01BC010596 · Role: Principal Investigator
• Pediatric Oncology Branch Clinical Care and Education
  NIH · Z01BC010764 · Role: Principal Investigator
• Experimental Therapeutics of Pediatric Hematopoietic Malignancies
  NIH · Z01SC010353 · Role: Principal Investigator
• Pediatric Graft-vs-Host Disease
  NIH · ZICBC010596 · Role: Principal Investigator
• Behavioral Science Core
  NIH · ZICBC011288 · Role: Principal Investigator
• Experimental Therapeutics of Pediatric Hematopoietic Malignancies
  NIH · ZICSC010353 · Role: Principal Investigator
• Pediatric Oncology Branch Clinical Care and Education
  NIH · ZIEBC010764 · Role: Principal Investigator

• Prominent Physician Alan S. Wayne Named Director at Children's Hospital Los Angeles
• Children's Hospital Los Angeles Names National Cancer Institute Pediatric Oncology Clinical Director as Head of its Children's Center for Cancer and Blood Diseases

• Wiemels, Joseph
• Bhojwani, Deepa
• Orgel, Etan
• Wood, Brent
• Lenz, Heinz-Josef
• Freyer, David