Albert Almada, PhD

Albert E. Almada, PhD is investigating one of the greatest mysteries in muscle regenerative biology—how stem cells rebuild functional muscle tissue after traumatic injury. His multidisciplinary team integrates state-of-the-art experimental and bioinformatic approaches to study this biological phenomenon at the molecular, cellular, and organ level in various animal models and in humans.

Recently, his laboratory discovered a new “Super-Healing” gene regulatory program, and they are exploring the biology and therapeutic potential of these pro-regenerative molecules in pre-clinical mouse models. Dr. Almada’s long-term goal is to translate his basic science discoveries into effective stem cell-based therapies that restore muscle function to injured athletes, wounded soldiers, the elderly, and patients suffering from degenerative muscular pathologies.

• Protocol for the isolation of mouse muscle stem cells using fluorescence-activated cell sorting STAR Protoc. 2023 Oct 22; 4(4):102656. . View in PubMed
• Prolonged FOS activity disrupts a global myogenic transcriptional program by altering 3D chromatin architecture in primary muscle progenitor cells Skelet Muscle. 2022 08 15; 12(1):20. . View in PubMed
• Dissecting dual roles of MyoD during lineage conversion to mature myocytes and myogenic stem cells Genes Dev. 2021 09 01; 35(17-18):1209-1228. . View in PubMed
• FOS licenses early events in stem cell activation driving skeletal muscle regeneration Cell Rep. 2021 01 26; 34(4):108656. . View in PubMed
• Direct Reprogramming of Mouse Fibroblasts into Functional Skeletal Muscle Progenitors Stem Cell Reports. 2018 05 08; 10(5):1505-1521. . View in PubMed
• Molecular circuitry of stem cell fate in skeletal muscle regeneration, ageing and disease Nat Rev Mol Cell Biol. 2016 05; 17(5):267-79. . View in PubMed
• Established cell surface markers efficiently isolate highly overlapping populations of skeletal muscle satellite cells by fluorescence-activated cell sorting Skelet Muscle. 2016; 6:35. . View in PubMed
• FOXP3+ T Cells Recruited to Sites of Sterile Skeletal Muscle Injury Regulate the Fate of Satellite Cells and Guide Effective Tissue Regeneration PLoS One. 2015; 10(6):e0128094. . View in PubMed
• Promoter directionality is controlled by U1 snRNP and polyadenylation signals Nature. 2013 Jul 18; 499(7458):360-3. . View in PubMed
• Divergent transcription of long noncoding RNA/mRNA gene pairs in embryonic stem cells Proc Natl Acad Sci U S A. 2013 Feb 19; 110(8):2876-81. . View in PubMed
• Antisense RNA polymerase II divergent transcripts are P-TEFb dependent and substrates for the RNA exosome Proc Natl Acad Sci U S A. 2011 Jun 28; 108(26):10460-5. . View in PubMed
• ProfileGrids as a new visual representation of large multiple sequence alignments: a case study of the RecA protein family BMC Bioinformatics. 2008 Dec 22; 9:554. . View in PubMed
• Effects of ribose supplementation prior to and during intense exercise on anaerobic capacity and metabolic markers Int J Sport Nutr Exerc Metab. 2005 Dec; 15(6):653-64. . View in PubMed
• Effects of oral D-ribose supplementation on anaerobic capacity and selected metabolic markers in healthy males Int J Sport Nutr Exerc Metab. 2003 Mar; 13(1):76-86. . View in PubMed

• Chuong, Cheng-Ming
• Chai, Yang
• Powers, Christopher