Albert Almada, PhD

Assistant Professor of Orthopaedic Surgery, Stem Cell Biology & Regenerative Medicine, and Gerontology

Culture and Engagement Champion

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Overview

Albert E. Almada, PhD is investigating one of the greatest mysteries in muscle regenerative biology—how stem cells rebuild functional muscle tissue after traumatic injury. His multidisciplinary team integrates state-of-the-art experimental and bioinformatic approaches to study this biological phenomenon at the molecular, cellular, and organ level in various animal models and in humans.

Recently, his laboratory discovered a new “Super-Healing” gene regulatory program, and they are exploring the biology and therapeutic potential of these pro-regenerative molecules in pre-clinical mouse models. Dr. Almada’s long-term goal is to translate his basic science discoveries into effective stem cell-based therapies that restore muscle function to injured athletes, wounded soldiers, the elderly, and patients suffering from degenerative muscular pathologies.

Education and Training

  • University of California, Irvine, Irvine, CA — BS — 2007 — Biological Sciences
  • Massachusetts Institute of Technology (MIT), Boston, MA — PhD — 2013 — Biology
  • Harvard University, Cambridge, MA — 2020 — Stem Cell & Regenerative Biology

Publications

  • Simultaneous RNA Fluorescent In Situ Hybridization and Immunofluorescent Staining of Mouse Muscle Stem Cells on Fresh Frozen Skeletal Muscle Sections. Bio Protoc. 2025 Sep 05; 15(17):e5435.. View in PubMed
  • Stem Cell Aging and Rejuvenation in the Skeletal Muscle System. Rejuvenation Res. 2025 Aug; 28(4):158-171.. View in PubMed
  • Soluble RAGE enhances muscle regeneration after cryoinjury in aged and diseased mice. PLoS One. 2025; 20(2):e0318754.. View in PubMed
  • Ilastik: a machine learning image analysis platform to interrogate stem cell fate decisions across multiple vertebrate species. bioRxiv. 2024 Dec 22.. View in PubMed
  • Protocol for the isolation of mouse muscle stem cells using fluorescence-activated cell sorting. STAR Protoc. 2023 12 15; 4(4):102656.. View in PubMed
  • Prolonged FOS activity disrupts a global myogenic transcriptional program by altering 3D chromatin architecture in primary muscle progenitor cells. Skelet Muscle. 2022 08 15; 12(1):20.. View in PubMed
  • Dissecting dual roles of MyoD during lineage conversion to mature myocytes and myogenic stem cells. Genes Dev. 2021 09 01; 35(17-18):1209-1228.. View in PubMed
  • FOS licenses early events in stem cell activation driving skeletal muscle regeneration. Cell Rep. 2021 01 26; 34(4):108656.. View in PubMed
  • Direct Reprogramming of Mouse Fibroblasts into Functional Skeletal Muscle Progenitors. Stem Cell Reports. 2018 05 08; 10(5):1505-1521.. View in PubMed
  • Established cell surface markers efficiently isolate highly overlapping populations of skeletal muscle satellite cells by fluorescence-activated cell sorting. Skelet Muscle. 2016; 6:35.. View in PubMed