Albert Almada, PhD

Assistant Professor of Orthopaedic Surgery and Stem Cell Biology & Regenerative Medicine

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Albert E. Almada, PhD is investigating one of the greatest mysteries in muscle regenerative biology—how stem cells rebuild functional muscle tissue after traumatic injury. His multidisciplinary team integrates state-of-the-art experimental and bioinformatic approaches to study this biological phenomenon at the molecular, cellular, and organ level in various animal models and in humans.

Recently, his laboratory discovered a new “Super-Healing” gene regulatory program, and they are exploring the biology and therapeutic potential of these pro-regenerative molecules in pre-clinical mouse models. Dr. Almada’s long-term goal is to translate his basic science discoveries into effective stem cell-based therapies that restore muscle function to injured athletes, wounded soldiers, the elderly, and patients suffering from degenerative muscular pathologies.


  • Protocol for the isolation of mouse muscle stem cells using fluorescence-activated cell sorting STAR Protoc. 2023 Dec 15; 4(4):102656. . View in PubMed
  • Prolonged FOS activity disrupts a global myogenic transcriptional program by altering 3D chromatin architecture in primary muscle progenitor cells Skelet Muscle. 2022 08 15; 12(1):20. . View in PubMed
  • Dissecting dual roles of MyoD during lineage conversion to mature myocytes and myogenic stem cells Genes Dev. 2021 09 01; 35(17-18):1209-1228. . View in PubMed
  • FOS licenses early events in stem cell activation driving skeletal muscle regeneration Cell Rep. 2021 01 26; 34(4):108656. . View in PubMed
  • Direct Reprogramming of Mouse Fibroblasts into Functional Skeletal Muscle Progenitors Stem Cell Reports. 2018 05 08; 10(5):1505-1521. . View in PubMed
  • Molecular circuitry of stem cell fate in skeletal muscle regeneration, ageing and disease Nat Rev Mol Cell Biol. 2016 05; 17(5):267-79. . View in PubMed
  • Established cell surface markers efficiently isolate highly overlapping populations of skeletal muscle satellite cells by fluorescence-activated cell sorting Skelet Muscle. 2016; 6:35. . View in PubMed
  • FOXP3+ T Cells Recruited to Sites of Sterile Skeletal Muscle Injury Regulate the Fate of Satellite Cells and Guide Effective Tissue Regeneration PLoS One. 2015; 10(6):e0128094. . View in PubMed
  • Promoter directionality is controlled by U1 snRNP and polyadenylation signals Nature. 2013 Jul 18; 499(7458):360-3. . View in PubMed
  • Divergent transcription of long noncoding RNA/mRNA gene pairs in embryonic stem cells Proc Natl Acad Sci U S A. 2013 Feb 19; 110(8):2876-81. . View in PubMed
  • Antisense RNA polymerase II divergent transcripts are P-TEFb dependent and substrates for the RNA exosome Proc Natl Acad Sci U S A. 2011 Jun 28; 108(26):10460-5. . View in PubMed
  • ProfileGrids as a new visual representation of large multiple sequence alignments: a case study of the RecA protein family BMC Bioinformatics. 2008 Dec 22; 9:554. . View in PubMed
  • Effects of ribose supplementation prior to and during intense exercise on anaerobic capacity and metabolic markers Int J Sport Nutr Exerc Metab. 2005 Dec; 15(6):653-64. . View in PubMed
  • Effects of oral D-ribose supplementation on anaerobic capacity and selected metabolic markers in healthy males Int J Sport Nutr Exerc Metab. 2003 Mar; 13(1):76-86. . View in PubMed