Alessandro Altoe, PhD

Instructor Of Research Otolaryngology-Head and Neck Surgery

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Overview

Dr. Altoè is an Electrical Engineer and Acoustician. Since 2018 he has been a member of the Auditory Physics Group, where he studies cochlear mechanics. His research has a keen focus on identifying the signal processing strategies within the cochlea that enable healthy ears outperform man-made technology.

Publications

  • The Long Outer-Hair-Cell RC Time Constant: A Feature, Not a Bug, of the Mammalian Cochlea J Assoc Res Otolaryngol. 2023 04; 24(2):129-145. . View in PubMed
  • The Remarkable Outer Hair Cell: Proceedings of a Symposium in Honour of WE. Brownell. J Assoc Res Otolaryngol. 2023 04; 24(2):117-127. . View in PubMed
  • Crucial 3-D viscous hydrodynamic contributions to the theoretical modeling of the cochlear response J Acoust Soc Am. 2023 01; 153(1):77. . View in PubMed
  • Estimating cochlear impulse responses using frequency sweeps J Acoust Soc Am. 2023 04 01; 153(4):2251. . View in PubMed
  • Intracochlear overdrive: Characterizing nonlinear wave amplification in the mouse apex J Acoust Soc Am. 2023 11 01; 154(5):3414-3428. . View in PubMed
  • Otoacoustic emissions reveal the micromechanical role of organ-of-Corti cytoarchitecture in cochlear amplification Proc Natl Acad Sci U S A. 2023 10 10; 120(41):e2305921120. . View in PubMed
  • Overturning the mechanisms of cochlear amplification via area deformations of the organ of Corti J Acoust Soc Am. 2022 10; 152(4):2227. . View in PubMed
  • The Elusive Cochlear Filter: Wave Origin of Cochlear Cross-Frequency Masking J Assoc Res Otolaryngol. 2021 12; 22(6):623-640. . View in PubMed
  • Cochlear outer hair cell electromotility enhances organ of Corti motion on a cycle-by-cycle basis at high frequencies in vivo Proc Natl Acad Sci U S A. 2021 10 26; 118(43). . View in PubMed
  • Nonlinear cochlear mechanics without direct vibration-amplification feedback Phys Rev Res. 2020 Feb-Apr; 2(1). . View in PubMed
  • Asymmetry and Microstructure of Temporal-Suppression Patterns in Basilar-Membrane Responses to Clicks: Relation to Tonal Suppression and Traveling-Wave Dispersion J Assoc Res Otolaryngol. 2020 04; 21(2):151-170. . View in PubMed
  • The cochlear ear horn: geometric origin of tonotopic variations in auditory signal processing Sci Rep. 2020 11 25; 10(1):20528. . View in PubMed
  • Optimized Tuning of Auditory Inner Hair Cells to Encode Complex Sound through Synergistic Activity of Six Independent K+ Current Entities Cell Rep. 2020 07 07; 32(1):107869. . View in PubMed
  • Constraints imposed by zero-crossing invariance on cochlear models with two mechanical degrees of freedom J Acoust Soc Am. 2019 09; 146(3):1685. . View in PubMed
  • The effects of the activation of the inner-hair-cell basolateral K+ channels on auditory nerve responses Hear Res. 2018 07; 364:68-80. . View in PubMed
  • Computational modeling of the human auditory periphery: Auditory-nerve responses, evoked potentials and hearing loss Hear Res. 2018 03; 360:55-75. . View in PubMed
  • Dynamics of cochlear nonlinearity: Automatic gain control or instantaneous damping? J Acoust Soc Am. 2017 12; 142(6):3510.. View in PubMed
  • Model-based estimation of the frequency tuning of the inner-hair-cell stereocilia from neural tuning curves J Acoust Soc Am. 2017 06; 141(6):4438. . View in PubMed
  • Integrated processing of spatial cues in human auditory cortex Hear Res. 2015 Sep; 327:143-52. . View in PubMed
  • Decoupling the level dependence of the basilar membrane gain and phase in nonlinear cochlea models J Acoust Soc Am. 2015 Aug; 138(2):EL155-60. . View in PubMed
  • Human cortical sensitivity to interaural time difference in high-frequency sounds Hear Res. 2015 May; 323:99-106. . View in PubMed
  • Transmission line cochlear models: improved accuracy and efficiency J Acoust Soc Am. 2014 Oct; 136(4):EL302-8. . View in PubMed