Keck School Faculty

Alicia A. McDonough, PhD, FAHA
Alicia A. McDonough, PhD, FAHA
Professor of Integrative Anatomical Sciences
Integrative Anatomical Sciences
MMR 508 1333 San Pablo Street Health Sciences Campus Los Angeles

American Physiological Society Epithelial Transport Group: Steve Hebert Lecturer, 2018

University of Southern California: Phi Kappa Phi Faculty Recognition Award, 2018

American Society of Nephrology: Robert W. Schrier Endowed Lectureship, 2017

Medical College of Wisconsin: J.J. Smith Endowed Lecture, 2016

KCVD Young Investigator Symposium: Keynote Speaker ANS Kidney Week, 2016

KCVD Young Investigator Symposium: Keynote Speaker ASN Kidney Week, 2016

Kansas State Univ. Veterinary Medicine: Clarenberg Distinguished Lecture, 2015

AHA Kidney in Cardiovascular Disease Council: Donald Seldin Lecture, 2014

SUNY Buffalo: Suk Ki Hong Memorial Lecturer, 2010

American Physiological Society: Ernest H. Starling Distinguished Lectureship, 2009

Keck School of Medicine: Outstanding Teaching Awards: '07, '12, '17, 2007-2018

Keck School of Medicine: Outstanding Teaching Award, 2007-2012

American Heart Association: Established Investigator Award, 1984-1989

Functional Implications of Sexual Dimorphism of Transporter Patterns along the Rat Proximal Tubule: Modeling and Analysis Am J Physiol Renal Physiol. 2018 May 30. . View in PubMed

Blood pressure regulation by the angiotensin type 1 receptor in the proximal tubule Curr Opin Nephrol Hypertens. 2018 01; 27(1):1-7. . View in PubMed

Downregulation of the Cl-/HCO3-Exchanger Pendrin in Kidneys of Mice with Cystic Fibrosis: Role in the Pathogenesis of Metabolic Alkalosis Cell Physiol Biochem. 2018; 45(4):1551-1565. . View in PubMed

Collecting duct prorenin receptor knockout reduces renal function, increases sodium excretion, and mitigates renal responses in ANG II-induced hypertensive mice Am J Physiol Renal Physiol. 2017 Dec 01; 313(6):F1243-F1253. . View in PubMed

Sexual Dimorphic Pattern of Renal Transporters and Electrolyte Homeostasis J Am Soc Nephrol. 2017 Dec; 28(12):3504-3517. . View in PubMed

Collecting Duct Nitric Oxide Synthase 1ß Activation Maintains Sodium Homeostasis During High Sodium Intake Through Suppression of Aldosterone and Renal Angiotensin II Pathways J Am Heart Assoc. 2017 Oct 24; 6(10). . View in PubMed

Renal Collectrin Protects against Salt-Sensitive Hypertension and Is Downregulated by Angiotensin II J Am Soc Nephrol. 2017 Jun; 28(6):1826-1837. . View in PubMed

Potassium Homeostasis: The Knowns, the Unknowns, and the Health Benefits Physiology (Bethesda). 2017 Mar; 32(2):100-111. . View in PubMed

Renal tubular angiotensin converting enzyme is responsible for nitro-L-arginine methyl ester (L-NAME)-induced salt sensitivity Kidney Int. 2017 04; 91(4):856-867. . View in PubMed

Cardiovascular benefits associated with higher dietary K+ vslower dietary Na+: evidence from population and mechanistic studies. Am J Physiol Endocrinol Metab. 2017 04 01; 312(4):E348-E356. . View in PubMed

ISN Forefronts Symposium 2015: Maintaining Balance Under Pressure-Hypertension and the Proximal Tubule Kidney Int Rep. 2016 Sep; 1(3):166-176. . View in PubMed

Paracellular epithelial sodium transport maximizes energy efficiency in the kidney J Clin Invest. 2016 Jul 01; 126(7):2509-18. . View in PubMed

Interleukin-1 Receptor Activation Potentiates Salt Reabsorption in Angiotensin II-Induced Hypertension via the NKCC2 Co-transporter in the Nephron Cell Metab. 2016 Feb 09; 23(2):360-8. . View in PubMed

The physiological role of glucagon-like peptide-1 in the regulation of renal function Am J Physiol Renal Physiol. 2016 Jan 15; 310(2):F123-7. . View in PubMed

Potassium Supplementation Prevents Sodium Chloride Cotransporter Stimulation During Angiotensin II Hypertension Hypertension. 2016 10; 68(4):904-12. . View in PubMed

Interleukin-17A Regulates Renal Sodium Transporters and Renal Injury in Angiotensin II-Induced Hypertension Hypertension. 2016 07; 68(1):167-74. . View in PubMed

Proximal tubule NHE3 activity is inhibited by beta-arrestin-biased angiotensin II type 1 receptor signaling Am J Physiol Cell Physiol. 2015 Oct 15; 309(8):C541-50. . View in PubMed

Short-term nonpressor angiotensin II infusion stimulates sodium transporters in proximal tubule and distal nephron Physiol Rep. 2015 Sep; 3(9). . View in PubMed

Salt Sensitivity in Response to Renal Injury Requires Renal Angiotensin-Converting Enzyme Hypertension. 2015 Sep; 66(3):534-42. . View in PubMed

Maintaining Balance Under Pressure: Integrated Regulation of Renal Transporters During Hypertension Hypertension. 2015 Sep; 66(3):450-5. . View in PubMed

Renal NCC is unchanged in the midpregnant rat and decreased in the late pregnant rat despite avid renal Na+ retention Am J Physiol Renal Physiol. 2015 Jul 01; 309(1):F63-70. . View in PubMed

The intrarenal generation of angiotensin II is required for experimental hypertension Curr Opin Pharmacol. 2015 Apr; 21:73-81. . View in PubMed

Considerations when quantitating protein abundance by immunoblot Am J Physiol Cell Physiol. 2015 Mar 15; 308(6):C426-33. . View in PubMed

Hypertension. 2015 Mar; 65(3):569-76. . View in PubMed

Paradoxical activation of the sodium chloride cotransporter (NCC) without hypertension in kidney deficient in a regulatory subunit of Na,K-ATPase, FXYD2 Physiol Rep. 2014 Dec 01; 2(12). . View in PubMed

Renal angiotensin-converting enzyme is essential for the hypertension induced by nitric oxide synthesis inhibition J Am Soc Nephrol. 2014 Dec; 25(12):2752-63. . View in PubMed

Am J Physiol Renal Physiol. 2014 Dec 01; 307(11):F1249-62. . View in PubMed

Of mice and men: modeling cardiovascular complexity in diabetesFocus on "Mitochondrial inefficiencies and anoxic ATP hydrolysis capacities in diabetic rat heart". Am J Physiol Cell Physiol. 2014 Sep 15; 307(6):C497-8. . View in PubMed

Renal generation of angiotensin II and the pathogenesis of hypertension Curr Hypertens Rep. 2014 Sep; 16(9):477. . View in PubMed

Increasing plasma [K+] by intravenous potassium infusion reduces NCC phosphorylation and drives kaliuresis and natriuresis Am J Physiol Renal Physiol. 2014 May 01; 306(9):F1059-68. . View in PubMed

Differential regulation of Na+ transporters along nephron during ANG II-dependent hypertension: distal stimulation counteracted by proximal inhibition Am J Physiol Renal Physiol. 2013 Aug 15; 305(4):F510-9. . View in PubMed

J Mol Med (Berl). 2013 Aug; 91(8):951-63. . View in PubMed

The absence of intrarenal ACE protects against hypertension J Clin Invest. 2013 May; 123(5):2011-23. . View in PubMed

Need to quickly excrete K(+)? Turn off NCC. Kidney Int. 2013 May; 83(5):779-82.. View in PubMed

Effects of ACE inhibition and ANG II stimulation on renal Na-Cl cotransporter distribution, phosphorylation, and membrane complex properties Am J Physiol Cell Physiol. 2013 Jan 15; 304(2):C147-63. . View in PubMed

Effects of K+-deficient diets with and without NaCl supplementation on Na+, K+, and H2O transporters' abundance along the nephron Am J Physiol Renal Physiol. 2012 Jul 01; 303(1):F92-104. . View in PubMed

Am J Physiol Cell Physiol. 2012 May 15; 302(10):C1434-5. . View in PubMed

How does potassium supplementation lower blood pressure? Am J Physiol Renal Physiol. 2012 May 01; 302(9):F1224-5.. View in PubMed

AT1A angiotensin receptors in the renal proximal tubule regulate blood pressure Cell Metab. 2011 Apr 06; 13(4):469-475. . View in PubMed

Mechanisms of proximal tubule sodium transport regulation that link extracellular fluid volume and blood pressure Am J Physiol Regul Integr Comp Physiol. 2010 Apr; 298(4):R851-61. . View in PubMed

Angiotensin II stimulates trafficking of NHE3, NaPi2, and associated proteins into the proximal tubule microvilli Am J Physiol Renal Physiol. 2010 Jan; 298(1):F177-86. . View in PubMed

Motoring down the microvilliFocus on "PTH-induced internalization of apical membrane NaPi2a: role of actin and myosin VI". Am J Physiol Cell Physiol. 2009 Dec; 297(6):C1331-2. . View in PubMed

Isoform specificity of cardiac glycosides binding to human Na+,K+-ATPase alpha1beta1, alpha2beta1 and alpha3beta1 Eur J Pharmacol. 2009 Nov 10; 622(1-3):7-14. . View in PubMed

Narrative review: evolving concepts in potassium homeostasis and hypokalemia Ann Intern Med. 2009 May 05; 150(9):619-25. . View in PubMed

Renal NHE3 and NaPi2 partition into distinct membrane domains Am J Physiol Cell Physiol. 2009 Apr; 296(4):C900-10. . View in PubMed

Acute hypertension provokes acute trafficking of distal tubule Na-Cl cotransporter (NCC) to subapical cytoplasmic vesicles Am J Physiol Renal Physiol. 2009 Apr; 296(4):F810-8. . View in PubMed

Recent advances in understanding integrative control of potassium homeostasis Annu Rev Physiol. 2009; 71:381-401. . View in PubMed

Effects of dietary salt on renal Na+ transporter subcellular distribution, abundance, and phosphorylation status Am J Physiol Renal Physiol. 2008 Oct; 295(4):F1003-16. . View in PubMed

Connexin 303 is expressed in the kidney but not regulated by dietary salt or high blood pressure. Cell Commun Adhes. 2008 May; 15(1):219-30. . View in PubMed

Slc26a6 (PAT1) deletion downregulates the apical Na+/H+ exchanger in the straight segment of the proximal tubule Am J Nephrol. 2008; 28(2):330-8. . View in PubMed

AMPK activation with AICAR provokes an acute fall in plasma [K+] Am J Physiol Cell Physiol. 2008 Jan; 294(1):C126-35. . View in PubMed

Reducing blood pressure in SHR with enalapril provokes redistribution of NHE3, NaPi2, and NCC and decreases NaPi2 and ACE abundance Am J Physiol Renal Physiol. 2007 Oct; 293(4):F1197-208. . View in PubMed

ANG II provokes acute trafficking of distal tubule Na+-Cl(-) cotransporter to apical membrane Am J Physiol Renal Physiol. 2007 Sep; 293(3):F662-9. . View in PubMed

Evidence for gut factor in K+ homeostasis Am J Physiol Renal Physiol. 2007 Aug; 293(2):F541-7. . View in PubMed

Redistribution of distal tubule Na+-Cl- cotransporter (NCC) in response to a high-salt diet Am J Physiol Renal Physiol. 2006 Aug; 291(2):F503-8. . View in PubMed

The proximal convoluted tubule is a target for the uroguanylin-regulated natriuretic response J Pediatr Gastroenterol Nutr. 2006 Jul; 43 Suppl 1:S74-81. . View in PubMed

Phenol injury-induced hypertension stimulates proximal tubule Na+/H+ exchanger activity Am J Physiol Renal Physiol. 2006 Jun; 290(6):F1543-50. . View in PubMed

Modest dietary K+ restriction provokes insulin resistance of cellular K+ uptake and phosphorylation of renal outer medulla K+ channel without fall in plasma K+ concentration Am J Physiol Cell Physiol. 2006 May; 290(5):C1355-63. . View in PubMed

Effects of ACE inhibition on proximal tubule sodium transport Am J Physiol Renal Physiol. 2006 Apr; 290(4):F854-63. . View in PubMed

Redistribution of myosin VI from top to base of proximal tubule microvilli during acute hypertension J Am Soc Nephrol. 2005 Oct; 16(10):2890-6. . View in PubMed

Role of muscle in regulating extracellular [K+] Semin Nephrol. 2005 Sep; 25(5):335-42. . View in PubMed

Differential traffic of proximal tubule Na+ transporters during hypertension or PTH: NHE3 to base of microvilli vsNaPi2 to endosomes. Am J Physiol Renal Physiol. 2004 Nov; 287(5):F896-906. . View in PubMed

Dexamethasone treatment causes resistance to insulin-stimulated cellular potassium uptake in the rat Am J Physiol Cell Physiol. 2004 Nov; 287(5):C1229-37. . View in PubMed

Acute hypotension induced by aortic clamp vsPTH provokes distinct proximal tubule Na+ transporter redistribution patterns. Am J Physiol Regul Integr Comp Physiol. 2004 Oct; 287(4):R878-85. . View in PubMed

Does membrane trafficking play a role in regulating the sodium/hydrogen exchanger isoform 3 in the proximal tubule? Curr Opin Nephrol Hypertens. 2003 Sep; 12(5):533-41.. View in PubMed

Chronic renal injury-induced hypertension alters renal NHE3 distribution and abundance Am J Physiol Renal Physiol. 2003 May; 284(5):F1056-65. . View in PubMed

Mechanisms of pressure natriuresis: how blood pressure regulates renal sodium transport Ann N Y Acad Sci. 2003 Apr; 986:669-77. . View in PubMed

Modest K+ restriction provokes insulin resistance of cellular K+ uptake without decrease in plasma K Ann N Y Acad Sci. 2003 Apr; 986:625-7. . View in PubMed

Responses of proximal tubule sodium transporters to acute injury-induced hypertension Am J Physiol Renal Physiol. 2003 Feb; 284(2):F313-22. . View in PubMed

Angiotensin II clamp prevents the second step in renal apical NHE3 internalization during acute hypertension Am J Physiol Renal Physiol. 2002 Nov; 283(5):F1142-50. . View in PubMed

Diuretic response to acute hypertension is blunted during angiotensin II clamp Am J Physiol Regul Integr Comp Physiol. 2002 Oct; 283(4):R837-42. . View in PubMed

Skeletal muscle regulates extracellular potassium Am J Physiol Renal Physiol. 2002 Jun; 282(6):F967-74. . View in PubMed

Independent regulation of in vivo insulin action on glucose versus K(+) uptake by dietary fat and K(+) content Diabetes. 2002 Apr; 51(4):915-20. . View in PubMed

Acute hypertension provokes internalization of proximal tubule NHE3 without inhibition of transport activity Am J Physiol Renal Physiol. 2002 Apr; 282(4):F730-40. . View in PubMed

Sodium pump isoform expression in heart failure: implication for treatment Basic Res Cardiol. 2002; 97 Suppl 1:I25-30. . View in PubMed

The cardiac sodium pump: structure and function Basic Res Cardiol. 2002; 97 Suppl 1:I19-24. . View in PubMed

Downstream shift in sodium pump activity along the nephron during acute hypertension J Am Soc Nephrol. 2001 Nov; 12(11):2231-40. . View in PubMed

All human Na(+)-K(+)-ATPase alpha-subunit isoforms have a similar affinity for cardiac glycosides Am J Physiol Cell Physiol. 2001 Oct; 281(4):C1336-43. . View in PubMed

Ouabain and substrate affinities of human Na(+)-K(+)-ATPase alpha(1)beta(1), alpha(2)beta(1), and alpha(3)beta(1) when expressed separately in yeast cells Am J Physiol Cell Physiol. 2001 Oct; 281(4):C1355-64. . View in PubMed

UT-A urea transporter protein in heart: increased abundance during uremia, hypertension, and heart failure Circ Res. 2001 Jul 20; 89(2):139-45. . View in PubMed

Region specific regulation of sodium pump isoform and Na,Ca-exchanger expression in the failing human heart--right atrium vs left ventricle Cell Mol Biol (Noisy-le-grand). 2001 Mar; 47(2):373-81. . View in PubMed

Glucocorticoids increase sodium pump alpha(2)- and beta(1)-subunit abundance and mRNA in rat skeletal muscle Am J Physiol Cell Physiol. 2001 Mar; 280(3):C509-16. . View in PubMed

Short-term K(+) deprivation provokes insulin resistance of cellular K(+) uptake revealed with the K(+) clamp Am J Physiol Renal Physiol. 2001 Jan; 280(1):F95-F102. . View in PubMed

Proximal tubule Na transporter responses are the same during acute and chronic hypertension Am J Physiol Renal Physiol. 2000 Aug; 279(2):F358-69. . View in PubMed

Developmental change in Na,K-ATPase alpha1 and beta1 expression in normal and hypothyroid rat renal cortex Am J Nephrol. 2000 May-Jun; 20(3):225-31. . View in PubMed

Molecular mechanisms of sodium transport inhibition in proximal tubule during acute hypertension Curr Opin Nephrol Hypertens. 2000 Mar; 9(2):149-56. . View in PubMed

Temporal responses of oxidative vsglycolytic skeletal muscles to K+ deprivation: Na+ pumps and cell cations. Am J Physiol. 1999 Jun; 276(6 Pt 1):C1411-9. . View in PubMed

In vivo PTH provokes apical NHE3 and NaPi2 redistribution and Na-K-ATPase inhibition Am J Physiol. 1999 May; 276(5 Pt 2):F711-9. . View in PubMed

Reduced sodium pump alpha1, alpha3, and beta1-isoform protein levels and Na+,K+-ATPase activity but unchanged Na+-Ca2+ exchanger protein levels in human heart failure Circulation. 1999 Apr 27; 99(16):2105-12. . View in PubMed

Am J Physiol. 1998 Nov; 275(5 Pt 1):C1179-81. . View in PubMed

Redistribution of Na+/H+ exchanger isoform NHE3 in proximal tubules induced by acute and chronic hypertension Am J Physiol. 1998 Oct; 275(4 Pt 2):F565-75. . View in PubMed

The cytochrome P-450 inhibitor cobalt chloride prevents inhibition of renal Na,K-ATPase and redistribution of apical NHE-3 during acute hypertension J Am Soc Nephrol. 1998 Apr; 9(4):531-7. . View in PubMed

Reversible effects of acute hypertension on proximal tubule sodium transporters Am J Physiol. 1998 Apr; 274(4 Pt 1):C1090-100. . View in PubMed

Posttranscriptional upregulation of Na(+)-K(+)-ATPase activity in newborn guinea pig renal cortex Am J Physiol. 1997 Aug; 273(2 Pt 2):F254-63. . View in PubMed

Skeletal muscle Na,K-ATPase alpha and beta subunit protein levels respond to hypokalemic challenge with isoform and muscle type specificity J Biol Chem. 1996 Dec 20; 271(51):32653-8. . View in PubMed

Regional expression of sodium pump subunits isoforms and Na+-Ca++ exchanger in the human heart J Clin Invest. 1996 Oct 01; 98(7):1650-8. . View in PubMed

Rapid redistribution and inhibition of renal sodium transporters during acute pressure natriuresis Am J Physiol. 1996 Jun; 270(6 Pt 2):F1004-14. . View in PubMed

Subcellular distribution of sodium pump isoform subunits in mammalian cardiac myocytes Am J Physiol. 1996 Apr; 270(4 Pt 1):C1221-7. . View in PubMed

Role of skeletal muscle sodium pumps in the adaptation to potassium deprivation Acta Physiol Scand. 1996 Mar; 156(3):295-304. . View in PubMed

Renal Na+/H+ exchanger isoforms and their regulation by thyroid hormone Am J Physiol. 1996 Feb; 270(2 Pt 1):C585-92. . View in PubMed

Reciprocal regulation of cardiac Na-K-ATPase and Na/Ca exchanger: hypertension, thyroid hormone, development Am J Physiol. 1995 Sep; 269(3 Pt 1):C675-82. . View in PubMed

Significance of sodium pump isoforms in digitalis therapy J Mol Cell Cardiol. 1995 Apr; 27(4):1001-9. . View in PubMed

Expression of Na(+)-K(+)-ATPase alpha- and beta-subunits along rat nephron: isoform specificity and response to hypokalemia Am J Physiol. 1994 Oct; 267(4 Pt 1):C901-8. . View in PubMed

Amiodarone decreases Na,K-ATPase alpha 2 and beta 2 expression specifically in cardiac ventricle J Mol Cell Cardiol. 1994 Apr; 26(4):417-24. . View in PubMed

Nicotine downregulates alpha 2 isoform of Na,K-ATPase at the blood-brain barrier and brain in rats Biochem Biophys Res Commun. 1994 Mar 30; 199(3):1422-7. . View in PubMed

Surface and intracellular pools of Na,K-ATPase catalytic and immuno-activities in rat exorbital lacrimal gland Exp Eye Res. 1993 Oct; 57(4):403-13. . View in PubMed

Surplus Na+ pumps: how low-K(+)-incubated LLC-PK1 cells respond to K+ restoration Am J Physiol. 1993 Oct; 265(4 Pt 1):C887-92. . View in PubMed

Thyroid hormone specifically regulates skeletal muscle Na(+)-K(+)-ATPase alpha 2- and beta 2-isoforms Am J Physiol. 1993 Sep; 265(3 Pt 1):C680-7. . View in PubMed

Regulation of Na,K-ATPase activity Curr Opin Nephrol Hypertens. 1993 Sep; 2(5):725-34. . View in PubMed

Na(+)-K(+)-ATPase alpha 1- and beta 1-subunit degradation: evidence for multiple subunit specific rates Am J Physiol. 1993 Mar; 264(3 Pt 1):C583-90. . View in PubMed

Physiologic rationale for multiple sodium pump isoformsDifferential regulation of alpha 1 vs alpha 2 by ionic stimuli. Ann N Y Acad Sci. 1992 Nov 30; 671:156-68; discussion 168-9. . View in PubMed

Low K+ increases Na(+)-K(+)-ATPase alpha- and beta-subunit mRNA and protein abundance in cultured renal proximal tubule cells Am J Physiol. 1992 Aug; 263(2 Pt 1):C436-42. . View in PubMed

Thyroid hormone induction of rat myocardial Na(+)-K(+)-ATPase: alpha 1-, alpha 2-, and beta 1-mRNA and -protein levels at steady state Am J Physiol. 1992 Feb; 262(2 Pt 1):C484-92. . View in PubMed

Synthesis and translocation of Na(+)-K(+)-ATPase alpha- and beta-subunits to plasma membrane in MDCK cells Am J Physiol. 1992 Feb; 262(2 Pt 1):C470-83. . View in PubMed

Differential regulation of sodium pump isoforms in heart Semin Nephrol. 1992 Jan; 12(1):49-55. . View in PubMed

Hypokalemia decreases Na(+)-K(+)-ATPase alpha 2- but not alpha 1-isoform abundance in heart, muscle, and brain Am J Physiol. 1991 May; 260(5 Pt 1):C958-64. . View in PubMed

Low K+ increases Na,K-ATPase abundance in LLC-PK1/Cl4 cells by differentially increasing beta, and not alpha, subunit mRNA J Biol Chem. 1990 Oct 15; 265(29):17935-40. . View in PubMed

Differential regulation of Na,K-ATPase alpha 1, alpha 2, and beta subunit mRNA and protein levels by thyroid hormone J Biol Chem. 1990 Aug 25; 265(24):14308-14. . View in PubMed

Ionic regulation of the biosynthesis of NaK-ATPase subunits Semin Nephrol. 1990 Jul; 10(4):400-9. . View in PubMed

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