Ana Claudia Maretti Garcia, PhD

Assistant Professor of Research Medicine

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Overview

Dr. Maretti-Garcia earned her B.S. degree in biomedical sciences, M.S. in Parasitology, and Ph.D. in Molecular and Cellular Biology in Brazil. After completing her postdoctoral training at the University of California, Los Angeles (UCLA), where she studied the immunopathology of tropical diseases, she joined the University of Southern California (USC) to study liver diseases.

Recently, Dr. Maretti-Garcia became an Assistant Professor at Keck School of Medicine of USC, and her research interest mainly concentrates on the contribution of the immune response to the progression of chronic liver diseases. She is an expert in cutting-edge technologies used for transcriptomic analyses and for real-time cellular behavior assays.

Awards

  • NIH: RCLD Young Investigator Award, 2017-2018
  • American Association for the Study of Liver Diseases: Presidential Poster of Distinction, 2016
  • American Association for the Study of Liver Diseases: Basic Science Young Investigator Travel Award, 2016
  • Brazilian Society of Protozoology: Best Scientific Presentation Award, 2007

Publications

  • Etiology of end-stage liver cirrhosis impacts hepatic natural killer cell heterogenicity Front Immunol. 2023; 14:1137034. . View in PubMed
  • Chronic HCV infection promotes cytotoxicity in antigen-specific CD8+ T cells regardless of virus specificity Frontiers in Virology. 2023; 3. . View in PubMed
  • Editorial: New strategies for the treatment of diseases caused by trypanosomatid parasitesFront. Cell. Infect. Microbiol. 2023; 13. . View in PubMed
  • Hepatic damage caused by long-term high cholesterol intake induces a dysfunctional restorative macrophage population in experimental NASH Front Immunol. 2022; 13:968366. . View in PubMed
  • Single-cell transcriptomic analyses of T cells in chronic HCV-infected patients dominated by DAA-induced interferon signaling changes PLoS Pathog. 2021 08; 17(8):e1009799. . View in PubMed
  • Cholesterol-Induced M4-Like Macrophages Recruit Neutrophils and Induce NETosis Front Immunol. 2021; 12:671073. . View in PubMed
  • Susceptibility of Rat Steatotic Liver to Ischemia-Reperfusion Is Treatable With Liver-Selective Matrix Metalloproteinase Inhibition Hepatology. 2020 11; 72(5):1771-1785. . View in PubMed
  • Sinusoids as Drivers of Liver Development: More Than Simple Chemistry Hepatology. 2019 08; 70(2):737-739. . View in PubMed
  • Incomplete Differentiation of Engrafted Bone Marrow Endothelial Progenitor Cells Initiates Hepatic Fibrosis in the Rat Hepatology. 2019 03; 69(3):1259-1272. . View in PubMed
  • Liver-Selective MMP-9 Inhibition in the Rat Eliminates Ischemia-Reperfusion Injury and Accelerates Liver Regeneration Hepatology. 2019 01; 69(1):314-328. . View in PubMed
  • Liver Sinusoidal Endothelial Cell: An Update Semin Liver Dis. 2017 11; 37(4):377-387. . View in PubMed
  • Severity of tegumentary leishmaniasis is not exclusively associated with Leishmania RNA virus 1 infection in Brazil Mem Inst Oswaldo Cruz. 2013 Aug; 108(5):665-7. . View in PubMed
  • Efficacy of synthetic peptides RP-1 and AA-RP-1 against Leishmania species in vitro and in vivo Antimicrob Agents Chemother. 2012 Feb; 56(2):658-65. . View in PubMed
  • Transcriptome patterns from primary cutaneous Leishmania braziliensis infections associate with eventual development of mucosal disease in humans PLoS Negl Trop Dis. 2012; 6(9):e1816. . View in PubMed
  • MMP-9 activity is induced by Leishmania braziliensis infection and correlates with mucosal leishmaniasis Acta Trop. 2011 Aug; 119(2-3):160-4. . View in PubMed
  • Influence of the Notch system in the therapeutic response of American tegumentary leishmaniasis Br J Dermatol. 2011 Jun; 164(6):1228-34. . View in PubMed
  • Therapeutic failure in American cutaneous leishmaniasis is associated with gelatinase activity and cytokine expression Clin Exp Immunol. 2011 Feb; 163(2):207-14. . View in PubMed
  • LXR deficiency confers increased protection against visceral Leishmania infection in mice PLoS Negl Trop Dis. 2010 Nov 16; 4(11):e886. . View in PubMed