Ana Claudia Maretti Garcia, PhD

Assistant Professor of Research Medicine

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Overview

Dr. Maretti-Garcia’s research focuses on uncovering how the immune system contributes to the progression of chronic liver diseases. She specializes in advanced transcriptomic and real-time cellular behavior assays, leveraging these technologies to investigate the molecular and cellular mechanisms underlying liver dysfunction. Dr. Maretti-Garcia has developed an innovative in vitro framework for studying MASLD by integrating 3D human liver spheroids and multi-omic technologies. Using this approach, she aims to investigate how environmental pollutants, like PFAS, influence the progression of MASLD and hepatocellular carcinoma (HCC). Dr. Maretti-Garcia is also interested in the role of dietary factors in the onset of MASLD and in identifying new strategies for disease prevention and treatment.

Awards

  • USC: USC Dean’s Pilot Award, 2024
  • AASLD: Presidential Poster of Distinction, 2023
  • USC: USC President Sustainability Initiative Award, 2023
  • USC: RCLD Young Investigator Award, 2017
     – 2018
  • AASLD: Basic Science Young Investigator Travel Award, 2016
  • AASLD: Presidential Poster of Distinction, 2016
  • Brazilian Society of Protozoology: Best Scientific Presentation Award, 2007

Education and Training

  • Universidade Federal do Rio de Janeiro, Brazil — BS — 2004 — Biomedical Sciences
  • FIOCRUZ, Brazil — MS — 2006 — Parasitology
  • FIOCRUZ, Brazil — PhD — 2011 — Molecular and Cellular Biology
  • University of California, Los Angeles, Los Angeles — 2013 — Post-doctoral, Immunology
  • Cedars-Sinai, Los Angeles — 2014 — Post-doctoral, Molecular Immunology
  • University of Southern California, Los Angeles — 2018 — Post-doctoral, Liver Biology
  • University of Southern California, Los Angeles — 2021 — Post-doctoral, Liver Immunology

Research Keywords

  • Non-alcoholic Steatohepatitis
  • Hepatitis C
  • Autoimmune Hepatitis
  • Immunology
  • Molecular Biology
  • PFAS

Publications

  • Associations between per- and polyfluoroalkyl substances and metabolic dysfunction-associated steatotic liver disease in adolescents and young adults: modifying roles of age, lifestyle factors, and PNPLA3 genotype. Environ Res. 2026 Jan 01; 288(Pt 2):123320.. View in PubMed
  • Translational framework linking perfluoroheptanoic acid (PFHpA) exposure to metabolic dysfunction associated steatotic liver disease in adolescents. Commun Med (Lond). 2025 Oct 29; 5(1):430.. View in PubMed
  • Assessing the impact of perfluoroalkyl substances on liver health: a comprehensive study using multi-donor human liver spheroids. Environ Int. 2025 Sep; 203:109763.. View in PubMed
  • Senescence-related genes are associated with the immunopathology signature of American tegumentary leishmaniasis lesions and may predict progression to mucosal leishmaniasis. Clin Exp Immunol. 2025 Jan 21; 219(1).. View in PubMed
  • Examining disparities in PFAS plasma concentrations: Impact of drinking water contamination, food access, proximity to industrial facilities and superfund sites. Environ Res. 2025 Jan 01; 264(Pt 1):120370.. View in PubMed
  • PFHpA alters lipid metabolism and increases the risk of metabolic dysfunction-associated steatotic liver disease in youth-a translational research framework. medRxiv. 2024 Jul 03.. View in PubMed
  • Circulating Neutrophil Profiles Undergo a Dynamic Shift during Metabolic Dysfunction-Associated Steatohepatitis (MASH) Progression. Biomedicines. 2024 May 16; 12(5).. View in PubMed
  • Single-cell transcriptomic analyses of T cells in chronic HCV-infected patients dominated by DAA-induced interferon signaling changes. PLoS Pathog. 2021 08; 17(8):e1009799.. View in PubMed
  • Cholesterol-Induced M4-Like Macrophages Recruit Neutrophils and Induce NETosis. Front Immunol. 2021; 12:671073.. View in PubMed
  • Susceptibility of Rat Steatotic Liver to Ischemia-Reperfusion Is Treatable With Liver-Selective Matrix Metalloproteinase Inhibition. Hepatology. 2020 11; 72(5):1771-1785.. View in PubMed