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Andrew S Lim, MD

Director of Brachytherapy

Assistant Professor of Clinical Radiation Oncology

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Email alim1769@usc.edu
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Overview

Andrew Lim, MD, is a radiation oncologist at USC Norris Comprehensive Cancer Center, part of Keck Medicine of USC, who specializes in today’s most advanced forms of radiation therapy, including interstitial and surface brachytherapy, volumetric modulated arc therapy and stereotactic body radiation therapy.At USC Norris, he serves as director of brachytherapy, a form of internal radiation therapy in which the radiation source is placed close to the cancer. Dr. Lim routinely treats prostate cancer, gynecologic cancers, sarcomas, skin cancer and metastatic cancers anywhere in the body.His research interests focus on the development of artificial intelligence (AI) algorithms capable of integrating clinical, biochemical, genomics and radiologic data, with a goal of making personalized, probabilistic medical predictions. Dr. Lim has received several awards for his outstanding research and cancer care.Away from work, he enjoys creating software tools that help people save time.

Awards

  • University of Alberta: The RJS and Ada Maude Wright Memorial Prize in Radiation Oncology, 2019-2020
  • St. Francis Xavier University: Yogi Joshi Prize For Excellence in Physics, 2008-2009
  • St. Francis Xavier University: Natural Sciences and Engineering Research Council of Canada Award, 2008-2009

Publications

  • Actigraphy-derived sleep fragmentation index: convergent validity and associations with clinical outcomes. J Clin Sleep Med. 2025 Sep 01; 21(9):1557-1565.. View in PubMed
  • Pilot trials of oral betaine in participants with metabolic dysfunction-associated steatotic liver disease and elevated alanine aminotransferase. Hepatology. 2025 Aug 04.. View in PubMed
  • Response letter: Examining the association between sleep apnea and total hippocampal volumes in cognitive impairment. Alzheimers Dement. 2025 Aug; 21(8):e70602.. View in PubMed
  • An international multi-cohort investigation of self-reported sleep and future depressive symptoms in older adults. Sci Rep. 2025 Jul 04; 15(1):23918.. View in PubMed
  • Node-positive carcinoma of the vulva treated with curative-intent radiotherapy. Int J Gynecol Cancer. 2025 Jul; 35(7):101916.. View in PubMed
  • Reduced Complexity of Pulse Rate Is Associated With Faster Cognitive Decline in Older Adults. J Am Heart Assoc. 2025 May 20; 14(10):e041448.. View in PubMed
  • Sleep trajectories across three cognitive-aging pathways in community older adults. Alzheimers Dement. 2025 May; 21(5):e70159.. View in PubMed
  • Retinal microvascular phenotypes can track small vessel disease burden and CPAP treatment effectiveness in obstructive sleep apnea. J Cereb Blood Flow Metab. 2025 Apr; 45(4):690-702.. View in PubMed
  • Examining the association between sleep apnea and total hippocampal volumes in cognitive impairment. Alzheimers Dement. 2025 Apr; 21(4):e70183.. View in PubMed
  • Clostridioides difficile infection and recurrence in cancer patients (CIRCA): A multicentre, international study. Int J Infect Dis. 2025 Apr; 153:107785.. View in PubMed
  • Combining 24-Hour Continuous Monitoring of Time-Locked Heart Rate, Physical Activity and Gait in Older Adults: Preliminary Findings. Sensors (Basel). 2025 Mar 20; 25(6).. View in PubMed
  • Clinical and dosimetric outcomes of a 3-fraction high-dose-rate brachytherapy boost for the treatment of locally advanced cervical cancer in a safety net hospital. Brachytherapy. 2025 Jan-Feb; 24(1):162-170.. View in PubMed
  • segcsvdWMH: A Convolutional Neural Network-Based Tool for Quantifying White Matter Hyperintensities in Heterogeneous Patient Cohorts. Hum Brain Mapp. 2024 Dec 15; 45(18):e70104.. View in PubMed
  • Impact of a national dementia research consortium: The Canadian Consortium on Neurodegeneration in Aging (CCNA). J Alzheimers Dis. 2024 Dec; 102(3):535-561.. View in PubMed
  • Updated consensus guidelines for management of moderate-to-severe atopic dermatitis in Singapore: Integrating biologics, Janus kinase inhibitors and conventional therapies. Ann Acad Med Singap. 2024 Nov 29; 53(11):670-682.. View in PubMed
  • Pioneering a multi-phase framework to harmonize self-reported sleep data across cohorts. Sleep. 2024 09 09; 47(9).. View in PubMed
  • Dosimetric characterization for GRID collimator-based spatially fractionated radiation therapy: Dosimetric parameter acquisition and machine interchangeability investigation. J Appl Clin Med Phys. 2024 Aug; 25(8):e14410.. View in PubMed
  • A phase 1 dose-escalation study of low-dose lenalidomide maintenance post-allogeneic stem cell transplantation for high-risk acute myeloid leukaemia or myelodysplastic syndrome. Bone Marrow Transplant. 2024 Jul; 59(7):1025-1027.. View in PubMed
  • Framework for Radiation Oncology Department-wide Evaluation and Implementation of Commercial Artificial Intelligence Autocontouring. Pract Radiat Oncol. 2024 Mar-Apr; 14(2):e150-e158.. View in PubMed
  • Dosimetric Validation for Prospective Clinical Trial of GRID Collimator-Based Spatially Fractionated Radiation Therapy: Dose Metrics Consistency and Heterogeneous Pattern Reproducibility. Int J Radiat Oncol Biol Phys. 2024 Feb 01; 118(2):565-573.. View in PubMed
  • Race and sex differences in the longitudinal changes in multidimensional self-reported sleep health characteristics in aging older adults. Sleep Health. 2023 12; 9(6):947-958.. View in PubMed
  • Critical care delivery across health care systems in low-income and low-middle-income country settings: A systematic review. J Glob Health. 2023 Dec 01; 13:04141.. View in PubMed
  • Sex differences in associations between APOE ε2 and longitudinal cognitive decline. Alzheimers Dement. 2023 10; 19(10):4651-4661.. View in PubMed
  • Continuous positive airway pressure increases CSF flow and glymphatic transport. JCI Insight. 2023 06 22; 8(12).. View in PubMed
  • Vegetation as a key driver of the distribution of microbial generalists that in turn shapes the overall microbial community structure in the low Arctic tundra. Environ Microbiome. 2023 May 10; 18(1):41.. View in PubMed
  • Fragmentation of rest periods, astrocyte activation, and cognitive decline in older adults with and without Alzheimer’s disease. Alzheimers Dement. 2023 05; 19(5):1888-1900.. View in PubMed
  • Correlates of Person-Specific Rates of Change in Sensor-Derived Physical Activity Metrics of Daily Living in the Rush Memory and Aging Project. Sensors (Basel). 2023 Apr 21; 23(8).. View in PubMed
  • Investigating changes in cognition associated with the use of CPAP in cognitive impairment and dementia: A retrospective study. Sleep Med. 2023 01; 101:437-444.. View in PubMed
  • Examining temporal features of BOLD-based cerebrovascular reactivity in clinical populations. Front Neurol. 2023; 14:1199805.. View in PubMed
  • Isatuximab plus carfilzomib and dexamethasone versus carfilzomib and dexamethasone in elderly patients with relapsed multiple myeloma: IKEMA subgroup analysis. Hematol Oncol. 2022 Dec; 40(5):1020-1029.. View in PubMed
  • A single-arm, open-label, multicenter, and comparative study of the ANNE sleep system vs polysomnography to diagnose obstructive sleep apnea. J Clin Sleep Med. 2022 12 01; 18(12):2703-2712.. View in PubMed
  • Isatuximab plus carfilzomib and dexamethasone in relapsed multiple myeloma patients with high-risk cytogenetics: IKEMA subgroup analysis. Eur J Haematol. 2022 Nov; 109(5):504-512.. View in PubMed
  • Impact of a policy to improve the management of oral medications when patients are fasting before a procedure: an interrupted time series analysis. BMJ Open Qual. 2022 05; 11(2).. View in PubMed
  • Feasibility of a continuous, multi-sensor remote health monitoring approach in persons living with neurodegenerative disease. J Neurol. 2022 May; 269(5):2673-2686.. View in PubMed
  • Protocol for SYNchronising Exercises, Remedies in GaIt and Cognition at Home (SYNERGIC@Home): feasibility of a home-based double-blind randomised controlled trial to improve gait and cognition in individuals at risk for dementia. BMJ Open. 2022 03 31; 12(3):e059988.. View in PubMed
  • Association between risk of obstructive sleep apnea, inflammation and cognition after 45 years old in the Canadian Longitudinal Study on Aging. Sleep Med. 2022 03; 91:21-30.. View in PubMed
  • Utility of machine learning of apparent diffusion coefficient (ADC) and T2-weighted (T2W) radiomic features in PI-RADS version 2.1 category 3 lesions to predict prostate cancer diagnosis. Abdom Radiol (NY). 2021 12; 46(12):5647-5658.. View in PubMed
  • High-Dose Rate Interstitial Spine Brachytherapy Using an Intraoperative Mobile Computed Tomography-Guided Surgical Navigation System. Oper Neurosurg (Hagerstown). 2021 11 15; 21(6):507-515.. View in PubMed
  • Association of accelerometer-derived sleep measures with lifetime psychiatric diagnoses: A cross-sectional study of 89,205 participants from the UK Biobank. PLoS Med. 2021 10; 18(10):e1003782.. View in PubMed
  • Disrupted Rest-Activity Rhythms and Cerebral Small Vessel Disease Pathology in Older Adults. Stroke. 2021 07; 52(7):2427-2431.. View in PubMed
  • MRI-visible perivascular space volumes, sleep duration and daytime dysfunction in adults with cerebrovascular disease. Sleep Med. 2021 07; 83:83-88.. View in PubMed
  • Phyllodes Tumors-The Predictors and Detection of Recurrence. Can Assoc Radiol J. 2021 May; 72(2):251-257.. View in PubMed
  • A Novel Composite Biomarker Panel For Detection Of Early Stage Non-small Cell Lung Cancer. Clin Invest Med. 2021 03 21; 44(1):E15-24.. View in PubMed
  • Feasibility of unattended home sleep apnea testing in a cognitively impaired clinic population. J Clin Sleep Med. 2021 03 01; 17(3):435-444.. View in PubMed
  • Prognostic performance of qSOFA in oncology patients admitted to the emergency department with suspected infection. Asia Pac J Clin Oncol. 2021 Feb; 17(1):94-100.. View in PubMed
  • Diurnal and seasonal molecular rhythms in the human brain and their relation to Alzheimer disease. Handb Clin Neurol. 2021; 179:271-284.. View in PubMed
  • Sleep Fragmentation and Cognitive Trajectories After Critical Illness. Chest. 2021 01; 159(1):366-381.. View in PubMed
  • Circadian disturbances in Alzheimer’s disease progression: a prospective observational cohort study of community-based older adults. Lancet Healthy Longev. 2020 12; 1(3):e96-e105.. View in PubMed
  • Assessment tool validation and technical skill improvement in the simulation of the Norwood operation using three-dimensional-printed heart models. Eur J Cardiothorac Surg. 2020 Nov 29.. View in PubMed
  • Implementation of the WHO Trauma Care Checklist: A qualitative analysis of facilitators and barriers to use. Int J Surg. 2020 Nov; 83:15-23.. View in PubMed
  • Development and validation of a procedure-specific assessment tool for hands-on surgical training in congenital heart surgery. J Thorac Cardiovasc Surg. 2020 07; 160(1):229-240.e1.. View in PubMed
  • CCCDTD5: Reducing the risk of later-life dementia. Evidence informing the Fifth Canadian Consensus Conference on the Diagnosis and Treatment of Dementia (CCCDTD-5). Alzheimers Dement (N Y). 2020; 6(1):e12083.. View in PubMed
  • CCCDTD5 recommendations on early non cognitive markers of dementia: A Canadian consensus. Alzheimers Dement (N Y). 2020; 6(1):e12068.. View in PubMed
  • Fragmentation of Rest/Activity Patterns in Community-Based Elderly Individuals Predicts Incident Heart Failure. Nat Sci Sleep. 2020; 12:299-307.. View in PubMed
  • Actigraphic measures of sleep on the wards after ICU discharge. J Crit Care. 2019 12; 54:163-169.. View in PubMed
  • Sleep fragmentation, microglial aging, and cognitive impairment in adults with and without Alzheimer’s dementia. Sci Adv. 2019 12; 5(12):eaax7331.. View in PubMed
  • More random motor activity fluctuations predict incident frailty, disability, and mortality. Sci Transl Med. 2019 10 30; 11(516).. View in PubMed
  • Smartphone EEG and remote online interpretation for children with epilepsy in the Republic of Guinea: Quality, characteristics, and practice implications. Seizure. 2019 Oct; 71:93-99.. View in PubMed
  • NaF PET/CT for response assessment of prostate cancer bone metastases treated with single fraction stereotactic ablative body radiotherapy. Radiat Oncol. 2019 Sep 05; 14(1):164.. View in PubMed
  • Physical activity, common brain pathologies, and cognition in community-dwelling older adults. Neurology. 2019 02 19; 92(8):e811-e822.. View in PubMed
  • The role of positron emission tomography in the selection of patients for salvage hysterectomy following chemoradiotherapy for locally advanced cervical cancer. Int J Gynecol Cancer. 2019 Feb; 29(2):266-271.. View in PubMed
  • Stereotactic Abative Body Radiotherapy (SABR) for Oligometastatic Prostate Cancer: A Prospective Clinical Trial. Eur Urol. 2018 10; 74(4):455-462.. View in PubMed
  • Seasonal plasticity of cognition and related biological measures in adults with and without Alzheimer disease: Analysis of multiple cohorts. PLoS Med. 2018 09; 15(9):e1002647.. View in PubMed
  • Fractal regulation and incident Alzheimer’s disease in elderly individuals. Alzheimers Dement. 2018 09; 14(9):1114-1125.. View in PubMed
  • Evaluating the effects of general anesthesia on sleep in children undergoing elective surgery: an observational case-control study. Sleep. 2018 08 01; 41(8).. View in PubMed
  • Sleep on the ward in intensive care unit survivors: a case series of polysomnography. Intern Med J. 2018 07; 48(7):795-802.. View in PubMed
  • Brain pathology is related to total daily physical activity in older adults. Neurology. 2018 05 22; 90(21):e1911-e1919.. View in PubMed
  • Association Between Quantitative Gait and Balance Measures and Total Daily Physical Activity in Community-Dwelling Older Adults. J Gerontol A Biol Sci Med Sci. 2018 04 17; 73(5):636-642.. View in PubMed
  • Actigraphy Detects Greater Intra-Individual Variability During Gait in Non-Manifesting LRRK2 Mutation Carriers. J Parkinsons Dis. 2018; 8(1):131-139.. View in PubMed
  • Sleep fragmentation and Parkinson’s disease pathology in older adults without Parkinson’s disease. Mov Disord. 2017 Dec; 32(12):1729-1737.. View in PubMed
  • Restless legs syndrome after high-risk TIA and minor stroke: association with reduced quality of life. Sleep Med. 2017 Sep; 37:135-140.. View in PubMed
  • A study protocol for an observational cohort investigating COGnitive outcomes and WELLness in survivors of critical illness: the COGWELL study. BMJ Open. 2017 Jul 13; 7(7):e015600.. View in PubMed
  • Circadian alterations during early stages of Alzheimer’s disease are associated with aberrant cycles of DNA methylation in BMAL1. Alzheimers Dement. 2017 Jun; 13(6):689-700.. View in PubMed
  • Reply to: “Periodic Limb Movements During Sleep and White Matter MRI Hyperintensity in Minor Stroke or TIA”. Sleep. 2017 05 01; 40(5).. View in PubMed
  • Diurnal and seasonal molecular rhythms in human neocortex and their relation to Alzheimer’s disease. Nat Commun. 2017 04 03; 8:14931.. View in PubMed
  • Validation of a smartphone-based EEG among people with epilepsy: A prospective study. Sci Rep. 2017 04 03; 7:45567.. View in PubMed
  • Periodic Limb Movements and White Matter Hyperintensities in First-Ever Minor Stroke or High-Risk Transient Ischemic Attack. Sleep. 2017 03 01; 40(3).. View in PubMed
  • Self-Reported Sleep in Older African Americans and White Americans. Ethn Dis. 2016 Oct 20; 26(4):521-528.. View in PubMed
  • Incident parkinsonism in older adults without Parkinson disease. Neurology. 2016 Sep 06; 87(10):1036-44.. View in PubMed
  • Medication prescribing and patient-reported outcome measures in people with epilepsy in Bhutan. Epilepsy Behav. 2016 06; 59:122-7.. View in PubMed
  • Response to Letter Regarding Article, “Sleep Fragmentation, Cerebral Arteriolosclerosis, and Brain Infarct Pathology in Community-Dwelling Older People”. Stroke. 2016 06; 47(6):e175.. View in PubMed
  • The effect of melatonin on sleep and quality of life in patients with advanced breast cancer. Support Care Cancer. 2016 Mar; 24(3):1097-105.. View in PubMed
  • Sleep Fragmentation, Cerebral Arteriolosclerosis, and Brain Infarct Pathology in Community-Dwelling Older People. Stroke. 2016 Feb; 47(2):516-8.. View in PubMed
  • Common variants in DRD2 are associated with sleep duration: the CARe consortium. Hum Mol Genet. 2016 Jan 01; 25(1):167-79.. View in PubMed
  • Regional Neocortical Gray Matter Structure and Sleep Fragmentation in Older Adults. Sleep. 2016 Jan 01; 39(1):227-35.. View in PubMed
  • A phantom assessment of achievable contouring concordance across multiple treatment planning systems. Radiother Oncol. 2015 Dec; 117(3):438-41.. View in PubMed
  • Suprachiasmatic neuron numbers and rest-activity circadian rhythms in older humans. Ann Neurol. 2015 Aug; 78(2):317-22.. View in PubMed
  • Irregular 24-hour activity rhythms and the metabolic syndrome in older adults. Chronobiol Int. 2015; 32(6):802-13.. View in PubMed
  • Stereotactic ablative body radiation therapy for primary kidney cancer: a 3-dimensional conformal technique associated with low rates of early toxicity. Int J Radiat Oncol Biol Phys. 2014 Dec 01; 90(5):1061-8.. View in PubMed
  • 24-hour rhythms of DNA methylation and their relation with rhythms of RNA expression in the human dorsolateral prefrontal cortex. PLoS Genet. 2014 Nov; 10(11):e1004792.. View in PubMed
  • Predicting C282Y homozygote genotype for hemochromatosis using serum ferritin and transferrin saturation values from 44,809 participants of the HEIRS study. Can J Gastroenterol Hepatol. 2014 Oct; 28(9):502-4.. View in PubMed
  • Sleep is related to neuron numbers in the ventrolateral preoptic/intermediate nucleus in older adults with and without Alzheimer’s disease. Brain. 2014 Oct; 137(Pt 10):2847-61.. View in PubMed
  • Sleep complaints and incident disability in a community-based cohort study of older persons. Am J Geriatr Psychiatry. 2014 Jul; 22(7):718-26.. View in PubMed
  • Screening with spirometry is a useful predictor of later development of noninfectious pulmonary syndromes in patients undergoing allogeneic stem cell transplantation. Biol Blood Marrow Transplant. 2014 Jun; 20(6):781-6.. View in PubMed
  • Compartmentalization of innate immune responses in the central nervous system during cryptococcal meningitis/HIV coinfection. AIDS. 2014 Mar 13; 28(5):657-66.. View in PubMed
  • Modification of the relationship of the apolipoprotein E ε4 allele to the risk of Alzheimer disease and neurofibrillary tangle density by sleep. JAMA Neurol. 2013 Dec; 70(12):1544-51.. View in PubMed
  • TB-IRIS after initiation of antiretroviral therapy is associated with expansion of preexistent Th1 responses against Mycobacterium tuberculosis antigens. J Acquir Immune Defic Syndr. 2013 Nov 01; 64(3):241-8.. View in PubMed
  • Does quality of radiation therapy predict outcomes of multicenter cooperative group trials? A literature review. Int J Radiat Oncol Biol Phys. 2013 Oct 01; 87(2):246-60.. View in PubMed
  • Sleep Fragmentation and the Risk of Incident Alzheimer’s Disease and Cognitive Decline in Older Persons. Sleep. 2013 Jul 01; 36(7):1027-1032.. View in PubMed
  • Sex difference in daily rhythms of clock gene expression in the aged human cerebral cortex. J Biol Rhythms. 2013 Apr; 28(2):117-29.. View in PubMed
  • A common polymorphism near PER1 and the timing of human behavioral rhythms. Ann Neurol. 2012 Sep; 72(3):324-34.. View in PubMed
  • Quantification of the fragmentation of rest-activity patterns in elderly individuals using a state transition analysis. Sleep. 2011 Nov 01; 34(11):1569-81.. View in PubMed
  • Global hemispheric CT hypoperfusion may differentiate headache with associated neurological deficits and lymphocytosis from acute stroke. Stroke. 2008 Feb; 39(2):492-3.. View in PubMed
  • Age and severity of nigrostriatal damage at onset of Parkinson’s disease. Synapse. 2003 Feb; 47(2):152-8.. View in PubMed

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