Anisa Shaker, MD

Associate Professor of Medicine

Director of the Swallowing and Esophageal Disorders Center

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Dr. Shaker is a physician-scientist with a clinical and research interest in esophageal disorders. Her research program is focused on understanding the mechanisms of esophageal injury, repair, and inflammation. Her work is supported by both federal and private funding. Dr. Shaker has authored several articles in peer-reviewed journals and serves as a mentor to physicians in training interested in gastrointestinal research.

Dr. Shaker earned her medical degree from Medical College of Wisconsin. She then performed her internship and residency at Brown University- Rhode Island Hospital, followed by a Gastroenterology Fellowship at Washington University School of Medicine- Barnes Jewish Hospital.

Lab site:


  • American Gastroenterology Association: Women’s Leadership Conference, 2015
  • Association of American Medical Colleges: Early Career Women Faculty Professional Development Seminar, 2011


  • The Travels of Signet-Ring Cell Carcinoma: From Colon to Stomach and Duodenum ACG Case Rep J. 2023 Dec; 10(12):e01239. . View in PubMed
  • Direct and indirect effects of alcohol and its toxic metabolite acetaldehyde on human esophageal myofibroblasts and epithelial cells Alcohol Clin Exp Res (Hoboken). 2023 Jul; 47(7):1297-1311. . View in PubMed
  • Inflammatory and Proliferative Pathway Activation in Human Esophageal Myofibroblasts Treated with Acidic Bile Salts Int J Mol Sci. 2022 Sep 08; 23(18). . View in PubMed
  • Pattern of methane levels with lactulose breath testing; can we shorten the test duration? JGH Open. 2021 Jul; 5(7):809-812.. View in PubMed
  • Gender-Specific Risk Factors for Reflux Esophagitis in a Predominantly Hispanic Population of a Large Safety-Net Hospital Dig Dis Sci. 2021 06; 66(6):1940-1948. . View in PubMed
  • Is Avoiding Stem Cell Exhaustion the New Therapeutic Approach in Colitis? Cell Mol Gastroenterol Hepatol. 2021; 11(4):1204-1206.. View in PubMed
  • Human esophageal myofibroblasts increase squamous epithelial thickness via paracrine mechanisms in an in vitro model of gastroesophageal reflux disease PLoS One. 2020; 15(9):e0238852. . View in PubMed
  • Human esophageal myofibroblast secretion of bone morphogenetic proteins and GREMLIN1 and paracrine regulation of squamous epithelial growth Sci Rep. 2018 08 17; 8(1):12354. . View in PubMed
  • Provocative testing of the esophagus and its future Ann N Y Acad Sci. 2016 09; 1380(1):33-47. . View in PubMed
  • Generation and Characterization of an Immortalized Human Esophageal Myofibroblast Line PLoS One. 2016; 11(4):e0153185. . View in PubMed
  • Human esophageal myofibroblasts secrete proinflammatory cytokines in response to acid and Toll-like receptor 4 ligands Am J Physiol Gastrointest Liver Physiol. 2015 Jun 01; 308(11):G904-23. . View in PubMed
  • Isolation of myofibroblasts from mouse and human esophagus J Vis Exp. 2015 Jan 18; (95):52215. . View in PubMed
  • Epimorphin(-/-) mice are protected, in part, from acute colitis via decreased interleukin 6 signaling Transl Res. 2014 Jul; 164(1):70-83. . View in PubMed
  • Multiple rapid swallow responses during esophageal high-resolution manometry reflect esophageal body peristaltic reserve Am J Gastroenterol. 2013 Nov; 108(11):1706-12. . View in PubMed
  • Epimorphin deletion inhibits polyposis in the Apcmin/+ mouse model of colon carcinogenesis via decreased myofibroblast HGF secretion Am J Physiol Gastrointest Liver Physiol. 2013 Oct 15; 305(8):G564-72. . View in PubMed
  • Stromal cells participate in the murine esophageal mucosal injury response Am J Physiol Gastrointest Liver Physiol. 2013 Apr 01; 304(7):G662-72. . View in PubMed
  • The value of multiple rapid swallows during preoperative esophageal manometry before laparoscopic antireflux surgery Surg Endosc. 2012 Dec; 26(12):3401-7. . View in PubMed
  • Modeling colitis-associated cancer with azoxymethane (AOM) and dextran sulfate sodium (DSS) J Vis Exp. 2012 Sep 11; (67). . View in PubMed
  • Stem cells: One step closer to gut repair Nature. 2012 May 09; 485(7397):181-2. . View in PubMed
  • Chronic intestinal inflammation: inflammatory bowel disease and colitis-associated colon cancer Front Immunol. 2012; 3:107. . View in PubMed
  • Intestinal stem cells and epithelial-mesenchymal interactions in the crypt and stem cell niche Transl Res. 2010 Sep; 156(3):180-7. . View in PubMed
  • Epimorphin deletion protects mice from inflammation-induced colon carcinogenesis and alters stem cell niche myofibroblast secretion J Clin Invest. 2010 Jun; 120(6):2081-93. . View in PubMed
  • Miriam Hospital morbidity and mortality conference, a case of chronic headaches Med Health R I. 2004 Sep; 87(9):280-3. . View in PubMed