Anisa Shaker, MD

Associate Professor of Medicine

Director of the Swallowing and Esophageal Disorders Center

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Overview

Dr. Shaker is a physician-scientist with a clinical and research interest in esophageal disorders. Her research program is focused on understanding the mechanisms of esophageal injury, repair, and inflammation. Her work is supported by both federal and private funding. Dr. Shaker has authored several articles in peer-reviewed journals and serves as a mentor to physicians in training interested in gastrointestinal research.

Dr. Shaker earned her medical degree from Medical College of Wisconsin. She then performed her internship and residency at Brown University- Rhode Island Hospital, followed by a Gastroenterology Fellowship at Washington University School of Medicine- Barnes Jewish Hospital.

Lab site: https://sites.usc.edu/shakerlab/

Awards

  • Association of American Medical Colleges: Early Career Women Faculty Professional Development Seminar, 2011
  • American Gastroenterology Association: Women’s Leadership Conference, 2015

Research Funding

  • The role of esophageal myofibroblasts in alcohol related esophageal squamous cell carcinoma.
    NIH · R21AA028891 · Mar 15, 2021 – Feb 29, 2024 · Role: Principal Investigator
  • The role of human esophageal myofibroblasts in regulating the epithelial response in GERD
    NIH · R01DK118065 · Sep 12, 2019 – May 31, 2025 · Role: Principal Investigator
  • Epithelial-stromal cross-talk in esophageal inflammation and carcinogenesis.
    NIH · R03CA198692 · Aug 1, 2015 – Jul 31, 2018 · Role: Principal Investigator
  • EPIMORPHIN DELETION ALTERS STEM CELL NICHE MYOFIBROBLAST SECRETION
    NIH · K08CA153036 · Jul 1, 2011 – Jan 31, 2018 · Role: Principal Investigator

Publications

  • Advancing Gastro Hep Advances: Building on Success, Looking Forward! Gastro Hep Adv. 2026; 5(8):101019. Shaker A , Associate Editors, Elsaid MI, Garcia MS, Gutierrez A, Peterson K, Jain AS, Schumacher . View in PubMed
  • Association of Foregut Testing and Intervention on Lung Transplant Outcomes. J Clin Gastroenterol. 2026 Mar 18.. View in PubMed
  • Transient Loss of Esophageal Striated Muscle Contractility After Cricopharyngeal Botulinum Toxin Injection for Retrograde Cricopharyngeal Dysfunction. Gastro Hep Adv. 2026; 5(5):100925.. View in PubMed
  • Prevalence of Eosinophilic Esophagitis Among Ethnic Groups in a Private Vs a Safety Net-Hospital in Southern California. Gastro Hep Adv. 2026; 5(2):100840.. View in PubMed
  • Gastroesophageal reflux disease related to laparoscopic sleeve gastrectomy. Mini Invasive Surg. 2025; 9.. View in PubMed
  • Physiologic and molecular effects of alcohol in the esophagus: a narrative review. Ann Esophagus. 2025 Jun 30; 8.. View in PubMed
  • Differential Contributions of Fibroblast Subpopulations to Intercellular Communication in Eosinophilic Esophagitis. Biology (Basel). 2024 Jun 21; 13(7).. View in PubMed
  • Esophageal remodeling in eosinophilic esophagitis. Curr Opin Gastroenterol. 2024 Jul 01; 40(4):291-298.. View in PubMed
  • The Travels of Signet-Ring Cell Carcinoma: From Colon to Stomach and Duodenum. ACG Case Rep J. 2023 Dec; 10(12):e01239.. View in PubMed
  • Direct and indirect effects of alcohol and its toxic metabolite acetaldehyde on human esophageal myofibroblasts and epithelial cells. Alcohol Clin Exp Res (Hoboken). 2023 Jul; 47(7):1297-1311.. View in PubMed