Keck School Faculty

Anna H Wu

Anna H Wu

Professor of Population and Public Health Sciences
Medicine
NOR 4443 1441 Eastlake Avenue Health Sciences Campus Los Angeles

Urinary phthalate exposures and risk of breast cancer: the Multiethnic Cohort study Breast Cancer Res. 2021 04 06; 23(1):44. . View in PubMed

Association between Airport-Related Ultrafine Particles and Risk of Malignant Brain Cancer: A Multiethnic Cohort Study Cancer Res. 2021 08 15; 81(16):4360-4369. . View in PubMed

Association between ambient air pollution and breast cancer risk: The multiethnic cohort study Int J Cancer. 2020 02 01; 146(3):699-711. . View in PubMed

Ovarian Cancer in Women of African Ancestry (OCWAA) consortium: a resource of harmonized data from eight epidemiologic studies of African American and white women Cancer Causes Control. 2019 Sep; 30(9):967-978. . View in PubMed

Correction to: Genetic variant predictors of gene expression provide new insight into risk of colorectal cancer Hum Genet. 2019 Jul; 138(7):789-791. . View in PubMed

Joint exposure to smoking, excessive weight, and physical inactivity and survival of ovarian cancer patients, evidence from the Ovarian Cancer Association Consortium Cancer Causes Control. 2019 May; 30(5):537-547. . View in PubMed

Genetic variant predictors of gene expression provide new insight into risk of colorectal cancer Hum Genet. 2019 Apr; 138(4):307-326. . View in PubMed

No Association Between Vitamin D Status and Risk of Barrett's Esophagus or Esophageal Adenocarcinoma: A Mendelian Randomization StudyClin Gastroenterol Hepatol. 2019 10; 17(11):2227-2235. e1. . View in PubMed

The functional ALDH2 polymorphism is associated with breast cancer risk: A pooled analysis from the Breast Cancer Association Consortium Mol Genet Genomic Med. 2019 06; 7(6):e707. . View in PubMed

Evaluation of vitamin D biosynthesis and pathway target genes reveals UGT2A1/2 and EGFR polymorphisms associated with epithelial ovarian cancer in African American Women Cancer Med. 2019 05; 8(5):2503-2513. . View in PubMed

A Pooled Analysis of Breastfeeding and Breast Cancer Risk by Hormone Receptor Status in Parous Hispanic Women Epidemiology. 2019 05; 30(3):449-457. . View in PubMed

Discovery of common and rare genetic risk variants for colorectal cancer Nat Genet. 2019 01; 51(1):76-87. . View in PubMed

Association between genetically predicted polycystic ovary syndrome and ovarian cancer: a Mendelian randomization study Int J Epidemiol. 2019 06 01; 48(3):822-830. . View in PubMed

Green Tea Catechin Extract Supplementation Does Not Influence Circulating Sex Hormones and Insulin-Like Growth Factor Axis Proteins in a Randomized Controlled Trial of Postmenopausal Women at High Risk of Breast Cancer J Nutr. 2019 04 01; 149(4):619-627. . View in PubMed

A comprehensive gene-environment interaction analysis in Ovarian Cancer using genome-wide significant common variants Int J Cancer. 2019 05 01; 144(9):2192-2205. . View in PubMed

Body mass index, comorbidities, and hormonal factors in relation to meningioma in an ethnically diverse population: the Multiethnic Cohort Neuro Oncol. 2019 03 18; 21(4):498-507. . View in PubMed

The genetic interplay between body mass index, breast size and breast cancer risk: a Mendelian randomization analysis Int J Epidemiol. 2019 06 01; 48(3):781-794. . View in PubMed

Shared heritability and functional enrichment across six solid cancers Nat Commun. 2019 01 25; 10(1):431. . View in PubMed

Genetic Data from Nearly 63,000 Women of European Descent Predicts DNA Methylation Biomarkers and Epithelial Ovarian Cancer Risk Cancer Res. 2019 02 01; 79(3):505-517. . View in PubMed

Mendelian randomization analysis of C-reactive protein on colorectal cancer risk Int J Epidemiol. 2019 06 01; 48(3):767-780. . View in PubMed

Evaluation of Medicare Claims Data as a Tool to Identify Dementia J Alzheimers Dis. 2019; 67(2):769-778. . View in PubMed

Novel Common Genetic Susceptibility Loci for Colorectal Cancer J Natl Cancer Inst. 2019 02 01; 111(2):146-157. . View in PubMed

Growth factor genes and change in mammographic density after stopping combined hormone therapy in the California Teachers Study BMC Cancer. 2018 Nov 06; 18(1):1072. . View in PubMed

Ovarian cancer risk, ALDH2 polymorphism and alcohol drinking: Asian data from the Ovarian Cancer Association Consortium Cancer Sci. 2018 Feb; 109(2):435-445. . View in PubMed

Interactions Between Genetic Variants and Environmental Factors Affect Risk of Esophageal Adenocarcinoma and Barrett's EsophagusClin Gastroenterol Hepatol. 2018 10; 16(10):1598-1606. e4. . View in PubMed

Mendelian randomisation study of age at menarche and age at menopause and the risk of colorectal cancer Br J Cancer. 2018 06; 118(12):1639-1647. . View in PubMed

Adult height is associated with increased risk of ovarian cancer: a Mendelian randomisation study Br J Cancer. 2018 04; 118(8):1123-1129. . View in PubMed

Prognostic impact of FOXF1 polymorphisms in gastric cancer patients Pharmacogenomics J. 2018 04; 18(2):262-269. . View in PubMed

Determining Risk of Barrett's Esophagus and Esophageal Adenocarcinoma Based on Epidemiologic Factors and Genetic VariantsGastroenterology. 2018 04; 154(5):1273-1281. e3. . View in PubMed

Polycystic Ovary Syndrome, Oligomenorrhea, and Risk of Ovarian Cancer Histotypes: Evidence from the Ovarian Cancer Association Consortium Cancer Epidemiol Biomarkers Prev. 2018 02; 27(2):174-182. . View in PubMed

Determinants of prolactin in postmenopausal Chinese women in Singapore Cancer Causes Control. 2018 01; 29(1):51-62. . View in PubMed

Variants in genes encoding small GTPases and association with epithelial ovarian cancer susceptibility PLoS One. 2018; 13(7):e0197561. . View in PubMed

rs495139 in the TYMS-ENOSF1 Region and Risk of Ovarian Carcinoma of Mucinous Histology Int J Mol Sci. 2018 08 21; 19(9). . View in PubMed

Menstrual pain and risk of epithelial ovarian cancer: Results from the Ovarian Cancer Association Consortium Int J Cancer. 2018 02 01; 142(3):460-469. . View in PubMed

Long-Term Ambient Temperature and Externalizing Behaviors in Adolescents Am J Epidemiol. 2018 09 01; 187(9):1931-1941. . View in PubMed

Racial/ethnic differences in the epidemiology of ovarian cancer: a pooled analysis of 12 case-control studies Int J Epidemiol. 2018 04 01; 47(2):460-472. . View in PubMed

Reproductive history, breast-feeding and risk of triple negative breast cancer: The Breast Cancer Etiology in Minorities (BEM) study Int J Cancer. 2018 06 01; 142(11):2273-2285. . View in PubMed

Robust Tests for Additive Gene-Environment Interaction in Case-Control Studies Using Gene-Environment Independence Am J Epidemiol. 2018 02 01; 187(2):366-377. . View in PubMed

A Transcriptome-Wide Association Study Among 97,898 Women to Identify Candidate Susceptibility Genes for Epithelial Ovarian Cancer Risk Cancer Res. 2018 09 15; 78(18):5419-5430. . View in PubMed

Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer Nat Genet. 2017 Dec; 49(12):1767-1778. . View in PubMed

A Randomized Controlled Trial of Green Tea Extract Supplementation and Mammographic Density in Postmenopausal Women at Increased Risk of Breast Cancer Cancer Prev Res (Phila). 2017 Dec; 10(12):710-718. . View in PubMed

Reproductive profiles and risk of breast cancer subtypes: a multi-center case-only study Breast Cancer Res. 2017 Nov 07; 19(1):119. . View in PubMed

Effect of Green Tea Supplements on Liver Enzyme Elevation: Results from a Randomized Intervention Study in the United States Cancer Prev Res (Phila). 2017 Oct; 10(10):571-579. . View in PubMed

Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer Nat Genet. 2017 May; 49(5):680-691. . View in PubMed

Use of common analgesic medications and ovarian cancer survival: results from a pooled analysis in the Ovarian Cancer Association Consortium Br J Cancer. 2017 Apr 25; 116(9):1223-1228. . View in PubMed

Enrichment of putative PAX8 target genes at serous epithelial ovarian cancer susceptibility loci Br J Cancer. 2017 Feb 14; 116(4):524-535. . View in PubMed

Genetic variations in immunomodulatory pathways to predict survival in patients with locoregional gastric cancer Pharmacogenomics J. 2017 12; 17(6):528-534. . View in PubMed

Germline variation in inflammation-related pathways and risk of Barrett's oesophagus and oesophageal adenocarcinoma Gut. 2017 10; 66(10):1739-1747. . View in PubMed

History of Comorbidities and Survival of Ovarian Cancer Patients, Results from the Ovarian Cancer Association Consortium Cancer Epidemiol Biomarkers Prev. 2017 09; 26(9):1470-1473. . View in PubMed

Stomach Cancer Disparity among Korean Americans by Tumor Characteristics: Comparison with Non-Hispanic Whites, Japanese Americans, South Koreans, and Japanese Cancer Epidemiol Biomarkers Prev. 2017 04; 26(4):587-596. . View in PubMed

No Evidence That Genetic Variation in the Myeloid-Derived Suppressor Cell Pathway Influences Ovarian Cancer Survival Cancer Epidemiol Biomarkers Prev. 2017 03; 26(3):420-424. . View in PubMed

Estrogen receptor-beta genetic variations and overall survival in patients with locally advanced gastric cancer Pharmacogenomics J. 2017 01; 17(1):36-41. . View in PubMed

BRCA2 Hypomorphic Missense Variants Confer Moderate Risks of Breast Cancer Cancer Res. 2017 06 01; 77(11):2789-2799. . View in PubMed

A pooled analysis of dietary sugar/carbohydrate intake and esophageal and gastric cardia adenocarcinoma incidence and survival in the USA Int J Epidemiol. 2017 12 01; 46(6):1836-1846. . View in PubMed

Association analysis identifies 65 new breast cancer risk loci Nature. 2017 11 02; 551(7678):92-94. . View in PubMed

Evaluating genetic variants associated with breast cancer risk in high and moderate-penetrance genes in Asians Carcinogenesis. 2017 05 01; 38(5):511-518. . View in PubMed

Timing of births and oral contraceptive use influences ovarian cancer risk Int J Cancer. 2017 12 15; 141(12):2392-2399. . View in PubMed

Metabolic conditions and breast cancer risk among Los Angeles County Filipina Americans compared with Chinese and Japanese Americans Int J Cancer. 2017 12 15; 141(12):2450-2461. . View in PubMed

Cigarette smoking is associated with adverse survival among women with ovarian cancer: Results from a pooled analysis of 19 studies Int J Cancer. 2017 06 01; 140(11):2422-2435. . View in PubMed

A splicing variant of TERT identified by GWAS interacts with menopausal estrogen therapy in risk of ovarian cancer Int J Cancer. 2016 Dec 15; 139(12):2646-2654. . View in PubMed

Evidence that the 5p12 Variant rs10941679 Confers Susceptibility to Estrogen-Receptor-Positive Breast Cancer through FGF10 and MRPS30 Regulation Am J Hum Genet. 2016 Oct 06; 99(4):903-911. . View in PubMed

Genome-wide association studies in oesophageal adenocarcinoma and Barrett's oesophagus: a large-scale meta-analysis Lancet Oncol. 2016 Oct; 17(10):1363-1373. . View in PubMed

Fine-scale mapping of 8q24 locus identifies multiple independent risk variants for breast cancer Int J Cancer. 2016 Sep 15; 139(6):1303-1317. . View in PubMed

Reproductive factors, hormone use and gastric cancer risk: The Singapore Chinese Health Study Int J Cancer. 2016 Jun 15; 138(12):2837-45. . View in PubMed

The Effect of Reduced Dietary Fat and Soy Supplementation on Circulating Adipocytokines in Postmenopausal Women: A Randomized Controlled 2-Month Trial Nutr Cancer. 2016 May-Jun; 68(4):554-9. . View in PubMed

Breast cancer risk variants at 6q25 display different phenotype associations and regulate ESR1, RMND1 and CCDC170 Nat Genet. 2016 Apr; 48(4):374-86. . View in PubMed

The association between socioeconomic status and tumour stage at diagnosis of ovarian cancer: A pooled analysis of 18 case-control studies Cancer Epidemiol. 2016 Apr; 41:71-9. . View in PubMed

Validation of self-reported comorbidity status of breast cancer patients with medical records: the California Breast Cancer Survivorship Consortium (CBCSC) Cancer Causes Control. 2016 Mar; 27(3):391-401. . View in PubMed

Polymorphisms in genes in the androgen pathway and risk of Barrett's esophagus and esophageal adenocarcinoma Int J Cancer. 2016 Mar 01; 138(5):1146-52. . View in PubMed

Investigation of Exomic Variants Associated with Overall Survival in Ovarian Cancer Cancer Epidemiol Biomarkers Prev. 2016 Mar; 25(3):446-54. . View in PubMed

A targeted genetic association study of epithelial ovarian cancer susceptibility Oncotarget. 2016 Feb 16; 7(7):7381-9. . View in PubMed

Effects of green tea catechin extract on serum lipids in postmenopausal women: a randomized, placebo-controlled clinical trial Am J Clin Nutr. 2016 12; 104(6):1671-1682. . View in PubMed

Traditional Breast Cancer Risk Factors in Filipina Americans Compared with Chinese and Japanese Americans in Los Angeles County Cancer Epidemiol Biomarkers Prev. 2016 12; 25(12):1572-1586. . View in PubMed

PALB2, CHEK2 and ATM rare variants and cancer risk: data from COGS J Med Genet. 2016 12; 53(12):800-811. . View in PubMed

Association of vitamin D levels and risk of ovarian cancer: a Mendelian randomization study Int J Epidemiol. 2016 10; 45(5):1619-1630. . View in PubMed

Leukocyte telomere length in relation to the risk of Barrett's esophagus and esophageal adenocarcinoma Cancer Med. 2016 09; 5(9):2657-65. . View in PubMed

Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types Cancer Discov. 2016 09; 6(9):1052-67. . View in PubMed

Assessing the genetic architecture of epithelial ovarian cancer histological subtypes Hum Genet. 2016 07; 135(7):741-56. . View in PubMed

The Effect of Patient and Contextual Characteristics on Racial/Ethnic Disparity in Breast Cancer Mortality Cancer Epidemiol Biomarkers Prev. 2016 07; 25(7):1064-72. . View in PubMed

Chronic Recreational Physical Inactivity and Epithelial Ovarian Cancer Risk: Evidence from the Ovarian Cancer Association Consortium Cancer Epidemiol Biomarkers Prev. 2016 07; 25(7):1114-24. . View in PubMed

Environmental Determinants of Aggression in Adolescents: Role of Urban Neighborhood Greenspace J Am Acad Child Adolesc Psychiatry. 2016 07; 55(7):591-601. . View in PubMed

Adult body mass index and risk of ovarian cancer by subtype: a Mendelian randomization study Int J Epidemiol. 2016 06; 45(3):884-95. . View in PubMed

Assessment of Multifactor Gene-Environment Interactions and Ovarian Cancer Risk: Candidate Genes, Obesity, and Hormone-Related Risk Factors Cancer Epidemiol Biomarkers Prev. 2016 05; 25(5):780-90. . View in PubMed

No clinical utility of KRAS variant rs61764370 for ovarian or breast cancer Gynecol Oncol. 2016 05; 141(2):386-401. . View in PubMed

No evidence that protein truncating variants in BRIP1 are associated with breast cancer risk: implications for gene panel testing J Med Genet. 2016 05; 53(5):298-309. . View in PubMed

Association Between Menopausal Estrogen-Only Therapy and Ovarian Carcinoma Risk Obstet Gynecol. 2016 05; 127(5):828-836. . View in PubMed

Inherited variants affecting RNA editing may contribute to ovarian cancer susceptibility: results from a large-scale collaboration Oncotarget. 2016 11 08; 7(45):72381-72394. . View in PubMed

An intergenic risk locus containing an enhancer deletion in 2q35 modulates breast cancer risk by deregulating IGFBP5 expression Hum Mol Genet. 2016 09 01; 25(17):3863-3876. . View in PubMed

Age-specific risk factor profiles of adenocarcinomas of the esophagus: A pooled analysis from the international BEACON consortium Int J Cancer. 2016 Jan 01; 138(1):55-64. . View in PubMed

Exome genotyping arrays to identify rare and low frequency variants associated with epithelial ovarian cancer risk Hum Mol Genet. 2016 08 15; 25(16):3600-3612. . View in PubMed

Assessment of variation in immunosuppressive pathway genes reveals TGFBR2 to be associated with risk of clear cell ovarian cancer Oncotarget. 2016 10 25; 7(43):69097-69110. . View in PubMed

Prediction of breast cancer risk based on common genetic variants in women of East Asian ancestry Breast Cancer Res. 2016 12 08; 18(1):124. . View in PubMed

Identification of independent association signals and putative functional variants for breast cancer risk through fine-scale mapping of the 12p11 locus Breast Cancer Res. 2016 06 21; 18(1):64. . View in PubMed

rs2735383, located at a microRNA binding site in the 3'UTR of NBS1, is not associated with breast cancer risk Sci Rep. 2016 11 15; 6:36874. . View in PubMed

Recreational physical inactivity and mortality in women with invasive epithelial ovarian cancer: evidence from the Ovarian Cancer Association Consortium Br J Cancer. 2016 06 28; 115(1):95-101. . View in PubMed

Fine-Mapping of the 1p112 Breast Cancer Susceptibility Locus. PLoS One. 2016; 11(8):e0160316. . View in PubMed

Fine scale mapping of the 17q22 breast cancer locus using dense SNPs, genotyped within the Collaborative Oncological Gene-Environment Study (COGs) Sci Rep. 2016 09 07; 6:32512. . View in PubMed

Functional mechanisms underlying pleiotropic risk alleles at the 19p131 breast-ovarian cancer susceptibility locus. Nat Commun. 2016 09 07; 7:12675. . View in PubMed

Intersection of Race/Ethnicity and Socioeconomic Status in Mortality After Breast Cancer J Community Health. 2015 Dec; 40(6):1287-99. . View in PubMed

Epithelial-Mesenchymal Transition (EMT) Gene Variants and Epithelial Ovarian Cancer (EOC) Risk Genet Epidemiol. 2015 Dec; 39(8):689-97. . View in PubMed

Genome-wide Analysis Identifies Novel Loci Associated with Ovarian Cancer Outcomes: Findings from the Ovarian Cancer Association Consortium Clin Cancer Res. 2015 Dec 01; 21(23):5264-76. . View in PubMed

Pleiotropic analysis of cancer risk loci on esophageal adenocarcinoma risk Cancer Epidemiol Biomarkers Prev. 2015 Nov; 24(11):1801-3. . View in PubMed

A newly identified susceptibility locus near FOXP1 modifies the association of gastroesophageal reflux with Barrett's esophagus Cancer Epidemiol Biomarkers Prev. 2015 Nov; 24(11):1739-47. . View in PubMed

Common variants at the CHEK2 gene locus and risk of epithelial ovarian cancer Carcinogenesis. 2015 Nov; 36(11):1341-53. . View in PubMed

Fine-scale mapping of the 4q24 locus identifies two independent loci associated with breast cancer risk Cancer Epidemiol Biomarkers Prev. 2015 Nov; 24(11):1680-91. . View in PubMed

Shared genetics underlying epidemiological association between endometriosis and ovarian cancer Hum Mol Genet. 2015 Oct 15; 24(20):5955-64. . View in PubMed

Double-Blind Randomized 12-Month Soy Intervention Had No Effects on Breast MRI Fibroglandular Tissue Density or Mammographic Density Cancer Prev Res (Phila). 2015 Oct; 8(10):942-51. . View in PubMed

Network-Based Integration of GWAS and Gene Expression Identifies a HOX-Centric Network Associated with Serous Ovarian Cancer Risk Cancer Epidemiol Biomarkers Prev. 2015 Oct; 24(10):1574-84. . View in PubMed

The Minnesota Green Tea Trial (MGTT), a randomized controlled trial of the efficacy of green tea extract on biomarkers of breast cancer risk: study rationale, design, methods, and participant characteristics Cancer Causes Control. 2015 Oct; 26(10):1405-19. . View in PubMed

Cis-eQTL analysis and functional validation of candidate susceptibility genes for high-grade serous ovarian cancer Nat Commun. 2015 Sep 22; 6:8234. . View in PubMed

The safety of green tea extract supplementation in postmenopausal women at risk for breast cancer: results of the Minnesota Green Tea Trial Food Chem Toxicol. 2015 Sep; 83:26-35. . View in PubMed

Obesity and survival among women with ovarian cancer: results from the Ovarian Cancer Association Consortium Br J Cancer. 2015 Sep 01; 113(5):817-26. . View in PubMed

Contribution of the neighborhood environment and obesity to breast cancer survival: the California Breast Cancer Survivorship Consortium Cancer Epidemiol Biomarkers Prev. 2015 Aug; 24(8):1282-90. . View in PubMed

Polymorphisms in a Putative Enhancer at the 10q212 Breast Cancer Risk Locus Regulate NRBF2 Expression. Am J Hum Genet. 2015 Jul 02; 97(1):22-34. . View in PubMed

African Americans and Hispanics Remain at Lower Risk of Ovarian Cancer Than Non-Hispanic Whites after Considering Nongenetic Risk Factors and Oophorectomy Rates Cancer Epidemiol Biomarkers Prev. 2015 Jul; 24(7):1094-100. . View in PubMed

Enhanced GAB2 Expression Is Associated with Improved Survival in High-Grade Serous Ovarian Cancer and Sensitivity to PI3K Inhibition Mol Cancer Ther. 2015 Jun; 14(6):1495-503. . View in PubMed

Fine-mapping identifies two additional breast cancer susceptibility loci at 9q312. Hum Mol Genet. 2015 May 15; 24(10):2966-84. . View in PubMed

Population distribution of lifetime risk of ovarian cancer in the United States Cancer Epidemiol Biomarkers Prev. 2015 Apr; 24(4):671-676. . View in PubMed

Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer Nat Genet. 2015 Apr; 47(4):373-80. . View in PubMed

Evaluating the ovarian cancer gonadotropin hypothesis: a candidate gene study Gynecol Oncol. 2015 Mar; 136(3):542-8. . View in PubMed

Polymorphisms near TBX5 and GDF7 are associated with increased risk for Barrett's esophagus Gastroenterology. 2015 Feb; 148(2):367-78. . View in PubMed

Diabetes and other comorbidities in breast cancer survival by race/ethnicity: the California Breast Cancer Survivorship Consortium (CBCSC) Cancer Epidemiol Biomarkers Prev. 2015 Feb; 24(2):361-8. . View in PubMed

Identification of six new susceptibility loci for invasive epithelial ovarian cancer Nat Genet. 2015 Feb; 47(2):164-71. . View in PubMed

Fine-scale mapping of the 5q112 breast cancer locus reveals at least three independent risk variants regulating MAP3K1. Am J Hum Genet. 2015 Jan 08; 96(1):5-20. . View in PubMed

Common Genetic Variation In Cellular Transport Genes and Epithelial Ovarian Cancer (EOC) Risk PLoS One. 2015; 10(6):e0128106. . View in PubMed

MiRNA-Related SNPs and Risk of Esophageal Adenocarcinoma and Barrett's Esophagus: Post Genome-Wide Association Analysis in the BEACON Consortium PLoS One. 2015; 10(6):e0128617. . View in PubMed

Identification and characterization of novel associations in the CASP8/ALS2CR12 region on chromosome 2 with breast cancer risk Hum Mol Genet. 2015 Jan 01; 24(1):285-98. . View in PubMed

Polymorphisms in Genes of Relevance for Oestrogen and Oxytocin Pathways and Risk of Barrett's Oesophagus and Oesophageal Adenocarcinoma: A Pooled Analysis from the BEACON Consortium PLoS One. 2015; 10(9):e0138738. . View in PubMed

Common Genetic Variation in Circadian Rhythm Genes and Risk of Epithelial Ovarian Cancer (EOC) J Genet Genome Res. 2015; 2(2). . View in PubMed

Hormone metabolism pathway genes and mammographic density change after quitting estrogen and progestin combined hormone therapy in the California Teachers Study Breast Cancer Res. 2014 Dec 11; 16(6):477. . View in PubMed

Integrative post-genome-wide association analysis of CDKN2A and TP53 SNPs and risk of esophageal adenocarcinoma Carcinogenesis. 2014 Dec; 35(12):2740-7. . View in PubMed

Common non-synonymous SNPs associated with breast cancer susceptibility: findings from the Breast Cancer Association Consortium Hum Mol Genet. 2014 Nov 15; 23(22):6096-111. . View in PubMed

Obesity and risk of esophageal adenocarcinoma and Barrett's esophagus: a Mendelian randomization study J Natl Cancer Inst. 2014 Nov; 106(11). . View in PubMed

Risk of esophageal adenocarcinoma decreases with height, based on consortium analysis and confirmed by Mendelian randomizationClin Gastroenterol Hepatol. 2014 Oct; 12(10):1667-76. e1. . View in PubMed

Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation Nat Commun. 2014 Sep 23; 4:4999. . View in PubMed

Cancer Epidemiol Biomarkers Prev. 2014 Jul; 23(7):1421-7. . View in PubMed

Genetic variation at CYP3A is associated with age at menarche and breast cancer risk: a case-control study Breast Cancer Res. 2014 May 26; 16(3):R51. . View in PubMed

Family history of cancer and gastroesophageal disorders and risk of esophageal and gastric adenocarcinomas: a case-control study BMC Cancer. 2014 Feb 04; 14:60. . View in PubMed

Gastroesophageal reflux in relation to adenocarcinomas of the esophagus: a pooled analysis from the Barrett's and Esophageal Adenocarcinoma Consortium (BEACON) PLoS One. 2014; 9(7):e103508. . View in PubMed

The California Breast Cancer Survivorship Consortium (CBCSC): prognostic factors associated with racial/ethnic differences in breast cancer survival Cancer Causes Control. 2013 Oct; 24(10):1821-36. . View in PubMed

Combined and interactive effects of environmental and GWAS-identified risk factors in ovarian cancer Cancer Epidemiol Biomarkers Prev. 2013 May; 22(5):880-90. . View in PubMed

Hormone metabolism genes and mammographic density in Singapore Chinese women Cancer Epidemiol Biomarkers Prev. 2013 May; 22(5):984-6. . View in PubMed

Genetic variation in transforming growth factor beta 1 and mammographic density in Singapore Chinese women Cancer Res. 2013 Mar 15; 73(6):1876-82. . View in PubMed

Sleep duration, spot urinary 6-sulfatoxymelatonin levels and risk of breast cancer among Chinese women in Singapore Int J Cancer. 2013 Feb 15; 132(4):891-6. . View in PubMed

Soy isoflavones and breast cancer Am Soc Clin Oncol Educ Book. 2013; 102-6. . View in PubMed

Variation in inflammatory cytokine/growth-factor genes and mammographic density in premenopausal women aged 50-55 PLoS One. 2013; 8(6):e65313. . View in PubMed

Epigenetic analysis leads to identification of HNF1B as a subtype-specific susceptibility gene for ovarian cancer Nat Commun. 2013; 4:1628. . View in PubMed

Biological effects of green tea capsule supplementation in pre-surgery postmenopausal breast cancer patients Front Oncol. 2013; 3:298. . View in PubMed

Diabetes and risk of esophageal and gastric adenocarcinomas Int J Cancer. 2012 Sep 15; 131(6):1417-22. . View in PubMed

Lowering oral contraceptive norethindrone dose increases estrogen and progesterone receptor levels with no reduction in proliferation of breast epithelium: a randomized trial Contraception. 2012 Sep; 86(3):238-43. . View in PubMed

Breast epithelial cell proliferation is markedly increased with short-term high levels of endogenous estrogen secondary to controlled ovarian hyperstimulation Breast Cancer Res Treat. 2012 Apr; 132(2):653-60. . View in PubMed

Genetic variation in peroxisome proliferator-activated receptor gamma, soy, and mammographic density in Singapore Chinese women Cancer Epidemiol Biomarkers Prev. 2012 Apr; 21(4):635-44. . View in PubMed

Association between endometriosis and risk of histological subtypes of ovarian cancer: a pooled analysis of case-control studies Lancet Oncol. 2012 Apr; 13(4):385-94. . View in PubMed

Effect of 2-month controlled green tea intervention on lipoprotein cholesterol, glucose, and hormone levels in healthy postmenopausal women Cancer Prev Res (Phila). 2012 Mar; 5(3):393-402. . View in PubMed

Invasive breast cancer incidence trends by detailed race/ethnicity and age Int J Cancer. 2012 Jan 15; 130(2):395-404. . View in PubMed

Birth weight and other prenatal factors and risk of breast cancer in Asian-Americans Breast Cancer Res Treat. 2011 Dec; 130(3):917-25. . View in PubMed

Soy food supplementation, dietary fat reduction and peripheral blood gene expression in postmenopausal women--a randomized, controlled trial Mol Nutr Food Res. 2011 Sep; 55 Suppl 2:S264-77. . View in PubMed

Genetic variation in insulin-like growth factor 2 may play a role in ovarian cancer risk Hum Mol Genet. 2011 Jun 01; 20(11):2263-72. . View in PubMed

Green tea and breast cancer Mol Nutr Food Res. 2011 Jun; 55(6):921-30. . View in PubMed

Epigenetic subgroups of esophageal and gastric adenocarcinoma with differential GATA5 DNA methylation associated with clinical and lifestyle factors PLoS One. 2011; 6(10):e25985. . View in PubMed

Generalizability and epidemiologic characterization of eleven colorectal cancer GWAS hits in multiple populations Cancer Epidemiol Biomarkers Prev. 2011 Jan; 20(1):70-81. . View in PubMed

Anthropometric, dietary, and hormonal correlates of serum adiponectin in Asian American women Nutr Cancer. 2011; 63(4):549-57. . View in PubMed

Genome-scale screen for DNA methylation-based detection markers for ovarian cancer PLoS One. 2011; 6(12):e28141. . View in PubMed

Hormone therapy, DNA methylation and colon cancer Carcinogenesis. 2010 Jun; 31(6):1060-7. . View in PubMed

Progesterone and estrogen receptors in pregnant and premenopausal non-pregnant normal human breast Breast Cancer Res Treat. 2009 Nov; 118(1):161-8. . View in PubMed

Dietary patterns and breast cancer risk in Asian American women Am J Clin Nutr. 2009 Apr; 89(4):1145-54. . View in PubMed

Markers of inflammation and risk of ovarian cancer in Los Angeles County Int J Cancer. 2009 Mar 15; 124(6):1409-15. . View in PubMed

Increased ovarian cancer risk associated with menopausal estrogen therapy is reduced by adding a progestin Cancer. 2009 Feb 01; 115(3):531-9. . View in PubMed

Validating genetic risk associations for ovarian cancer through the international Ovarian Cancer Association Consortium Br J Cancer. 2009 Jan 27; 100(2):412-20. . View in PubMed

Green tea, soy, and mammographic density in Singapore Chinese women Cancer Epidemiol Biomarkers Prev. 2008 Dec; 17(12):3358-65. . View in PubMed

Consortium analysis of 7 candidate SNPs for ovarian cancer Int J Cancer. 2008 Jul 15; 123(2):380-388. . View in PubMed

Soy intake and breast cancer risk in Singapore Chinese Health Study Br J Cancer. 2008 Jul 08; 99(1):196-200. . View in PubMed

Sleep duration, melatonin and breast cancer among Chinese women in Singapore Carcinogenesis. 2008 Jun; 29(6):1244-8. . View in PubMed

Comprehensive association testing of common genetic variation in DNA repair pathway genes in relationship with breast cancer risk in multiple populations Hum Mol Genet. 2008 Mar 15; 17(6):825-34. . View in PubMed

Comprehensive evaluation of ESR2 variation and ovarian cancer risk Cancer Epidemiol Biomarkers Prev. 2008 Feb; 17(2):393-6. . View in PubMed

Progesterone receptor variation and risk of ovarian cancer is limited to the invasive endometrioid subtype: results from the Ovarian Cancer Association Consortium pooled analysis Br J Cancer. 2008 Jan 29; 98(2):282-8. . View in PubMed

Epidemiology of soy exposures and breast cancer risk Br J Cancer. 2008 Jan 15; 98(1):9-14. . View in PubMed

Fiber intake and risk of adenocarcinomas of the esophagus and stomach Cancer Causes Control. 2007 Sep; 18(7):713-22. . View in PubMed

A common genetic risk factor for colorectal and prostate cancer Nat Genet. 2007 Aug; 39(8):954-6. . View in PubMed

Tamoxifen, soy, and lifestyle factors in Asian American women with breast cancer J Clin Oncol. 2007 Jul 20; 25(21):3024-30. . View in PubMed

Diabetes and risk of breast cancer in Asian-American women Carcinogenesis. 2007 Jul; 28(7):1561-6. . View in PubMed

Body size, hormone therapy and risk of breast cancer in Asian-American women Int J Cancer. 2007 Feb 15; 120(4):844-52. . View in PubMed

Estrogens, progestins, and risk of breast cancer Ernst Schering Found Symp Proc. 2007; (1):127-50. . View in PubMed

Occupational physical activity and risk of adenocarcinomas of the esophagus and stomach Int J Cancer. 2006 Feb 15; 118(4):1004-9. . View in PubMed

Tea, hormone-related cancers and endogenous hormone levels Mol Nutr Food Res. 2006 Feb; 50(2):160-9. . View in PubMed

Dense breast stromal tissue shows greatly increased concentration of breast epithelium but no increase in its proliferative activity Breast Cancer Res. 2006; 8(2):R24. . View in PubMed

Associations between soy, diet, reproductive factors, and mammographic density in Singapore Chinese women Nutr Cancer. 2006; 56(2):128-35. . View in PubMed

Etiologic clues from the similarity of histology-specific trends in esophageal and lung cancers Cancer Causes Control. 2005 Nov; 16(9):1065-74. . View in PubMed

Tea and circulating estrogen levels in postmenopausal Chinese women in Singapore Carcinogenesis. 2005 May; 26(5):976-80. . View in PubMed

A controlled 2-mo dietary fat reduction and soy food supplementation study in postmenopausal women Am J Clin Nutr. 2005 May; 81(5):1133-41. . View in PubMed

Clarifying the PROGINS allele association in ovarian and breast cancer risk: a haplotype-based analysis J Natl Cancer Inst. 2005 Jan 05; 97(1):51-9. . View in PubMed

Greatly increased occurrence of breast cancers in areas of mammographically dense tissue Breast Cancer Res. 2005; 7(5):R605-8. . View in PubMed

Prevention of cancers of the breast, endometrium and ovary Oncogene. 2004 Aug 23; 23(38):6379-91. . View in PubMed

Hormonal factors and the risk of invasive ovarian cancer: a population-based case-control study Fertil Steril. 2004 Jul; 82(1):186-95. . View in PubMed

Does mammographic density reflect ethnic differences in breast cancer incidence rates? Am J Epidemiol. 2004 Jan 15; 159(2):140-7.. View in PubMed

Plasma isoflavone levels versus self-reported soy isoflavone levels in Asian-American women in Los Angeles County Carcinogenesis. 2004 Jan; 25(1):77-81. . View in PubMed

Tea intake, COMT genotype, and breast cancer in Asian-American women Cancer Res. 2003 Nov 01; 63(21):7526-9. . View in PubMed

Green tea and risk of breast cancer in Asian Americans Int J Cancer. 2003 Sep 10; 106(4):574-579. . View in PubMed

Hiatal hernia, reflux symptoms, body size, and risk of esophageal and gastric adenocarcinoma Cancer. 2003 Sep 01; 98(5):940-8. . View in PubMed

Physical activity and breast cancer risk among Asian-American women in Los Angeles: a case-control study Cancer. 2003 May 15; 97(10):2565-75. . View in PubMed

HSD17B1 and CYP17 polymorphisms and breast cancer risk among Chinese women in Singapore Int J Cancer. 2003 Apr 20; 104(4):450-7. . View in PubMed

Mammographic density and breast cancer in three ethnic groups Cancer Epidemiol Biomarkers Prev. 2003 Apr; 12(4):332-8. . View in PubMed

Role of Helicobacter pylori CagA+ strains and risk of adenocarcinoma of the stomach and esophagus Int J Cancer. 2003 Mar 01; 103(6):815-21. . View in PubMed

Adolescent and adult soy intake and risk of breast cancer in Asian-Americans Carcinogenesis. 2002 Sep; 23(9):1491-6. . View in PubMed

Soy intake and other lifestyle determinants of serum estrogen levels among postmenopausal Chinese women in Singapore Cancer Epidemiol Biomarkers Prev. 2002 Sep; 11(9):844-51. . View in PubMed

Is residual confounding a reasonable explanation for the apparent protective effects of beta-carotene found in epidemiologic studies of lung cancer in smokers? Am J Epidemiol. 2002 Apr 01; 155(7):622-8.. View in PubMed

Dietary heterocyclic amines and microsatellite instability in colon adenocarcinomas Carcinogenesis. 2001 Oct; 22(10):1681-4. . View in PubMed

A multiethnic population-based study of smoking, alcohol and body size and risk of adenocarcinomas of the stomach and esophagus (United States) Cancer Causes Control. 2001 Oct; 12(8):721-32. . View in PubMed

Mismatch repair deficiency and CpG island hypermethylation in sporadic colon adenocarcinomas Cancer Epidemiol Biomarkers Prev. 2001 Jul; 10(7):799-803. . View in PubMed

A genome screen of families with multiple cases of prostate cancer: evidence of genetic heterogeneity Am J Hum Genet. 2001 Jul; 69(1):148-58. . View in PubMed

Lifestyle determinants of 5alpha-reductase metabolites in older African-American, white, and Asian-American men Cancer Epidemiol Biomarkers Prev. 2001 May; 10(5):533-8. . View in PubMed

Soy and risk of hormone-related and other cancers Adv Exp Med Biol. 2001; 492:19-28. . View in PubMed

A meta-analysis of soyfoods and risk of stomach cancer: the problem of potential confounders Cancer Epidemiol Biomarkers Prev. 2000 Oct; 9(10):1051-8. . View in PubMed

Effects of soy foods on ovarian function in premenopausal women Br J Cancer. 2000 Jun; 82(11):1879-86. . View in PubMed

Diet and breast carcinoma in multiethnic populations Cancer. 2000 Mar 01; 88(5 Suppl):1239-44. . View in PubMed

Exposure misclassification bias in studies of environmental tobacco smoke and lung cancer Environ Health Perspect. 1999 Dec; 107 Suppl 6:873-7. . View in PubMed

Breast cancer and oral contraceptive use in Asian-American women Am J Epidemiol. 1999 Sep 15; 150(6):561-7. . View in PubMed

Meta-analysis: dietary fat intake, serum estrogen levels, and the risk of breast cancer J Natl Cancer Inst. 1999 Mar 17; 91(6):529-34. . View in PubMed

Soy intake and risk of breast cancer in Asians and Asian Americans Am J Clin Nutr. 1998 12; 68(6 Suppl):1437S-1443S. . View in PubMed

Colon and Rectal Cancer among Asian Americans and Pacific Islanders Asian Am Pac Isl J Health. 1998; 6(2):184-200. . View in PubMed

Breast Cancer among Asian Americans and Pacific Islanders Asian Am Pac Isl J Health. 1998; 6(2):327-343. . View in PubMed

Smoking, alcohol use, dietary factors and risk of small intestinal adenocarcinoma Int J Cancer. 1997 Mar 04; 70(5):512-7. . View in PubMed

Tofu and risk of breast cancer in Asian-Americans Cancer Epidemiol Biomarkers Prev. 1996 Nov; 5(11):901-6. . View in PubMed

Family history of cancer and risk of lung cancer among lifetime nonsmoking women in the United States Am J Epidemiol. 1996 Mar 15; 143(6):535-42. . View in PubMed

Menstrual and reproductive factors and risk of breast cancer in Asian-Americans Br J Cancer. 1996 Mar; 73(5):680-6. . View in PubMed

Serum androgens and sex hormone-binding globulins in relation to lifestyle factors in older African-American, white, and Asian men in the United States and Canada Cancer Epidemiol Biomarkers Prev. 1995 Oct-Nov; 4(7):735-41. . View in PubMed

Previous lung disease and risk of lung cancer among lifetime nonsmoking women in the United States Am J Epidemiol. 1995 Jun 01; 141(11):1023-32. . View in PubMed

Comparison of dietary habits, physical activity and body size among Chinese in North America and China Int J Epidemiol. 1994 Oct; 23(5):984-90. . View in PubMed

Environmental tobacco smoke and lung cancer in nonsmoking womenA multicenter study. JAMA. 1994 Jun 08; 271(22):1752-9. . View in PubMed

Migration patterns and breast cancer risk in Asian-American women J Natl Cancer Inst. 1993 Nov 17; 85(22):1819-27. . View in PubMed

Occupation and lung cancer risk among women in northern China Am J Ind Med. 1993 Jul; 24(1):67-79. . View in PubMed

Risk assessment for aflatoxin B1: a modeling approach Risk Anal. 1992 Dec; 12(4):559-67. . View in PubMed

Reproductive factors and colorectal cancer risk among Chinese females Cancer Res. 1991 May 01; 51(9):2307-11. . View in PubMed

Lung cancer among women in north-east China Br J Cancer. 1990 Dec; 62(6):982-7. . View in PubMed

Diet, physical activity, and colorectal cancer among Chinese in North America and China J Natl Cancer Inst. 1990 Jun 06; 82(11):915-26. . View in PubMed

Life-style, workplace, and stomach cancer by subsite in young men of Los Angeles County Cancer Res. 1990 May 01; 50(9):2569-76. . View in PubMed

Environmental tobacco smoke: exposure-response relationships in epidemiologic studies Risk Anal. 1990 Mar; 10(1):39-48. . View in PubMed

Ethnic distribution of amyloidosis: an autopsy study Mod Pathol. 1989 Jul; 2(4):372-7. . View in PubMed

Personal and family history of lung disease as risk factors for adenocarcinoma of the lung Cancer Res. 1988 Dec 15; 48(24 Pt 1):7279-84. . View in PubMed

Dr. Wu's research focuses on the epidemiology of cancer with emphasis on understanding the increase of various (e.g., breast, ovarian, colon) cancers among Asian migrants to the US. A unifying theme of my research is to identify modifiable lifestyle and environmental factors to reduce the risk of specific cancers and to improve outcomes among those diagnosed with cancer. In addition to observational epidemiologic studies, I have conducted a series of controlled intervention studies to investigate the short-term effects of dietary (e.g., soy, green tea) and hormonal (e.g., oral contraceptives) agents on breast-tissue (e.g., mammographic density) and circulating sex hormones and other biomarkers.
Since 2014, I began to use the well-established Multiethnic Cohort (MEC) to address research questions on environmental exposures (e.g., air pollution, endocrine disrupting chemicals) that have been challenging to study. In addition, I am participating in two multicenter survivorship studies on breast cancer and ovarian cancer.
sc ctsi logoPowered by SC CTSI