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Bangyan L Stiles, PhD

Professor

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Phone +1 323 442 2184
Email [email protected]
CTSI Profile

Research Funding

  • The Role of ERRa in liver lipid dysfunction and pathology
    NIH · R01DK131492 · Dec 1, 2021 – Nov 30, 2025 · Role: Principal Investigator
  • Robust Inference in the Presence of Data Heterogeneity and Structured Missing Data
    NIH · R01LM013315 · Sep 1, 2019 – Aug 31, 2022 · Role: Co-Principal Investigator
  • The role of PTEN and AKT2 in the malignant transformation of liver progenitor cel
    NIH · R01CA154986 · Apr 1, 2013 – Mar 31, 2020 · Role: Principal Investigator
  • The mechanism of beta-cell regeneration
    NIH · R01DK084241 · Aug 5, 2010 – Jun 30, 2017 · Role: Principal Investigator
  • The Role of PTEN in B-cell regeneration through epithelial-mesenchymal transition
    NIH · R21DK075928 · Jul 1, 2007 – Jun 30, 2010 · Role: Principal Investigator

Publications

  • PTEN-AKT2 Regulates Mixed Lineage Liver Cancer Development and Sensitizes Cancer Cells to TGFβ Treatment. Res Sq. 2026 Jan 30.. View in PubMed
  • Expression and functional diversity of the glucagon-like peptide-1 receptor across tumor types. Discov Oncol. 2025 Dec 03; 17(1):36.. View in PubMed
  • A targeted liver cancer therapy independent of immune checkpoint block. Hepatology. 2026 Aug 01; 84(2):343-345.. View in PubMed
  • Characterizing Kupffer Cell Production of CD5 Antigen-Like and Its Function on Regulating Migration of Natural Killer T Cells. Am J Pathol. 2025 10; 195(10):1839-1853.. View in PubMed
  • Isoform specific regulation of osteopontin by AKT2 in hepatocytes and livers. Cell Signal. 2025 Aug; 132:111799.. View in PubMed
  • Proinflammatory macrophages release CXCL5 to regulate T cell function and limit effects of αPD-1 in steatosis-driven liver cancer. JHEP Rep. 2025 Jun; 7(6):101385.. View in PubMed
  • A snoRNA-tRNA modification network governs codon-biased cellular states. Proc Natl Acad Sci U S A. 2023 10 10; 120(41):e2312126120.. View in PubMed
  • Eicosanoids and other oxylipins in liver injury, inflammation and liver cancer development. Front Physiol. 2023; 14:1098467.. View in PubMed
  • Hepatic macrophage mediated immune response in liver steatosis driven carcinogenesis. Front Oncol. 2022; 12:958696.. View in PubMed
  • Discovery of an NAD+ analogue with enhanced specificity for PARP1. Chem Sci. 2022 Feb 16; 13(7):1982-1991.. View in PubMed
  • Chronic Exposure to Palmitic Acid Down-Regulates AKT in Beta-Cells through Activation of mTOR. Am J Pathol. 2022 01; 192(1):130-145.. View in PubMed
  • Transformation of SOX9+ cells by Pten deletion synergizes with steatotic liver injury to drive development of hepatocellular and cholangiocarcinoma. Sci Rep. 2021 06 03; 11(1):11823.. View in PubMed
  • Cholesterol-binding translocator protein TSPO regulates steatosis and bile acid synthesis in nonalcoholic fatty liver disease. iScience. 2021 May 21; 24(5):102457.. View in PubMed
  • Inhibition of Estrogen-Related Receptor α Blocks Liver Steatosis and Steatohepatitis and Attenuates Triglyceride Biosynthesis. Am J Pathol. 2021 07; 191(7):1240-1254.. View in PubMed
  • A Bifunctional NAD+ for Profiling Poly-ADP-Ribosylation-Dependent Interacting Proteins. ACS Chem Biol. 2021 02 19; 16(2):389-396.. View in PubMed
  • AKT1 Regulates Endoplasmic Reticulum Stress and Mediates the Adaptive Response of Pancreatic β Cells. Mol Cell Biol. 2020 05 14; 40(11).. View in PubMed
  • Regulation of basal expression of hepatic PEPCK and G6Pase by AKT2. Biochem J. 2020 03 13; 477(5):1021-1031.. View in PubMed
  • Repression of the transcriptional activity of ERRα with sequence-specific DNA-binding polyamides. Med Chem Res. 2020 Apr; 29(4):607-616.. View in PubMed
  • Dual-Specific Protein and Lipid Phosphatase PTEN and Its Biological Functions. Cold Spring Harb Perspect Med. 2020 01 02; 10(1).. View in PubMed
  • Inhibiting the Hexosamine Biosynthetic Pathway Lowers O-GlcNAcylation Levels and Sensitizes Cancer to Environmental Stress. Biochemistry. 2020 09 01; 59(34):3169-3179.. View in PubMed
  • Extracellular vesicle microRNA quantification from plasma using an integrated microfluidic device. Commun Biol. 2019; 2:189.. View in PubMed
  • Brain metabolic and functional alterations in a liver-specific PTEN knockout mouse model. PLoS One. 2018; 13(9):e0204043.. View in PubMed
  • PTEN: Tumor Suppressor and Metabolic Regulator. Front Endocrinol (Lausanne). 2018; 9:338.. View in PubMed
  • Mitophagy and hepatic cancer stem cells. Autophagy. 2018; 14(4):715-716.. View in PubMed
  • Loss of Pten and Activation of Kras Synergistically Induce Formation of Intraductal Papillary Mucinous Neoplasia From Pancreatic Ductal Cells in Mice. Gastroenterology. 2018 04; 154(5):1509-1523.e5.. View in PubMed
  • Wnt/β-catenin activation and macrophage induction during liver cancer development following steatosis. Oncogene. 2017 10 26; 36(43):6020-6029.. View in PubMed
  • Crosstalk of LKB1- and PTEN-regulated signals in liver morphogenesis and tumor development. Hepatol Commun. 2017 Apr; 1(2):153-167.. View in PubMed
  • Activation of hepatic stellate cell in Pten null liver injury model. Fibrogenesis Tissue Repair. 2016; 9:8.. View in PubMed
  • Maf1, A New PTEN Target Linking RNA and Lipid Metabolism. Trends Endocrinol Metab. 2016 10; 27(10):742-750.. View in PubMed
  • Liver-Specific Deletion of Phosphatase and Tensin Homolog Deleted on Chromosome 10 Significantly Ameliorates Chronic EtOH-Induced Increases in Hepatocellular Damage. PLoS One. 2016; 11(4):e0154152.. View in PubMed
  • Crosstalk Between Activated Myofibroblasts and β Cells in Injured Mouse Pancreas. Pancreas. 2015 Oct; 44(7):1111-20.. View in PubMed
  • High-fat diet induces hepatic insulin resistance and impairment of synaptic plasticity. PLoS One. 2015; 10(5):e0128274.. View in PubMed
  • Maf1 is a novel target of PTEN and PI3K signaling that negatively regulates oncogenesis and lipid metabolism. PLoS Genet. 2014 Dec; 10(12):e1004789.. View in PubMed
  • A unified nomenclature and amino acid numbering for human PTEN. Sci Signal. 2014 Jul 01; 7(332):pe15.. View in PubMed
  • Monoamine oxidase A mediates prostate tumorigenesis and cancer metastasis. J Clin Invest. 2014 Jul; 124(7):2891-908.. View in PubMed
  • Short term feeding of a high fat diet exerts an additive effect on hepatocellular damage and steatosis in liver-specific PTEN knockout mice. PLoS One. 2014; 9(5):e96553.. View in PubMed
  • Liver-specific knockout of GRP94 in mice disrupts cell adhesion, activates liver progenitor cells, and accelerates liver tumorigenesis. Hepatology. 2014 Mar; 59(3):947-57.. View in PubMed
  • Adult-onset deletion of Pten increases islet mass and beta cell proliferation in mice. Diabetologia. 2014 Feb; 57(2):352-61.. View in PubMed
  • GRP78 as a regulator of liver steatosis and cancer progression mediated by loss of the tumor suppressor PTEN. Oncogene. 2014 Oct 16; 33(42):4997-5005.. View in PubMed
  • Extracellular heat shock protein 90 signals through subdomain II and the NPVY motif of LRP-1 receptor to Akt1 and Akt2: a circuit essential for promoting skin cell migration in vitro and wound healing in vivo. Mol Cell Biol. 2013 Dec; 33(24):4947-59.. View in PubMed
  • PTEN controls β-cell regeneration in aged mice by regulating cell cycle inhibitor p16ink4a. Aging Cell. 2013 Dec; 12(6):1000-11.. View in PubMed
  • Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) signaling regulates mitochondrial biogenesis and respiration via estrogen-related receptor α (ERRα). J Biol Chem. 2013 Aug 30; 288(35):25007-25024.. View in PubMed
  • PI3K/AKT signaling regulates bioenergetics in immortalized hepatocytes. Free Radic Biol Med. 2013 Jul; 60:29-40.. View in PubMed
  • Autophagy: resetting glutamine-dependent metabolism and oxygen consumption. Autophagy. 2012 Oct; 8(10):1477-93.. View in PubMed
  • miR-200b restoration and DNA methyltransferase inhibitor block lung metastasis of mesenchymal-phenotype hepatocellular carcinoma. Oncogenesis. 2012 Jun 11; 1:e15.. View in PubMed
  • Apolipoprotein B secretion is regulated by hepatic triglyceride, and not insulin, in a model of increased hepatic insulin signaling. Arterioscler Thromb Vasc Biol. 2012 Feb; 32(2):236-46.. View in PubMed
  • Adaptive basal phosphorylation of eIF2α is responsible for resistance to cellular stress-induced cell death in Pten-null hepatocytes. Mol Cancer Res. 2011 Dec; 9(12):1708-17.. View in PubMed
  • Liver-specific deletion of prohibitin 1 results in spontaneous liver injury, fibrosis, and hepatocellular carcinoma in mice. Hepatology. 2010 Dec; 52(6):2096-108.. View in PubMed
  • Expansion of hepatic tumor progenitor cells in Pten-null mice requires liver injury and is reversed by loss of AKT2. Gastroenterology. 2010 Dec; 139(6):2170-82.. View in PubMed
  • Epithelial-to-mesenchymal transition of murine liver tumor cells promotes invasion. Hepatology. 2010 Sep; 52(3):945-53.. View in PubMed
  • The critical role of AKT2 in hepatic steatosis induced by PTEN loss. Am J Pathol. 2010 May; 176(5):2302-8.. View in PubMed
  • The Role of PTEN in β-Cell Growth. Open Endocrinol J. 2010; 4:23-32.. View in PubMed
  • PI-3-K and AKT: Onto the mitochondria. Adv Drug Deliv Rev. 2009 Nov 30; 61(14):1276-82.. View in PubMed
  • Expansion of CD133-expressing liver cancer stem cells in liver-specific phosphatase and tensin homolog deleted on chromosome 10-deleted mice. Stem Cells. 2009 Feb; 27(2):290-9.. View in PubMed
  • Phosphatase and tensin homologue deleted on chromosome 10: extending its PTENtacles. Int J Biochem Cell Biol. 2009 Apr; 41(4):757-61.. View in PubMed
  • Hydrophobic surfaces for enhanced differentiation of embryonic stem cell-derived embryoid bodies. Proc Natl Acad Sci U S A. 2008 Sep 23; 105(38):14459-64.. View in PubMed
  • Induction of intrahepatic cholangiocellular carcinoma by liver-specific disruption of Smad4 and Pten in mice. J Clin Invest. 2006 Jul; 116(7):1843-52.. View in PubMed
  • Titan Radar Mapper observations from Cassini’s T3 fly-by. Nature. 2006 Jun 08; 441(7094):709-13.. View in PubMed
  • Selective deletion of Pten in pancreatic beta cells leads to increased islet mass and resistance to STZ-induced diabetes. Mol Cell Biol. 2006 Apr; 26(7):2772-81.. View in PubMed
  • Pten constrains centroacinar cell expansion and malignant transformation in the pancreas. Cancer Cell. 2005 Sep; 8(3):185-95.. View in PubMed
  • Cassini radar views the surface of Titan. Science. 2005 May 13; 308(5724):970-4.. View in PubMed
  • Insulin hypersensitivity and resistance to streptozotocin-induced diabetes in mice lacking PTEN in adipose tissue. Mol Cell Biol. 2005 Mar; 25(6):2498-510.. View in PubMed
  • PTENless means more. Dev Biol. 2004 Sep 15; 273(2):175-84.. View in PubMed
  • MicroPET imaging of Cre-loxP-mediated conditional activation of a herpes simplex virus type 1 thymidine kinase reporter gene. Gene Ther. 2004 Apr; 11(7):609-18.. View in PubMed
  • Liver-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity [corrected]. Proc Natl Acad Sci U S A. 2004 Feb 17; 101(7):2082-7.. View in PubMed
  • Essential role of AKT-1/protein kinase B alpha in PTEN-controlled tumorigenesis. Mol Cell Biol. 2002 Jun; 22(11):3842-51.. View in PubMed
  • Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR. Proc Natl Acad Sci U S A. 2001 Aug 28; 98(18):10314-9.. View in PubMed