Bozena Barbara Wrobel, MD

Professor Of Clinical Otolaryngology - Head and Neck Surgery and Neurological Surgery (Educational Scholar)

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Dr. Bozena B. Wrobel, is a Polish born rhinologist. She received her undergraduate and M.D. degree from the Medical University of Warsaw in Poland. She completed an Otolaryngology Residency at the University of Colorado. She is Board-Certified by the American Board of Otolaryngology – Head and Neck Surgery. She completed a one-year fellowship in Rhinology (including advanced endoscopic sinus surgery) and Chemosensory Disorders (Smell & Taste) at the University of Nebraska with Donald A. Leopold, M.D., F.A.C.S. In 2004. She also visited several times with Peter J. Wormald, M.D. at Adelaide University in Australia, to study and observe endoscopic surgical approaches to the anterior skull-base.

Dr. Wrobel joined the full-time faculty at the USC Keck School of Medicine in Los Angeles, CA. Dr. Wrobel is the Director of the Allergy Clinic for the USC Head & Neck Group. For the past five years Dr. Wrobel has been an active reviewer for the American Journal of Rhinology. Presently she serves as a Vice-President of the Los Angeles Society of Otolaryngology.

Dr. Wrobel is the Course Director of the annual USC Advanced Endoscopic Sinus Surgery Course and for last few years bi-annual USC Endoscopic Skull Base Courses. In March 2008 she organized and conducted the 1st International Endoscopic Sinus Surgery Course in Kajetany, Poland which became annual event with the 4th one coming up in June 2011. Dr. Wrobel is an invited Speaker on national and international sinus surgery courses and rhinology conferences.

Dr. Wrobel’s medical practice is oriented toward Rhinology and complex disorders of the Paranasal Sinuses. Her research interests include endoscopic anterior skull-base surgical approaches, advanced endoscopic frontal sinus surgery and chemosensory disorders of smell and taste. Dr. Wrobel is fluent in English and Polish.

Dr. Wrobel has been awarded for the 2nd consecutive year “Patient’s Choice Award”.

USC Caruso Department of Otolaryngology – Head & Neck Surgery


  • Efficacy of a RADA-16 peptide hydrogel versus chitosan-based polymer in improving patient comfort during postoperative debridement: A randomized controlled trial Int Forum Allergy Rhinol. 2024 Jun 27. . View in PubMed
  • Endoscopic Endonasal Transsphenoidal Resection of Pituitary Adenomas in Patients Presenting With Monocular Blindness Oper Neurosurg (Hagerstown). 2024 Apr 10. . View in PubMed
  • Ectopic Olfactory Neuroblastoma: Systematic Review of a Rare Clinical Entity among Sinonasal Tumors J Neurol Surg B Skull Base. 2024 Apr; 85(2):109-118. . View in PubMed
  • Gender-Specific Differences in Preoperative Concerns in Patients Undergoing Endoscopic Sinus Surgery for Chronic Rhinosinusitis Ann Otol Rhinol Laryngol. 2024 Apr; 133(4):454-457. . View in PubMed
  • Radiofrequency Neurolysis of the Posterior Nasal Nerve: A Systematic Review and Meta-Analysis Laryngoscope. 2024 Feb; 134(2):507-516. . View in PubMed
  • Association of ethnicity and time to surgery among patients with chronic rhinosinusitis Laryngoscope Investig Otolaryngol. 2023 Dec; 8(6):1442-1448. . View in PubMed
  • Optical Coherence Tomography as a Tool for Imaging the Sinonasal Mucosa in Patients: A Systematic Review Ear Nose Throat J. 2023 Nov 30; 1455613231214622. . View in PubMed
  • An Endoscopic Endonasal Attempt at Pediatric Meningoencephalocele Repair Ear Nose Throat J. 2023 Sep; 102(9_suppl):24S-26S. . View in PubMed
  • Unplanned 30-Day ER Visit Rate and Factors Associated With ER Visits After Ambulatory Sinus Surgery Am J Rhinol Allergy. 2023 Sep; 37(5):541-549. . View in PubMed
  • Anatomic Considerations Guiding Single Versus Multiportal Endoscopic Approaches for Resection of Juvenile Nasopharyngeal Angiofibroma: Cases Series With Graded Multicorridor Resections Oper Neurosurg (Hagerstown). 2023 08 01; 25(2):150-160. . View in PubMed
  • A Case of Mediastinal Emphysema Following Functional Endoscopic Sinus Surgery Ear Nose Throat J. 2022 Dec; 101(10_suppl):44S-46S. . View in PubMed
  • Endoscopic endonasal approaches for reconstruction of traumatic anterior skull base fractures and associated cerebrospinal fistulas: patient series J Neurosurg Case Lessons. 2022 Jun 20; 3(25):CASE2214. . View in PubMed
  • International consensus statement on allergy and rhinology: Olfaction Int Forum Allergy Rhinol. 2022 04; 12(4):327-680. . View in PubMed
  • Robotic and robot-assisted skull base neurosurgery: systematic review of current applications and future directions Neurosurg Focus. 2022 01; 52(1):E15. . View in PubMed
  • Validation of Machine Learning-Based Automated Surgical Instrument Annotation Using Publicly Available Intraoperative Video Oper Neurosurg (Hagerstown). 2022 09 01; 23(3):235-240. . View in PubMed
  • Deep Neural Networks Can Accurately Detect Blood Loss and Hemorrhage Control Task Success From Video Neurosurgery. 2022 06 01; 90(6):823-829. . View in PubMed
  • Expert surgeons and deep learning models can predict the outcome of surgical hemorrhage from 1 min of video Sci Rep. 2022 05 17; 12(1):8137. . View in PubMed
  • Utility of the Simulated Outcomes Following Carotid Artery Laceration Video Data Set for Machine Learning Applications JAMA Netw Open. 2022 03 01; 5(3):e223177. . View in PubMed
  • Use of Salvage Surgery or Stereotactic Radiosurgery for Multiply Recurrent Skull Base Chordomas: A Single-Institution Experience and Review of the Literature J Neurol Surg B Skull Base. 2021 Apr; 82(2):161-174. . View in PubMed
  • Improved surgeon performance following cadaveric simulation of internal carotid artery injury during endoscopic endonasal surgery: training outcomes of a nationwide prospective educational intervention J Neurosurg. 2021 Mar 19; 135(5):1347-1355. . View in PubMed
  • Thermal Conductance Through the Skull Base From Endoscopic Surgery Cauterization Instruments: Cadaver and Goat Model Otolaryngol Head Neck Surg. 2021 12; 165(6):899-904. . View in PubMed
  • Safety and Effectiveness of the Direct Endoscopic Endonasal Approach for Primary Sellar Pathology: A Contemporary Case Series of More Than 400 Patients World Neurosurg. 2021 04; 148:e536-e546. . View in PubMed
  • Chronic Aspiration Pneumonitis Caused by Spontaneous Cerebrospinal Fluid Fistulae of the Skull Base Laryngoscope. 2021 03; 131(3):462-466. . View in PubMed
  • Association Between Olfactory Dysfunction and Mortality in US Adults JAMA Otolaryngol Head Neck Surg. 2021 01 01; 147(1):49-55. . View in PubMed
  • Smell and Taste Impairment in a Nationwide Sample of US Adults With Chronic Rhinosinusitis Symptoms OTO Open. 2021 Jan-Mar; 5(1):2473974X20986756. . View in PubMed
  • Geographic Variation in Epistaxis Interventions Among Medicare Beneficiaries Ann Otol Rhinol Laryngol. 2020 Sep; 129(9):878-885. . View in PubMed
  • Characterization of Chronic Sinonasal Disease Symptoms in an Urban Homeless Population Am J Rhinol Allergy. 2020 Jul; 34(4):494-501. . View in PubMed
  • Emerging Trends in Nasal Surgery: What Is the Impact of a Bioabsorbable Nasal Implant? Laryngoscope. 2020 12; 130(12):2785-2790.. View in PubMed
  • Patient characteristics of suspected mast-cell activation syndrome with sinonasal obstruction: a single institution experience Int Forum Allergy Rhinol. 2020 08; 10(8):996-1000. . View in PubMed
  • Impact of tumor characteristics and pre- and postoperative hormone levels on hormonal remission following endoscopic transsphenoidal surgery in patients with acromegaly Neurosurg Focus. 2020 06; 48(6):E10. . View in PubMed
  • Quantifying the use of opioids in the immediate postoperative period after endoscopic sinus surgery Laryngoscope. 2020 05; 130(5):1122-1127. . View in PubMed
  • Gene Expression in Patient-Derived Neural Progenitors Implicates WNT5A Signaling in the Etiology of Schizophrenia Biol Psychiatry. 2020 08 01; 88(3):236-247. . View in PubMed
  • COX-2 Overexpression in Schneiderian Papillomas Allergy Rhinol (Providence). 2020 Jan-Dec; 11:2152656720973689. . View in PubMed
  • Optic Neuropathy due to an Ethmoid Mucocele: A Case Report and Literature Review Case Rep Ophthalmol. 2019 May-Aug; 10(2):227-234. . View in PubMed
  • Open Versus Endoscopic Approach for Sinonasal Melanoma: A Systematic Review and Meta-analysis Am J Rhinol Allergy. 2019 Mar; 33(2):162-169. . View in PubMed
  • Sinus irrigation penetration after balloon sinuplasty vs functional endoscopic sinus surgery in a cadaveric model Int Forum Allergy Rhinol. 2019 09; 9(9):953-957. . View in PubMed
  • Costs and training results of an objectively validated cadaveric perfusion-based internal carotid artery injury simulation during endoscopic skull base surgery Int Forum Allergy Rhinol. 2019 07; 9(7):787-794. . View in PubMed
  • International assessment of inter- and intrarater reliability of the International Frontal Sinus Anatomy Classification system Int Forum Allergy Rhinol. 2019 01; 9(1):39-45. . View in PubMed
  • Assessment of Trends in Utilization of Nasal Endoscopy in the Medicare Population, 2000-2016 JAMA Otolaryngol Head Neck Surg. 2019 03 01; 145(3):258-263. . View in PubMed
  • Endoscopic Endonasal Repair of Spontaneous Cerebrospinal Fluid Leaks Using Multilayer Composite Graft and Vascularized Pedicled Nasoseptal Flap Technique Allergy Rhinol (Providence). 2019 Jan-Dec; 10:2152656719888622. . View in PubMed
  • Teaching Residents Frontal Sinus Anatomy Using a Novel 3-Dimensional Conceptualization Planning Software-Based Module Am J Rhinol Allergy. 2018 Nov; 32(6):526-532. . View in PubMed
  • Pediatric Benign Paranasal Sinus Osteoneogenic Tumors: A Case Series and Systematic Review of Outcomes, Techniques, and a Multiportal Approach Am J Rhinol Allergy. 2018 Nov; 32(6):465-472. . View in PubMed
  • Complications associated with microscopic and endoscopic transsphenoidal pituitary surgery: experience of 1153 consecutive cases treated at a single tertiary care pituitary center J Neurosurg. 2018 Jun 01; 1-8. . View in PubMed
  • Association of alterations in smell and taste with depression in older adults Laryngoscope Investig Otolaryngol. 2018 Apr; 3(2):94-99. . View in PubMed
  • The endoscopic modified lothrop procedure: Review of single institution experience and long-term outcomes Laryngoscope Investig Otolaryngol. 2018 Apr; 3(2):105-109. . View in PubMed
  • Perfusion-based human cadaveric specimen as a simulation training model in repairing cerebrospinal fluid leaks during endoscopic endonasal skull base surgery J Neurosurg. 2018 09; 129(3):792-796. . View in PubMed
  • Identification and repair of intraoperative cerebrospinal fluid leaks in endonasal transsphenoidal pituitary surgery: surgical experience in a series of 1002 patients J Neurosurg. 2018 08; 129(2):425-429. . View in PubMed
  • Olfactory dysfunction and cognition among older adults in the United States Int Forum Allergy Rhinol. 2018 05; 8(5):648-654. . View in PubMed
  • Objective Validation of Perfusion-Based Human Cadaveric Simulation Training Model for Management of Internal Carotid Artery Injury in Endoscopic Endonasal Sinus and Skull Base Surgery Oper Neurosurg (Hagerstown). 2018 08 01; 15(2):231-238. . View in PubMed
  • Paraganglioma Presenting as a Nasal Septal Mass: Case Report and Literature Review Case Rep Otolaryngol. 2018; 2018:1413960. . View in PubMed
  • Development of a Perfusion-Based Cadaveric Simulation Model Integrated into Neurosurgical Training: Feasibility Based On Reconstitution of Vascular and Cerebrospinal Fluid Systems Oper Neurosurg (Hagerstown). 2018 01 01; 14(1):72-80. . View in PubMed
  • Extended endoscopic endonasal approach for resection of tuberculum sellae meningioma Neurosurg Focus. 2017 Oct; 43(VideoSuppl2):V2. . View in PubMed
  • Impact of sinonasal disease on depression, sleep duration, and productivity among adults in the United States Laryngoscope Investig Otolaryngol. 2017 10; 2(5):288-294. . View in PubMed
  • Erratum: Determinants and Evaluation of Nasal Airflow Perception Facial Plast Surg. 2017 10; 33(5):553-554. . View in PubMed
  • Determinants and Evaluation of Nasal Airflow Perception Facial Plast Surg. 2017 08; 33(4):372-377. . View in PubMed
  • Resolution of Chronic Aspiration Pneumonitis Following Endoscopic Endonasal Repair of Spontaneous Cerebrospinal Fluid Fistula of the Skull Base J Neurol Surg Rep. 2016 Jun; 77(2):e73-6. . View in PubMed
  • Endoscopic endonasal transsphenoidal surgery: implementation of an operative and perioperative checklist Neurosurg Focus. 2014; 37(4):E1. . View in PubMed
  • Immunoglobulin G4-related disease presenting as an ethmoid and maxillary mass Ann Allergy Asthma Immunol. 2013 Jul; 111(1):75-7. . View in PubMed
  • Relationship of eosinophils and plasma cells to biofilm in chronic rhinosinusitis Am J Rhinol Allergy. 2013 Jul-Aug; 27(4):e85-90. . View in PubMed
  • Assessing the efficacy of endoscopic office olfactory biopsy sites to produce neural progenitor cell cultures for the study of neuropsychiatric disorders Int Forum Allergy Rhinol. 2013 Feb; 3(2):133-8. . View in PubMed
  • Olfactory neuroepithelium-derived neural progenitor cells as a model system for investigating the molecular mechanisms of neuropsychiatric disorders Psychiatr Genet. 2011 Oct; 21(5):217-28. . View in PubMed
  • Decreased nasal mucosal sensitivity in older subjects Am J Rhinol. 2006 May-Jun; 20(3):364-8. . View in PubMed
  • Olfactory and sensory attributes of the nose Otolaryngol Clin North Am. 2005 Dec; 38(6):1163-70. . View in PubMed
  • Clinical assessment of patients with smell and taste disorders Otolaryngol Clin North Am. 2004 Dec; 37(6):1127-42. . View in PubMed
  • Smell and taste disorders Facial Plast Surg Clin North Am. 2004 Nov; 12(4):459-68vii. . View in PubMed