Carole Ann Spencer, PhD

Professor of Research Medicine

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Overview

Dr. Spencer’s major areas of research interest are thyroid physiology and pathology, thyroglobulin and thyroid cancer, immunoassay techniques, thyroid hormone metabolism, and the cost-effective use of thyroid tests. Her current research includes clinical significance of Tg and TgAb in patients with thyroid cancers, parameters for optimizing thyroid hormone suppression of TSH for DTC. Studies on hypothalamic/pituitary mechanisms for regulating TSH, and testing for thyroid dysfunction during pregnancy.

Dr. Spencer earned her PhD from Glasgow University in Scotland. She then went on to complete two fellowships, one in Clinical Biochemistry at Glasgow, and the other at the National Academy of Clinical Biochemistry.

Awards

  • London Academy of Music and Dramatic Art: Gold Medal, 1967
  • American Association for Clinical Chemistry: Outstanding Speaker, 1992
  • American Association for Clinical Chemistry: Outstanding Speaker, 1997
  • Clinical Ligand Assay Society: Distinguished Scientist Award, 1998
  • American Association for Clinical Chemistry: Outstanding Speaker, 1998
  • American Association of Clinical Chemistry: Albert L. Chaney Award, 2003
  • National Academy of Clinical Biochemistry: Distinguished Scientist Award, 2004
  • Endocrine Society: International Award for Publishing Excellence, 2011

Publications

  • Influence of Thyroglobulin Autoantibodies on Thyroglobulin Levels Measured by Different Methodologies: IMA, LC-MS/MS, and RIA. J Clin Endocrinol Metab. 2024 11 18; 109(12):3254-3263.. View in PubMed
  • Response to Fitzgerald et al. re: “Thyroid Stimulating Hormone and Thyroid Hormones (Triiodothyronine and Thyroxine): An American Thyroid Association-Commissioned Review of Current Clinical and Laboratory Status”. Thyroid. 2024 02; 34(2):276-278.. View in PubMed
  • Thyroid Stimulating Hormone and Thyroid Hormones (Triiodothyronine and Thyroxine): An American Thyroid Association-Commissioned Review of Current Clinical and Laboratory Status. Thyroid. 2023 09; 33(9):1013-1028.. View in PubMed
  • Clinical Interpretation of Thyroid Tests: Considerations for Reference Intervals. Thyroid. 2023 04; 33(4):404-406.. View in PubMed
  • Laboratory Thyroid Tests: A Historical Perspective. Thyroid. 2023 04; 33(4):407-419.. View in PubMed
  • Marginal Iodine Status and High Rate of Subclinical Hypothyroidism in Washington DC Women Planning Conception. Thyroid. 2015 Oct; 25(10):1151-4.. View in PubMed
  • Thyroglobulin (Tg) Testing Revisited: Tg Assays, TgAb Assays, and Correlation of Results With Clinical Outcomes. J Clin Endocrinol Metab. 2015 Aug; 100(8):E1074-83.. View in PubMed
  • Evaluation of risk-factor-based screening for thyroid peroxidase antibody positivity in pregnancy. Clin Endocrinol (Oxf). 2016 Mar; 84(3):417-22.. View in PubMed
  • Serum thyroglobulin (Tg) monitoring of patients with differentiated thyroid cancer using sensitive (second-generation) immunometric assays can be disrupted by false-negative and false-positive serum thyroglobulin autoantibody misclassifications. J Clin Endocrinol Metab. 2014 Dec; 99(12):4589-99.. View in PubMed
  • How sensitive (second-generation) thyroglobulin measurement is changing paradigms for monitoring patients with differentiated thyroid cancer, in the absence or presence of thyroglobulin autoantibodies. Curr Opin Endocrinol Diabetes Obes. 2014 Oct; 21(5):394-404.. View in PubMed