Charles Emerson Murry

Visiting Professor of Stem Cell Biology and Regenerative Medicine

Chair of the Department of Stem Cell Biology and Regenerative Medicine

Director of the Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research

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Publications

  • Modulation of FGF pathway signaling and vascular differentiation using designed oligomeric assemblies Cell. 2024 Jun 07. . View in PubMed
  • Long-term engraftment and maturation of autologous iPSC-derived cardiomyocytes in two rhesus macaques Cell Stem Cell. 2024 May 29. . View in PubMed
  • Quantifying Microvascular Structure in Healthy and Infarcted Rat Hearts Using Optical Coherence Tomography Angiography IEEE Trans Med Imaging. 2024 Apr 03; PP. . View in PubMed
  • Genetically Encoded XTEN-based Hydrogels with Tunable Viscoelasticity and Biodegradability for Injectable Cell Therapies Adv Sci (Weinh). 2024 Mar 13; e2301708. . View in PubMed
  • Targeted CRISPR activation is functional in engineered human pluripotent stem cells but undergoes silencing after differentiation into cardiomyocytes and endothelium Cell Mol Life Sci. 2024 Feb 19; 81(1):95. . View in PubMed
  • Multiplexed Functional Assessments of MYH7 Variants in Human Cardiomyocytes Circ Genom Precis Med. 2024 Feb 16; e004377. . View in PubMed
  • Gene editing to prevent ventricular arrhythmias associated with cardiomyocyte cell therapy Cell Stem Cell. 2023 May 04; 30(5):741. . View in PubMed
  • Cell based dATP delivery as a therapy for chronic heart failure bioRxiv. 2023 Apr 28. . View in PubMed
  • Cardiomyocyte Apoptosis Is Associated with Contractile Dysfunction in Stem Cell Model of MYH7 E848G Hypertrophic Cardiomyopathy Int J Mol Sci. 2023 Mar 03; 24(5). . View in PubMed
  • CRaTER enrichment for on-target gene-editing enables generation of variant libraries in hiPSCs bioRxiv. 2023 Jan 26. . View in PubMed
  • Cardiomyocyte apoptosis contributes to contractile dysfunction in stem cell model of MYH7 E848G hypertrophic cardiomyopathy bioRxiv. 2023 Jan 25. . View in PubMed
  • Stacking thick perfusable human microvascular grafts enables dense vascularity and rapid integration into infarcted rat hearts Biomaterials. 2023 10; 301:122250. . View in PubMed
  • Graft-host coupling changes can lead to engraftment arrhythmia: a computational study J Physiol. 2023 07; 601(13):2733-2749. . View in PubMed
  • CRaTER enrichment for on-target gene editing enables generation of variant libraries in hiPSCs J Mol Cell Cardiol. 2023 06; 179:60-71. . View in PubMed
  • dATP elevation induces myocardial metabolic remodeling to support improved cardiac function J Mol Cell Cardiol. 2023 02; 175:1-12. . View in PubMed
  • Engineered tissue vascularization and engraftment depends on host model Sci Rep. 2023 02 03; 13(1):1973. . View in PubMed
  • Lessons learnt, and still to learn, in first in human stem cell trials Stem Cell Reports. 2023 08 08; 18(8):1599-1609. . View in PubMed
  • Epicardially secreted fibronectin drives cardiomyocyte maturation in 3D-engineered heart tissues Stem Cell Reports. 2023 04 11; 18(4):936-951. . View in PubMed
  • Gene editing to prevent ventricular arrhythmias associated with cardiomyocyte cell therapyCell Stem Cell. 2023 04 06; 30(4):396-414. e9. . View in PubMed
  • Dynamic chromatin organization and regulatory interactions in human endothelial cell differentiation Stem Cell Reports. 2023 01 10; 18(1):159-174. . View in PubMed
  • Amino acid primed mTOR activity is essential for heart regeneration iScience. 2022 Jan 21; 25(1):103574. . View in PubMed
  • Flexing Their Muscles: Maturation of Stem Cell-Derived Cardiomyocytes on Elastomeric Substrates to Enhance Cardiac Repair Circulation. 2022 05 03; 145(18):1427-1430. . View in PubMed
  • Polarization sensitive optical coherence tomography with single input for imaging depth-resolved collagen organizations Light Sci Appl. 2021 Nov 24; 10(1):237. . View in PubMed
  • Tunable electroconductive decellularized extracellular matrix hydrogels for engineering human cardiac microphysiological systems Biomaterials. 2021 05; 272:120764. . View in PubMed
  • Gain-of-function cardiomyopathic mutations in RBM20 rewire splicing regulation and re-distribute ribonucleoprotein granules within processing bodies Nat Commun. 2021 11 03; 12(1):6324. . View in PubMed
  • High-resolution 3D fluorescent imaging of intact tissues Int J Cardiol Cardiovasc Dis. 2021; 1(1):1-14. . View in PubMed
  • Sarcomere function activates a p53-dependent DNA damage response that promotes polyploidization and limits in vivo cell engraftment Cell Rep. 2021 05 04; 35(5):109088. . View in PubMed
  • Rescuing human fetal tissue research in the United States: A call for additional regulatory reform Stem Cell Reports. 2021 12 14; 16(12):2839-2843. . View in PubMed
  • Cross-validation of SARS-CoV-2 responses in kidney organoids and clinical populations JCI Insight. 2021 12 22; 6(24). . View in PubMed
  • Engrafted Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Undergo Clonal Expansion In Vivo Circulation. 2021 04 20; 143(16):1635-1638. . View in PubMed
  • SARS-CoV-2 Infects Human Pluripotent Stem Cell-Derived Cardiomyocytes, Impairing Electrical and Mechanical Function Stem Cell Reports. 2021 03 09; 16(3):478-492. . View in PubMed
  • Pharmacologic therapy for engraftment arrhythmia induced by transplantation of human cardiomyocytes Stem Cell Reports. 2021 10 12; 16(10):2473-2487. . View in PubMed
  • Delta-1 Functionalized Hydrogel Promotes hESC-Cardiomyocyte Graft Proliferation and Maintains Heart Function Post-Injury Mol Ther Methods Clin Dev. 2020 Jun 12; 17:986-998. . View in PubMed
  • Stem cells and the heart-the road ahead Science. 2020 Feb 21; 367(6480):854-855. . View in PubMed
  • Cardiomyocyte maturation: advances in knowledge and implications for regenerative medicine Nat Rev Cardiol. 2020 06; 17(6):341-359. . View in PubMed
  • Engineering anisotropic 3D tubular tissues with flexible thermoresponsive nanofabricated substrates Biomaterials. 2020 05; 240:119856. . View in PubMed
  • NanoMEA: A Tool for High-Throughput, Electrophysiological Phenotyping of Patterned Excitable Cells Nano Lett. 2020 03 11; 20(3):1561-1570. . View in PubMed
  • Author Correction: TFPa/HADHA is required for fatty acid beta-oxidation and cardiolipin re-modeling in human cardiomyocytes Nat Commun. 2020 05 08; 11(1):2387. . View in PubMed
  • Cell Therapy Strategies With No Safety Concerns and Demonstrated Benefits Warrant Study – Reply Circ J. 2020 10 23; 84(11):2122. . View in PubMed
  • A Rainbow Reporter Tracks Single Cells and Reveals Heterogeneous Cellular Dynamics among Pluripotent Stem Cells and Their Differentiated Derivatives Stem Cell Reports. 2020 07 14; 15(1):226-241. . View in PubMed
  • Absence of full-length dystrophin impairs normal maturation and contraction of cardiomyocytes derived from human-induced pluripotent stem cells Cardiovasc Res. 2020 02 01; 116(2):368-382. . View in PubMed
  • Sonic Hedgehog upregulation does not enhance the survival and engraftment of stem cell-derived cardiomyocytes in infarcted hearts PLoS One. 2020; 15(1):e0227780. . View in PubMed
  • Learn from Your Elders: Developmental Biology Lessons to Guide Maturation of Stem Cell-Derived Cardiomyocytes Pediatr Cardiol. 2019 Oct; 40(7):1367-1387. . View in PubMed
  • Substrate Stiffness, Cell Anisotropy, and Cell-Cell Contact Contribute to Enhanced Structural and Calcium Handling Properties of Human Embryonic Stem Cell-Derived Cardiomyocytes ACS Biomater Sci Eng. 2019 Aug 12; 5(8):3876-3888. . View in PubMed
  • Epicardial cells derived from human embryonic stem cells augment cardiomyocyte-driven heart regeneration Nat Biotechnol. 2019 08; 37(8):895-906. . View in PubMed
  • Regenerating the field of cardiovascular cell therapy Nat Biotechnol. 2019 03; 37(3):232-237. . View in PubMed
  • Cronos Titin Is Expressed in Human Cardiomyocytes and Necessary for Normal Sarcomere Function Circulation. 2019 11 12; 140(20):1647-1660. . View in PubMed
  • TFPa/HADHA is required for fatty acid beta-oxidation and cardiolipin re-modeling in human cardiomyocytes Nat Commun. 2019 10 11; 10(1):4671. . View in PubMed
  • Dynamics of genome reorganization during human cardiogenesis reveal an RBM20-dependent splicing factory Nat Commun. 2019 04 04; 10(1):1538. . View in PubMed
  • The K219T-Lamin mutation induces conduction defects through epigenetic inhibition of SCN5A in human cardiac laminopathy Nat Commun. 2019 05 22; 10(1):2267. . View in PubMed
  • Function Follows Form – A Review of Cardiac Cell Therapy Circ J. 2019 11 25; 83(12):2399-2412. . View in PubMed
  • Lost in the fire Science. 2019 04 12; 364(6436):123-124. . View in PubMed
  • Fatty Acids Enhance the Maturation of Cardiomyocytes Derived from Human Pluripotent Stem Cells Stem Cell Reports. 2019 10 08; 13(4):657-668. . View in PubMed
  • Patterned human microvascular grafts enable rapid vascularization and increase perfusion in infarcted rat hearts Nat Commun. 2019 02 04; 10(1):584. . View in PubMed
  • A Proteomic Perspective on Cardiomyocyte Maturation Circ Res. 2019 11 08; 125(11):954-956. . View in PubMed
  • Chromatin compartment dynamics in a haploinsufficient model of cardiac laminopathy J Cell Biol. 2019 09 02; 218(9):2919-2944. . View in PubMed
  • Novel Adult-Onset Systolic Cardiomyopathy Due to MYH7 E848G Mutation in Patient-Derived Induced Pluripotent Stem Cells JACC Basic Transl Sci. 2018 Dec; 3(6):728-740. . View in PubMed
  • Human Organ-Specific Endothelial Cell Heterogeneity iScience. 2018 Jun 29; 4:20-35. . View in PubMed
  • The Challenges of First-in-Human Stem Cell Clinical Trials: What Does This Mean for Ethics and Institutional Review Boards? Stem Cell Reports. 2018 May 08; 10(5):1429-1431.. View in PubMed
  • ALPK2 Promotes Cardiogenesis in Zebrafish and Human Pluripotent Stem Cells iScience. 2018 Apr 27; 2:88-100. . View in PubMed
  • Hallmarks of cardiac regeneration Nat Rev Cardiol. 2018 10; 15(10):579-580. . View in PubMed
  • Human embryonic stem cell-derived cardiomyocytes restore function in infarcted hearts of non-human primates Nat Biotechnol. 2018 08; 36(7):597-605. . View in PubMed
  • Regulation of skeletal myotube formation and alignment by nanotopographically controlled cell-secreted extracellular matrix J Biomed Mater Res A. 2018 06; 106(6):1543-1551. . View in PubMed
  • Afterload promotes maturation of human induced pluripotent stem cell derived cardiomyocytes in engineered heart tissues J Mol Cell Cardiol. 2018 05; 118:147-158. . View in PubMed
  • Human Pluripotent Stem Cell-Derived Engineered Tissues: Clinical Considerations Cell Stem Cell. 2018 03 01; 22(3):294-297. . View in PubMed
  • Genetic Lineage Tracing of Sca-1+ Cells Reveals Endothelial but Not Myogenic Contribution to the Murine Heart Circulation. 2018 12 18; 138(25):2931-2939. . View in PubMed
  • Inducible CRISPR genome editing platform in naive human embryonic stem cells reveals JARID2 function in self-renewal Cell Cycle. 2018; 17(5):535-549. . View in PubMed
  • Evidence for Minimal Cardiogenic Potential of Stem Cell Antigen 1-Positive Cells in the Adult Mouse Heart Circulation. 2018 12 18; 138(25):2960-2962. . View in PubMed
  • Single-Cell Transcriptomic Analysis of Cardiac Differentiation from Human PSCs Reveals HOPX-Dependent Cardiomyocyte MaturationCell Stem Cell. 2018 10 04; 23(4):586-598. e8. . View in PubMed
  • Erratum: Human embryonic stem cell-derived cardiomyocytes restore function in infarcted hearts of non-human primates Nat Biotechnol. 2018 09 06; 36(9):899. . View in PubMed
  • Micro- and nano-patterned conductive graphene-PEG hybrid scaffolds for cardiac tissue engineering Chem Commun (Camb). 2017 Jun 29; 53(53):7412-7415. . View in PubMed
  • Sustained miRNA release regenerates the heart Nat Biomed Eng. 2017 12; 1(12):931-933. . View in PubMed
  • Cardiomyocyte Regeneration: A Consensus Statement Circulation. 2017 08 15; 136(7):680-686. . View in PubMed
  • One Stride Forward: Maturation and Scalable Production of Engineered Human Myocardium Circulation. 2017 05 09; 135(19):1848-1850. . View in PubMed
  • In Vivo Maturation of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes in Neonatal and Adult Rat Hearts Stem Cell Reports. 2017 02 14; 8(2):278-289. . View in PubMed
  • Generating high-purity cardiac and endothelial derivatives from patterned mesoderm using human pluripotent stem cells Nat Protoc. 2017 Jan; 12(1):15-31. . View in PubMed
  • Chromatin and Transcriptional Analysis of Mesoderm Progenitor Cells Identifies HOPX as a Regulator of Primitive Hematopoiesis Cell Rep. 2017 08 15; 20(7):1597-1608. . View in PubMed
  • Translation of Cardiac Myosin Activation with 2-deoxy-ATP to Treat Heart Failure via an Experimental Ribonucleotide Reductase-Based Gene Therapy JACC Basic Transl Sci. 2016 Dec; 1(7):666-679. . View in PubMed
  • Mechanical Stress Conditioning and Electrical Stimulation Promote Contractility and Force Maturation of Induced Pluripotent Stem Cell-Derived Human Cardiac Tissue Circulation. 2016 Nov 15; 134(20):1557-1567. . View in PubMed
  • New ISSCR guidelines: clinical translation of stem cell research Lancet. 2016 May 14; 387(10032):1979-81. . View in PubMed
  • SCIENTIFIC COMMUNITYConfronting stem cell hype. Science. 2016 May 13; 352(6287):776-7. . View in PubMed
  • Imprecision Medicine: A One-Size-Fits-Many Approach for Muscle Dystrophy Cell Stem Cell. 2016 Apr 07; 18(4):423-4. . View in PubMed
  • Stromal Cells in Dense Collagen Promote Cardiomyocyte and Microvascular Patterning in Engineered Human Heart Tissue Tissue Eng Part A. 2016 Apr; 22(7-8):633-44. . View in PubMed
  • AAV6-mediated Cardiac-specific Overexpression of Ribonucleotide Reductase Enhances Myocardial Contractility Mol Ther. 2016 Feb; 24(2):240-250. . View in PubMed
  • Quantitative proteomics identify DAB2 as a cardiac developmental regulator that inhibits WNT/ß-catenin signaling Proc Natl Acad Sci U S A. 2016 Jan 26; 113(4):1002-7. . View in PubMed
  • Prosurvival Factors Improve Functional Engraftment of Myogenically Converted Dermal Cells into Dystrophic Skeletal Muscle Stem Cells Dev. 2016 10; 25(20):1559-1569. . View in PubMed
  • Setting Global Standards for Stem Cell Research and Clinical Translation: The 2016 ISSCR Guidelines Stem Cell Reports. 2016 06 14; 6(6):787-797. . View in PubMed
  • Erratum to: Statistically based splicing detection reveals neural enrichment and tissue-specific induction of circular RNA during human fetal development Genome Biol. 2016 12 19; 17(1):263. . View in PubMed
  • Nanotopography-Induced Structural Anisotropy and Sarcomere Development in Human Cardiomyocytes Derived from Induced Pluripotent Stem Cells ACS Appl Mater Interfaces. 2016 08 31; 8(34):21923-32. . View in PubMed
  • Policy: Global standards for stem-cell research Nature. 2016 05 19; 533(7603):311-3. . View in PubMed
  • Depth-resolved 3D visualization of coronary microvasculature with optical microangiography Phys Med Biol. 2016 11 07; 61(21):7536-7550. . View in PubMed
  • Isolation and Mechanical Measurements of Myofibrils from Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Stem Cell Reports. 2016 06 14; 6(6):885-896. . View in PubMed
  • Distilling complexity to advance cardiac tissue engineering Sci Transl Med. 2016 06 08; 8(342):342ps13. . View in PubMed
  • Comparison of Human Embryonic Stem Cell-Derived Cardiomyocytes, Cardiovascular Progenitors, and Bone Marrow Mononuclear Cells for Cardiac Repair Stem Cell Reports. 2015 Nov 10; 5(5):753-762. . View in PubMed
  • The advancement of human pluripotent stem cell-derived therapies into the clinic Development. 2015 Oct 15; 142(20):3614. . View in PubMed
  • Defined MicroRNAs Induce Aspects of Maturation in Mouse and Human Embryonic-Stem-Cell-Derived Cardiomyocytes Cell Rep. 2015 Sep 29; 12(12):1960-7. . View in PubMed
  • The advancement of human pluripotent stem cell-derived therapies into the clinic Development. 2015 Sep 15; 142(18):3077-84. . View in PubMed
  • Inhibition of ß-catenin signaling respecifies anterior-like endothelium into beating human cardiomyocytes Development. 2015 Sep 15; 142(18):3198-209. . View in PubMed
  • Ribonucleotide reductase-mediated increase in dATP improves cardiac performance via myosin activation in a large animal model of heart failure Eur J Heart Fail. 2015 Aug; 17(8):772-81. . View in PubMed
  • Mechanical Stress Promotes Maturation of Human Myocardium From Pluripotent Stem Cell-Derived Progenitors Stem Cells. 2015 Jul; 33(7):2148-57. . View in PubMed
  • Statistically based splicing detection reveals neural enrichment and tissue-specific induction of circular RNA during human fetal development Genome Biol. 2015 Jun 16; 16:126. . View in PubMed
  • Response to cardiac regeneration validated Nat Biotechnol. 2015 Jun; 33(6):587. . View in PubMed
  • Functional analysis of a chromosomal deletion associated with myelodysplastic syndromes using isogenic human induced pluripotent stem cells Nat Biotechnol. 2015 Jun; 33(6):646-55. . View in PubMed
  • Let-7 family of microRNA is required for maturation and adult-like metabolism in stem cell-derived cardiomyocytes Proc Natl Acad Sci U S A. 2015 May 26; 112(21):E2785-94. . View in PubMed
  • The winding road to regenerating the human heart Cardiovasc Pathol. 2015 May-Jun; 24(3):133-40. . View in PubMed
  • Enhanced Electrical Integration of Engineered Human Myocardium via Intramyocardial versus Epicardial Delivery in Infarcted Rat Hearts PLoS One. 2015; 10(7):e0131446. . View in PubMed
  • Cardiac development in zebrafish and human embryonic stem cells is inhibited by exposure to tobacco cigarettes and e-cigarettes PLoS One. 2015; 10(5):e0126259. . View in PubMed
  • Cardiac regeneration using pluripotent stem cells–progression to large animal models Stem Cell Res. 2014 Nov; 13(3 Pt B):654-65. . View in PubMed
  • Letter by Murry et al regarding article, “Embryonic stem cell-derived cardiac myocytes are not ready for human trials” Circ Res. 2014 Oct 24; 115(10):e28-9. . View in PubMed
  • Clinical imaging in regenerative medicine Nat Biotechnol. 2014 Aug; 32(8):804-18. . View in PubMed
  • Heart regeneration with engineered myocardial tissue Annu Rev Biomed Eng. 2014 Jul 11; 16:1-28. . View in PubMed
  • Tri-iodo-l-thyronine promotes the maturation of human cardiomyocytes-derived from induced pluripotent stem cells J Mol Cell Cardiol. 2014 Jul; 72:296-304. . View in PubMed
  • Cell-based delivery of dATP via gap junctions enhances cardiac contractility J Mol Cell Cardiol. 2014 Jul; 72:350-9. . View in PubMed
  • Thin filament incorporation of an engineered cardiac troponin C variant (L48Q) enhances contractility in intact cardiomyocytes from healthy and infarcted hearts J Mol Cell Cardiol. 2014 Jul; 72:219-27. . View in PubMed
  • Magnetic Resonance Imaging Tracking of Graft Survival in the Infarcted Heart: Iron Oxide Particles Versus Ferritin Overexpression Approach J Cardiovasc Pharmacol Ther. 2014 Jul; 19(4):358-367. . View in PubMed
  • Human embryonic-stem-cell-derived cardiomyocytes regenerate non-human primate hearts Nature. 2014 Jun 12; 510(7504):273-7. . View in PubMed
  • Capillary force lithography for cardiac tissue engineering J Vis Exp. 2014 Jun 10; (88). . View in PubMed
  • Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies Nat Med. 2014 Jun; 20(6):616-23. . View in PubMed
  • Thermoresponsive nanofabricated substratum for the engineering of three-dimensional tissues with layer-by-layer architectural control ACS Nano. 2014 May 27; 8(5):4430-9. . View in PubMed
  • Proliferation at the heart of preadolescence Cell. 2014 May 08; 157(4):765-7. . View in PubMed
  • Measuring the contractile forces of human induced pluripotent stem cell-derived cardiomyocytes with arrays of microposts J Biomech Eng. 2014 May; 136(5):051005. . View in PubMed
  • Vascular Perfusion of Implanted Human Engineered Cardiac Tissue Proc IEEE Annu Northeast Bioeng Conf. 2014 Apr; 2014. . View in PubMed
  • Engineered biomaterials control differentiation and proliferation of human-embryonic-stem-cell-derived cardiomyocytes via timed Notch activation Stem Cell Reports. 2014 Mar 11; 2(3):271-81. . View in PubMed
  • Dystrophin-deficient cardiomyocytes derived from human urine: new biologic reagents for drug discovery Stem Cell Res. 2014 Mar; 12(2):467-80. . View in PubMed
  • Engineering adolescence: maturation of human pluripotent stem cell-derived cardiomyocytes Circ Res. 2014 Jan 31; 114(3):511-23. . View in PubMed
  • Proangiogenic microtemplated fibrin scaffolds containing aprotinin promote improved wound healing responses Angiogenesis. 2014 Jan; 17(1):195-205. . View in PubMed
  • Trends in cardiovascular engineering: organizing the human heart Trends Cardiovasc Med. 2013 Nov; 23(8):282-6. . View in PubMed
  • SLIT3-ROBO4 activation promotes vascular network formation in human engineered tissue and angiogenesis in vivo J Mol Cell Cardiol. 2013 Nov; 64:124-31. . View in PubMed
  • Improving survival and efficacy of pluripotent stem cell-derived cardiac grafts J Cell Mol Med. 2013 Nov; 17(11):1355-62. . View in PubMed
  • An improved cryosection method for polyethylene glycol hydrogels used in tissue engineering Tissue Eng Part C Methods. 2013 Oct; 19(10):794-801. . View in PubMed
  • Transmembrane protein 88: a Wnt regulatory protein that specifies cardiomyocyte development Development. 2013 Sep; 140(18):3799-808. . View in PubMed
  • Developmental fate and cellular maturity encoded in human regulatory DNA landscapes Cell. 2013 Aug 15; 154(4):888-903. . View in PubMed
  • Progenitor cells identified by PDGFR-alpha expression in the developing and diseased human heart Stem Cells Dev. 2013 Jul 01; 22(13):1932-43. . View in PubMed
  • Cardiopoietry in motion: primed mesenchymal stem cells for ischemic cardiomyopathy J Am Coll Cardiol. 2013 Jun 11; 61(23):2339-40. . View in PubMed
  • Effects of cell grafting on coronary remodeling after myocardial infarction J Am Heart Assoc. 2013 May 30; 2(3):e000202. . View in PubMed
  • Transgenic overexpression of ribonucleotide reductase improves cardiac performance Proc Natl Acad Sci U S A. 2013 Apr 09; 110(15):6187-92. . View in PubMed
  • Human myocardial grafts: do they meet all the criteria for true heart regeneration? Future Cardiol. 2013 Mar; 9(2):151-4.. View in PubMed
  • Monocyte chemoattractant protein 1-mediated migration of mesenchymal stem cells is a source of intimal hyperplasia Arterioscler Thromb Vasc Biol. 2013 06; 33(6):1271-9. . View in PubMed
  • Lack of thrombospondin-2 reduces fibrosis and increases vascularity around cardiac cell grafts Cardiovasc Pathol. 2013 Jan-Feb; 22(1):91-5. . View in PubMed
  • Quantification of MRI signal of transgenic grafts overexpressing ferritin in murine myocardial infarcts NMR Biomed. 2012 Oct; 25(10):1187-95. . View in PubMed
  • A temporal chromatin signature in human embryonic stem cells identifies regulators of cardiac development Cell. 2012 Sep 28; 151(1):221-32. . View in PubMed
  • Human ES-cell-derived cardiomyocytes electrically couple and suppress arrhythmias in injured hearts Nature. 2012 Sep 13; 489(7415):322-5. . View in PubMed
  • Is it possible to transform cardiac scar tissue into beating heart muscle in humans? Regen Med. 2012 Sep; 7(5):623-5.. View in PubMed
  • Regenerative medicine: Reprogramming the injured heart Nature. 2012 May 31; 485(7400):585-6. . View in PubMed
  • Truncations of titin causing dilated cardiomyopathy N Engl J Med. 2012 Feb 16; 366(7):619-28. . View in PubMed
  • Retrograde perfusion and filling of mouse coronary vasculature as preparation for micro computed tomography imaging J Vis Exp. 2012 Feb 10; (60):e3740. . View in PubMed
  • Human embryonic stem cells differentiated to lung lineage-specific cells ameliorate pulmonary fibrosis in a xenograft transplant mouse model PLoS One. 2012; 7(3):e33165. . View in PubMed
  • Synthetic matrices to serve as niches for muscle cell transplantation Cells Tissues Organs. 2012; 195(1-2):48-59. . View in PubMed
  • Targeted genomic integration of a selectable floxed dual fluorescence reporter in human embryonic stem cells PLoS One. 2012; 7(10):e46971. . View in PubMed
  • Upregulation of cardiomyocyte ribonucleotide reductase increases intracellular 2 deoxy-ATP, contractility, and relaxation J Mol Cell Cardiol. 2011 Dec; 51(6):894-901. . View in PubMed
  • Growth of engineered human myocardium with mechanical loading and vascular coculture Circ Res. 2011 Jun 24; 109(1):47-59. . View in PubMed
  • Heart regeneration Nature. 2011 May 19; 473(7347):326-35. . View in PubMed
  • Developing vasculature and stroma in engineered human myocardium Tissue Eng Part A. 2011 May; 17(9-10):1219-28. . View in PubMed
  • A repair “kit” for the infarcted heart Cell Stem Cell. 2011 Apr 08; 8(4):350-2. . View in PubMed
  • Delivery of basic fibroblast growth factor with a pH-responsive, injectable hydrogel to improve angiogenesis in infarcted myocardium Biomaterials. 2011 Mar; 32(9):2407-16. . View in PubMed
  • Engineered human cardiac tissue Pediatr Cardiol. 2011 Mar; 32(3):334-41. . View in PubMed
  • Reprogramming fibroblasts into cardiomyocytes N Engl J Med. 2011 Jan 13; 364(2):177-8. . View in PubMed
  • Evidence that gene activation and silencing during stem cell differentiation requires a transcriptionally paused intermediate state PLoS One. 2011; 6(8):e22416. . View in PubMed
  • Human embryonic stem cell-derived cardiomyocytes engraft but do not alter cardiac remodeling after chronic infarction in rats J Mol Cell Cardiol. 2010 Dec; 49(6):941-9. . View in PubMed
  • Cardiogenesis from human embryonic stem cells Circ J. 2010 Nov; 74(12):2517-26. . View in PubMed
  • Differentiation of cardiomyocytes from human embryonic stem cells is accompanied by changes in the extracellular matrix production of versican and hyaluronan J Cell Biochem. 2010 Oct 15; 111(3):585-96. . View in PubMed
  • The role of macrophage-derived urokinase plasminogen activator in myocardial infarct repair: urokinase attenuates ventricular remodeling J Mol Cell Cardiol. 2010 Sep; 49(3):516-24. . View in PubMed
  • Proangiogenic scaffolds as functional templates for cardiac tissue engineering Proc Natl Acad Sci U S A. 2010 Aug 24; 107(34):15211-6. . View in PubMed
  • Ferritin overexpression for noninvasive magnetic resonance imaging-based tracking of stem cells transplanted into the heart Mol Imaging. 2010 Aug; 9(4):201-10. . View in PubMed
  • Endogenous Wnt/beta-catenin signaling is required for cardiac differentiation in human embryonic stem cells PLoS One. 2010 Jun 15; 5(6):e11134. . View in PubMed
  • Taking a load off: nuclear remodeling after mechanically supporting the failing human heart Circulation. 2010 Mar 02; 121(8):957-9. . View in PubMed
  • VEGF induces differentiation of functional endothelium from human embryonic stem cells: implications for tissue engineering Arterioscler Thromb Vasc Biol. 2010 Jan; 30(1):80-9. . View in PubMed
  • Cell therapy enhances function of remote non-infarcted myocardium J Mol Cell Cardiol. 2009 Nov; 47(5):603-13. . View in PubMed
  • Myostatin represses physiological hypertrophy of the heart and excitation-contraction coupling J Physiol. 2009 Oct 15; 587(Pt 20):4873-86. . View in PubMed
  • Physiological function and transplantation of scaffold-free and vascularized human cardiac muscle tissue Proc Natl Acad Sci U S A. 2009 Sep 29; 106(39):16568-73. . View in PubMed
  • Scaffold-free human cardiac tissue patch created from embryonic stem cells Tissue Eng Part A. 2009 Jun; 15(6):1211-22. . View in PubMed
  • Development biologyTurnover after the fallout. Science. 2009 Apr 03; 324(5923):47-8. . View in PubMed
  • Retention and biodistribution of microspheres injected into ischemic myocardium J Biomed Mater Res A. 2009 Mar 01; 88(3):704-10. . View in PubMed
  • Systems approaches to preventing transplanted cell death in cardiac repair J Mol Cell Cardiol. 2008 Oct; 45(4):567-81. . View in PubMed
  • Get with the (re)program: cardiovascular potential of skin-derived induced pluripotent stem cells Circulation. 2008 Jul 29; 118(5):472-5. . View in PubMed
  • Bones of contention: marrow-derived cells in myocardial regeneration J Mol Cell Cardiol. 2008 Jun; 44(6):950-953. . View in PubMed
  • A hierarchical network controls protein translation during murine embryonic stem cell self-renewal and differentiation Cell Stem Cell. 2008 May 08; 2(5):448-60. . View in PubMed
  • Chromatin remodeling during mouse and human embryonic stem cell differentiation Dev Dyn. 2008 May; 237(5):1389-98. . View in PubMed
  • Differentiation of embryonic stem cells to clinically relevant populations: lessons from embryonic development Cell. 2008 Feb 22; 132(4):661-80. . View in PubMed
  • Absence of regeneration in the MRL/MpJ mouse heart following infarction or cryoinjury Cardiovasc Pathol. 2008 Jan-Feb; 17(1):6-13. . View in PubMed
  • Fibroblast growth factor-2 regulates myocardial infarct repair: effects on cell proliferation, scar contraction, and ventricular function Am J Pathol. 2007 Nov; 171(5):1431-40. . View in PubMed
  • Cardiomyocytes derived from human embryonic stem cells in pro-survival factors enhance function of infarcted rat hearts Nat Biotechnol. 2007 Sep; 25(9):1015-24. . View in PubMed
  • Cardiac aid to the injured but not the elderly? Nat Med. 2007 Aug; 13(8):901-2.. View in PubMed
  • Selective control of endothelial cell proliferation with a synthetic dimerizer of FGF receptor-1 Lab Invest. 2007 Aug; 87(8):828-35. . View in PubMed
  • Biphasic role for Wnt/beta-catenin signaling in cardiac specification in zebrafish and embryonic stem cells Proc Natl Acad Sci U S A. 2007 Jun 05; 104(23):9685-90. . View in PubMed
  • Chemical dimerization of fibroblast growth factor receptor-1 induces myoblast proliferation, increases intracardiac graft size, and reduces ventricular dilation in infarcted hearts Hum Gene Ther. 2007 May; 18(5):401-12. . View in PubMed
  • Transplantation of undifferentiated murine embryonic stem cells in the heart: teratoma formation and immune response FASEB J. 2007 May; 21(7):1345-57. . View in PubMed
  • Cell-based therapy for myocardial ischemia and infarction: pathophysiological mechanisms Annu Rev Pathol. 2007; 2:307-39. . View in PubMed
  • rAAV6-microdystrophin preserves muscle function and extends lifespan in severely dystrophic mice Nat Med. 2006 Jul; 12(7):787-9. . View in PubMed
  • Regeneration gaps: observations on stem cells and cardiac repair J Am Coll Cardiol. 2006 May 02; 47(9):1777-85. . View in PubMed
  • Proliferation of cardiomyocytes derived from human embryonic stem cells is mediated via the IGF/PI 3-kinase/Akt signaling pathway J Mol Cell Cardiol. 2005 Dec; 39(6):865-73. . View in PubMed
  • Cell-based cardiac repair: reflections at the 10-year point Circulation. 2005 Nov 15; 112(20):3174-83. . View in PubMed
  • Extracardiac progenitor cells repopulate most major cell types in the transplanted human heart Circulation. 2005 Nov 08; 112(19):2951-8. . View in PubMed
  • Formation of human myocardium in the rat heart from human embryonic stem cells Am J Pathol. 2005 Sep; 167(3):663-71. . View in PubMed
  • Regenerating the heart Nat Biotechnol. 2005 Jul; 23(7):845-56. . View in PubMed
  • Myogenic fusion of human bone marrow stromal cells, but not hematopoietic cells Blood. 2004 Jul 01; 104(1):290-4. . View in PubMed
  • Gene transfer of connexin43 into skeletal muscle Hum Gene Ther. 2004 Jul; 15(7):627-36. . View in PubMed
  • NFATc3-induced reductions in voltage-gated K+ currents after myocardial infarction Circ Res. 2004 May 28; 94(10):1340-50. . View in PubMed
  • Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts Nature. 2004 Apr 08; 428(6983):664-8. . View in PubMed
  • Evidence for fusion between cardiac and skeletal muscle cells Circ Res. 2004 Apr 02; 94(6):e56-60. . View in PubMed
  • Myofibroblast and endothelial cell proliferation during murine myocardial infarct repair Am J Pathol. 2003 Dec; 163(6):2433-40. . View in PubMed
  • Spatially organized layers of cardiomyocytes on biodegradable polyurethane films for myocardial repair J Biomed Mater Res A. 2003 Sep 01; 66(3):586-95. . View in PubMed
  • Friends or foes? J Am Coll Cardiol. 2003 Apr 02; 41(7):1084-6.. View in PubMed
  • Immunohistologic labeling of murine endothelium Cardiovasc Pathol. 2003 Mar-Apr; 12(2):82-90. . View in PubMed
  • Cell grafting for cardiac repair Methods Mol Biol. 2003; 219:97-112. . View in PubMed
  • Intracoronary E-/L-selectin blockade reduces neutrophil infiltration in heart transplantation Ann Thorac Surg. 2002 Dec; 74(6):2064-70; discussion 2070-1. . View in PubMed
  • Muscle cell grafting for the treatment and prevention of heart failure J Card Fail. 2002 Dec; 8(6 Suppl):S532-41. . View in PubMed
  • In vitro generation of differentiated cardiac myofibers on micropatterned laminin surfaces J Biomed Mater Res. 2002 Jun 05; 60(3):472-9. . View in PubMed
  • Evidence for cardiomyocyte repopulation by extracardiac progenitors in transplanted human hearts Circ Res. 2002 Apr 05; 90(6):634-40. . View in PubMed
  • Taking the death toll after cardiomyocyte grafting: a reminder of the importance of quantitative biology J Mol Cell Cardiol. 2002 Mar; 34(3):251-3. . View in PubMed
  • Skeletal muscle stem cells do not transdifferentiate into cardiomyocytes after cardiac grafting J Mol Cell Cardiol. 2002 Feb; 34(2):241-9. . View in PubMed
  • Cellular therapies for myocardial infarct repair Cold Spring Harb Symp Quant Biol. 2002; 67:519-26. . View in PubMed
  • Control of myoblast proliferation with a synthetic ligand J Biol Chem. 2001 Nov 02; 276(44):41191-6. . View in PubMed
  • Cardiomyocyte grafting for cardiac repair: graft cell death and anti-death strategies J Mol Cell Cardiol. 2001 May; 33(5):907-21. . View in PubMed
  • Fatal parvovirus myocarditis in a 5-year-old girl Hum Pathol. 2001 Mar; 32(3):342-5. . View in PubMed
  • Too much of a good thing? Cardiovasc Pathol. 2000 Nov-Dec; 9(6):337-44.. View in PubMed
  • Cellular FLIP is expressed in cardiomyocytes and down-regulated in TUNEL-positive grafted cardiac tissues Cardiovasc Res. 2000 Oct; 48(1):101-10. . View in PubMed
  • Phosphate regulation of vascular smooth muscle cell calcification Circ Res. 2000 Sep 29; 87(7):E10-7. . View in PubMed
  • Electromechanical coupling between skeletal and cardiac muscleImplications for infarct repair. J Cell Biol. 2000 May 01; 149(3):731-40. . View in PubMed
  • Shear stress stimulation of p130(cas) tyrosine phosphorylation requires calcium-dependent c-Src activation J Biol Chem. 1999 Sep 17; 274(38):26803-9. . View in PubMed
  • Survival, integration, and differentiation of cardiomyocyte grafts: a study in normal and injured rat hearts Circulation. 1999 Jul 13; 100(2):193-202. . View in PubMed
  • New possibilities for prenatal diagnosis of muscular dystrophies: forced myogenesis with an adenoviral MyoD-vector Lancet. 1999 Feb 27; 353(9154):727-8. . View in PubMed
  • High efficiency myogenic conversion of human fibroblasts by adenoviral vector-mediated MyoD gene transferAn alternative strategy for ex vivo gene therapy of primary myopathies. J Clin Invest. 1998 May 15; 101(10):2119-28. . View in PubMed
  • Clonal architecture of normal and atherosclerotic aorta: implications for atherogenesis and vascular development Am J Pathol. 1998 Apr; 152(4):913-23. . View in PubMed
  • A quantitative method for determination of endothelial mRNA expression in vivo: induction of platelet-derived growth factor by endotoxin Am J Pathol. 1998 Apr; 152(4):903-12. . View in PubMed
  • Evidence for a role of osteopontin in macrophage infiltration in response to pathological stimuli in vivo Am J Pathol. 1998 Feb; 152(2):353-8. . View in PubMed
  • Proliferation and the monoclonal origins of atherosclerotic lesions Annu Rev Med. 1998; 49:437-60. . View in PubMed
  • Monoclonality of smooth muscle cells in human atherosclerosis Am J Pathol. 1997 Sep; 151(3):697-705. . View in PubMed
  • Skeletal myoblast transplantation for repair of myocardial necrosis J Clin Invest. 1996 Dec 01; 98(11):2512-23. . View in PubMed
  • Muscle differentiation during repair of myocardial necrosis in rats via gene transfer with MyoD J Clin Invest. 1996 Nov 15; 98(10):2209-17. . View in PubMed
  • Detection and quantitation of perlecan mRNA levels in Alzheimer’s disease and normal aged hippocampus by competitive reverse transcription-polymerase chain reaction J Neurochem. 1996 Sep; 67(3):1132-44. . View in PubMed
  • Platelet-derived growth factor-A mRNA expression in fetal, normal adult, and atherosclerotic human aortasAnalysis by competitive polymerase chain reaction. Circulation. 1996 Mar 15; 93(6):1095-106. . View in PubMed
  • The intima: development and monoclonal responses to injury Atherosclerosis. 1995 Dec; 118 Suppl:S125-40. . View in PubMed
  • Healing of myocardial infarcts in dogsEffects of late reperfusion. Circulation. 1995 Oct 01; 92(7):1891-901. . View in PubMed
  • Osteopontin expression in cardiovascular diseases Ann N Y Acad Sci. 1995 Apr 21; 760:109-26. . View in PubMed
  • Macrophages express osteopontin during repair of myocardial necrosis Am J Pathol. 1994 Dec; 145(6):1450-62. . View in PubMed
  • Superoxide dismutase plus catalase therapy delays neither cell death nor the loss of the TTC reaction in experimental myocardial infarction in dogs J Mol Cell Cardiol. 1993 Apr; 25(4):367-78. . View in PubMed
  • Tissue invasion by Pneumocystis carinii: a possible cause of cavitary pneumonia and pneumothorax Hum Pathol. 1992 Dec; 23(12):1380-7. . View in PubMed
  • Energy metabolism in preconditioned and control myocardium: effect of total ischemia J Mol Cell Cardiol. 1991 Dec; 23(12):1449-58. . View in PubMed
  • Preconditioning myocardium with ischemia Cardiovasc Drugs Ther. 1991 Oct; 5(5):933-8. . View in PubMed
  • A CD18 monoclonal antibody increases the incidence and severity of subcutaneous abscess formation after high-dose Staphylococcus aureus injection in rabbits Surgery. 1991 Aug; 110(2):213-9; discussion 219-20. . View in PubMed
  • New insights into potential mechanisms of ischemic preconditioning Circulation. 1991 Jul; 84(1):442-5. . View in PubMed
  • Myocardial protection is lost before contractile function recovers from ischemic preconditioning Am J Physiol. 1991 Mar; 260(3 Pt 2):H796-804. . View in PubMed
  • Hypoxic reperfusion to remove ischaemic catabolites prior to arterial reperfusion does not limit the size of myocardial infarcts in dogs Cardiovasc Res. 1991 Jan; 25(1):7-16. . View in PubMed
  • Cardiac adaptation to ischemiaIschemic preconditioning increases myocardial tolerance to subsequent ischemic episodes. Circulation. 1990 Dec; 82(6):2266-8. . View in PubMed
  • Electrophysiological effects of monophasic and biphasic stimuli in normal and infarcted dogs Pacing Clin Electrophysiol. 1990 Sep; 13(9):1158-72. . View in PubMed
  • Development of cell injury in sustained acute ischemia Circulation. 1990 Sep; 82(3 Suppl):II2-12. . View in PubMed
  • Ischemic preconditioning slows energy metabolism and delays ultrastructural damage during a sustained ischemic episode Circ Res. 1990 Apr; 66(4):913-31. . View in PubMed
  • Evaluation of free radical injury in myocardium Toxicol Pathol. 1990; 18(4 Pt 1):470-80. . View in PubMed
  • Myocardial effects of brief periods of ischemia followed by reperfusion Adv Cardiol. 1990; 37:7-31. . View in PubMed
  • Oxygen-derived free radicals and postischemic myocardial reperfusion: therapeutic implications Fundam Clin Pharmacol. 1990; 4(1):85-103. . View in PubMed
  • The role of neutrophils and free radicals in the ischemic-reperfused heart: why the confusion and controversy? J Mol Cell Cardiol. 1989 Dec; 21(12):1225-39.. View in PubMed
  • Myocardial neutrophil accumulation during reperfusion after reversible or irreversible ischemic injury Am J Physiol. 1988 Nov; 255(5 Pt 2):H1188-98. . View in PubMed
  • Therapy to reduce free radicals during early reperfusion does not limit the size of myocardial infarcts caused by 90 minutes of ischemia in dogs Circulation. 1988 Aug; 78(2):473-80. . View in PubMed
  • The xanthine oxidase inhibitor oxypurinol does not limit infarct size in a canine model of 40 minutes of ischemia with reperfusion J Am Coll Cardiol. 1988 Jul; 12(1):209-17. . View in PubMed
  • Three-dimensional distribution of collateral blood flow within the anatomic area at risk after circumflex coronary artery occlusion in dogs Basic Res Cardiol. 1987 Sep-Oct; 82(5):473-85. . View in PubMed
  • Failure of superoxide dismutase to limit size of myocardial infarction after 40 minutes of ischemia and 4 days of reperfusion in dogs Circulation. 1987 Jun; 75(6):1237-48. . View in PubMed
  • Four brief periods of myocardial ischemia cause no cumulative ATP loss or necrosis Am J Physiol. 1986 Dec; 251(6 Pt 2):H1306-15. . View in PubMed
  • Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium Circulation. 1986 Nov; 74(5):1124-36. . View in PubMed

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