Chih-Lin Hsieh, PhD

Professor of Urology

Catherine and Joseph Aresty Chair in Urologic Research

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Overview

I am a human geneticist by training and am certified in both clinical cytogenetics and clinical molecular genetics by the American Board of Medical Genetics since 1993. My research has primarily focused on 1) prostate cancer genetics; 2) function and mechanism of DNA methylation and how it is related to chromatin structure; 3) mechanism of recurring chromosomal translocations; (4) aging due to DNA damage; and 5) mitochondrial biology.

Education and Training

  • National Taiwan University, Taipei, Taiwan — B.S. — 1979 — Zoolofy
  • California State University, Fresno, CA — M.A. — 1982 — Biology
  • The University of Texas at Austin, Austin, TX — Ph.D. — 1987 — Genetics
  • Northwestern California University, Sacramento, CA — J.D. — 2009 — Law

Research Funding

  • GENETIC HETEROGENEITY AMONG HUMAN SOMATIC CELLS AND ITS ACCUMULATION WITH AGE
    NIH · R56AG067615 · Aug 1, 2020 – Jul 31, 2027 · Role: Principal Investigator
  • GENETIC HETEROGENEITY AMONG HUMAN SOMATIC CELLS AND ITS ACCUMULATION WITH AGE
    NIH · R01AG067615 · Aug 1, 2020 – Apr 30, 2025 · Role: Principal Investigator

Publications

  • Mutation count and mutation profile analyses of single-nucleotide variants in single human colon crypts. bioRxiv. 2026 Jun 14.. View in PubMed
  • Complex Indel Detection: A Simulation-Based Framework and Parsing with FreeBayes. bioRxiv. 2026 May 29.. View in PubMed
  • Fine Structural Features of Complex InDels and NHEJ Repair at Naturally Occurring Damage Sites in Normal Human Colon Crypts. bioRxiv. 2026 Apr 03.. View in PubMed
  • Analysis of Naturally Occurring Somatic Insertions in the Human Genome. bioRxiv. 2025 Oct 01.. View in PubMed
  • High-depth Whole Genome Sequencing of Single Human Colon Crypts Uncovers New View on Crypt Clonality. bioRxiv. 2025 Sep 26.. View in PubMed
  • On the mechanism of NPM1 mutations in acute myeloid leukemia. Leukemia. 2025 Oct; 39(10):2340-2343.. View in PubMed
  • The RNA tether model for human chromosomal translocation fragile zones. Trends Biochem Sci. 2024 05; 49(5):391-400.. View in PubMed
  • Construction of high coverage whole-genome sequencing libraries from single colon crypts without DNA extraction or whole-genome amplification. BMC Res Notes. 2023 Apr 27; 16(1):66.. View in PubMed
  • Artemis inhibition as a therapeutic strategy for acute lymphoblastic leukemia. Front Cell Dev Biol. 2023; 11:1134121.. View in PubMed
  • The mRNA tether model for activation-induced deaminase and its relevance for Ig somatic hypermutation and class switch recombination. DNA Repair (Amst). 2022 02; 110:103271.. View in PubMed