Christian Hendershot, PhD

Professor of Population and Public Health Sciences, Psychology, and Psychiatry and the Behavioral Sciences

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Overview

Dr. Hendershot is a Professor of Population and Public Health Sciences and Director of Clinical Research, USC Institute for Addiction Science. He is also a member of the USC Norris Comprehensive Cancer Center. He completed his Ph.D. in clinical psychology at the University of Washington, followed by postdoctoral training at the University of New Mexico. Prior to joining USC Dr. Hendershot held faculty positions at the University of North Carolina at Chapel Hill and the Centre for Addiction and Mental Health/University of Toronto, where he held a Canada Research Chair in Alcohol Use Disorders. Dr. Hendershot’s research utilizes clinical, cognitive, neuroscience and psychopharmacology methods to study risk factors and candidate treatments for substance use disorder. His current projects include clinical trials to investigate the efficacy of glucagon-like peptide-1 (GLP-1) receptor agonists as novel treatments for alcohol use disorder and tobacco use disorder.

Awards

  • Government of Canada: Canada Research Chair, 2016
     – 2021
  • Canadian Institutes of Health Research: The Peter Lougheed New Investigator Award, 2013

Education and Training

  • University of Washington, Seattle, WA — Ph.D. — 2009 — Clinical Psychology
  • University of New Mexico, Albuquerque, NM — Postdoctoral Fellowship — 2010

Publications

  • GLP-1 Receptor Agonists: Informing Mechanistic Models and Innovative Targets in the Treatment and Prevention of Mental and Substance Use Disorders. Biol Psychiatry. 2026 Oct 15; 100(8):799-801.. View in PubMed
  • Associations among alcohol sensitivity, acquired tolerance, and drinking outcomes in late adolescence. Exp Clin Psychopharmacol. 2026 Oct 01.. View in PubMed
  • Feasibility and Acceptability of a Group-Based Relapse Prevention Program for Liver Transplant Recipients With Alcohol-Associated Liver. Clin Transplant. 2026 Sep; 40(9):e70667.. View in PubMed
  • Identifying Behavior Change Techniques for Digital Interventions Addressing Alcohol and Tobacco Co-Use: Findings From a Delphi Consensus Study. JMIR Form Res. 2026 07 03; 10:e88996.. View in PubMed
  • The Effects of Personalized Feedback About ALDH2*2, Alcohol Use, and Associated Health Risks on Drinking Intention and Consumption: The Role of Self-Efficacy and Perceived Threat. Alcohol Clin Exp Res (Hoboken). 2026 Jun; 50(6):e70291.. View in PubMed
  • Predictive and discriminant validity of the Impaired Control Scale – Cannabis (ICS-C): an intensive longitudinal study of daily cannabis use outcomes. J Cannabis Res. 2026 May 09; 8(1).. View in PubMed
  • GLP-1 therapies: an emerging approach for alcohol reduction? Lancet. 2026 May 02; 407(10540):1658-1659. Hendershot CS , Klein KR . View in PubMed
  • Once-Weekly Semaglutide in Adults With Daily Cigarette Use: A Randomized Clinical Trial. JAMA Netw Open. 2026 05 01; 9(5):e2614898.. View in PubMed
  • Therapeutic Potential of Glucagon-Like Peptide-1 Receptor Agonists for Smoking Cessation. Biol Psychiatry. 2026 Apr 10.. View in PubMed
  • Correction: Histamine H3 Receptor as a target for alcohol use disorder: challenging the predictability of animal models for clinical translation in drug development. Transl Psychiatry. 2026 Mar 16; 16(1).. View in PubMed