USC.edu
Are You a Patient?

Christopher J.L. Newth, MD

Professor of Pediatrics and Anesthesiology

Image of Christopher J.L. Newth, MD
Websites
Is this your profile? Click to edit
Email [email protected]
CTSI Profile

Research Funding

  • Translating an Adult Ventilator Computer Protocol to Pediatric Critical Care
    NIH · R21HD061870 · Mar 5, 2011 – Feb 28, 2014 · Role: Principal Investigator
  • Los Angeles Center of the Collaborative Pediatric Critical Care Research Network
    NIH · UG1HD050012 · May 1, 2005 – Nov 30, 2015 · Role: Principal Investigator
  • Controlled Trial of Two Lung Protective Ventilation Modes in Acute Lung Injury
    NIH · U10HD050012 · May 1, 2005 – Nov 30, 2014 · Role: Principal Investigator

Publications

  • The Accuracy of Plateau and Driving Pressures During Assisted and Spontaneous Ventilation Depends on the Degree of Inspiratory Effort and Duration of the Inspiratory Hold. Respir Care. 2026 Jun 11; 19433654261450212.. View in PubMed
  • Diaphragm Thickening Fraction for Predicting Esophageal Pressure and Ventilator Weaning in Children. Chest. 2026 Mar 23.. View in PubMed
  • Plasma Linoleic Acid Is Associated With Pediatric Sepsis Phenotype and Acute Kidney Injury. Pediatr Crit Care Med. 2026 Apr 01; 27(4):356-366.. View in PubMed
  • Electrical impedance tomography guided single lung ventilation in a pediatric patient with ARDS. Am J Respir Crit Care Med. 2026 Mar 01; 212(3):526-529.. View in PubMed
  • Inhaled L-Epinephrine As a Rescue Therapy in Critical Bronchiolitis. Crit Care Explor. 2026 Feb; 8(2):e1368.. View in PubMed
  • Inhaled L-Epinephrine As a Rescue Therapy in Critical Bronchiolitis. Crit Care Explor. 2026 Feb 01; 8(2):e1368.. View in PubMed
  • Decision Assist During Mechanical Ventilation. Respir Care. 2026 02; 71(2):226-236.. View in PubMed
  • Deleterious variants in LTBP4 are associated with severe pediatric sepsis. Pediatr Res. 2026 Jun; 99(5):2007-2018.. View in PubMed
  • Noninvasive estimation of oxygenation index in pediatric critical care: an independent retrospective observational validation. Front Pediatr. 2025; 13:1675130.. View in PubMed
  • Differentiating Lung From Chest Wall Mechanics Is Difficult Without Esophageal Manometry in Children With Acute Respiratory Distress Syndrome. Crit Care Med. 2025 Nov 01; 53(11):e2211-e2221.. View in PubMed
  • Intravenous Bronchodilators in Pediatric Critical Asthma: A Systematic Review and Network Meta-Analysis. Pediatr Pulmonol. 2025 Jul; 60(7):e71192.. View in PubMed
  • Application of New Pediatric Sepsis Definition to a Multicenter Observational Cohort of Previously Enrolled Severe Sepsis Patients Defined by SIRS Plus Organ Dysfunction. J Intensive Care Med. 2025 Dec; 40(12):1260-1268.. View in PubMed
  • Randomized Trial of Lung and Diaphragm Protective Ventilation in Children. NEJM Evid. 2025 Jun; 4(6):EVIDoa2400360.. View in PubMed
  • AARC and PALISI Clinical Practice Guideline: Pediatric Critical Asthma. Respir Care. 2025 05; 70(5):593-609.. View in PubMed
  • Invasive Respiratory Support in Critical Pediatric Asthma. Respir Care. 2025 06; 70(6):777-793.. View in PubMed
  • Extubation Failure in the PICU: A Virtual Pediatric Systems Database Study, 2017-2021. Pediatr Crit Care Med. 2025 Mar 01; 26(3):e364-e373.. View in PubMed
  • Challenges in using the ROX index as a predictor of failure in high flow nasal cannula in infants with respiratory failure. Pediatr Pulmonol. 2025 Jan; 60(1):e27332.. View in PubMed
  • Phenotypes based on respiratory drive and effort to identify the risk factors when P0.1 fails to estimate ∆PES in ventilated children. Crit Care. 2024 10 04; 28(1):325.. View in PubMed
  • Non-invasive positive pressure ventilation for acute asthma in children. Cochrane Database Syst Rev. 2024 10 02; 10:CD012067.. View in PubMed
  • IMPACT OF ABCC8 AND TRPM4 GENETIC VARIATION IN CENTRAL NERVOUS SYSTEM DYSFUNCTION ASSOCIATED WITH PEDIATRIC SEPSIS. Shock. 2024 11 01; 62(5):688-697.. View in PubMed
  • Risk factors for prolonged infection and secondary infection in pediatric severe sepsis. Infection. 2025 Feb; 53(1):241-251.. View in PubMed
  • Association of extreme hyperoxemic events and mortality in pediatric critical care: an observational cohort study. Front Pediatr. 2024; 12:1429882.. View in PubMed
  • Framework for Research Gaps in Pediatric Ventilator Liberation. Chest. 2024 Nov; 166(5):1056-1070.. View in PubMed
  • Noninvasive Surrogate for Physiologic Dead Space Using the Carbon Dioxide Ventilatory Equivalent: Testing in a Single-Center Cohort, 2017-2023. Pediatr Crit Care Med. 2024 Sep 01; 25(9):784-794.. View in PubMed
  • Factors associated with family decision-making after pediatric out-of-hospital cardiac arrest. Resuscitation. 2024 08; 201:110233.. View in PubMed
  • Viral DNAemia and DNA Virus Seropositivity and Mortality in Pediatric Sepsis. JAMA Netw Open. 2024 02 05; 7(2):e240383.. View in PubMed
  • Estimation of inspiratory effort using airway occlusion maneuvers in ventilated children: a secondary analysis of an ongoing randomized trial testing a lung and diaphragm protective ventilation strategy. Crit Care. 2023 11 29; 27(1):466.. View in PubMed
  • Determining an Optimal Oxygen Saturation Target Range Based on Neonatal Maturity: Demonstration of a Decision Tree Analytic. Diagnostics (Basel). 2023 Oct 26; 13(21).. View in PubMed
  • Hyperferritinemic sepsis, macrophage activation syndrome, and mortality in a pediatric research network: a causal inference analysis. Crit Care. 2023 09 06; 27(1):347.. View in PubMed
  • Early, Persistent Lymphopenia Is Associated With Prolonged Multiple Organ Failure and Mortality in Septic Children. Crit Care Med. 2023 12 01; 51(12):1766-1776.. View in PubMed
  • Acute Disorders of Consciousness in Pediatric Severe Sepsis and Organ Failure: Secondary Analysis of the Multicenter Phenotyping Sepsis-Induced Multiple Organ Failure Study. Pediatr Crit Care Med. 2023 10 01; 24(10):840-848.. View in PubMed
  • Assessment of Brain Magnetic Resonance and Spectroscopy Imaging Findings and Outcomes After Pediatric Cardiac Arrest. JAMA Netw Open. 2023 06 01; 6(6):e2320713.. View in PubMed
  • Effort and work-of-breathing parameters strongly correlate with increased resistance in an animal model. Pediatr Res. 2023 09; 94(3):944-949.. View in PubMed
  • The end-tidal alveolar dead space fraction for risk stratification during the first week of invasive mechanical ventilation: an observational cohort study. Crit Care. 2023 02 09; 27(1):54.. View in PubMed
  • Executive Summary of the Second International Guidelines for the Diagnosis and Management of Pediatric Acute Respiratory Distress Syndrome (PALICC-2). Pediatr Crit Care Med. 2023 02 01; 24(2):143-168.. View in PubMed
  • Leveraging Clinical Informatics and Data Science to Improve Care and Facilitate Research in Pediatric Acute Respiratory Distress Syndrome: From the Second Pediatric Acute Lung Injury Consensus Conference. Pediatr Crit Care Med. 2023 02 01; 24(12 Suppl 2):S1-S11.. View in PubMed
  • Executive Summary: International Clinical Practice Guidelines for Pediatric Ventilator Liberation, A Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network Document. Am J Respir Crit Care Med. 2023 01 01; 207(1):17-28.. View in PubMed
  • Operational Definitions Related to Pediatric Ventilator Liberation. Chest. 2023 05; 163(5):1130-1143.. View in PubMed
  • Computer clinical decision support that automates personalized clinical care: a challenging but needed healthcare delivery strategy. J Am Med Inform Assoc. 2022 12 13; 30(1):178-194.. View in PubMed
  • Mortality Risk in Pediatric Sepsis Based on C-reactive Protein and Ferritin Levels. Pediatr Crit Care Med. 2022 12 01; 23(12):968-979.. View in PubMed
  • Association of Blood-Based Brain Injury Biomarker Concentrations With Outcomes After Pediatric Cardiac Arrest. JAMA Netw Open. 2022 09 01; 5(9):e2230518.. View in PubMed
  • A 30-Minute Spontaneous Breathing Trial Misses Many Children Who Go On to Fail a 120-Minute Spontaneous Breathing Trial. Chest. 2023 01; 163(1):115-127.. View in PubMed
  • Executive Summary: International Clinical Practice Guidelines for Pediatric Ventilator Liberation, A PALISI Network Document. Am J Respir Crit Care Med. 2022 Aug 15.. View in PubMed
  • Association of Pathogen Type With Outcomes of Children Encountering Community-Acquired Pediatric Septic Shock. Pediatr Crit Care Med. 2022 08 01; 23(8):635-645.. View in PubMed
  • Clinical Challenges in Pediatric Ventilation Liberation: A Meta-Narrative Review. Pediatr Crit Care Med. 2022 12 01; 23(12):999-1008.. View in PubMed
  • Development of a Pleural Pressure Catheter via Continuous Fiberoptic Esophageal Pressure Measurements. Annu Int Conf IEEE Eng Med Biol Soc. 2022 07; 2022:3269-3272.. View in PubMed
  • Continuous noninvasive blood gas estimation in critically ill pediatric patients with respiratory failure. Sci Rep. 2022 06 14; 12(1):9853.. View in PubMed
  • The Association of Early Corticosteroid Therapy With Clinical and Health-Related Quality of Life Outcomes in Children With Septic Shock. Pediatr Crit Care Med. 2022 09 01; 23(9):687-697.. View in PubMed
  • Normalization to Predicted Body Weight May Underestimate Mechanical Energy in Pediatric Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med. 2022 06 01; 205(11):1360-1363.. View in PubMed
  • Machine learning derivation of four computable 24-h pediatric sepsis phenotypes to facilitate enrollment in early personalized anti-inflammatory clinical trials. Crit Care. 2022 05 07; 26(1):128.. View in PubMed
  • High-Flow Nasal Cannula Reduces Effort of Breathing But Not Consistently via Positive End-Expiratory Pressure. Chest. 2022 10; 162(4):861-871.. View in PubMed
  • Health Resource Use in Survivors of Pediatric Septic Shock in the United States. Pediatr Crit Care Med. 2022 06 01; 23(6):e277-e288.. View in PubMed
  • Anticoagulation practices associated with bleeding and thrombosis in pediatric extracorporeal membrane oxygenation; a multi-center secondary analysis. Perfusion. 2023 03; 38(2):363-372.. View in PubMed
  • Mechanical power in pediatric acute respiratory distress syndrome: a PARDIE study. Crit Care. 2022 01 03; 26(1):2.. View in PubMed
  • Prevalence of Pathogenic and Potentially Pathogenic Inborn Error of Immunity Associated Variants in Children with Severe Sepsis. J Clin Immunol. 2022 02; 42(2):350-364.. View in PubMed
  • Outcomes Associated With Early RBC Transfusion in Pediatric Severe Sepsis: A Propensity-Adjusted Multicenter Cohort Study. Shock. 2022 01 01; 57(1):88-94.. View in PubMed
  • Subglottic Post-Extubation Upper Airway Obstruction Is Associated With Long-Term Airway Morbidity in Children. Pediatr Crit Care Med. 2021 10 01; 22(10):e502-e512.. View in PubMed
  • Adherence to Lung-Protective Ventilation Principles in Pediatric Acute Respiratory Distress Syndrome: A Pediatric Acute Respiratory Distress Syndrome Incidence and Epidemiology Study. Crit Care Med. 2021 10 01; 49(10):1779-1789.. View in PubMed
  • A New Trick for an Old Dog: L-Epinephrine Delivered Continuously in the Vapor Phase. Crit Care Explor. 2021 Oct; 3(10):e0541.. View in PubMed
  • Improvement in Health-Related Quality of Life After Community Acquired Pediatric Septic Shock. Front Pediatr. 2021; 9:675374.. View in PubMed
  • Machine learning model for early prediction of acute kidney injury (AKI) in pediatric critical care. Crit Care. 2021 08 10; 25(1):288.. View in PubMed
  • Enabling a learning healthcare system with automated computer protocols that produce replicable and personalized clinician actions. J Am Med Inform Assoc. 2021 06 12; 28(6):1330-1344.. View in PubMed
  • Frequency and Risk Factors for Reverse Triggering in Pediatric Acute Respiratory Distress Syndrome during Synchronized Intermittent Mandatory Ventilation. Ann Am Thorac Soc. 2021 05; 18(5):820-829.. View in PubMed
  • Health-Related Quality of Life After Community-Acquired Septic Shock in Children With Preexisting Severe Developmental Disabilities. Pediatr Crit Care Med. 2021 05 01; 22(5):e302-e313.. View in PubMed
  • Declining Procedures in Pediatric Critical Care Medicine Using a National Database. Crit Care Explor. 2021 Mar; 3(3):e0359.. View in PubMed
  • Direction and Magnitude of Change in Plateau From Peak Pressure During Inspiratory Holds Can Identify the Degree of Spontaneous Effort and Elastic Workload in Ventilated Patients. Crit Care Med. 2021 03 01; 49(3):517-526.. View in PubMed
  • Machine Learning to Predict Cardiac Death Within 1 Hour After Terminal Extubation. Pediatr Crit Care Med. 2021 02 01; 22(2):161-171.. View in PubMed
  • To Change Is to Improve. Respir Care. 2020 12; 65(12):1933-1935.. View in PubMed
  • Risk Factors for Mortality in Refractory Pediatric Septic Shock Supported with Extracorporeal Life Support. ASAIO J. 2020 Nov.. View in PubMed
  • Real-Time Effort Driven Ventilator Management: A Pilot Study. Pediatr Crit Care Med. 2020 11; 21(11):933-940.. View in PubMed
  • Underweight is the highest PICU mortality risk factor among all other weight categories. J Pediatr. 2020 11; 226:309-313.. View in PubMed
  • Ventilator Liberation in the Pediatric ICU. Respir Care. 2020 Oct; 65(10):1601-1610.. View in PubMed
  • Trajectories and Risk Factors for Altered Physical and Psychosocial Health-Related Quality of Life After Pediatric Community-Acquired Septic Shock. Pediatr Crit Care Med. 2020 10; 21(10):869-878.. View in PubMed
  • The Association Between Ventilatory Ratio and Mortality in Children and Young Adults. Respir Care. 2021 Feb; 66(2):205-212.. View in PubMed
  • High Breath-by-Breath Variability Is Associated With Extubation Failure in Children. Crit Care Med. 2020 08; 48(8):1165-1174.. View in PubMed
  • Spontaneous Breathing and Imposed Work During Pediatric Mechanical Ventilation: A Bench Study. Pediatr Crit Care Med. 2020 07; 21(7):e449-e455.. View in PubMed
  • Association between time of day and CPR quality as measured by CPR hemodynamics during pediatric in-hospital CPR. Resuscitation. 2020 08; 153:209-216.. View in PubMed
  • Thresholds for oximetry alarms and target range in the NICU: an observational assessment based on likely oxygen tension and maturity. BMC Pediatr. 2020 06 27; 20(1):317.. View in PubMed
  • Survival and Hemodynamics During Pediatric Cardiopulmonary Resuscitation for Bradycardia and Poor Perfusion Versus Pulseless Cardiac Arrest. Crit Care Med. 2020 06; 48(6):881-889.. View in PubMed
  • Critical Illness Factors Associated With Long-Term Mortality and Health-Related Quality of Life Morbidity Following Community-Acquired Pediatric Septic Shock. Crit Care Med. 2020 03; 48(3):319-328.. View in PubMed
  • Trajectory of Mortality and Health-Related Quality of Life Morbidity Following Community-Acquired Pediatric Septic Shock. Crit Care Med. 2020 03; 48(3):329-337.. View in PubMed
  • The role of computer-based clinical decision support systems to deliver protective mechanical ventilation. Curr Opin Crit Care. 2020 02; 26(1):73-81.. View in PubMed
  • Surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children. Intensive Care Med. 2020 02; 46(Suppl 1):10-67.. View in PubMed
  • Surviving Sepsis Campaign International Guidelines for the Management of Septic Shock and Sepsis-Associated Organ Dysfunction in Children. Pediatr Crit Care Med. 2020 02; 21(2):e52-e106.. View in PubMed
  • Executive summary: surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children. Intensive Care Med. 2020 02; 46(Suppl 1):1-9.. View in PubMed
  • Executive Summary: Surviving Sepsis Campaign International Guidelines for the Management of Septic Shock and Sepsis-Associated Organ Dysfunction in Children. Pediatr Crit Care Med. 2020 02; 21(2):186-195.. View in PubMed
  • Platelet Transfusion Practice and Related Outcomes in Pediatric Extracorporeal Membrane Oxygenation. Pediatr Crit Care Med. 2020 02; 21(2):178-185.. View in PubMed
  • Structured Chart Review: Assessment of a Structured Chart Review Methodology. Hosp Pediatr. 2020 01; 10(1):61-69.. View in PubMed
  • Survival and Cardiopulmonary Resuscitation Hemodynamics Following Cardiac Arrest in Children With Surgical Compared to Medical Heart Disease. Pediatr Crit Care Med. 2019 12; 20(12):1126-1136.. View in PubMed
  • A Multicenter Network Assessment of Three Inflammation Phenotypes in Pediatric Sepsis-Induced Multiple Organ Failure. Pediatr Crit Care Med. 2019 12; 20(12):1137-1146.. View in PubMed
  • A Phase II randomized controlled trial for lung and diaphragm protective ventilation (Real-time Effort Driven VENTilator management). Contemp Clin Trials. 2020 01; 88:105893.. View in PubMed
  • Ventilation Rates and Pediatric In-Hospital Cardiac Arrest Survival Outcomes. Crit Care Med. 2019 11; 47(11):1627-1636.. View in PubMed
  • Evaluating the Practice of Repositioning Endotracheal Tubes in Neonates and Children Based on Radiographic Location. Pediatr Crit Care Med. 2019 11; 20(11):1057-1060.. View in PubMed
  • Functional outcomes among survivors of pediatric in-hospital cardiac arrest are associated with baseline neurologic and functional status, but not with diastolic blood pressure during CPR. Resuscitation. 2019 10; 143:57-65.. View in PubMed
  • The association of immediate post cardiac arrest diastolic hypertension and survival following pediatric cardiac arrest. Resuscitation. 2019 08; 141:88-95.. View in PubMed
  • Change in functional status among children treated in the intensive care unit after injury. J Trauma Acute Care Surg. 2019 05; 86(5):810-816.. View in PubMed
  • Development of the Pediatric Extracorporeal Membrane Oxygenation Prediction Model for Risk-Adjusting Mortality. Pediatr Crit Care Med. 2019 05; 20(5):426-434.. View in PubMed
  • Characteristics and Outcomes of Critical Illness in Children With Feeding and Respiratory Technology Dependence. Pediatr Crit Care Med. 2019 05; 20(5):417-425.. View in PubMed
  • Short-Term Adverse Outcomes Associated With Hypoglycemia in Critically Ill Children. Crit Care Med. 2019 05; 47(5):706-714.. View in PubMed
  • Body Habitus and Risk of Mortality in Pediatric Sepsis and Septic Shock: A Retrospective Cohort Study. J Pediatr. 2019 07; 210:178-183.e2.. View in PubMed

Similar People