Daniel Nation

Professor of Gerontology and Medicine, Merle H. Bensinger Professorship in Gerontology

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Publications

  • Older Adults With Smaller and Less Complex Social Networks Show Deficits in Medial Temporal Cerebrovascular Reactivity J Am Heart Assoc. 2024 Jul 16; e034390. . View in PubMed
  • Spontaneous cerebrovascular reactivity at rest in older adults with and without mild cognitive impairment and memory deficits medRxiv. 2024 Jun 19. . View in PubMed
  • Central autonomic network dysfunction and plasma Alzheimer’s disease biomarkers in older adults Alzheimers Res Ther. 2024 Jun 08; 16(1):124. . View in PubMed
  • Blood Pressure Variability, Central Autonomic Network Dysfunction, and Cerebral Small-Vessel Disease in APOE4 Carriers J Am Heart Assoc. 2024 May 07; 13(9):e034116. . View in PubMed
  • The interactive effect of intra-beat and inter-beat blood pressure variability on neurodegeneration in older adults medRxiv. 2024 May 03. . View in PubMed
  • Reliability of beat-to-beat blood pressure variability in older adults Res Sq. 2024 Apr 19. . View in PubMed
  • Older adults with reduced cerebrovascular reactivity exhibit high white matter hyperintensity burden Neurobiol Aging. 2024 Mar 30; 139:5-10. . View in PubMed
  • Short-term blood pressure variability and brain functional network connectivity in older adults Neuroimage Rep. 2024 Mar; 4(1). . View in PubMed
  • Robust reference group normative data for neuropsychological tests accounting for primary language use in Asian American older adults J Int Neuropsychol Soc. 2024 05; 30(4):402-409. . View in PubMed
  • 24-Hour Blood Pressure Variability Via Ambulatory Monitoring and Risk for Probable Dementia in the SPRINT Trial J Prev Alzheimers Dis. 2024; 11(3):684-692. . View in PubMed
  • Blood Pressure Variability and Plasma Alzheimer’s Disease Biomarkers in the SPRINT Trial J Alzheimers Dis. 2024; 97(4):1851-1860. . View in PubMed
  • Pulse pressure and APOE e4 dose interact to affect cerebral blood flow in older adults without dementia Cereb Circ Cogn Behav. 2024; 6:100206. . View in PubMed
  • Blood pressure variability, central autonomic network dysfunction and cerebral small vessel disease in APOE4 carriers medRxiv. 2023 Dec 14. . View in PubMed
  • Enlarged perivascular spaces and plasma Aß42/Aß40 ratio in older adults without dementia Neurobiol Aging. 2023 08; 128:43-48. . View in PubMed
  • The small HDL particle hypothesis of Alzheimer’s disease Alzheimers Dement. 2023 02; 19(2):391-404. . View in PubMed
  • Increasing coordination and responsivity of emotion-related brain regions with a heart rate variability biofeedback randomized trial Cogn Affect Behav Neurosci. 2023 02; 23(1):66-83. . View in PubMed
  • White Matter Hyperintensity Volume and Amyloid-PET Synergistically Impact Memory Independent of Tau-PET in Older Adults Without Dementia J Alzheimers Dis. 2023; 94(2):695-707. . View in PubMed
  • Multimodal neuroimaging data from a 5-week heart rate variability biofeedback randomized clinical trial Sci Data. 2023 07 29; 10(1):503. . View in PubMed
  • Blood-Derived Progenitor Cells Are Depleted in Older Adults with Cognitive Impairment: A Role for Vascular Resilience? J Alzheimers Dis. 2023; 93(3):1041-1050.. View in PubMed
  • Short-term blood pressure variability is inversely related to regional amplitude of low frequency fluctuations in older and younger adults Aging Brain. 2023; 4:100085. . View in PubMed
  • Blood Pressure Variability and Cerebral Perfusion Decline: A Post Hoc Analysis of the SPRINT MIND Trial J Am Heart Assoc. 2023 06 20; 12(12):e029797. . View in PubMed
  • Blood Pressure Variability and Cognitive Decline: A Post Hoc Analysis of the SPRINT MIND Trial Am J Hypertens. 2023 02 24; 36(3):168-175. . View in PubMed
  • Visit-to-Visit Blood Pressure Variability and Cognitive Decline in Apolipoprotein? 3 Homozygotes. J Alzheimers Dis. 2023; 93(2):533-543.. View in PubMed
  • Modulating heart rate oscillation affects plasma amyloid beta and tau levels in younger and older adults Sci Rep. 2023 03 09; 13(1):3967. . View in PubMed
  • Older Adults With Higher Blood Pressure Variability Exhibit Cerebrovascular Reactivity Deficits Am J Hypertens. 2023 01 01; 36(1):63-68. . View in PubMed
  • Blood pressure variability and medial temporal atrophy in apolipoprotein? 4 carriers. Brain Imaging Behav. 2022 Apr; 16(2):792-801.. View in PubMed
  • Selective vulnerability of medial temporal regions to short-term blood pressure variability and cerebral hypoperfusion in older adults Neuroimage Rep. 2022 Mar; 2(1). . View in PubMed
  • Visit-To-Visit Blood Pressure Variability and Subthreshold Depressive Symptoms in Older Adults Am J Geriatr Psychiatry. 2022 10; 30(10):1110-1119. . View in PubMed
  • Imaging subtle leaks in the blood-brain barrier in the aging human brain: potential pitfalls, challenges, and possible solutions Geroscience. 2022 06; 44(3):1339-1351. . View in PubMed
  • Cerebrovascular reactivity deficits in cognitively unimpaired older adults: vasodilatory versus vasoconstrictive responses Neurobiol Aging. 2022 05; 113:55-62. . View in PubMed
  • Visit-to-Visit Blood Pressure Variability and Longitudinal Tau Accumulation in Older Adults Hypertension. 2022 03; 79(3):629-637. . View in PubMed
  • Platelet-derived growth factor-BB and white matter hyperintensity burden in APOE4 carriers Cereb Circ Cogn Behav. 2022; 3. . View in PubMed
  • Interactive Effects of Pulse Pressure and Tau Imaging on Longitudinal Cognition J Alzheimers Dis. 2022; 89(2):633-640. . View in PubMed
  • Editorial: The importance of cognitive practice effects in aging neuroscience Front Aging Neurosci. 2022; 14:1079021. . View in PubMed
  • Blood pressure variability and plasma Alzheimer’s disease biomarkers in older adults Sci Rep. 2022 10 13; 12(1):17197. . View in PubMed
  • Older adults with perivascular spaces exhibit cerebrovascular reactivity deficits Neuroimage. 2022 12 01; 264:119746. . View in PubMed
  • Neuropsychological Decline Stratifies Dementia Risk in Cognitively Unimpaired and Impaired Older Adults Front Aging Neurosci. 2022; 14:838459. . View in PubMed
  • Visit-to-Visit Blood Pressure Variability and CSF Alzheimer Disease Biomarkers in Cognitively Unimpaired and Mildly Impaired Older Adults Neurology. 2022 06 14; 98(24):e2446-e2453. . View in PubMed
  • Brainstem substructures and cognition in prodromal Alzheimer’s disease Brain Imaging Behav. 2021 Oct; 15(5):2572-2582. . View in PubMed
  • Blood-Brain Barrier Crossing Renin-Angiotensin Drugs and Cognition in the Elderly: A Meta-Analysis Hypertension. 2021 09; 78(3):629-643. . View in PubMed
  • Visit-to-visit blood pressure variability and regional cerebral perfusion decline in older adults Neurobiol Aging. 2021 09; 105:57-63. . View in PubMed
  • Role of Notch signaling in neurovascular aging and Alzheimer’s disease Semin Cell Dev Biol. 2021 08; 116:90-97. . View in PubMed
  • Increased Levels of Circulating Angiogenic Cells and Signaling Proteins in Older Adults With Cerebral Small Vessel Disease Front Aging Neurosci. 2021; 13:711784. . View in PubMed
  • Reader Response: Simple MRI Score Aids Prediction of Dementia in Cerebral Small Vessel Disease Neurology. 2021 01 05; 96(1):39-40. . View in PubMed
  • Arterial Stiffening Moderates the Relationship Between Type-2 Diabetes Mellitus and White Matter Hyperintensity Burden in Older Adults With Mild Cognitive Impairment Front Aging Neurosci. 2021; 13:716638. . View in PubMed
  • Resting-State Functional Connectivity Signatures of Apathy in Community-Living Older Adults Front Aging Neurosci. 2021; 13:691710. . View in PubMed
  • Antemortem Visit-To-Visit Blood Pressure Variability Predicts Cerebrovascular Lesion Burden in Autopsy-Confirmed Alzheimer’s Disease J Alzheimers Dis. 2021; 83(1):65-75. . View in PubMed
  • A novel sensitive assay for detection of a biomarker of pericyte injury in cerebrospinal fluid Alzheimers Dement. 2020 06; 16(6):821-830. . View in PubMed
  • APOE4 leads to blood-brain barrier dysfunction predicting cognitive decline Nature. 2020 05; 581(7806):71-76. . View in PubMed
  • APOE4 Accelerates Development of Dementia After Stroke: Is There a Role for Cerebrovascular Dysfunction? Stroke. 2020 03; 51(3):699-700.. View in PubMed
  • Affective Neuropsychiatric Symptoms as Early Signs of Dementia Risk in Older Adults J Alzheimers Dis. 2020; 77(3):1195-1207. . View in PubMed
  • Hypertension and Alzheimer’s disease: indirect effects through circle of Willis atherosclerosis Brain Commun. 2020; 2(2):fcaa114. . View in PubMed
  • Long-Term Blood Pressure Variability Across the Clinical and Biomarker Spectrum of Alzheimer’s Disease J Alzheimers Dis. 2020; 77(4):1655-1669. . View in PubMed
  • Brainstem Volumetric Integrity in Preclinical and Prodromal Alzheimer’s Disease J Alzheimers Dis. 2020; 77(4):1579-1594. . View in PubMed
  • Distilling Heterogeneity of Mild Cognitive Impairment in the National Alzheimer Coordinating Center Database Using Latent Profile Analysis JAMA Netw Open. 2020 03 02; 3(3):e200413. . View in PubMed
  • J Alzheimers Dis. 2020; 78(1):23-48. . View in PubMed
  • Undetectable gadolinium brain retention in individuals with an age-dependent blood-brain barrier breakdown in the hippocampus and mild cognitive impairment Alzheimers Dement. 2019 12; 15(12):1568-1575. . View in PubMed
  • Importance of Treatment Status in Links Between Type 2 Diabetes and Alzheimer’s Disease Diabetes Care. 2019 05; 42(5):972-979. . View in PubMed
  • Blood-brain barrier breakdown is an early biomarker of human cognitive dysfunction Nat Med. 2019 02; 25(2):270-276. . View in PubMed
  • Vascular dysfunction-The disregarded partner of Alzheimer’s disease Alzheimers Dement. 2019 01; 15(1):158-167. . View in PubMed
  • Neuropsychological Deficit Profiles, Vascular Risk Factors, and Neuropathological Findings in Hispanic Older Adults with Autopsy-Confirmed Alzheimer’s Disease J Alzheimers Dis. 2019; 67(1):291-302. . View in PubMed
  • Neuropsychological Decline Improves Prediction of Dementia Beyond Alzheimer’s Disease Biomarker and Mild Cognitive Impairment Diagnoses J Alzheimers Dis. 2019; 69(4):1171-1182. . View in PubMed
  • Disentangling Heterogeneity in Alzheimer’s Disease: Two Empirically-Derived Subtypes J Alzheimers Dis. 2019; 70(1):227-239. . View in PubMed
  • Meta-analysis of cognitive ability differences by apolipoprotein e genotype in young humans Neurosci Biobehav Rev. 2018 11; 94:49-58. . View in PubMed
  • Cognitive benefits of angiotensin IV and angiotensin-(1-7): A systematic review of experimental studies Neurosci Biobehav Rev. 2018 09; 92:209-225. . View in PubMed
  • Neuropsychological Profiles and Trajectories in Preclinical Alzheimer’s Disease J Int Neuropsychol Soc. 2018 08; 24(7):693-702. . View in PubMed
  • Blood Pressure and Cerebral Blood Flow in Alzheimer Disease Hypertension. 2018 07; 72(1):68-69. . View in PubMed
  • Assessing Working Memory in Mild Cognitive Impairment with Serial Order Recall J Alzheimers Dis. 2018; 61(3):917-928. . View in PubMed
  • Reduced Regional Cerebral Blood Flow Relates to Poorer Cognition in Older Adults With Type 2 Diabetes Front Aging Neurosci. 2018; 10:270. . View in PubMed
  • Circulating Progenitor Cells Correlate with Memory, Posterior Cortical Thickness, and Hippocampal Perfusion J Alzheimers Dis. 2018; 61(1):91-101. . View in PubMed
  • J Alzheimers Dis. 2018; 62(4):1567-1578. . View in PubMed
  • Cerebrovascular resistance: effects on cognitive decline, cortical atrophy, and progression to dementia Brain. 2017 Jul 01; 140(7):1987-2001. . View in PubMed
  • Memory is preserved in older adults taking AT1 receptor blockers Alzheimers Res Ther. 2017 Apr 26; 9(1):33. . View in PubMed
  • Correction to: Detectable Neuropsychological Differences in Early Preclinical Alzheimer’s Disease: a Meta-Analysis Neuropsychol Rev. 2017 12; 27(4):326-327. . View in PubMed
  • Detectable Neuropsychological Differences in Early Preclinical Alzheimer’s Disease: A Meta-Analysis Neuropsychol Rev. 2017 12; 27(4):305-325. . View in PubMed
  • Mechanisms of Memory Dysfunction during High Altitude Hypoxia Training in Military Aircrew J Int Neuropsychol Soc. 2017 01; 23(1):1-10. . View in PubMed
  • Cerebral Blood Flow and Amyloid-ß Interact to Affect Memory Performance in Cognitively Normal Older Adults Front Aging Neurosci. 2017; 9:181. . View in PubMed
  • Pulse Pressure Is Associated With Early Brain Atrophy and Cognitive Decline: Modifying Effects of APOE-e4 Alzheimer Dis Assoc Disord. 2016 Jul-Sep; 30(3):210-5. . View in PubMed
  • Brain imaging of neurovascular dysfunction in Alzheimer’s disease Acta Neuropathol. 2016 May; 131(5):687-707. . View in PubMed
  • Patterns of Cortical and Subcortical Amyloid Burden across Stages of Preclinical Alzheimer’s Disease J Int Neuropsychol Soc. 2016 11; 22(10):978-990. . View in PubMed
  • Visuoconstructional Impairment in Subtypes of Mild Cognitive Impairment Appl Neuropsychol Adult. 2016; 23(1):43-52. . View in PubMed
  • Cortical Amyloid Burden Differences Across Empirically-Derived Mild Cognitive Impairment Subtypes and Interaction with APOE? 4 Genotype. J Alzheimers Dis. 2016 03 29; 52(3):849-61.. View in PubMed
  • Older Adults Taking AT1-Receptor Blockers Exhibit Reduced Cerebral Amyloid Retention J Alzheimers Dis. 2016; 50(3):779-89. . View in PubMed
  • Interaction Between Midlife Blood Glucose and APOE Genotype Predicts Later Alzheimer’s Disease Pathology J Alzheimers Dis. 2016 07 06; 53(4):1553-62. . View in PubMed
  • Pulse pressure in relation to tau-mediated neurodegeneration, cerebral amyloidosis, and progression to dementia in very old adults JAMA Neurol. 2015 May; 72(5):546-53. . View in PubMed
  • Aggregate effects of vascular risk factors on cerebrovascular changes in autopsy-confirmed Alzheimer’s diseaseAlzheimers Dement. 2015 Apr; 11(4):394-403. e1. . View in PubMed
  • Susceptibility of the conventional criteria for mild cognitive impairment to false-positive diagnostic errors Alzheimers Dement. 2015 Apr; 11(4):415-24. . View in PubMed
  • Elevated cerebrovascular resistance index is associated with cognitive dysfunction in the very-old Alzheimers Res Ther. 2015 01 21; 7(1):3. . View in PubMed
  • Neuropsychological criteria for mild cognitive impairment improves diagnostic precision, biomarker associations, and progression rates J Alzheimers Dis. 2014; 42(1):275-89. . View in PubMed
  • White matter integrity in veterans with mild traumatic brain injury: associations with executive function and loss of consciousness J Head Trauma Rehabil. 2014 Jan-Feb; 29(1):21-32. . View in PubMed
  • Interactive effects of vascular risk burden and advanced age on cerebral blood flow Front Aging Neurosci. 2014; 6:159. . View in PubMed
  • Neuropsychological syndromes associated with Alzheimer’s/vascular dementia: a latent class analysis J Alzheimers Dis. 2014; 42(3):999-1014. . View in PubMed
  • Pulse pressure is associated with Alzheimer biomarkers in cognitively normal older adults Neurology. 2013 Dec 03; 81(23):2024-7. . View in PubMed
  • APOE genotype modifies the relationship between midlife vascular risk factors and later cognitive decline J Stroke Cerebrovasc Dis. 2013 Nov; 22(8):1361-9. . View in PubMed
  • Are empirically-derived subtypes of mild cognitive impairment consistent with conventional subtypes? J Int Neuropsychol Soc. 2013 Jul; 19(6):635-45.. View in PubMed
  • An accelerometry-based study of lower and upper limb tremor in Parkinson’s disease J Clin Neurosci. 2013 Jun; 20(6):827-30. . View in PubMed
  • Cortical and subcortical cerebrovascular resistance index in mild cognitive impairment and Alzheimer’s disease J Alzheimers Dis. 2013; 36(4):689-98. . View in PubMed
  • Antemortem pulse pressure elevation predicts cerebrovascular disease in autopsy-confirmed Alzheimer’s disease J Alzheimers Dis. 2012; 30(3):595-603. . View in PubMed
  • Posterior cingulum white matter disruption and its associations with verbal memory and stroke risk in mild cognitive impairment J Alzheimers Dis. 2012; 29(3):589-603. . View in PubMed
  • Stress, exercise, and Alzheimer’s disease: a neurovascular pathway Med Hypotheses. 2011 Jun; 76(6):847-54. . View in PubMed
  • Altered brain response for semantic knowledge in Alzheimer’s disease Neuropsychologia. 2011 Feb; 49(3):392-404. . View in PubMed
  • Elevated pulse pressure is associated with age-related decline in language ability J Int Neuropsychol Soc. 2010 Sep; 16(5):933-8. . View in PubMed
  • Oxytocin attenuates atherosclerosis and adipose tissue inflammation in socially isolated ApoE-/- mice Psychosom Med. 2010 May; 72(4):376-82. . View in PubMed
  • Subthreshold depression in Parkinson’s disease Int J Geriatr Psychiatry. 2009 Sep; 24(9):937-43. . View in PubMed
  • A questionnaire-based (UM-PDHQ) study of hallucinations in Parkinson’s disease BMC Neurol. 2008 Jun 20; 8:21. . View in PubMed