Danny J Wang

I am a Professor of Neurology and Radiology, Director of Imaging Technology Innovation in the Mark & Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine, University of Southern California. I am also directing the Laboratory of Functional MRI Technology (LOFT)(www.loft-lab.org). During the past 25+ years, my research has been focused on the technical development and clinical translations of novel functional and physiological Magnetic Resonance Imaging (MRI) technologies, in particular noninvasive blood flow/perfusion imaging. I am a recognized expert in perfusion and functional MRI with extensive experience in clinical applications related to neurologic and psychiatric disorders as well as body organs. I have also been supporting the scientific community by disseminating arterial spin labeling (ASL) sequences to more than 300 Siemens imaging research centers around the world. In addition to MRI, I have experience in the technical development and clinical applications of Computed Tomography (CT) and Positron Emission Tomography (PET).

• International Society of Magnetic Resonance in Medicine (ISMRM): ISMRM Senior Fellow, 2022
• American Institute of Medical and Biological Engineering (AIMBE): AIMBE Fellow, 2025

• Fudan University, Shanghai — BS — 07/1993 — Biophysics
• University of Sci&Tech China, Beijing — PhD — 12/1998 — Biophysics
• University of Pennsylvania, Philadelphia — MSCE — 12/2010 — Clinical Epidemiology
• University of Pennsylvania, Philadelphia — Postdoc — 12/2002 — MRI Biophysics and Neuroscience

• Non-invasive MRI mapping of BBB water exchange rate and permeability
  NIH · R01NS134712 · Aug 1, 2024 – May 31, 2029 · Role: Principal Investigator
• Imaging Cerebral Small Vessels in Vascular Cognitive Impairment and Dementia (VCID)
  NIH · R01AG084072 · Sep 1, 2023 – Aug 31, 2028 · Role: Principal Investigator
• Imaging Cerebral Small Vessels in Vascular Cognitive Impairment and Dementia (VCID)
  NIH · RF1AG084072 · Sep 1, 2023 – Aug 31, 2026 · Role: Principal Investigator
• Reduced BBB Water Exchange as a Preclinical Biomarker of Small Vessel Disease
  NIH · R01NS122028 · Feb 1, 2022 – Jan 31, 2027 · Role: Co-Principal Investigator
• Validation of Imaging and Blood-based Small Vessel VCID Biomarkers in Multiethnic Population
  NIH · U01NS100614 · Sep 30, 2021 – Jul 31, 2026 · Role: Principal Investigator
• Laminar Hemodynamic and Metabolic Imaging
  NIH · R01EB032169 · Aug 1, 2021 – Jul 31, 2030 · Role: Principal Investigator
• Massively parallel high-speed 3D functional photoacoustic computed tomography of the adult human brain
  NIH · U01EB029823 · Sep 8, 2020 – Aug 31, 2025 · Role: Principal Investigator
• Complexity of FMRI in Alzheimer's Disease
  NIH · R01AG066711 · Apr 15, 2020 – Mar 31, 2025 · Role: Co-Principal Investigator
• BBB Permeability Imaging in CADASIL
  NIH · R01NS114382 · Feb 1, 2020 – Jan 31, 2025 · Role: Principal Investigator
• Multiband ASL for Neurodevelopment Study
  NIH · R01EB028297 · Jul 5, 2019 – Mar 31, 2025 · Role: Principal Investigator
• NOVA PTX Coil for Ultrahigh Field Imaging
  NIH · S10OD025312 · Aug 1, 2018 – Jul 31, 2020 · Role: Principal Investigator
• Imaging-guided tDCS therapy in major depression
  NIH · R33MH110526 · Aug 1, 2017 – Jul 31, 2023 · Role: Co-Principal Investigator
• Imaging-guided tDCS therapy in major depression
  NIH · R61MH110526 · Aug 1, 2017 – Jul 31, 2022 · Role: Co-Principal Investigator
• Novel Algorithms for Reducing Radiation Dose of CT Perfusion
  NIH · R44EB024438 · Aug 1, 2017 – May 31, 2022 · Role: Co-Principal Investigator
• A Novel System for Reducing Radiation Dose of CT Perfusion
  NIH · R41EB024438 · Aug 1, 2017 – Jul 31, 2020 · Role: Principal Investigator
• Validation of Imaging and Blood-based Small Vessel VCID Biomarkers in Multiethnic Population
  NIH · UF1NS100614 · Sep 30, 2016 – Jul 31, 2023 · Role: Principal Investigator
• Imaging Cerebral and Retinal Microvasculature in Cerebral Small Vessel Disease
  NIH · UH3NS100614 · Sep 30, 2016 – Jul 31, 2021 · Role: Principal Investigator
• Imaging Cerebral and Retinal Microvasculature in Cerebral Small Vessel Disease
  NIH · UH2NS100614 · Sep 30, 2016 – Jul 31, 2018 · Role: Principal Investigator
• Perturbation of the treatment resistant depression connectome by fast-acting therapies
  NIH · U01MH110008 · Sep 2, 2016 – May 31, 2021 · Role: Co-Principal Investigator
• Non-contrast 4-D Dynamic MRA in Arteriovenous Malformation (AVM)
  NIH · R01EB014922 · Dec 14, 2012 – Nov 30, 2018 · Role: Principal Investigator
• Arterial Spin Labeled Perfusion MRI in Acute Ischemic Stroke
  NIH · R01NS081077 · Sep 15, 2012 – Aug 31, 2016 · Role: Principal Investigator
• Pediatric Template of Brain Perfusion
  NIH · R01MH080892 · Apr 15, 2009 – Jun 30, 2015 · Role: Principal Investigator
• Hemodynamic neuroimaging of pediatric stroke
  NIH · R21HD049893 · Sep 15, 2005 – Aug 31, 2008 · Role: Principal Investigator
• Pediatric template of brain perfusion
  NIH · R21MH072576 · Jan 1, 2005 – Nov 30, 2007 · Role: Principal Investigator

• USC study finds new evidence linking dementia to problems with the brain’s waste clearance system
• Keck School researchers hit FDA clearance milestone for CT software (11/2021)
• New MRI technique can detect early dysfunction of the blood-brain barrier with small vessel disease (5/2021)
• Laminar perfusion fMRI at 7T featured in NIH Director’s Blog (12/2021)

• Thompson, Paul
• Toga, Arthur
• Nayak, Krishna
• Zlokovic, Berislav
• Peterson, Bradley
• Wood, John