Keck School Faculty

Darcy Spicer, MD
Darcy Spicer, MD
Associate Professor of Clinical Medicine;Chief, Division of Oncology, Department of Medicine;Co-Director, Lynne Cohen Clinic
Medicine
NOR 3446 Health Sciences Campus Los Angeles
Dr. Spicer has been on faculty at the Keck School of Medicine at USC since 1980 when he began as a Clinical Instructor of Medicine in the Department of Oncology. Dr. Spicer holds several United States patents for his medical inventions. He is a medical oncology attending physician at both the LAC+USC Medical Center and the USC Norris Comprehensive Cancer Center.

Aerobic and Resistance Exercise Improves Shoulder Function in Women Who Are Overweight or Obese and Have Breast Cancer: Randomized, Controlled Trial Phys Ther. 2019 Jul 16. . View in PubMed

Effect of Aerobic and Resistance Exercise Intervention on Cardiovascular Disease Risk in Women With Early-Stage Breast Cancer: A Randomized Clinical Trial JAMA Oncol. 2019 May 01; 5(5):710-714. . View in PubMed

Hispanic ethnicity as a moderator of the effects of aerobic and resistance exercise in survivors of breast cancer Cancer. 2019 Mar 15; 125(6):910-920. . View in PubMed

Adipose tissue inflammation in breast cancer survivors: effects of a 16-week combined aerobic and resistance exercise training intervention Breast Cancer Res Treat. 2018 Feb; 168(1):147-157. . View in PubMed

Overcoming endocrine resistance in metastatic hormone receptor-positive breast cancer J Hematol Oncol. 2018 06 11; 11(1):80. . View in PubMed

Aerobic and resistance exercise improves physical fitness, bone health, and quality of life in overweight and obese breast cancer survivors: a randomized controlled trial Breast Cancer Res. 2018 10 19; 20(1):124. . View in PubMed

Effects of Aerobic and Resistance Exercise on Metabolic Syndrome, Sarcopenic Obesity, and Circulating Biomarkers in Overweight or Obese Survivors of Breast Cancer: A Randomized Controlled Trial J Clin Oncol. 2018 03 20; 36(9):875-883. . View in PubMed

Reply to EParkin et al. J Clin Oncol. 2018 07 10; 36(20):2129-2130. . View in PubMed

Double-Blind Randomized 12-Month Soy Intervention Had No Effects on Breast MRI Fibroglandular Tissue Density or Mammographic Density Cancer Prev Res (Phila). 2015 Oct; 8(10):942-51. . View in PubMed

Treatment of Endometriosis with the GnRHa Deslorelin and Add-Back Estradiol and Supplementary Testosterone Biomed Res Int. 2015; 2015:934164. . View in PubMed

Biological effects of green tea capsule supplementation in pre-surgery postmenopausal breast cancer patients Front Oncol. 2013; 3:298. . View in PubMed

Lowering oral contraceptive norethindrone dose increases estrogen and progesterone receptor levels with no reduction in proliferation of breast epithelium: a randomized trial Contraception. 2012 Sep; 86(3):238-43. . View in PubMed

Soy isoflavones for breast cancer risk reduction Cancer Prev Res (Phila). 2012 Jul; 5(7):984-5; author reply 986-7. . View in PubMed

Breast epithelial cell proliferation is markedly increased with short-term high levels of endogenous estrogen secondary to controlled ovarian hyperstimulation Breast Cancer Res Treat. 2012 Apr; 132(2):653-60. . View in PubMed

Effect of 2-month controlled green tea intervention on lipoprotein cholesterol, glucose, and hormone levels in healthy postmenopausal women Cancer Prev Res (Phila). 2012 Mar; 5(3):393-402. . View in PubMed

Characteristics of triple-negative breast cancer in patients with a BRCA1 mutation: results from a population-based study of young women J Clin Oncol. 2011 Nov 20; 29(33):4373-80. . View in PubMed

GRP78 as potential predictor for breast cancer response to adjuvant taxane therapy Int J Cancer. 2011 Feb 01; 128(3):726-31. . View in PubMed

Preoperative concurrent paclitaxel-radiation in locally advanced breast cancer: pathologic response correlates with five-year overall survival Breast Cancer Res Treat. 2010 Dec; 124(3):723-32. . View in PubMed

Progesterone and estrogen receptors in pregnant and premenopausal non-pregnant normal human breast Breast Cancer Res Treat. 2009 Nov; 118(1):161-8. . View in PubMed

Phase II studies of gemcitabine and cisplatin in heavily and minimally pretreated metastatic breast cancer J Clin Oncol. 2009 May 01; 27(13):2163-9. . View in PubMed

Tamoxifen, soy, and lifestyle factors in Asian American women with breast cancer J Clin Oncol. 2007 Jul 20; 25(21):3024-30. . View in PubMed

Reduced mammographic density with use of a gonadotropin-releasing hormone agonist-based chemoprevention regimen in BRCA1 carriers Clin Cancer Res. 2007 Jan 15; 13(2 Pt 1):654-8. . View in PubMed

Estrogens, progestins, and risk of breast cancer Ernst Schering Found Symp Proc. 2007; (1):127-50. . View in PubMed

GRP78 as a novel predictor of responsiveness to chemotherapy in breast cancer Cancer Res. 2006 Aug 15; 66(16):7849-53. . View in PubMed

Effect of valspodar on the pharmacokinetics of unbound paclitaxel Invest New Drugs. 2003 Aug; 21(3):291-8. . View in PubMed

Preoperative twice-weekly paclitaxel with concurrent radiation therapy followed by surgery and postoperative doxorubicin-based chemotherapy in locally advanced breast cancer: a phase I/II trial J Clin Oncol. 2003 Mar 01; 21(5):864-70. . View in PubMed

Low HER2/neu gene expression is associated with pathological response to concurrent paclitaxel and radiation therapy in locally advanced breast cancer Int J Radiat Oncol Biol Phys. 2002 Feb 01; 52(2):397-405. . View in PubMed

Reversal of gonadotropin-releasing hormone agonist induced reductions in mammographic densities on stopping treatment Cancer Epidemiol Biomarkers Prev. 2001 Nov; 10(11):1117-20. . View in PubMed

Mammographic density changes during the menstrual cycle Cancer Epidemiol Biomarkers Prev. 2001 Feb; 10(2):141-2. . View in PubMed

Hormonal contraception and chemoprevention of female cancers Endocr Relat Cancer. 2000 Jun; 7(2):73-83. . View in PubMed

Weekly lometrexol with daily oral folic acid is appropriate for phase II evaluation Cancer Chemother Pharmacol. 2000; 45(2):103-10. . View in PubMed

Future possibilities in the prevention of breast cancer: luteinizing hormone-releasing hormone agonists Breast Cancer Res. 2000; 2(4):264-7. . View in PubMed

Problems involved in including women with simple hysterectomy in epidemiologic studies measuring the effects of hormone replacement therapy on breast cancer risk Am J Epidemiol. 1998 Apr 15; 147(8):718-21. . View in PubMed

The detection of changes in mammographic densities Cancer Epidemiol Biomarkers Prev. 1998 Jan; 7(1):43-7. . View in PubMed

Progesterone concentrations--physiologic or pharmacologic? Fertil Steril. 1996 May; 65(5):1077-8.. View in PubMed

Experiments on proliferation of normal human breast tissue in nude mice do not show that progesterone does not stimulate breast cells Endocrinology. 1996 Apr; 137(4):1505-6. . View in PubMed

Can mammographic densities predict effects of tamoxifen on the breast? J Natl Cancer Inst. 1996 Jan 17; 88(2):128-9.. View in PubMed

Phase II clinical trial of carboplatin, ifosfamide, with oral mesna for metastatic breast carcinoma Cancer Invest. 1995; 13(2):160-4. . View in PubMed

The endocrine prevention of breast cancer Cancer Invest. 1995; 13(5):495-504. . View in PubMed

Changes in mammographic densities induced by a hormonal contraceptive designed to reduce breast cancer risk J Natl Cancer Inst. 1994 Mar 16; 86(6):431-6. . View in PubMed

Sex steroids and breast cancer prevention J Natl Cancer Inst Monogr. 1994; (16):139-47. . View in PubMed

Contraception and cancer prevention Adv Contracept Deliv Syst. 1994; 10(3-4):369-86. . View in PubMed

Breast cancer prevention through modulation of endogenous hormones Breast Cancer Res Treat. 1993 Nov; 28(2):179-93. . View in PubMed

Hormone replacement after breast cancer Lancet. 1993 Jul 17; 342(8864):183-4. . View in PubMed

Pilot trial of a gonadotropin hormone agonist with replacement hormones as a prototype contraceptive to prevent breast cancer Contraception. 1993 May; 47(5):427-44. . View in PubMed

Tamoxifen and prevention Lancet. 1993 Mar 13; 341(8846):693-4; author reply 695. . View in PubMed

The chemoprevention of breast cancer by reducing sex steroid exposure: perspectives from epidemiology J Cell Biochem Suppl. 1993; 17G:26-36. . View in PubMed

Estrogens, progestogens, normal breast cell proliferation, and breast cancer risk Epidemiol Rev. 1993; 15(1):17-35. . View in PubMed

Low-dose recombinant interleukin-2 and low-dose cyclophosphamide in metastatic breast cancer Cancer Immunol Immunother. 1992; 34(6):424-6. . View in PubMed

The prevention of breast cancer through reduced ovarian steroid exposure Acta Oncol. 1992; 31(2):167-74. . View in PubMed

GnRH agonists as contraceptive agents: predicted significantly reduced risk of breast cancer Contraception. 1991 Sep; 44(3):289-310. . View in PubMed

Ovarian cancer and long-term tamoxifen in premenopausal women Lancet. 1991 Jun 08; 337(8754):1414. . View in PubMed

Tamoxifen and estrogen replacement therapy as agents of disease prevention J Natl Cancer Inst. 1991 Jan 02; 83(1):63-4. . View in PubMed

Tolerance of extended (28 day) continuous infusion of 5-fluorouracil in advanced head and neck cancer Sel Cancer Ther. 1991; 7(1):17-21. . View in PubMed

Reevaluation of the maximum tolerated dose of continuous venous infusion of 5-fluorouracil with pharmacokinetics Cancer Res. 1988 Jan 15; 48(2):459-61. . View in PubMed

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