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Dat Q. Tran, PhD

Assistant Professor Of Research Pathology

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Phone +1 323 442 7955
Email [email protected]
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Publications

  • Preclinical Pharmacokinetics and Safety of Intravenous RTD-1. Antimicrob Agents Chemother. 2022 03 15; 66(3):e0212521.. View in PubMed
  • A host-directed macrocyclic peptide therapeutic for MDR gram negative bacterial infections. Sci Rep. 2021 12 06; 11(1):23447.. View in PubMed
  • Host Defense Peptides as Templates for Antifungal Drug Development. J Fungi (Basel). 2020 Oct 23; 6(4).. View in PubMed
  • RTD-1 therapeutically normalizes synovial gene signatures in rat autoimmune arthritis and suppresses proinflammatory mediators in RA synovial fibroblasts. Physiol Genomics. 2019 12 01; 51(12):657-667.. View in PubMed
  • Rhesus Theta Defensin 1 Promotes Long Term Survival in Systemic Candidiasis by Host Directed Mechanisms. Sci Rep. 2019 11 15; 9(1):16905.. View in PubMed
  • Antibiotic-modulated microbiome suppresses lethal inflammation and prolongs lifespan in Treg-deficient mice. Microbiome. 2019 11 07; 7(1):145.. View in PubMed
  • Lactobacillus reuteri Reduces the Severity of Experimental Autoimmune Encephalomyelitis in Mice by Modulating Gut Microbiota. Front Immunol. 2019; 10:385.. View in PubMed
  • Fungicidal Potency and Mechanisms of θ-Defensins against Multidrug-Resistant Candida Species. Antimicrob Agents Chemother. 2018 06; 62(6).. View in PubMed
  • Macrocyclic θ-defensins suppress tumor necrosis factor-α (TNF-α) shedding by inhibition of TNF-α-converting enzyme. J Biol Chem. 2018 02 23; 293(8):2725-2734.. View in PubMed
  • Suppression and resolution of autoimmune arthritis by rhesus θ-defensin-1, an immunomodulatory macrocyclic peptide. PLoS One. 2017; 12(11):e0187868.. View in PubMed
  • Resetting microbiota by Lactobacillus reuteri inhibits T reg deficiency-induced autoimmunity via adenosine A2A receptors. J Exp Med. 2017 01; 214(1):107-123.. View in PubMed
  • Rhesus θ-defensin-1 (RTD-1) exhibits in vitro and in vivo activity against cystic fibrosis strains of Pseudomonas aeruginosa. J Antimicrob Chemother. 2016 Jan; 71(1):181-8.. View in PubMed
  • Immune dysregulation in human subjects with heterozygous germline mutations in CTLA4. Science. 2014 Sep 26; 345(6204):1623-1627.. View in PubMed
  • Lactobacillus reuteri DSM 17938 differentially modulates effector memory T cells and Foxp3+ regulatory T cells in a mouse model of necrotizing enterocolitis. Am J Physiol Gastrointest Liver Physiol. 2014 Jul 15; 307(2):G177-86.. View in PubMed
  • Killing of staphylococci by θ-defensins involves membrane impairment and activation of autolytic enzymes. Antibiotics (Basel). 2014; 3(4):617-31.. View in PubMed

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