Keck School Faculty

David R. Freyer
David R. Freyer
Professor of Clinical Pediatrics
CHL Mail Stop 54 Off Campus Los Angeles
Dr. David Freyer joined Children's Hospital Los Angeles in January 2008. As Director of the LIFE Program, he oversees all aspects of its services, which include clinical assessments of more than 350 patients annually, research regarding their long-term outcomes, and training of fellows, residents, and other health care professionals in the care of childhood cancer survivors. His clinical and research activities have focused principally on cancer survivorship and cancer control, including the recognition, management and prevention of short-and long-term morbidity of treatment, as well as health care transition for young adult survivors of childhood cancer, adolescent and young adult (AYA) oncology, palliative care, and decision-making at the end of life. Dr. Freyer is a member of the Children's Oncology Group where he serves as chair of the AYA Committee, on the Steering Committees for the Survivorship & Outcomes and Cancer Control Committees, and on several protocol and administrative committees. Dr. Freyer graduated magna cum laude from DePauw University, obtained his medical degree from the Des Moines University College of Osteopathic Medicine and Surgery, and completed post-graduate medical training at Chicago College of Osteopathic Medicine and Hospitals, Rush University Medical Center and the University of Michigan Medical Center. In 2007, he obtained a MS degree in Clinical Research Design and Statistical Analysis from the University of Michigan School of Public Health.

Assessment of provider perspectives on otoprotection research for children and adolescents: A Children's Oncology Group Cancer Control and Supportive Care Committee survey Pediatr Blood Cancer. 2020 Sep 04; e28647. . View in PubMed

Estimating cancer treatment intensity from SEER cancer registry data: methods and implications for population-based registry studies of pediatric cancers Cancer Causes Control. 2020 Aug 05. . View in PubMed

Effect of a Daily Text Messaging and Directly Supervised Therapy Intervention on Oral Mercaptopurine Adherence in Children With Acute Lymphoblastic Leukemia: A Randomized Clinical Trial JAMA Netw Open. 2020 Aug 03; 3(8):e2014205. . View in PubMed

The Children's Oncology Group Adolescent and Young Adult Responsible Investigator Network: A New Model for Addressing Site-Level Factors Impacting Clinical Trial Enrollment J Adolesc Young Adult Oncol. 2020 Aug; 9(4):522-527. . View in PubMed

Profiles of emotional distress and growth among adolescents and young adults with cancer: A longitudinal study Health Psychol. 2020 May; 39(5):370-380. . View in PubMed

Systematic review of barriers and facilitators to clinical trial enrollment among adolescents and young adults with cancer: Identifying opportunities for intervention Cancer. 2020 Mar 01; 126(5):949-957. . View in PubMed

Enrollment of adolescents and young adults onto SWOG cancer research network clinical trials: A comparative analysis by treatment site and era Cancer Med. 2020 03; 9(6):2146-2152. . View in PubMed

Late mortality and chronic health conditions in long-term survivors of early-adolescent and young adult cancers: a retrospective cohort analysis from the Childhood Cancer Survivor Study Lancet Oncol. 2020 03; 21(3):421-435. . View in PubMed

Prevention of cisplatin-induced ototoxicity in children and adolescents with cancer: a clinical practice guideline Lancet Child Adolesc Health. 2020 02; 4(2):141-150. . View in PubMed

Mapping child and adolescent self-reported symptom data to clinician-reported adverse event grading to improve pediatric oncology care and research Cancer. 2020 01 01; 126(1):140-147. . View in PubMed

Emerging Cancer Survival Trends, Disparities, and Priorities in Adolescents and Young Adults: A California Cancer Registry-Based Study JNCI Cancer Spectr. 2019 Jun; 3(2):pkz031. . View in PubMed

Evaluating and providing quality health information for adolescents and young adults with cancer Pediatr Blood Cancer. 2019 10; 66(10):e27931. . View in PubMed

Obesity and Risk for Second Malignant Neoplasms in Childhood Cancer Survivors: A Case-Control Study Utilizing the California Cancer Registry Cancer Epidemiol Biomarkers Prev. 2019 10; 28(10):1612-1620. . View in PubMed

Interventions for cisplatin-induced hearing loss in children and adolescents with cancer Lancet Child Adolesc Health. 2019 08; 3(8):578-584. . View in PubMed

Response to Siegel et al J Natl Cancer Inst. 2019 06 01; 111(6):635-636. . View in PubMed

A Reappraisal of Sex-Specific Cancer Survival Trends Among Adolescents and Young Adults in the United States J Natl Cancer Inst. 2019 05 01; 111(5):509-518. . View in PubMed

A comparative analysis of clinicopathological features and survival among early adolescents/young adults and children with low-grade glioma: a report from the Children's Oncology Group J Neurooncol. 2018 Dec; 140(3):575-582. . View in PubMed

Prevention of cisplatin-induced hearing loss in children: Informing the design of future clinical trials Cancer Med. 2018 May 30. . View in PubMed

Prevalence and correlates of health information-seeking among Hispanic and non-Hispanic childhood cancer survivors Support Care Cancer. 2018 Apr; 26(4):1305-1313. . View in PubMed

Cognitive outcomes among Latino survivors of childhood acute lymphoblastic leukemia and lymphoma: A cross-sectional cohort study using culturally competent, performance-based assessment Pediatr Blood Cancer. 2018 Feb; 65(2). . View in PubMed

Childhood Cancer Survivorship and Substance Use Behaviors: A Matched Case-Control Study Among Hispanic Adolescents and Young Adults J Adolesc Health. 2018 07; 63(1):115-117. . View in PubMed

Depressive Symptoms and Quality of Life Among Adolescent and Young Adult Cancer Survivors: Impact of Gender and Latino Culture J Adolesc Young Adult Oncol. 2018 06; 7(3):384-388. . View in PubMed

Child and adolescent self-report symptom measurement in pediatric oncology research: a systematic literature review Qual Life Res. 2018 02; 27(2):291-319. . View in PubMed

Limitations of body mass index to assess body composition due to sarcopenic obesity during leukemia therapy Leuk Lymphoma. 2018 01; 59(1):138-145. . View in PubMed

A prospective, observational cohort study comparing cancer clinical trial availability and enrollment between early adolescents/young adults and children Cancer. 2018 03 01; 124(5):983-990. . View in PubMed

Pediatric-Inspired Treatment Regimens for Adolescents and Young Adults With Philadelphia Chromosome-Negative Acute Lymphoblastic Leukemia: A Review JAMA Oncol. 2018 05 01; 4(5):725-734. . View in PubMed

A prospective comparison of cancer clinical trial availability and enrollment among adolescents/young adults treated at an adult cancer hospital or affiliated children's hospital Cancer. 2018 10 15; 124(20):4064-4071. . View in PubMed

Sexual functioning among young adult cancer patients: A 2-year longitudinal study Cancer. 2018 01 15; 124(2):398-405. . View in PubMed

Sodium Thiosulfate and Cisplatin-Induced Hearing Loss N Engl J Med. 2018 09 20; 379(12):1180-1. . View in PubMed

Identifying metrics of success for transitional care practices in childhood cancer survivorship: A qualitative study of survivorship providers Pediatr Blood Cancer. 2017 Nov; 64(11). . View in PubMed

Long-term follow-up of endocrine function among young children with newly diagnosed malignant central nervous system tumors treated with irradiation-avoiding regimens Pediatr Blood Cancer. 2017 Nov; 64(11). . View in PubMed

A randomized controlled trial testing an adherence-optimized Vitamin D regimen to mitigate bone change in adolescents being treated for acute lymphoblastic leukemia Leuk Lymphoma. 2017 Oct; 58(10):2370-2378. . View in PubMed

Development of a Culturally Competent Service to Improve Academic Functioning for Latino Survivors of Acute Lymphoblastic Leukemia: Methodological Considerations J Pediatr Oncol Nurs. 2017 May/Jun; 34(3):222-229. . View in PubMed

Cognitive Interview-Based Validation of the Patient-Reported Outcomes Version of the Common Terminology Criteria for Adverse Events in Adolescents with Cancer J Pain Symptom Manage. 2017 04; 53(4):759-766. . View in PubMed

Eliciting the child's voice in adverse event reporting in oncology trials: Cognitive interview findings from the Pediatric Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events initiative Pediatr Blood Cancer. 2017 03; 64(3). . View in PubMed

Group-Wide, Prospective Study of Ototoxicity Assessment in Children Receiving Cisplatin Chemotherapy (ACCL05C1): A Report From the Children's Oncology Group J Clin Oncol. 2017 02; 35(4):440-445. . View in PubMed

Supporting long-term follow-up of young adult survivors of childhood cancer: Correlates of healthcare self-efficacy Pediatr Blood Cancer. 2017 02; 64(2):358-363. . View in PubMed

Effects of sodium thiosulfate versus observation on development of cisplatin-induced hearing loss in children with cancer (ACCL0431): a multicentre, randomised, controlled, open-label, phase 3 trial Lancet Oncol. 2017 01; 18(1):63-74. . View in PubMed

Next steps for adolescent and young adult oncology workshop: An update on progress and recommendations for the future Cancer. 2016 Apr 01; 122(7):988-99. . View in PubMed

Low Enrollment of Adolescents and Young Adults Onto Cancer Trials: Insights From the Community Clinical Oncology Program J Oncol Pract. 2016 Apr; 12(4):e388-95. . View in PubMed

Early injury to cortical and cancellous bone from induction chemotherapy for adolescents and young adults treated for acute lymphoblastic leukemia Bone. 2016 Apr; 85:131-7. . View in PubMed

Effect of Sensorineural Hearing Loss on Neurocognitive Functioning in Pediatric Brain Tumor Survivors Pediatr Blood Cancer. 2016 Mar; 63(3):527-34. . View in PubMed

Substance use among adolescent and young adult cancer survivors Psychooncology. 2016 11; 25(11):1357-1362. . View in PubMed

A parent-directed intervention for addressing academic risk in Latino survivors of childhood leukemia: results of a pilot study Psychooncology. 2016 10; 25(10):1246-1249. . View in PubMed

Reconsidering Physical Activity Restrictions for Mononephric Survivors of Childhood Cancer: A Report From the Children's Oncology Group J Pediatr Oncol Nurs. 2016 07; 33(4):306-13. . View in PubMed

Nonrandomized comparison of neurofibromatosis type 1 and non-neurofibromatosis type 1 children who received carboplatin and vincristine for progressive low-grade glioma: A report from the Children's Oncology Group Cancer. 2016 06 15; 122(12):1928-36. . View in PubMed

Case-linked analysis of clinical trial enrollment among adolescents and young adults at a National Cancer Institute-designated comprehensive cancer center Cancer. 2015 Dec 15; 121(24):4398-406. . View in PubMed

Comparative Toxicity by Sex Among Children Treated for Acute Lymphoblastic Leukemia: A Report From the Children's Oncology Group Pediatr Blood Cancer. 2015 Dec; 62(12):2140-9. . View in PubMed

Enhancing Adolescent and Young Adult Oncology Research Within the National Clinical Trials Network: Rationale, Progress, and Emerging Strategies Semin Oncol. 2015 Oct; 42(5):740-7. . View in PubMed

Early Cardiac Iron Overload in a Child on Treatment of Acute Lymphoblastic Leukemia Pediatrics. 2015 Sep; 136(3):e697-700. . View in PubMed

Late Mortality After Dexrazoxane Treatment: A Report From the Children's Oncology Group J Clin Oncol. 2015 Aug 20; 33(24):2639-45. . View in PubMed

Inclusion of Adolescents and Young Adults in Cancer Clinical Trials Semin Oncol Nurs. 2015 Aug; 31(3):197-205. . View in PubMed

The Clinical Trials Gap for Adolescents and Young Adults with Cancer: Recent Progress and Conceptual Framework for Continued Research Curr Pediatr Rep. 2015 Jun; 3(2):137-145. . View in PubMed

Institutional adherence to cardiovascular risk factor screening guidelines for young survivors of acute lymphoblastic leukemia J Pediatr Hematol Oncol. 2015 May; 37(4):e253-7. . View in PubMed

Cancer-related follow-up care among Hispanic and non-Hispanic childhood cancer survivors: The Project Forward study Cancer. 2015 Feb 15; 121(4):605-13. . View in PubMed

Obesity is associated with residual leukemia following induction therapy for childhood B-precursor acute lymphoblastic leukemia Blood. 2014 Dec 18; 124(26):3932-8. . View in PubMed

Screening for cardiac dysfunction in anthracycline-exposed childhood cancer survivors Clin Cancer Res. 2014 Dec 15; 20(24):6314-23. . View in PubMed

Characterization of transfusion-derived iron deposition in childhood cancer survivors Cancer Epidemiol Biomarkers Prev. 2014 Sep; 23(9):1913-9. . View in PubMed

Pulmonary outcomes in patients with Hodgkin lymphoma treated with involved field radiation Pediatr Blood Cancer. 2014 Jul; 61(7):1277-81. . View in PubMed

Carnitine and cardiac dysfunction in childhood cancer survivors treated with anthracyclines Cancer Epidemiol Biomarkers Prev. 2014 Jun; 23(6):1109-14. . View in PubMed

Impact on survival and toxicity by duration of weight extremes during treatment for pediatric acute lymphoblastic leukemia: A report from the Children's Oncology Group J Clin Oncol. 2014 May 01; 32(13):1331-7. . View in PubMed

Comparison of secondary and primary thyroid cancer in adolescents and young adults Cancer. 2014 Apr 15; 120(8):1155-61. . View in PubMed

Facilitating accrual to cancer control and supportive care trials: the clinical research associate perspective BMC Med Res Methodol. 2013 Dec 31; 13:154. . View in PubMed

Differences in outcomes of newly diagnosed acute myeloid leukemia for adolescent/young adult and younger patients: a report from the Children's Oncology Group Cancer. 2013 Dec 01; 119(23):4162-9. . View in PubMed

Early cardiac outcomes following contemporary treatment for childhood acute myeloid leukemia: a North American perspective Pediatr Blood Cancer. 2013 Sep; 60(9):1528-33. . View in PubMed

Correlation of clinical and dosimetric factors with adverse pulmonary outcomes in children after lung irradiation Int J Radiat Oncol Biol Phys. 2013 Aug 01; 86(5):942-8. . View in PubMed

The first step to integrating the child's voice in adverse event reporting in oncology trials: a content validation study among pediatric oncology clinicians Pediatr Blood Cancer. 2013 Jul; 60(7):1231-6. . View in PubMed

Children's Oncology Group's 2013 blueprint for research: adolescent and young adult oncology Pediatr Blood Cancer. 2013 Jun; 60(6):1055-8. . View in PubMed

Association of projected transfusional iron burden with treatment intensity in childhood cancer survivors Pediatr Blood Cancer. 2012 Oct; 59(4):697-702. . View in PubMed

Exercise recommendations for childhood cancer survivors exposed to cardiotoxic therapies: an institutional clinical practice initiative J Pediatr Oncol Nurs. 2012 Sep-Oct; 29(5):246-52. . View in PubMed

Randomized study of two chemotherapy regimens for treatment of low-grade glioma in young children: a report from the Children's Oncology Group J Clin Oncol. 2012 Jul 20; 30(21):2641-7. . View in PubMed

Platinum-induced ototoxicity in children: a consensus review on mechanisms, predisposition, and protection, including a new International Society of Pediatric Oncology Boston ototoxicity scale J Clin Oncol. 2012 Jul 01; 30(19):2408-17. . View in PubMed

Hearing loss among survivors of childhood brain tumors treated with an irradiation-sparing approach Pediatr Blood Cancer. 2012 Jun; 58(6):953-8. . View in PubMed

Cancer survivorship practices, services, and delivery: a report from the Children's Oncology Group (COG) nursing discipline, adolescent/young adult, and late effects committees J Cancer Surviv. 2011 Dec; 5(4):345-57. . View in PubMed

Postrelapse survival in childhood acute lymphoblastic leukemia is independent of initial treatment intensity: a report from the Children's Oncology Group Blood. 2011 Mar 17; 117(11):3010-5. . View in PubMed

Clinical outcomes after long-term treatment with alglucosidase alfa in infants and children with advanced Pompe disease Genet Med. 2009 Mar; 11(3):210-9. . View in PubMed

Prevention of hearing loss in children receiving cisplatin chemotherapy J Clin Oncol. 2009 Jan 10; 27(2):317-8; author reply 318-9. . View in PubMed

The effect of cyproheptadine hydrochloride (periactin) and megestrol acetate (megace) on weight in children with cancer/treatment-related cachexia J Pediatr Hematol Oncol. 2008 Nov; 30(11):791-7. . View in PubMed

Adolescent and young adult oncology: transition of care Pediatr Blood Cancer. 2008 May; 50(5 Suppl):1116-9. . View in PubMed

Early postinduction intensification therapy improves survival for children and adolescents with high-risk acute lymphoblastic leukemia: a report from the Children's Oncology Group Blood. 2008 Mar 01; 111(5):2548-55. . View in PubMed

Measuring the impact of dexrazoxane cardioprotection Pediatr Blood Cancer. 2007 Apr; 48(4):483-4; author reply 485. . View in PubMed

In sickness and in health: transition of cancer-related care for older adolescents and young adults Cancer. 2006 Oct 01; 107(7 Suppl):1702-9. . View in PubMed

Multidisciplinary care of the dying adolescent Child Adolesc Psychiatr Clin N Am. 2006 Jul; 15(3):693-715. . View in PubMed

Models of care for survivors of childhood cancer Pediatr Blood Cancer. 2006 Feb; 46(2):159-68. . View in PubMed

Flow cytometric diagnosis of X-linked hyper-IgM syndrome: application of an accurate and convenient procedure J Pediatr Hematol Oncol. 2004 Jun; 26(6):363-70. . View in PubMed

Care of the dying adolescent: special considerations Pediatrics. 2004 Feb; 113(2):381-8. . View in PubMed

Successful nonoperative management of typhlitis in pediatric oncology patients J Pediatr Surg. 2002 Aug; 37(8):1151-5. . View in PubMed

Induced hypothermia in experimental pneumococcal meningitis J Cereb Blood Flow Metab. 2000 May; 20(5):834-8. . View in PubMed

Intravenous methohexital for brief sedation of pediatric oncology outpatients: physiologic and behavioral responses Pediatrics. 1997 May; 99(5):E8. . View in PubMed

Juvenile xanthogranuloma: forms of systemic disease and their clinical implications J Pediatr. 1996 Aug; 129(2):227-37. . View in PubMed

Pleuropulmonary blastoma: a marker for familial disease J Pediatr. 1996 Feb; 128(2):220-4. . View in PubMed

Brief unconscious sedation for painful pediatric oncology proceduresIntravenous methohexital with appropriate monitoring is safe and effective. Am J Pediatr Hematol Oncol. 1993 Nov; 15(4):370-6. . View in PubMed

Extrarenal Wilms' tumorUnusual presentation in the lumbosacral region. Am J Pediatr Hematol Oncol. 1993 Feb; 15(1):117-9. . View in PubMed

Children with cancer: special considerations in the discontinuation of life-sustaining treatment Med Pediatr Oncol. 1992; 20(2):136-42. . View in PubMed

Regulation of superoxide responses of human neutrophils by adenine compoundsIndependence of requirement for cytoplasmic granules. Lab Invest. 1989 Nov; 61(5):515-21. . View in PubMed

Surface Mo1 (CD11b/CD18) glycoprotein is up-modulated by neutrophils recruited to sites of inflammation in vivo Inflammation. 1989 Oct; 13(5):495-505. . View in PubMed

Primary primitive neuroectodermal tumor of the spinal cord associated with neural tube defect Pediatr Neurosci. 1989; 15(4):181-7. . View in PubMed

Stimulation of human neutrophil adhesive properties by adenine nucleotides J Immunol. 1988 Jul 15; 141(2):580-6. . View in PubMed

The CD11/CD18 leukocyte glycoprotein deficiency Hematol Oncol Clin North Am. 1988 Mar; 2(1):13-31. . View in PubMed

Modulation of surface CD11/CD18 glycoproteins (Mo1, LFA-1, p150,95) by human mononuclear phagocytes Clin Immunol Immunopathol. 1988 Feb; 46(2):272-83. . View in PubMed

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