David R. Freyer, DO, MS

Professor of Clinical Pediatrics, Medicine and Population and Public Health Sciences

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Overview

David R. Freyer, DO, MS is Professor of Clinical Pediatrics, Medicine, and Population and Public Health Sciences at the Keck School of Medicine, University of Southern California (USC). He currently serves as Director of the Survivorship and Supportive Care Program in the Cancer and Blood Disease Institute at Children’s Hospital Los Angeles (CHLA), and as Director of the Cancer Survivorship Program and Co-Director of the Adolescent and Young Adult (AYA) Cancer Program at the USC Norris Comprehensive Cancer Center. He is founding Co-Director of the Southern California Center for Young Adult Cancer Survivorship Research, now a three-institution, multi-state research collaborative focused on all aspects of young adult cancer survivorship, including health disparities.

Dr. Freyer’s clinical care and research are concentrated in cancer survivorship, cancer control/supportive care, and AYA oncology with interests in treatment-related toxicity, survivorship care transition, cancer care disparities, and patient-reported outcomes. He continues as PI or Co-I on multiple, federally funded grants in these areas. From 2009-2019 he served as Chair of the Children’s Oncology Group (COG) AYA Oncology Discipline Committee and continues as an active investigator in this and other COG committees. In 2018, Dr. Freyer was honored with the Robert M. McAllister Faculty Mentoring Award in the Keck School of Medicine at USC. In 2023, Dr. Freyer received an NCI Director’s Award for his role in developing and implementing AYA clinical trials in the NCI National Clinical Trials Network. For numerous consecutive years, his clinical expertise has been recognized with citations in “Best Doctors in America.” In 2025, Dr. Freyer was ordained a permanent deacon for the Roman Catholic Archdiocese of Los Angeles.

Research Funding

  • Patient Navigation for Improving Transition Success Among Multiply Disadvantaged Young Adult Survivors of Childhood Cancer
    NIH · R01CA303651 · Sep 10, 2025 – Aug 31, 2029 · Role: Principal Investigator
  • Project Milestones: Young Adult Cancer Survivorship
    NIH · R01CA237230 · Jul 1, 2019 – Dec 31, 2024 · Role: Co-Principal Investigator
  • CHANGE OF GRANTEE INSTITUTION: Creating and Validating Child Adverse Event Reporting in Oncology Trials
    NIH · R01CA175759 · Apr 1, 2013 – Mar 31, 2021 · Role: Co-Principal Investigator

Publications

  • Longitudinal Change in Cardiac Function After Doxorubicin and Dexrazoxane: A Report From Children’s Oncology Group ALTE11C2. J Clin Oncol. 2026 Aug 06.. View in PubMed
  • Inconsistent reporting of adolescent and young adult (AYA) status in non-interventional cancer research: a critical barrier to evidence usability. BMJ Open. 2026 07 29; 16(7):e107742.. View in PubMed
  • On Hierarchical Composite Endpoints in Pediatric Cancer Supportive Care: Illustrative Examples From Two Multi-Center Phase-III Randomized Clinical Trials. Pediatr Blood Cancer. 2026 Jul 25.. View in PubMed
  • Adolescents and Young Adults With Acute Lymphoblastic Leukemia: Qualitative Barriers and Facilitators to Guideline-Concordant Care. Cancer Control. 2026 Jan-Dec; 33:10732748261469238.. View in PubMed
  • AYA POWER: Feasibility and Early Outcomes of a Global Virtual AYA Oncology Education Curriculum. J Adolesc Young Adult Oncol. 2026 Jul 15; 21565333261470564.. View in PubMed
  • Impact of Cisplatin-Induced Hearing Loss on Quality of Life in Childhood Cancer Survivors. JCO Oncol Pract. 2026 Jun 22.. View in PubMed
  • Factors associated with unplanned healthcare encounters in pediatric cancer patients. Support Care Cancer. 2026 May 21; 34(6).. View in PubMed
  • Survival After Diagnosis of Cardiovascular Disease in Survivors of Adolescent and Young Adult Lymphoma. Eur J Haematol. 2026 Oct; 117(4):953-959.. View in PubMed
  • Beyond the Hospital: Understanding Psychosocial Support Uptake for Adolescents and Young Adults With Cancer in Community-Based and Nonprofit Programs. Cancer Control. 2026 Jan-Dec; 33:10732748261450729.. View in PubMed
  • Availability of cancer survivorship services for adolescents and young adults: Findings from the 2022 NCI Community Oncology Research Program Landscape Assessment. J Cancer Surviv. 2026 Apr 28.. View in PubMed