David R. Friedland, MD, PhD

Professor of Clinical Otolaryngology - Head & Neck Surgery

Director of Clinical Artificial Intelligence (AI) applications

Associate Dean for Clinical Research

Director of Clinical Research Support, Southern California Clinical and Translational Science Institute

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Overview

David R. Friedland, M.D., Ph.D., is Professor of Clinical Otolaryngology-Head and Neck Surgery; Associate Dean for Clinical Research; Director of Clinical Artificial Intelligence Applications; and Director of the Clinical Research Services Core in Keck School of Medicine at the University of Southern California (USC) in Los Angeles.

Scientifically, Dr. Friedland has conducted research into the use of big data and machine learning for improving care in otolaryngologic (ear, nose and throat) disorders. This work has devised novel algorithms for helping to diagnose vestibular disorders and identified disparities in healthcare by geographic and social demographics. Dr. Friedland has also significantly contributed to the understanding of the relationship between cardiovascular disease and hearing loss. He has identified patterns of hearing loss that are associated with higher risks of heart attack and stroke.

Administratively, Dr. Friedland has led efforts to improve the efficiency and scope of clinical trials at academic medical centers. Prior to his joining USC he directed the Clinical & Translational Research Center at the Medical College of Wisconsin and led efforts to expand the clinical trials workforce, identify compensation models for participating faculty, and design comprehensive clinical trials programs for academic units. At USC he seeks to streamline clinical trials processes, increase the portfolio of trials, promote greater alignment between the School of Medicine and Hospital partners, and promote junior faculty career development. In addition, as Director of Clinical Applications for MESH Strategic Partnerships, he will promote partnerships across USC and with industry to adopt and develop novel technology solutions for healthcare and research operations and delivery.

Dr. Friedland received his medical degree from the Icahn School of Medicine at Mount Sinai in New York City where he also completed residency training in Otolaryngology-Head and Neck Surgery. He completed his fellowship training in Neurotology and Skull Base Surgery at Johns Hopkins University, Baltimore, MD. He started his career at the Medical College of Wisconsin, Milwaukee where he was Division Chief of Otology and Neuro-otologic Skull Base Surgery, Chief of the Division of Research, and Vice-Chair of Otolaryngology and Communication Science.

A native of Brooklyn, NY, Dr. Friedland enjoys cycling, hiking, reading, crossword puzzles and building miniature furniture.

Education and Training

  • City University of New York, New York — PhD — 10/1993 — Biomedical Science
  • Mount Sinai School of Medicine, New York — MD — 06/1995 — Medicine
  • Mount Sinai School of Medicine, New York — 06/2000 — Otolaryngology
  • Johns Hopkins School of Medicine, Baltimore — 06/2002 — Neurotology/Skull Base Surgery

Research Funding

  • microRNA Regulation of Cholesteatoma Growth
    NIH · R21DC010038 · Apr 1, 2010 – Mar 31, 2013 · Role: Principal Investigator
  • Differential Gene Expression in the Cochlear Nucleus
    NIH · K08DC006227 · Apr 1, 2004 – Mar 31, 2010 · Role: Principal Investigator

Publications

  • Multidisciplinary management of pediatric head and neck lymphatic malformations: a 10-year single-institution experience. Int J Pediatr Otorhinolaryngol. 2026 May; 204:112794.. View in PubMed
  • Explainable AI reveals temporal risk pathways in fall prediction: Extracting clinical insights from multi-horizon machine learning models. Geroscience. 2026 Feb 04.. View in PubMed
  • Risk Prediction and Interpretation for Fall Events Using Explainable AI and Large Language Models. Proc 2025 9th Int Conf Med Health Inform (2025). 2025; 2025:270-277.. View in PubMed
  • Correlation Between Life Stress and Tinnitus Severity. Otol Neurotol. 2026 Feb 01; 47(2):221-226.. View in PubMed
  • Tumoral Skin Invasion Is an Independent Predictor of Rapid Recurrence in Head and Neck Cancer. Head Neck. 2026 02; 48(2):535-542.. View in PubMed
  • Pediatric facial trauma: how social determinants of health impact injury patterns. Int J Pediatr Otorhinolaryngol. 2025 Nov; 198:112572.. View in PubMed
  • Integrated clinical research ensembles: A pathway to increased academic productivity. J Clin Transl Sci. 2025; 9(1):e209.. View in PubMed
  • Assessment of Anesthetic Modalities in Otologic Surgery. Otol Neurotol Open. 2025 Sep; 5(3):e075.. View in PubMed
  • Investigating Utility of the Preoperative Systemic Immune-Inflammatory Index in Chronic Rhinosinusitis. Clin Otolaryngol. 2025 11; 50(6):967-972.. View in PubMed
  • Response to Oral Steroids for Sudden Sensorineural Hearing Loss: Considerations of Age, Time to Treatment, and Degree of Hearing Loss. Audiol Neurootol. 2025; 30(6):471-479.. View in PubMed