David Richard Friedland

David R. Friedland, M.D., Ph.D., is Professor of Clinical Otolaryngology-Head and Neck Surgery; Associate Dean for Clinical Research; Director of Clinical Artificial Intelligence Applications; and Director of the Clinical Research Services Core in Keck School of Medicine at the University of Southern California (USC) in Los Angeles.

Scientifically, Dr. Friedland has conducted research into the use of big data and machine learning for improving care in otolaryngologic (ear, nose and throat) disorders. This work has devised novel algorithms for helping to diagnose vestibular disorders and identified disparities in healthcare by geographic and social demographics. Dr. Friedland has also significantly contributed to the understanding of the relationship between cardiovascular disease and hearing loss. He has identified patterns of hearing loss that are associated with higher risks of heart attack and stroke.

Administratively, Dr. Friedland has led efforts to improve the efficiency and scope of clinical trials at academic medical centers. Prior to his joining USC he directed the Clinical & Translational Research Center at the Medical College of Wisconsin and led efforts to expand the clinical trials workforce, identify compensation models for participating faculty, and design comprehensive clinical trials programs for academic units. At USC he seeks to streamline clinical trials processes, increase the portfolio of trials, promote greater alignment between the School of Medicine and Hospital partners, and promote junior faculty career development. In addition, as Director of Clinical Applications for MESH Strategic Partnerships, he will promote partnerships across USC and with industry to adopt and develop novel technology solutions for healthcare and research operations and delivery.

Dr. Friedland received his medical degree from the Icahn School of Medicine at Mount Sinai in New York City where he also completed residency training in Otolaryngology-Head and Neck Surgery. He completed his fellowship training in Neurotology and Skull Base Surgery at Johns Hopkins University, Baltimore, MD. He started his career at the Medical College of Wisconsin, Milwaukee where he was Division Chief of Otology and Neuro-otologic Skull Base Surgery, Chief of the Division of Research, and Vice-Chair of Otolaryngology and Communication Science.

A native of Brooklyn, NY, Dr. Friedland enjoys cycling, hiking, reading, crossword puzzles and building miniature furniture.

• Advancing personalized healthcare: leveraging explainable AI for BPPV risk assessment Health Inf Sci Syst. 2025 Dec; 13(1):1. . View in PubMed
• Cardiovascular Diseases and Sensorineural Hearing Loss-A Systematic Review of the Literature Otol Neurotol. 2024 Nov 21. . View in PubMed
• Wound Healing Complications Associated with Staged Reconstruction after Facial Lentigo Maligna Resection Facial Plast Surg Aesthet Med. 2024 Nov-Dec; 26(6):793-799. . View in PubMed
• Socioeconomic Determinants of Health and Reflux Management: Insights from a Tertiary Medical Center Laryngoscope. 2024 Oct 23. . View in PubMed
• Disparities in polysomnography referral in a high-risk cardiac population Sleep Breath. 2024 Oct; 28(5):1969-1976. . View in PubMed
• Amplitude Parameters Are Predictive of Hearing Preservation in a Randomized Controlled Trial of Intracochlear Electrocochleography During Cochlear Implant Surgery Otol Neurotol. 2024 Sep 01; 45(8):887-894. . View in PubMed
• The Impact of Sociodemographic Factors on Rates of Tympanostomy Tube Placement for Pediatric Otitis Media OTO Open. 2024 Jul-Sep; 8(3):e159. . View in PubMed
• Failure in HiRes Ultra Series Recall Devices Does Not Necessarily Lead to Decrement in Performance Otol Neurotol. 2024 Jul 01; 45(6):651-655. . View in PubMed
• BPI24-200: Delays in Adjuvant Therapy in Head and Neck Cancers: Identifying Population Disparities and Implementing SolutionsJ Natl Compr Canc Netw. 2024 Apr 05; 22(2. 5). . View in PubMed
• Evaluation of Social Determinants of Health on Dysphagia Care Pathways at a Tertiary Care Facility Laryngoscope. 2024 03; 134(3):1139-1146. . View in PubMed
• Factors associated with delayed referral and hearing rehabilitation for congenital sensorineural hearing loss Int J Pediatr Otorhinolaryngol. 2023 Dec; 175:111770. . View in PubMed
• Establishment of novel immortalized middle ear cell lines as models for otitis media Laryngoscope Investig Otolaryngol. 2023 Oct; 8(5):1428-1435. . View in PubMed
• Impacts of Socioeconomic Status on Dentoalveolar Trauma WMJ. 2023 Mar; 122(1):32-37. . View in PubMed
• Stroke of Genius: A Customizable Card Game Structure to Exercise Differential Diagnostic Skills J Grad Med Educ. 2023 06; 15(3):393-394. . View in PubMed
• The Demographics of Menière’s Disease: Selection Bias or Differential Susceptibility? Otol Neurotol. 2023 02 01; 44(2):e95-e102.. View in PubMed
• Demographic differences in the treatment of unilateral vocal fold paralysis Laryngoscope Investig Otolaryngol. 2022 Dec; 7(6):1915-1921. . View in PubMed
• Medial orbital wall decompression: Demographics influencing surgical follow-up and complications: Impacts on follow-up and complications Am J Otolaryngol. 2022 Sep-Oct; 43(5):103578. . View in PubMed
• Duration of effectiveness of coblation for recurrent epistaxis in hereditary hemorrhagic telangiectasia Am J Otolaryngol. 2022 May-Jun; 43(3):103409. . View in PubMed
• Analysis of socioeconomic factors in laryngology clinic utilization for treatment of dysphonia Laryngoscope Investig Otolaryngol. 2022 Feb; 7(1):202-209. . View in PubMed
• Clinical perspectives on nasopharyngeal morphology in humans Anat Rec (Hoboken). 2022 08; 305(8):2065-2074. . View in PubMed
• Can Electrocochleography Help Preserve Hearing After Cochlear Implantation With Full Electrode Insertion? Otol Neurotol. 2022 08 01; 43(7):789-796.. View in PubMed
• Standardization of Outcome Measures for Intratympanic Steroid Treatment for Idiopathic Sudden Sensorineural Hearing Loss Otol Neurotol. 2022 12 01; 43(10):1137-1143. . View in PubMed
• Impact of Demographics and Clinical Features on Initial Treatment Pathway for Vestibular Schwannoma Otol Neurotol. 2022 10 01; 43(9):1078-1084. . View in PubMed
• The impact of social determinants of health and clinical comorbidities on post-tympanotomy tube otorrhea Int J Pediatr Otorhinolaryngol. 2022 Jan; 152:110986. . View in PubMed
• Abnormal hearing patterns are not associated with endothelium-dependent vasodilation and carotid intima-media thickness: The Framingham Heart Study Vasc Med. 2021 Dec; 26(6):595-601. . View in PubMed
• Gamma Knife Treatment of Vestibular Schwannoma Planned With Computed Tomography Cisternography Adv Radiat Oncol. 2021 May-Jun; 6(3):100631. . View in PubMed
• Socioeconomic Determinants of Tertiary Rhinology Care Utilization OTO Open. 2021 Apr-Jun; 5(2):2473974X211009830. . View in PubMed
• Analysis of Inflammatory Signaling in Human Middle Ear Cell Culture Models of Pediatric Otitis Media Laryngoscope. 2021 02; 131(2):410-416. . View in PubMed
• Cochlear Implant Performance in Candidates With Moderate Hearing Loss Qualifying in Noise Otol Neurotol. 2021 12 01; 42(10):1484-1491. . View in PubMed
• Development of in-house genetic screening for pediatric hearing loss Laryngoscope Investig Otolaryngol. 2020 Jun; 5(3):497-505. . View in PubMed
• Unique Clinical Language Patterns Among Expert Vestibular Providers Can Predict Vestibular Diagnoses Otol Neurotol. 2018 10; 39(9):1163-1171. . View in PubMed
• Outcomes Following Modified Tympanomastoidectomy With Soft-wall Reconstruction Otol Neurotol. 2018 10; 39(9):1139-1146. . View in PubMed
• Tablet-based Screening for Hearing Loss: Feasibility of Testing in Nonspecialty Locations Otol Neurotol. 2018 04; 39(4):410-416. . View in PubMed
• Multicenter US Clinical Trial With an Electric-Acoustic Stimulation (EAS) System in Adults: Final Outcomes Otol Neurotol. 2018 03; 39(3):299-305. . View in PubMed
• Assessment of a Statistical Algorithm for the Prediction of Benign Paroxysmal Positional Vertigo JAMA Otolaryngol Head Neck Surg. 2018 10 01; 144(10):883-886. . View in PubMed
• Temporal and spectral contributions to musical instrument identification and discrimination among cochlear implant users World J Otorhinolaryngol Head Neck Surg. 2016 Sep; 2(3):148-156. . View in PubMed
• Development of a Statistical Model for the Prediction of Common Vestibular Diagnoses JAMA Otolaryngol Head Neck Surg. 2016 Apr; 142(4):351-6. . View in PubMed
• Association of TMTC2 With Human Nonsyndromic Sensorineural Hearing Loss JAMA Otolaryngol Head Neck Surg. 2016 09 01; 142(9):866-72. . View in PubMed
• Differences in Perception of Musical Stimuli among Acoustic, Electric, and Combined Modality Listeners J Am Acad Audiol. 2015 May; 26(5):494-501. . View in PubMed
• Patient Outcomes in Magnet-Based Implantable Auditory Assist Devices JAMA Otolaryngol Head Neck Surg. 2014 Jun; 140(6):513-20. . View in PubMed
• The perception of telephone-processed speech by combined electric and acoustic stimulation Trends Amplif. 2013 Sep-Dec; 17(3):189-96. . View in PubMed
• Statistical model for prediction of hearing loss in patients receiving cisplatin chemotherapy JAMA Otolaryngol Head Neck Surg. 2013 Mar; 139(3):256-64. . View in PubMed
• A novel otoferlin splice-site mutation in siblings with auditory neuropathy spectrum disorder Audiol Neurootol. 2013; 18(6):374-82. . View in PubMed
• Single and multiple microphone noise reduction strategies in cochlear implants Trends Amplif. 2012 Jun; 16(2):102-16. . View in PubMed
• Recovery from forward masking in elderly cochlear implant users Otol Neurotol. 2012 Apr; 33(3):355-63. . View in PubMed
• Electrode failure and device failure in adult cochlear implantation Cochlear Implants Int. 2012 Feb; 13(1):35-40. . View in PubMed
• Aiding and occluding the contralateral ear in implanted children with auditory neuropathy spectrum disorder J Am Acad Audiol. 2011 Oct; 22(9):567-577. . View in PubMed
• Hearing preservation surgery: proposal for an evidence-based grading scale Cochlear Implants Int. 2011 May; 12 Suppl 1:S76-7. . View in PubMed
• Rate of neural recovery in implanted children with auditory neuropathy spectrum disorder Otolaryngol Head Neck Surg. 2011 Feb; 144(2):274-9. . View in PubMed
• Association of hearing loss with PHACE syndrome Arch Dermatol. 2010 Dec; 146(12):1391-6. . View in PubMed
• Gamma knife surgery of vestibular schwannomas: volumetric dosimetry correlations to hearing loss suggest stria vascularis devascularization as the mechanism of early hearing loss Otol Neurotol. 2010 Dec; 31(9):1480-7. . View in PubMed
• Management and outcomes of facial paralysis from intratemporal blunt trauma: a systematic review Laryngoscope. 2010 Jul; 120(7):1397-404. . View in PubMed
• Case-control analysis of cochlear implant performance in elderly patients Arch Otolaryngol Head Neck Surg. 2010 May; 136(5):432-8. . View in PubMed
• Management and outcomes of facial paralysis from intratemporal blunt trauma: a systematic review Laryngoscope. 2010; 120 Suppl 4:S214. . View in PubMed
• Acute auditory and vestibular symptoms associated with heat and transdermal lidocaine Clin J Pain. 2010 Jan; 26(1):58-9. . View in PubMed
• Cholesteatoma growth and proliferation: posttranscriptional regulation by microRNA-21 Otol Neurotol. 2009 Oct; 30(7):998-1005. . View in PubMed
• Soft cochlear implantation: rationale for the surgical approach Trends Amplif. 2009 Jun; 13(2):124-38. . View in PubMed
• Audiometric pattern as a predictor of cardiovascular status: development of a model for assessment of risk Laryngoscope. 2009 Mar; 119(3):473-86. . View in PubMed
• Recurrent sudden sensorineural hearing loss sensitive to transtympanic and systemic steroid treatment: case report Ear Nose Throat J. 2009 Mar; 88(3):E14-9. . View in PubMed
• Neuromagnetic source imaging of abnormal spontaneous activity in tinnitus patient modulated by electrical cortical stimulation Annu Int Conf IEEE Eng Med Biol Soc. 2009; 2009:1940-4. . View in PubMed
• Sudden sensorineural hearing loss: an evaluation of treatment and management approaches by referring physicians Otolaryngol Head Neck Surg. 2009 Jan; 140(1):86-91. . View in PubMed
• Identification of a novel Vamp1 splice variant in the cochlear nucleus Hear Res. 2008 Sep; 243(1-2):105-12. . View in PubMed
• Recurrent petrous apex cholesteatoma in a patient with basal cell nevus syndrome Otolaryngol Head Neck Surg. 2008 Sep; 139(3):480-1. . View in PubMed
• Transcervical resection of the styloid process in Eagle syndrome Ear Nose Throat J. 2008 Jul; 87(7):399-401. . View in PubMed
• Pulsatile tinnitus Otol Neurotol. 2008 Apr; 29(3):416. . View in PubMed
• Outcomes for conservative management of traumatic conductive hearing loss Otol Neurotol. 2008 Apr; 29(3):344-9. . View in PubMed
• Feasibility of auditory cortical stimulation for the treatment of tinnitus Otol Neurotol. 2007 Dec; 28(8):1005-12. . View in PubMed
• Potassium channel gene expression in the rat cochlear nucleus Hear Res. 2007 Jun; 228(1-2):31-43. . View in PubMed
• Simultaneous astrocytoma and vestibular schwannoma arising from the vestibulocochlear nerve Otol Neurotol. 2007 Feb; 28(2):286-7. . View in PubMed
• Differentially expressed genes in the rat cochlear nucleus Neuroscience. 2006 Oct 27; 142(3):753-68. . View in PubMed
• Structure and function in the auditory system: From cochlea to cortex Anat Rec A Discov Mol Cell Evol Biol. 2006 Apr; 288(4):326-30. . View in PubMed
• Cranial thickness in superior canal dehiscence syndrome: implications for canal resurfacing surgery Otol Neurotol. 2006 Apr; 27(3):346-54. . View in PubMed
• Differential expression of cytoskeletal genes in the cochlear nucleus Anat Rec A Discov Mol Cell Evol Biol. 2006 Apr; 288(4):447-65. . View in PubMed
• A modified Golgi staining protocol for use in the human brain stem and cerebellum J Neurosci Methods. 2006 Jan 15; 150(1):90-5. . View in PubMed
• Temporal bone fractures: traditional classification and clinical relevance Laryngoscope. 2004 Oct; 114(10):1734-41. . View in PubMed
• Choice of ear for cochlear implantation: the effect of history and residual hearing on predicted postoperative performance Otol Neurotol. 2003 Jul; 24(4):582-9. . View in PubMed
• Ultrastructural examination of the somatic innervation of ventrotubercular cells in the rat J Comp Neurol. 2003 Apr 21; 459(1):77-89. . View in PubMed
• Gene discovery using a human vestibular schwannoma cDNA library constructed from a patient with neurofibromatosis type 2 (NF2) Otolaryngol Head Neck Surg. 2003 Mar; 128(3):364-71. . View in PubMed
• Radiology quiz case 2Cochlear otosclerosis. Arch Otolaryngol Head Neck Surg. 2002 Oct; 128(10):12141216-7. . View in PubMed
• Bacterial colonization of endotracheal tubes in intubated neonates Arch Otolaryngol Head Neck Surg. 2001 May; 127(5):525-8. . View in PubMed
• Lymphatic malformation: predictive factors for recurrence Otolaryngol Head Neck Surg. 2000 Dec; 123(6):706-10. . View in PubMed
• Rapid resolution of fetal goiter associated with maternal Grave’s disease: a case report Int J Pediatr Otorhinolaryngol. 2000 Aug 11; 54(1):59-62. . View in PubMed
• Cochlear implantation for auditory rehabilitation in Camurati-Engelmann disease Ann Otol Rhinol Laryngol. 2000 Feb; 109(2):160-2. . View in PubMed
• A critical appraisal of spontaneous perilymphatic fistulas of the inner ear Am J Otol. 1999 Mar; 20(2):261-76; discussion 276-9. . View in PubMed
• Evaluation of surgical approaches to endoscopic auditory brainstem implantation Laryngoscope. 1999 Feb; 109(2 Pt 1):175-80. . View in PubMed
• A cost-effectiveness analysis of the high risk register and auditory brainstem response Int J Pediatr Otorhinolaryngol. 1996 Dec 20; 38(2):115-30. . View in PubMed
• Use of the novel carbocyanine tracer fast-DiI for investigating upper respiratory tract cranial nerves in prenatal rats Lab Anim Sci. 1996 Apr; 46(2):220-5. . View in PubMed
• Naturally occurring motoneuron cell death in rat upper respiratory tract motor nuclei: a histological, fast DiI and immunocytochemical study in the hypoglossal nucleus J Neurobiol. 1995 Aug; 27(4):520-34. . View in PubMed
• Naturally occurring motoneuron cell death in rat upper respiratory tract motor nuclei: a histological, fast DiI and immunocytochemical study of the nucleus ambiguus J Neurobiol. 1995 Apr; 26(4):563-78. . View in PubMed

• Goldsworthy, Raymond
• Oghalai, John
• Eisenberg, Laurie
• Choi, Janet
• Shera, Christopher
• Abdala, Carolina
• Doherty, Joni
• Runge, Christina