Denis Evseenko, MD, PhD

Professor of Orthopaedic Surgery

Director of Skeletal Regeneration

Vice Chair for Research of Orthopaedic Surgery

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Dr. Denis Evseenko is currently a Professor of Orthopaedic Surgery, Stem Cell Research and Regenerative Medicine at USC. He holds the J. Harold and Edna La Briola Chair in Genetic Orthopaedic Research and is Director of Skeletal Regeneration, as well as Vice Chair for Research in Orthopaedic Surgery. Dr Evseenko was trained in both medicine and molecular pharmacology. His research focuses on the development of novel translational stem cell and small molecule-based approaches for prevention of arthritis and restoration of damaged articular cartilage. Dr Evseenko has been involved in translational research for over 10 years and is the author of numerous peer-reviewed research articles, presentations, and patents.


  • USC: USC Stevens Technology Advancement Grant, 2016
  • Wright Foundation: Wright Foundation Award, 2016
  • Arthritis National Research Foundation: James Klinenberg Award, 2015


  • Influence of donor age and comorbidities on transduced human adipose-derived stem cell in vitro osteogenic potential Gene Ther. 2023 04; 30(3-4):369-376. . View in PubMed
  • Stability analysis of tranexamic acid in the presence of various antiseptic solutions J Orthop Res. 2023 03; 41(3):692-697. . View in PubMed
  • STAT3 promotes a youthful epigenetic state in articular chondrocytes Aging Cell. 2023 02; 22(2):e13773. . View in PubMed
  • Inhibition of a signaling modality within the gp130 receptor enhances tissue regeneration and mitigates osteoarthritis Sci Transl Med. 2023 03 22; 15(688):eabq2395. . View in PubMed
  • Distinct human skeletal muscle-derived CD90 progenitor subsets for myo-fibro-adipogenic disease modeling and treatment in multiplexed conditions Front Cell Dev Biol. 2023; 11:1173794. . View in PubMed
  • Author Correction: gp130/STAT3 signaling is required for homeostatic proliferation and anabolism in postnatal growth plate and articular chondrocytes Commun Biol. 2022 Feb 25; 5(1):200. . View in PubMed
  • gp130/STAT3 signaling is required for homeostatic proliferation and anabolism in postnatal growth plate and articular chondrocytes Commun Biol. 2022 01 17; 5(1):64. . View in PubMed
  • A new mouse model of post-traumatic joint injury allows to identify the contribution of Gli1+ mesenchymal progenitors in arthrofibrosis and acquired heterotopic endochondral ossification Front Cell Dev Biol. 2022; 10:954028. . View in PubMed
  • Cross-Communication Between Knee Osteoarthritis and Fibrosis: Molecular Pathways and Key Molecules Open Access J Sports Med. 2022; 13:1-15. . View in PubMed
  • Long-term repair of porcine articular cartilage using cryopreservable, clinically compatible human embryonic stem cell-derived chondrocytes NPJ Regen Med. 2021 Nov 23; 6(1):77. . View in PubMed
  • Zika virus NS3 protease induces bone morphogenetic protein-dependent brain calcification in human fetuses Nat Microbiol. 2021 04; 6(4):455-466. . View in PubMed
  • Symmetry breaking of tissue mechanics in wound induced hair follicle regeneration of laboratory and spiny mice Nat Commun. 2021 05 10; 12(1):2595. . View in PubMed
  • A Single-Cell Culture System for Dissecting Microenvironmental Signaling in Development and Disease of Cartilage Tissue Front Cell Dev Biol. 2021; 9:725854. . View in PubMed
  • A Human Skeletal Muscle Atlas Identifies the Trajectories of Stem and Progenitor Cells across Development and from Human Pluripotent Stem Cells Cell Stem Cell. 2020 Jul 02; 27(1):181-185. . View in PubMed
  • Modulation of Hedgehog Signaling by Kappa Opioids to Attenuate Osteoarthritis Arthritis Rheumatol. 2020 08; 72(8):1278-1288. . View in PubMed
  • A Human Skeletal Muscle Atlas Identifies the Trajectories of Stem and Progenitor Cells across Development and from Human Pluripotent Stem CellsCell Stem Cell. 2020 07 02; 27(1):158-176. e10. . View in PubMed
  • Nomenclature Inconsistency and Selective Outcome Reporting Hinder Understanding of Stem Cell Therapy for the Knee J Bone Joint Surg Am. 2019 Jan 16; 101(2):186-195. . View in PubMed
  • Lentiviral Gene Therapy for Bone Repair Using Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Hum Gene Ther. 2019 07; 30(7):906-917. . View in PubMed
  • CaMKII inhibition in human primary and pluripotent stem cell-derived chondrocytes modulates effects of TGFß and BMP through SMAD signaling Osteoarthritis Cartilage. 2019 01; 27(1):158-171. . View in PubMed
  • In vitro behavior of tendon stem/progenitor cells on bioactive electrospun nanofiber membranes for tendon-bone tissue engineering applications Int J Nanomedicine. 2019; 14:5831-5848. . View in PubMed
  • Molecular characterization of physis tissue by RNA sequencing Gene. 2018 Aug 20; 668:87-96. . View in PubMed
  • Genetic ablation of adenosine receptor A3 results in articular cartilage degeneration J Mol Med (Berl). 2018 10; 96(10):1049-1060. . View in PubMed
  • Drug-induced modulation of gp130 signalling prevents articular cartilage degeneration and promotes repair Ann Rheum Dis. 2018 05; 77(5):760-769. . View in PubMed
  • Leukemia Inhibitory Factor Increases Survival of Pluripotent Stem Cell-Derived Cardiomyocytes J Cardiovasc Transl Res. 2018 02; 11(1):1-13. . View in PubMed
  • Correction to: Leukemia Inhibitory Factor Increases Survival of Pluripotent Stem Cell-Derived Cardiomyocytes J Cardiovasc Transl Res. 2018 02; 11(1):14. . View in PubMed
  • ERBB3 and NGFR mark a distinct skeletal muscle progenitor cell in human development and hPSCs Nat Cell Biol. 2018 01; 20(1):46-57. . View in PubMed
  • Mapping molecular landmarks of human skeletal ontogeny and pluripotent stem cell-derived articular chondrocytes Nat Commun. 2018 09 07; 9(1):3634. . View in PubMed
  • A Small Molecule Mimetic of the Humanin Peptide as a Candidate for Modulating NMDA-Induced Neurotoxicity ACS Chem Neurosci. 2018 03 21; 9(3):462-468. . View in PubMed
  • Lactate dehydrogenase activity drives hair follicle stem cell activation Nat Cell Biol. 2017 Sep; 19(9):1017-1026. . View in PubMed
  • Perivascular Stem Cells Diminish Muscle Atrophy Following Massive Rotator Cuff Tears in a Small Animal Model J Bone Joint Surg Am. 2017 Feb 15; 99(4):331-341. . View in PubMed
  • The Wnt5a Receptor, Receptor Tyrosine Kinase-Like Orphan Receptor 2, Is a Predictive Cell Surface Marker of Human Mesenchymal Stem Cells with an Enhanced Capacity for Chondrogenic Differentiation Stem Cells. 2017 11; 35(11):2280-2291. . View in PubMed
  • Parylene scaffold for cartilage lesion Biomed Microdevices. 2017 06; 19(2):26. . View in PubMed
  • Kappa opioid receptor signaling protects cartilage tissue against posttraumatic degeneration JCI Insight. 2017 01 12; 2(1):e88553. . View in PubMed
  • Right-Left Differences in Knee Extension Stiffness for the Normal Rat Knee: In Vitro Measurements Using a New Testing Apparatus J Biomech Eng. 2016 Apr; 138(4):044501. . View in PubMed
  • Chondrocytes Cocultured with Stromal Vascular Fraction of Adipose Tissue Present More Intense Chondrogenic Characteristics Than with Adipose Stem Cells Tissue Eng Part A. 2016 Feb; 22(3-4):336-48. . View in PubMed
  • Hypoxic culture conditions induce increased metabolic rate and collagen gene expression in ACL-derived cells J Orthop Res. 2016 06; 34(6):985-94. . View in PubMed
  • Genetic Tagging During Human Mesoderm Differentiation Reveals Tripotent Lateral Plate Mesodermal Progenitors Stem Cells. 2016 05; 34(5):1239-50. . View in PubMed
  • Adventitial Cells and Perictyes Support Chondrogenesis Through Different Mechanisms in 3-Dimensional Cultures With or Without Nanoscaffolds J Biomed Nanotechnol. 2015 Oct; 11(10):1799-807. . View in PubMed
  • Ensemble multivariate analysis to improve identification of articular cartilage disease in noisy Raman spectra J Biophotonics. 2015 Jul; 8(7):555-66. . View in PubMed
  • Covalently conjugated transforming growth factor-ß1 in modular chitosan hydrogels for the effective treatment of articular cartilage defects Biomater Sci. 2015 May; 3(5):742-52. . View in PubMed
  • Lysophosphatidic acid mediates fibrosis in injured joints by regulating collagen type I biosynthesis Osteoarthritis Cartilage. 2015 Feb; 23(2):308-18. . View in PubMed
  • Visible-light-initiated hydrogels preserving cartilage extracellular signaling for inducing chondrogenesis of mesenchymal stem cells Acta Biomater. 2015 Jan; 12:30-41. . View in PubMed
  • TGF-ß1 conjugated chitosan collagen hydrogels induce chondrogenic differentiation of human synovium-derived stem cells J Biol Eng. 2015; 9:1. . View in PubMed
  • Platelets contain tissue factor pathway inhibitor-2 derived from megakaryocytes and inhibits fibrinolysis J Biol Chem. 2014 Nov 07; 289(45):31647-61. . View in PubMed
  • Extracellular matrix domain formation as an indicator of chondrocyte dedifferentiation and hypertrophy Tissue Eng Part C Methods. 2014 Feb; 20(2):160-8. . View in PubMed
  • Rigid microenvironments promote cardiac differentiation of mouse and human embryonic stem cells Sci Technol Adv Mater. 2013 Aug 01; 14(2). . View in PubMed
  • Novel aspects of parenchymal-mesenchymal interactions: from cell types to molecules and beyond Cell Biochem Funct. 2013 Jun; 31(4):271-80. . View in PubMed
  • Perivascular support of human hematopoietic stem/progenitor cells Blood. 2013 Apr 11; 121(15):2891-901. . View in PubMed
  • Lysophosphatidic acid mediates myeloid differentiation within the human bone marrow microenvironment PLoS One. 2013; 8(5):e63718. . View in PubMed
  • Human developmental chondrogenesis as a basis for engineering chondrocytes from pluripotent stem cells Stem Cell Reports. 2013; 1(6):575-89. . View in PubMed
  • Characterization and therapeutic potential of induced pluripotent stem cell-derived cardiovascular progenitor cells PLoS One. 2012; 7(10):e45603. . View in PubMed
  • Homeobox gene Distal-less 3 (DLX3) is a regulator of villous cytotrophoblast differentiation Placenta. 2011 Oct; 32(10):745-51. . View in PubMed
  • Dysregulated gene expression during hematopoietic differentiation from human embryonic stem cells Mol Ther. 2011 Apr; 19(4):768-81. . View in PubMed
  • Mapping the first stages of mesoderm commitment during differentiation of human embryonic stem cells Proc Natl Acad Sci U S A. 2010 Aug 03; 107(31):13742-7. . View in PubMed
  • Identification of the critical extracellular matrix proteins that promote human embryonic stem cell assembly Stem Cells Dev. 2009 Jul-Aug; 18(6):919-28. . View in PubMed
  • The ABC transporter BCRP/ABCG2 is a placental survival factor, and its expression is reduced in idiopathic human fetal growth restriction FASEB J. 2007 Nov; 21(13):3592-605. . View in PubMed
  • Expression, localisation and activity of ATP binding cassette (ABC) family of drug transporters in human amnion membranes Placenta. 2007 Aug-Sep; 28(8-9):868-77. . View in PubMed
  • The xenobiotic transporter ABCG2 plays a novel role in differentiation of trophoblast-like BeWo cells Placenta. 2007 Apr; 28 Suppl A:S116-20. . View in PubMed
  • Independent regulation of apical and basolateral drug transporter expression and function in placental trophoblasts by cytokines, steroids, and growth factors Drug Metab Dispos. 2007 Apr; 35(4):595-601. . View in PubMed
  • ABC drug transporter expression and functional activity in trophoblast-like cell lines and differentiating primary trophoblast Am J Physiol Regul Integr Comp Physiol. 2006 May; 290(5):R1357-65. . View in PubMed
  • Active transport across the human placenta: impact on drug efficacy and toxicity Expert Opin Drug Metab Toxicol. 2006 Feb; 2(1):51-69. . View in PubMed