Keck School Faculty

Denis Evseenko

Denis Evseenko

Associate Professor of Orthopaedic Surgery
Director of Skeletal Regeneration
Vice Chair for Research of Orthopaedic Surgery
Orthopaedic Surgery
NRT - 1450 Biggy Street, #4503 Health Sciences Campus Los Angeles

USC: USC Stevens Technology Advancement Grant, 2016

Wright Foundation: Wright Foundation Award, 2016

Arthritis National Research Foundation: James Klinenberg Award, 2015

A Human Skeletal Muscle Atlas Identifies the Trajectories of Stem and Progenitor Cells across Development and from Human Pluripotent Stem CellsCell Stem Cell. 2020 Jul 02; 27(1):158-176. e10. . View in PubMed

Modulation of Hedgehog Signaling by Kappa Opioids to Attenuate Osteoarthritis Arthritis Rheumatol. 2020 Apr 05. . View in PubMed

Lentiviral Gene Therapy for Bone Repair Using Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Hum Gene Ther. 2019 07; 30(7):906-917. . View in PubMed

Molecular characterization of physis tissue by RNA sequencing Gene. 2018 Aug 20; 668:87-96. . View in PubMed

Genetic ablation of adenosine receptor A3 results in articular cartilage degeneration J Mol Med (Berl). 2018 10; 96(10):1049-1060. . View in PubMed

Drug-induced modulation of gp130 signalling prevents articular cartilage degeneration and promotes repair Ann Rheum Dis. 2018 05; 77(5):760-769. . View in PubMed

ERBB3 and NGFR mark a distinct skeletal muscle progenitor cell in human development and hPSCs Nat Cell Biol. 2018 01; 20(1):46-57. . View in PubMed

Mapping molecular landmarks of human skeletal ontogeny and pluripotent stem cell-derived articular chondrocytes Nat Commun. 2018 09 07; 9(1):3634. . View in PubMed

A Small Molecule Mimetic of the Humanin Peptide as a Candidate for Modulating NMDA-Induced Neurotoxicity ACS Chem Neurosci. 2018 03 21; 9(3):462-468. . View in PubMed

Perivascular Stem Cells Diminish Muscle Atrophy Following Massive Rotator Cuff Tears in a Small Animal Model J Bone Joint Surg Am. 2017 Feb 15; 99(4):331-341. . View in PubMed

The Wnt5a Receptor, Receptor Tyrosine Kinase-Like Orphan Receptor 2, Is a Predictive Cell Surface Marker of Human Mesenchymal Stem Cells with an Enhanced Capacity for Chondrogenic Differentiation Stem Cells. 2017 11; 35(11):2280-2291. . View in PubMed

Parylene scaffold for cartilage lesion Biomed Microdevices. 2017 06; 19(2):26. . View in PubMed

Kappa opioid receptor signaling protects cartilage tissue against posttraumatic degeneration JCI Insight. 2017 01 12; 2(1):e88553. . View in PubMed

Right-Left Differences in Knee Extension Stiffness for the Normal Rat Knee: In Vitro Measurements Using a New Testing Apparatus J Biomech Eng. 2016 Apr; 138(4):044501. . View in PubMed

Chondrocytes Cocultured with Stromal Vascular Fraction of Adipose Tissue Present More Intense Chondrogenic Characteristics Than with Adipose Stem Cells Tissue Eng Part A. 2016 Feb; 22(3-4):336-48. . View in PubMed

Hypoxic culture conditions induce increased metabolic rate and collagen gene expression in ACL-derived cells J Orthop Res. 2016 06; 34(6):985-94. . View in PubMed

Genetic Tagging During Human Mesoderm Differentiation Reveals Tripotent Lateral Plate Mesodermal Progenitors Stem Cells. 2016 05; 34(5):1239-50. . View in PubMed

Adventitial Cells and Perictyes Support Chondrogenesis Through Different Mechanisms in 3-Dimensional Cultures With or Without Nanoscaffolds J Biomed Nanotechnol. 2015 Oct; 11(10):1799-807. . View in PubMed

Ensemble multivariate analysis to improve identification of articular cartilage disease in noisy Raman spectra J Biophotonics. 2015 Jul; 8(7):555-66. . View in PubMed

Covalently conjugated transforming growth factor-ß1 in modular chitosan hydrogels for the effective treatment of articular cartilage defects Biomater Sci. 2015 May; 3(5):742-52. . View in PubMed

TGF-ß1 conjugated chitosan collagen hydrogels induce chondrogenic differentiation of human synovium-derived stem cells J Biol Eng. 2015; 9:1. . View in PubMed

Visible-light-initiated hydrogels preserving cartilage extracellular signaling for inducing chondrogenesis of mesenchymal stem cells Acta Biomater. 2015 Jan; 12:30-41. . View in PubMed

Platelets contain tissue factor pathway inhibitor-2 derived from megakaryocytes and inhibits fibrinolysis J Biol Chem. 2014 Nov 07; 289(45):31647-61. . View in PubMed

Extracellular matrix domain formation as an indicator of chondrocyte dedifferentiation and hypertrophy Tissue Eng Part C Methods. 2014 Feb; 20(2):160-8. . View in PubMed

Rigid microenvironments promote cardiac differentiation of mouse and human embryonic stem cells Sci Technol Adv Mater. 2013 Aug 01; 14(2). . View in PubMed

Novel aspects of parenchymal-mesenchymal interactions: from cell types to molecules and beyond Cell Biochem Funct. 2013 Jun; 31(4):271-80. . View in PubMed

Perivascular support of human hematopoietic stem/progenitor cells Blood. 2013 Apr 11; 121(15):2891-901. . View in PubMed

Lysophosphatidic acid mediates myeloid differentiation within the human bone marrow microenvironment PLoS One. 2013; 8(5):e63718. . View in PubMed

Human developmental chondrogenesis as a basis for engineering chondrocytes from pluripotent stem cells Stem Cell Reports. 2013; 1(6):575-89. . View in PubMed

Characterization and therapeutic potential of induced pluripotent stem cell-derived cardiovascular progenitor cells PLoS One. 2012; 7(10):e45603. . View in PubMed

Dysregulated gene expression during hematopoietic differentiation from human embryonic stem cells Mol Ther. 2011 Apr; 19(4):768-81. . View in PubMed

Mapping the first stages of mesoderm commitment during differentiation of human embryonic stem cells Proc Natl Acad Sci U S A. 2010 Aug 03; 107(31):13742-7. . View in PubMed

Identification of the critical extracellular matrix proteins that promote human embryonic stem cell assembly Stem Cells Dev. 2009 Jul-Aug; 18(6):919-28. . View in PubMed

Dr. Denis Evseenko is currently an Associate Professor of Orthopaedic Surgery, Stem Cell Research and Regenerative Medicine at USC. Dr Evseenko was trained in both medicine and molecular pharmacology. His research focuses on the development of novel translational stem cell and small molecule-based approaches for prevention of arthritis and restoration of damaged articular cartilage. Dr Evseenko has been involved in translational research for over 10 years and is the author of numerous peer-reviewed research articles, presentations and patents.

Evseenko Lab Website
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