Dillon P Cogan

Assistant Professor of Pharmacology and Pharmaceutical Sciences

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Publications

  • Structure and Mechanisms of Assembly-Line Polyketide Synthases Annu Rev Biochem. 2024 Apr 25. . View in PubMed
  • Discovery and Characterization of Antibody Probes of Module 2 of the 6-Deoxyerythronolide B Synthase Biochemistry. 2023 06 06; 62(11):1589-1593. . View in PubMed
  • In vivo visualization and molecular targeting of the cardiac conduction system J Clin Invest. 2022 10 17; 132(20). . View in PubMed
  • Structure and mechanism for iterative amide N-methylation in the biosynthesis of channel-forming peptide cytotoxins Proc Natl Acad Sci U S A. 2022 03 29; 119(13):e2116578119. . View in PubMed
  • Mapping the catalytic conformations of an assembly-line polyketide synthase module Science. 2021 Nov 05; 374(6568):729-734. . View in PubMed
  • Structural Basis for Enzymatic Off-Loading of Hybrid Polyketides by Dieckmann Condensation ACS Chem Biol. 2020 10 16; 15(10):2783-2791. . View in PubMed
  • Antibody Probes of Module 1 of the 6-Deoxyerythronolide B Synthase Reveal an Extended Conformation During Ketoreduction J Am Chem Soc. 2020 09 02; 142(35):14933-14939. . View in PubMed
  • Characterization of glutamyl-tRNA-dependent dehydratases using nonreactive substrate mimics Proc Natl Acad Sci U S A. 2019 08 27; 116(35):17245-17250. . View in PubMed
  • Substrate-assisted enzymatic formation of lysinoalanine in duramycin Nat Chem Biol. 2018 10; 14(10):928-933. . View in PubMed
  • Structural basis of transcriptional regulation by CouR, a repressor of coumarate catabolism, in Rhodopseudomonas palustris J Biol Chem. 2018 07 27; 293(30):11727-11735. . View in PubMed
  • Two Flavoenzymes Catalyze the Post-Translational Generation of 5-Chlorotryptophan and 2-Aminovinyl-Cysteine during NAI-107 Biosynthesis ACS Chem Biol. 2017 02 17; 12(2):548-557. . View in PubMed
  • Structural insights into enzymatic [4+2] aza-cycloaddition in thiopeptide antibiotic biosynthesis Proc Natl Acad Sci U S A. 2017 12 05; 114(49):12928-12933. . View in PubMed
  • Molecular Basis for Resistance Against Phosphonate Antibiotics and Herbicides Medchemcomm. 2016 Jan 01; 7(1):28-36. . View in PubMed
  • Inhibition of the human proteasome by imidazoline scaffolds J Med Chem. 2013 Jul 25; 56(14):5974-8. . View in PubMed

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