Keck School Faculty

Edward David Crandall, PhD, MD
Edward David Crandall, PhD, MD
Professor of Medicine;Hastings Foundation Professorship in Medicine
Medicine
2020 Zonal Avenue Off Campus Los Angeles
Dr. Crandall's research has been focused on the following topics: markers of alveolar epithelial cell development and differentiation, regulation of pulmonary epithelial cell differentiation, acute and chronic lung injury and the factors that influence recovery, transport properties of pulmonary alveolar epithelium, and biology of nanoparticle interactions with alveolar epithelial cells.

Dr. Crandall received his B.Ch.E. from Cooper Union, his M.S. and Ph.D. in chemical engineering from Northwestern University, and his M.D. from the University of Pennsylvania. His training in internal medicine and pulmonary/critical care medicine was undertaken at the Hospital of the University of Pennsylvania.

: Best Doctors of America, 2005-Pres

: Ooops. Something went wrong., 2005-Pres

National Institutes of Health: MERIT Award, 1987-1997

National Institutes of Health: Ooops. Something went wrong., 1987-1997

National Institutes of Health: Research Career Development Award, 1975-1980

National Institutes of Health: Ooops. Something went wrong., 1975-1980

CLDN181 attenuates malignancy and related signaling pathways of lung adenocarcinoma in vivo and in vitro. Int J Cancer. 2018 Dec 15; 143(12):3169-3180. . View in PubMed

CLDN181 attenuates malignancy and related signaling pathways of lung adenocarcinoma in vivo and in vitro. Int J Cancer. 2018 Oct 16. . View in PubMed

Alveolar epithelial cell processing of nanoparticles activates autophagy and lysosomal exocytosis Am J Physiol Lung Cell Mol Physiol. 2018 Aug 01; 315(2):L286-L300. . View in PubMed

Alveolar epithelial cell processing of nanoparticles activates autophagy and lysosomal exocytosis Am J Physiol Lung Cell Mol Physiol. 2018 May 03. . View in PubMed

Claudin-18-mediated YAP activity regulates lung stem and progenitor cell homeostasis and tumorigenesis J Clin Invest. 2018 Mar 01; 128(3):970-984. . View in PubMed

Oligopeptide Transport in Rat Lung Alveolar Epithelial Cells is Mediated by Pept2 Pharm Res. 2017 Dec; 34(12):2488-2497. . View in PubMed

Astrocytic tight junctions control inflammatory CNS lesion pathogenesis J Clin Invest. 2017 Aug 01; 127(8):3136-3151. . View in PubMed

Astrocytic tight junctions control inflammatory CNS lesion pathogenesis J Clin Invest. 2017 Aug 01; 127(8):3136-3151. . View in PubMed

Cell-specific expression of aquaporin-5 (Aqp5) in alveolar epithelium is directed by GATA6/Sp1 via histone acetylation Sci Rep. 2017 Jun 14; 7(1):3473. . View in PubMed

Cross-Species Transcriptome Profiling Identifies New Alveolar Epithelial Type I Cell-Specific Genes Am J Respir Cell Mol Biol. 2017 03; 56(3):310-321. . View in PubMed

Cell-specific expression of aquaporin-5 (Aqp5) in alveolar epithelium is directed by GATA6/Sp1 via histone acetylation Sci Rep. 2017 06 14; 7(1):3473. . View in PubMed

IL-1R1-MyD88 axis elicits papain-induced lung inflammation Eur J Immunol. 2016 11; 46(11):2531-2541. . View in PubMed

Knockout Mice Reveal a Major Role for Alveolar Epithelial Type I Cells in Alveolar Fluid Clearance Am J Respir Cell Mol Biol. 2016 09; 55(3):395-406. . View in PubMed

A fluid secretion pathway unmasked by acinar-specific Tmem16A gene ablation in the adult mouse salivary gland Proc Natl Acad Sci U S A. 2015 Feb 17; 112(7):2263-8. . View in PubMed

Claudin 4 knockout mice: normal physiological phenotype with increased susceptibility to lung injury Am J Physiol Lung Cell Mol Physiol. 2014 Oct 01; 307(7):L524-36. . View in PubMed

Knockout mice reveal key roles for claudin 18 in alveolar barrier properties and fluid homeostasis Am J Respir Cell Mol Biol. 2014 Aug; 51(2):210-22. . View in PubMed

DiseaseConnect: a comprehensive web server for mechanism-based disease-disease connections Nucleic Acids Res. 2014 Jul; 42(Web Server issue):W137-46. . View in PubMed

Nanoparticle translocation across mouse alveolar epithelial cell monolayers: species-specific mechanisms Nanomedicine. 2013 Aug; 9(6):786-94. . View in PubMed

Interlaboratory evaluation of in vitro cytotoxicity and inflammatory responses to engineered nanomaterials: the NIEHS Nano GO Consortium Environ Health Perspect. 2013 Jun; 121(6):683-90. . View in PubMed

Interactions between ß-catenin and transforming growth factor-ß signaling pathways mediate epithelial-mesenchymal transition and are dependent on the transcriptional co-activator cAMP-response element-binding protein (CREB)-binding protein (CBP) J Biol Chem. 2012 Mar 02; 287(10):7026-38. . View in PubMed

Ligand-independent transforming growth factor-ß type I receptor signalling mediates type I collagen-induced epithelial-mesenchymal transition J Pathol. 2012 Mar; 226(4):633-44. . View in PubMed

Nanomaterial interactions with and trafficking across the lung alveolar epithelial barrier: implications for health effects of air-pollution particles Air Qual Atmos Health. 2011 Mar 01; 4(1):65-78. . View in PubMed

Alveolar epithelial cell injury due to zinc oxide nanoparticle exposure Am J Respir Crit Care Med. 2010 Dec 01; 182(11):1398-409. . View in PubMed

Directed expression of Cre in alveolar epithelial type 1 cells Am J Respir Cell Mol Biol. 2010 Aug; 43(2):173-8. . View in PubMed

Mechanisms of alveolar epithelial translocation of a defined population of nanoparticles Am J Respir Cell Mol Biol. 2010 May; 42(5):604-14. . View in PubMed

More life for a "terminal" cell Am J Physiol Lung Cell Mol Physiol. 2009 Dec; 297(6):L1042-4. . View in PubMed

Characterization of mouse alveolar epithelial cell monolayers Am J Physiol Lung Cell Mol Physiol. 2009 Jun; 296(6):L1051-8. . View in PubMed

Conjugation with cationic cell-penetrating peptide increases pulmonary absorption of insulin Mol Pharm. 2009 Mar-Apr; 6(2):492-503. . View in PubMed

GATA-6 mediates transcriptional activation of aquaporin-5 through interactions with Sp1 Am J Physiol Cell Physiol. 2008 Nov; 295(5):C1141-50. . View in PubMed

Characterization of protein factor(s) in rat bronchoalveolar lavage fluid that enhance insulin transport via transcytosis across primary rat alveolar epithelial cell monolayers Eur J Pharm Biopharm. 2008 Aug; 69(3):808-16. . View in PubMed

Molecular and functional expression of multidrug resistance-associated protein-1 in primary cultured rat alveolar epithelial cells J Pharm Sci. 2008 Jun; 97(6):2340-9. . View in PubMed

Foxp2 inhibits Nkx21-mediated transcription of SP-C via interactions with the Nkx2. 1 homeodomain. Am J Respir Cell Mol Biol. 2008 Jun; 38(6):750-8. . View in PubMed

Expression and biological activity of ABCA1 in alveolar epithelial cells Am J Respir Cell Mol Biol. 2008 Mar; 38(3):283-92. . View in PubMed

Functional characterization and cloning of amino acid transporter B(0,+) (ATB(0,+)) in primary cultured rat pneumocytes J Cell Physiol. 2008 Mar; 214(3):645-54. . View in PubMed

Effects of KGF on alveolar epithelial cell transdifferentiation are mediated by JNK signaling Am J Respir Cell Mol Biol. 2008 Feb; 38(2):239-46. . View in PubMed

Nanoparticle effects on rat alveolar epithelial cell monolayer barrier properties Toxicol In Vitro. 2007 Dec; 21(8):1373-81. . View in PubMed

Enhancement of insulin transport across primary rat alveolar epithelial cell monolayers by endogenous cellular factor(s) Pharm Res. 2007 Sep; 24(9):1713-9. . View in PubMed

Conserved elements within first intron of aquaporin-5 (Aqp5) function as transcriptional enhancers Biochem Biophys Res Commun. 2007 Apr 27; 356(1):26-31. . View in PubMed

Hypertonic induction of aquaporin-5: novel role of hypoxia-inducible factor-1alpha Am J Physiol Cell Physiol. 2007 Apr; 292(4):C1280-90. . View in PubMed

Induction of epithelial-mesenchymal transition in alveolar epithelial cells by transforming growth factor-beta1: potential role in idiopathic pulmonary fibrosis Am J Pathol. 2005 May; 166(5):1321-32. . View in PubMed

Development of a lung slice preparation for recording ion channel activity in alveolar epithelial type I cells Respir Res. 2005 Apr 27; 6:40. . View in PubMed

Net absorption of IgG via FcRn-mediated transcytosis across rat alveolar epithelial cell monolayers Am J Physiol Lung Cell Mol Physiol. 2004 Sep; 287(3):L616-22. . View in PubMed

Alveolar epithelial type I cells express beta2-adrenergic receptors and G-protein receptor kinase 2 J Histochem Cytochem. 2004 Jun; 52(6):759-67. . View in PubMed

Modulation of ion conductance and active transport by TGF-beta 1 in alveolar epithelial cell monolayers Am J Physiol Lung Cell Mol Physiol. 2003 Dec; 285(6):L1192-200. . View in PubMed

Identification of three genes of known function expressed by alveolar epithelial type I cells Am J Respir Cell Mol Biol. 2003 Jul; 29(1):98-105. . View in PubMed

Absorption of intact albumin across rat alveolar epithelial cell monolayers Am J Physiol Lung Cell Mol Physiol. 2003 Mar; 284(3):L458-65. . View in PubMed

Na transport proteins are expressed by rat alveolar epithelial type I cells Am J Physiol Lung Cell Mol Physiol. 2002 Apr; 282(4):L599-608. . View in PubMed

Hypoxia decreases active Na transport across primary rat alveolar epithelial cell monolayers Am J Physiol Lung Cell Mol Physiol. 2002 Apr; 282(4):L659-65. . View in PubMed

A useful in vitro model for transport studies of alveolar epithelial barrier Pharm Res. 2001 Mar; 18(3):253-5. . View in PubMed

Alveolar epithelial transportBasic science to clinical medicine. Am J Respir Crit Care Med. 2001 Mar; 163(4):1021-9. . View in PubMed

Differential regulation of rat aquaporin-5 promoter/enhancer activities in lung and salivary epithelial cells J Biol Chem. 2000 Aug 25; 275(34):26507-14. . View in PubMed

Epidermal growth factor regulation in adult rat alveolar type II cells of amiloride-sensitive cation channels Am J Physiol. 1999 12; 277(6):C1058-65. . View in PubMed

Keratinocyte growth factor modulates alveolar epithelial cell phenotype in vitro: expression of aquaporin 5 Am J Respir Cell Mol Biol. 1998 Apr; 18(4):554-61. . View in PubMed

Mechanisms of EGF-induced stimulation of sodium reabsorption by alveolar epithelial cells Am J Physiol. 1998 07; 275(1):C82-92. . View in PubMed

Modulation of t1alpha expression with alveolar epithelial cell phenotype in vitro Am J Physiol. 1998 07; 275(1):L155-64. . View in PubMed

Effects of Mycobacterium tuberculosis on the bioelectric properties of the alveolar epithelium Infect Immun. 1997 Feb; 65(2):692-8. . View in PubMed

Horseradish peroxidase transport across rat alveolar epithelial cell monolayers Pharm Res. 1996 Sep; 13(9):1331-5. . View in PubMed

Effects of EGF on alveolar epithelial junctional permeability and active sodium transport Am J Physiol. 1996 Apr; 270(4 Pt 1):L559-65. . View in PubMed

Models for investigation of peptide and protein transport across cultured mammalian respiratory epithelial barriers Pharm Biotechnol. 1996; 8:325-46. . View in PubMed

Basolateral localization of Na(+)-HCO3- cotransporter activity in alveolar epithelial cells Respir Physiol. 1995 Apr; 100(1):15-24. . View in PubMed

Cl(-)-HCO3- exchanger isoform AE2 is restricted to the basolateral surface of alveolar epithelial cell monolayers Am J Respir Cell Mol Biol. 1995 Feb; 12(2):211-9. . View in PubMed

Late appearance of a type I alveolar epithelial cell marker during fetal rat lung development Histochemistry. 1994 Oct; 102(4):297-304. . View in PubMed

Defined medium for primary culture de novo of adult rat alveolar epithelial cells In Vitro Cell Dev Biol Anim. 1994 Feb; 30A(2):99-104. . View in PubMed

Measurement of solute fluxes in isolated rat lungs Respir Physiol. 1993 Mar; 91(2-3):321-34. . View in PubMed

Evidence for amiloride-sensitive sodium channels in alveolar epithelial cells Am J Physiol. 1992 Apr; 262(4 Pt 1):L405-11. . View in PubMed

Contribution of active Na+ and Cl- fluxes to net ion transport by alveolar epithelium Respir Physiol. 1991 Aug; 85(2):245-56. . View in PubMed

Na(+)-HCO3- symport modulates intracellular pH in alveolar epithelial cells Am J Physiol. 1991 Jun; 260(6 Pt 1):L555-61. . View in PubMed

NO2 decreases paracellular resistance to ion and solute flow in alveolar epithelial monolayers Exp Lung Res. 1990 Nov-Dec; 16(6):561-75. . View in PubMed

NHLBI workshop summaryWorkshop on techniques to evaluate lung alveolar-microvascular injury. Am Rev Respir Dis. 1990 Apr; 141(4 Pt 1):1071-7. . View in PubMed

Evidence for active H+ secretion by rat alveolar epithelial cells Am J Physiol. 1989 Dec; 257(6 Pt 1):L438-45. . View in PubMed

Cl-/HCO3- exchange modulates intracellular pH in rat type II alveolar epithelial cells J Biol Chem. 1988 Apr 25; 263(12):5599-606. . View in PubMed

Effects of culture conditions on susceptibility of alveolar epithelial cell monolayers to NO2 Toxicol Lett. 1988 Mar; 40(3):247-55. . View in PubMed

Effects of nitrogen dioxide on alveolar epithelial barrier properties Res Rep Health Eff Inst. 1987 Oct; (13):3-19. . View in PubMed

Characterization of Na+-H+ antiport in type II alveolar epithelial cells Am J Physiol. 1987 May; 252(5 Pt 1):C490-8. . View in PubMed

Effects of exposure to NO2 on dome formation in alveolar epithelial cell monolayers Environ Res. 1987 Feb; 42(1):1-11. . View in PubMed

Historical perspectives on lung edema clearance J Appl Physiol (1985). 2002 Oct; 93(4):1527-32. . View in PubMed

Effects of terbutaline on sodium transport in isolated perfused rat lung J Appl Physiol (1985). 1986 Jan; 60(1):289-94. . View in PubMed

Estimation of paracellular conductance of primary rat alveolar epithelial cell monolayers J Appl Physiol (1985). 2005 Jan; 98(1):138-43. . View in PubMed

Effects of transdifferentiation and EGF on claudin isoform expression in alveolar epithelial cells J Appl Physiol (1985). 2005 Jan; 98(1):322-8. . View in PubMed

Hydrophilic solute transport across rat alveolar epithelium J Appl Physiol (1985). 1989 May; 66(5):2320-7. . View in PubMed

Asymmetric [14C]albumin transport across bullfrog alveolar epithelium J Appl Physiol (1985). 1985 Oct; 59(4):1290-7. . View in PubMed

Evidence for active sodium transport across alveolar epithelium of isolated rat lung J Appl Physiol (1985). 1987 Jun; 62(6):2460-6. . View in PubMed

Effects of dextran-bound inhibitors on carbonic anhydrase activity in isolated rat lungs J Appl Physiol (1985). 1986 Nov; 61(5):1849-56. . View in PubMed

Analysis of the determinants of renal cortical PCO2 Am J Physiol. 1984 Sep; 247(3 Pt 2):F466-74. . View in PubMed

Effects of cell swelling on fluid flow across alveolar epithelium J Appl Physiol Respir Environ Exerc Physiol. 1984 Jan; 56(1):72-7. . View in PubMed

Evidence for active Na+ transport by cultured monolayers of pulmonary alveolar epithelial cells Am J Physiol. 1983 Jul; 245(1):C78-83. . View in PubMed

Heteropore populations of bullfrog alveolar epithelium J Appl Physiol Respir Environ Exerc Physiol. 1983 Jan; 54(1):140-6. . View in PubMed

Dome formation in primary cultured monolayers of alveolar epithelial cells Am J Physiol. 1982 Jul; 243(1):C96-100. . View in PubMed

Effects of lung inflation on alveolar epithelial solute and water transport properties J Appl Physiol Respir Environ Exerc Physiol. 1982 Jun; 52(6):1498-505. . View in PubMed

Effects of exposure to acid on alveolar epithelial water and solute transport J Appl Physiol Respir Environ Exerc Physiol. 1982 Apr; 52(4):902-9. . View in PubMed

Effects of salicylate on HCO-3/Cl- exchange across the human erythrocyte membrane J Membr Biol. 1982; 65(1-2):139-45. . View in PubMed

Effects of inhibition of RBC HCO3-/Cl- exchange on CO2 excretion and downstream pH disequilibrium in isolated rat lungs J Clin Invest. 1981 Oct; 68(4):853-62. . View in PubMed

Effects of red blood cell HCO3(-)/Cl- exchange kinetics on lung CO2 transfer: theory J Appl Physiol Respir Environ Exerc Physiol. 1981 Feb; 50(2):265-71. . View in PubMed

Exchange of HCO3- for monovalent anions across the human erythrocyte membrane J Membr Biol. 1980; 52(2):173-9. . View in PubMed

HCO3-/Cl- exchange across the human erythrocyte membrane: effects of pH and temperature J Membr Biol. 1979 Oct 05; 50(1):23-41. . View in PubMed

Kinetics of bicarbonate/chloride exchange in dogfish erythrocytes Am J Physiol. 1979 Sep; 237(3):R132-8. . View in PubMed

Influence of pH on elastic deformability of the human erythrocyte membrane Am J Physiol. 1978 Nov; 235(5):C269-78. . View in PubMed

Analysis of PCO2 differences during rebreathing due to slow pH equilibration in blood J Appl Physiol Respir Environ Exerc Physiol. 1978 Nov; 45(5):666-73. . View in PubMed

Analysis of the effects of pulsatile capillary blood flow and volume on gas exchange Respir Physiol. 1978 Oct; 35(1):27-42. . View in PubMed

Bicarbonate-chloride exchange in erythrocyte suspensionsStopped-flow pH electrode measurements. Biophys J. 1978 Oct; 24(1):35-47. . View in PubMed

Direct evidence of participation of rat lung carbonic anhydrase in CO2 reactions J Clin Invest. 1978 Sep; 62(3):618-22. . View in PubMed

Analysis of postcapillary pH changes in blood in vivo after gas exchange J Appl Physiol Respir Environ Exerc Physiol. 1978 May; 44(5):770-81. . View in PubMed

Kinetics of bicarbonate-chloride exchange across the human red blood cell membrane J Gen Physiol. 1976 Dec; 68(6):633-52. . View in PubMed

Hydroxyl ion movements across the human erythrocyte membraneMeasurement of rapid pH changes in red cell suspensions. J Gen Physiol. 1971 Jun; 57(6):664-83. . View in PubMed

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