Keck School Faculty

Characteristics of Passive Solute Transport across Primary Rat Alveolar Epithelial Cell Monolayers Membranes (Basel). 2021 Apr 30; 11(5). . View in PubMed

Biokinetic modeling of nanoparticle interactions with lung alveolar epithelial cells: uptake, intracellular processing, and egress Am J Physiol Regul Integr Comp Physiol. 2021 01 01; 320(1):R36-R43. . View in PubMed

Epithelial Vegfa Specifies a Distinct Endothelial Population in the Mouse LungDev Cell. 2020 03 09; 52(5):617-630. e6. . View in PubMed

Evidence for Nanoparticle-Induced Lysosomal Dysfunction in Lung Adenocarcinoma (A549) Cells Int J Mol Sci. 2019 Oct 23; 20(21). . View in PubMed

Transcriptional control of lung alveolar type 1 cell development and maintenance by NK homeobox 2-1 Proc Natl Acad Sci U S A. 2019 10 08; 116(41):20545-20555. . View in PubMed

Claudin-18-mediated YAP activity regulates lung stem and progenitor cell homeostasis and tumorigenesis J Clin Invest. 2018 03 01; 128(3):970-984. . View in PubMed

CLDN181 attenuates malignancy and related signaling pathways of lung adenocarcinoma in vivo and in vitro. Int J Cancer. 2018 12 15; 143(12):3169-3180. . View in PubMed

Alveolar epithelial cell processing of nanoparticles activates autophagy and lysosomal exocytosis Am J Physiol Lung Cell Mol Physiol. 2018 08 01; 315(2):L286-L300. . View in PubMed

Platelet CLEC-2 protects against lung injury via effects of its ligand podoplanin on inflammatory alveolar macrophages in the mouse Am J Physiol Lung Cell Mol Physiol. 2017 Dec 01; 313(6):L1016-L1029. . View in PubMed

Oligopeptide Transport in Rat Lung Alveolar Epithelial Cells is Mediated by Pept2 Pharm Res. 2017 Dec; 34(12):2488-2497. . View in PubMed

Astrocytic tight junctions control inflammatory CNS lesion pathogenesis J Clin Invest. 2017 Aug 01; 127(8):3136-3151. . View in PubMed

Cross-Species Transcriptome Profiling Identifies New Alveolar Epithelial Type I Cell-Specific Genes Am J Respir Cell Mol Biol. 2017 03; 56(3):310-321. . View in PubMed

Cell-specific expression of aquaporin-5 (Aqp5) in alveolar epithelium is directed by GATA6/Sp1 via histone acetylation Sci Rep. 2017 06 14; 7(1):3473. . View in PubMed

Region-specific role for Pten in maintenance of epithelial phenotype and integrity Am J Physiol Lung Cell Mol Physiol. 2017 01 01; 312(1):L131-L142. . View in PubMed

J Biol Chem. 2016 Mar 18; 291(12):6569-82. . View in PubMed

IL-1R1-MyD88 axis elicits papain-induced lung inflammation Eur J Immunol. 2016 11; 46(11):2531-2541. . View in PubMed

Knockout Mice Reveal a Major Role for Alveolar Epithelial Type I Cells in Alveolar Fluid Clearance Am J Respir Cell Mol Biol. 2016 09; 55(3):395-406. . View in PubMed

A fluid secretion pathway unmasked by acinar-specific Tmem16A gene ablation in the adult mouse salivary gland Proc Natl Acad Sci U S A. 2015 Feb 17; 112(7):2263-8. . View in PubMed

Claudin 4 knockout mice: normal physiological phenotype with increased susceptibility to lung injury Am J Physiol Lung Cell Mol Physiol. 2014 Oct 01; 307(7):L524-36. . View in PubMed

Knockout mice reveal key roles for claudin 18 in alveolar barrier properties and fluid homeostasis Am J Respir Cell Mol Biol. 2014 Aug; 51(2):210-22. . View in PubMed

DiseaseConnect: a comprehensive web server for mechanism-based disease-disease connections Nucleic Acids Res. 2014 Jul; 42(Web Server issue):W137-46. . View in PubMed

Polystyrene nanoparticle exposure induces ion-selective pores in lipid bilayers Biochim Biophys Acta. 2013 Sep; 1828(9):2215-22. . View in PubMed

Nanoparticle translocation across mouse alveolar epithelial cell monolayers: species-specific mechanisms Nanomedicine. 2013 Aug; 9(6):786-94. . View in PubMed

Interlaboratory evaluation of in vitro cytotoxicity and inflammatory responses to engineered nanomaterials: the NIEHS Nano GO Consortium Environ Health Perspect. 2013 Jun; 121(6):683-90. . View in PubMed

J Biol Chem. 2012 Mar 02; 287(10):7026-38. . View in PubMed

J Pathol. 2012 Mar; 226(4):633-44. . View in PubMed

Troglitazone attenuates TGF-? -independent mechanism. PLoS One. 2012; 7(6):e38827.. View in PubMed

Polystyrene nanoparticle trafficking across MDCK-II Nanomedicine. 2011 Oct; 7(5):588-94. . View in PubMed

Role of endoplasmic reticulum stress in epithelial-mesenchymal transition of alveolar epithelial cells: effects of misfolded surfactant protein Am J Respir Cell Mol Biol. 2011 Sep; 45(3):498-509. . View in PubMed

Nanomaterial interactions with and trafficking across the lung alveolar epithelial barrier: implications for health effects of air-pollution particles Air Qual Atmos Health. 2011 Mar 01; 4(1):65-78. . View in PubMed

Translocation of PEGylated quantum dots across rat alveolar epithelial cell monolayers Int J Nanomedicine. 2011; 6:2849-57. . View in PubMed

Alveolar epithelial cell injury due to zinc oxide nanoparticle exposure Am J Respir Crit Care Med. 2010 Dec 01; 182(11):1398-409. . View in PubMed

Directed expression of Cre in alveolar epithelial type 1 cells Am J Respir Cell Mol Biol. 2010 Aug; 43(2):173-8. . View in PubMed

Mechanisms of alveolar epithelial translocation of a defined population of nanoparticles Am J Respir Cell Mol Biol. 2010 May; 42(5):604-14. . View in PubMed

More life for a "terminal" cell Am J Physiol Lung Cell Mol Physiol. 2009 Dec; 297(6):L1042-4. . View in PubMed

Characterization of mouse alveolar epithelial cell monolayers Am J Physiol Lung Cell Mol Physiol. 2009 Jun; 296(6):L1051-8. . View in PubMed

Conjugation with cationic cell-penetrating peptide increases pulmonary absorption of insulin Mol Pharm. 2009 Mar-Apr; 6(2):492-503. . View in PubMed

GATA-6 mediates transcriptional activation of aquaporin-5 through interactions with Sp1 Am J Physiol Cell Physiol. 2008 Nov; 295(5):C1141-50. . View in PubMed

Characterization of protein factor(s) in rat bronchoalveolar lavage fluid that enhance insulin transport via transcytosis across primary rat alveolar epithelial cell monolayers Eur J Pharm Biopharm. 2008 Aug; 69(3):808-16. . View in PubMed

Retention of human bone marrow-derived cells in murine lungs following bleomycin-induced lung injury Am J Physiol Lung Cell Mol Physiol. 2008 Aug; 295(2):L285-92. . View in PubMed

Rat aquaporin-5 43-kb 5'-flanking region differentially regulates expression in salivary gland and lung in vivo. Am J Physiol Cell Physiol. 2008 Jul; 295(1):C111-20. . View in PubMed

Polystyrene nanoparticle trafficking across alveolar epithelium Nanomedicine. 2008 Jun; 4(2):139-45. . View in PubMed

Molecular and functional expression of multidrug resistance-associated protein-1 in primary cultured rat alveolar epithelial cells J Pharm Sci. 2008 Jun; 97(6):2340-9. . View in PubMed

Foxp2 inhibits Nkx21-mediated transcription of SP-C via interactions with the Nkx2. 1 homeodomain. Am J Respir Cell Mol Biol. 2008 Jun; 38(6):750-8. . View in PubMed

Functional characterization and cloning of amino acid transporter B(0,+) (ATB(0,+)) in primary cultured rat pneumocytes J Cell Physiol. 2008 Mar; 214(3):645-54. . View in PubMed

Expression and biological activity of ABCA1 in alveolar epithelial cells Am J Respir Cell Mol Biol. 2008 Mar; 38(3):283-92. . View in PubMed

Effects of KGF on alveolar epithelial cell transdifferentiation are mediated by JNK signaling Am J Respir Cell Mol Biol. 2008 Feb; 38(2):239-46. . View in PubMed

Nanoparticle effects on rat alveolar epithelial cell monolayer barrier properties Toxicol In Vitro. 2007 Dec; 21(8):1373-81. . View in PubMed

Enhancement of insulin transport across primary rat alveolar epithelial cell monolayers by endogenous cellular factor(s) Pharm Res. 2007 Sep; 24(9):1713-9. . View in PubMed

Conserved elements within first intron of aquaporin-5 (Aqp5) function as transcriptional enhancers Biochem Biophys Res Commun. 2007 Apr 27; 356(1):26-31. . View in PubMed

Hypertonic induction of aquaporin-5: novel role of hypoxia-inducible factor-1alpha Am J Physiol Cell Physiol. 2007 Apr; 292(4):C1280-90. . View in PubMed

SUMOylation attenuates sensitivity toward hypoxia- or desferroxamine-induced injury by modulating adaptive responses in salivary epithelial cells Am J Pathol. 2006 May; 168(5):1452-63. . View in PubMed

Induction of epithelial-mesenchymal transition in alveolar epithelial cells by transforming growth factor-beta1: potential role in idiopathic pulmonary fibrosis Am J Pathol. 2005 May; 166(5):1321-32. . View in PubMed

Development of a lung slice preparation for recording ion channel activity in alveolar epithelial type I cells Respir Res. 2005 Apr 27; 6:40. . View in PubMed

Net absorption of IgG via FcRn-mediated transcytosis across rat alveolar epithelial cell monolayers Am J Physiol Lung Cell Mol Physiol. 2004 Sep; 287(3):L616-22. . View in PubMed

Alveolar epithelial type I cells express beta2-adrenergic receptors and G-protein receptor kinase 2 J Histochem Cytochem. 2004 Jun; 52(6):759-67. . View in PubMed

Subunit-specific coordinate upregulation of sodium pump activity in alveolar epithelial cells by lentivirus-mediated gene transfer Hum Gene Ther. 2004 May; 15(5):457-68. . View in PubMed

The critical care crisis in the United States: a report from the profession Chest. 2004 Apr; 125(4):1514-7. . View in PubMed

Modulation of ion conductance and active transport by TGF-beta 1 in alveolar epithelial cell monolayers Am J Physiol Lung Cell Mol Physiol. 2003 Dec; 285(6):L1192-200. . View in PubMed

Transcytosis of GCSF-transferrin across rat alveolar epithelial cell monolayers Pharm Res. 2003 Aug; 20(8):1231-8. . View in PubMed

Identification of three genes of known function expressed by alveolar epithelial type I cells Am J Respir Cell Mol Biol. 2003 Jul; 29(1):98-105. . View in PubMed

Phenotype-dependent synthesis of transferrin receptor in rat alveolar epithelial cell monolayers Cell Tissue Res. 2003 Jun; 312(3):313-8. . View in PubMed

Absorption of intact albumin across rat alveolar epithelial cell monolayers Am J Physiol Lung Cell Mol Physiol. 2003 Mar; 284(3):L458-65. . View in PubMed

Hypoxia decreases active Na transport across primary rat alveolar epithelial cell monolayers Am J Physiol Lung Cell Mol Physiol. 2002 Apr; 282(4):L659-65. . View in PubMed

Na transport proteins are expressed by rat alveolar epithelial type I cells Am J Physiol Lung Cell Mol Physiol. 2002 Apr; 282(4):L599-608. . View in PubMed

Polarity of alveolar epithelial cell acid-base permeability Am J Physiol Lung Cell Mol Physiol. 2002 Apr; 282(4):L675-83. . View in PubMed

Vesicular stomatitis virus G-pseudotyped lentivirus vectors mediate efficient apical transduction of polarized quiescent primary alveolar epithelial cells J Virol. 2001 Dec; 75(23):11747-54. . View in PubMed

Re-evaluating the Na(+) conductance of adult rat alveolar type II pneumocytes: evidence for the involvement of cGMP-activated cation channels J Physiol. 2001 Nov 01; 536(Pt 3):693-701. . View in PubMed

A useful in vitro model for transport studies of alveolar epithelial barrier Pharm Res. 2001 Mar; 18(3):253-5. . View in PubMed

Alveolar epithelial transportBasic science to clinical medicine. Am J Respir Crit Care Med. 2001 Mar; 163(4):1021-9. . View in PubMed

Differential regulation of rat aquaporin-5 promoter/enhancer activities in lung and salivary epithelial cells J Biol Chem. 2000 Aug 25; 275(34):26507-14. . View in PubMed

Rates of protein transport across rat alveolar epithelial cell monolayers J Drug Target. 2000; 7(5):335-42. . View in PubMed

Epidermal growth factor regulation in adult rat alveolar type II cells of amiloride-sensitive cation channels Am J Physiol. 1999 12; 277(6):C1058-65. . View in PubMed

Keratinocyte growth factor modulates alveolar epithelial cell phenotype in vitro: expression of aquaporin 5 Am J Respir Cell Mol Biol. 1998 Apr; 18(4):554-61. . View in PubMed

Mechanisms of EGF-induced stimulation of sodium reabsorption by alveolar epithelial cells Am J Physiol. 1998 07; 275(1):C82-92. . View in PubMed

Modulation of t1alpha expression with alveolar epithelial cell phenotype in vitro Am J Physiol. 1998 07; 275(1):L155-64. . View in PubMed

Size-dependent dextran transport across rat alveolar epithelial cell monolayers J Pharm Sci. 1997 Mar; 86(3):305-9. . View in PubMed

Effects of Mycobacterium tuberculosis on the bioelectric properties of the alveolar epithelium Infect Immun. 1997 Feb; 65(2):692-8. . View in PubMed

Horseradish peroxidase transport across rat alveolar epithelial cell monolayers Pharm Res. 1996 Sep; 13(9):1331-5. . View in PubMed

Effects of EGF on alveolar epithelial junctional permeability and active sodium transport Am J Physiol. 1996 Apr; 270(4 Pt 1):L559-65. . View in PubMed

Models for investigation of peptide and protein transport across cultured mammalian respiratory epithelial barriers Pharm Biotechnol. 1996; 8:325-46. . View in PubMed

Reversible transdifferentiation of alveolar epithelial cells Am J Respir Cell Mol Biol. 1995 May; 12(5):497-502. . View in PubMed

Basolateral localization of Na(+)-HCO3- cotransporter activity in alveolar epithelial cells Respir Physiol. 1995 Apr; 100(1):15-24. . View in PubMed

Cl(-)-HCO3- exchanger isoform AE2 is restricted to the basolateral surface of alveolar epithelial cell monolayers Am J Respir Cell Mol Biol. 1995 Feb; 12(2):211-9. . View in PubMed

Rat serum inhibits progression of alveolar epithelial cells toward the type I cell phenotype in vitro Am J Respir Cell Mol Biol. 1995 Jan; 12(1):50-5. . View in PubMed

Late appearance of a type I alveolar epithelial cell marker during fetal rat lung development Histochemistry. 1994 Oct; 102(4):297-304. . View in PubMed

Polarized distribution of Na(+)-H+ antiport activity in rat alveolar epithelial cells Am J Physiol. 1994 Feb; 266(2 Pt 1):L138-47. . View in PubMed

Defined medium for primary culture de novo of adult rat alveolar epithelial cells In Vitro Cell Dev Biol Anim. 1994 Feb; 30A(2):99-104. . View in PubMed

Measurement of solute fluxes in isolated rat lungs Respir Physiol. 1993 Mar; 91(2-3):321-34. . View in PubMed

Evidence for amiloride-sensitive sodium channels in alveolar epithelial cells Am J Physiol. 1992 Apr; 262(4 Pt 1):L405-11. . View in PubMed

Reactivity of alveolar epithelial cells in primary culture with type I cell monoclonal antibodies Am J Respir Cell Mol Biol. 1992 Mar; 6(3):296-306. . View in PubMed

Regulation of intracellular pH in alveolar epithelial cells Am J Physiol. 1992 Jan; 262(1 Pt 1):L1-14. . View in PubMed

Contribution of active Na+ and Cl- fluxes to net ion transport by alveolar epithelium Respir Physiol. 1991 Aug; 85(2):245-56. . View in PubMed

Na(+)-HCO3- symport modulates intracellular pH in alveolar epithelial cells Am J Physiol. 1991 Jun; 260(6 Pt 1):L555-61. . View in PubMed

NO2 decreases paracellular resistance to ion and solute flow in alveolar epithelial monolayers Exp Lung Res. 1990 Nov-Dec; 16(6):561-75. . View in PubMed

NHLBI workshop summaryWorkshop on techniques to evaluate lung alveolar-microvascular injury. Am Rev Respir Dis. 1990 Apr; 141(4 Pt 1):1071-7. . View in PubMed

Evidence for active H+ secretion by rat alveolar epithelial cells Am J Physiol. 1989 Dec; 257(6 Pt 1):L438-45. . View in PubMed

Protein traffic across lung epithelia Am J Respir Cell Mol Biol. 1989 Oct; 1(4):255. . View in PubMed

Type I cell-like morphology in tight alveolar epithelial monolayers Exp Cell Res. 1989 Oct; 184(2):375-87. . View in PubMed

Tight monolayers of rat alveolar epithelial cells: bioelectric properties and active sodium transport Am J Physiol. 1989 Mar; 256(3 Pt 1):C688-93. . View in PubMed

Cl-/HCO3- exchange modulates intracellular pH in rat type II alveolar epithelial cells J Biol Chem. 1988 Apr 25; 263(12):5599-606. . View in PubMed

Effects of culture conditions on susceptibility of alveolar epithelial cell monolayers to NO2 Toxicol Lett. 1988 Mar; 40(3):247-55. . View in PubMed

Effects of nitrogen dioxide on alveolar epithelial barrier properties Res Rep Health Eff Inst. 1987 Oct; (13):3-19. . View in PubMed

Characterization of Na+-H+ antiport in type II alveolar epithelial cells Am J Physiol. 1987 May; 252(5 Pt 1):C490-8. . View in PubMed

Effects of exposure to NO2 on dome formation in alveolar epithelial cell monolayers Environ Res. 1987 Feb; 42(1):1-11. . View in PubMed

Sodium-dependent lysine flux across bullfrog alveolar epithelium J Appl Physiol (1985). 1988 Oct; 65(4):1655-61. . View in PubMed

Hydrophilic solute transport across rat alveolar epithelium J Appl Physiol (1985). 1989 May; 66(5):2320-7. . View in PubMed

Effects of transdifferentiation and EGF on claudin isoform expression in alveolar epithelial cells J Appl Physiol (1985). 2005 Jan; 98(1):322-8. . View in PubMed

Estimation of paracellular conductance of primary rat alveolar epithelial cell monolayers J Appl Physiol (1985). 2005 Jan; 98(1):138-43. . View in PubMed

Historical perspectives on lung edema clearance J Appl Physiol (1985). 2002 Oct; 93(4):1527-32. . View in PubMed

Effects of terbutaline on sodium transport in isolated perfused rat lung J Appl Physiol (1985). 1986 Jan; 60(1):289-94. . View in PubMed

Effects of dextran-bound inhibitors on carbonic anhydrase activity in isolated rat lungs J Appl Physiol (1985). 1986 Nov; 61(5):1849-56. . View in PubMed

Evidence for active sodium transport across alveolar epithelium of isolated rat lung J Appl Physiol (1985). 1987 Jun; 62(6):2460-6. . View in PubMed

Sodium-amino acid cotransport by type II alveolar epithelial cells J Appl Physiol (1985). 1985 Nov; 59(5):1616-22. . View in PubMed

Asymmetric [14C]albumin transport across bullfrog alveolar epithelium J Appl Physiol (1985). 1985 Oct; 59(4):1290-7. . View in PubMed

Regulation of transport across pulmonary alveolar epithelial cell monolayers J Appl Physiol Respir Environ Exerc Physiol. 1984 Sep; 57(3):703-10. . View in PubMed

Analysis of the determinants of renal cortical PCO2 Am J Physiol. 1984 Sep; 247(3 Pt 2):F466-74. . View in PubMed

Effects of cell swelling on fluid flow across alveolar epithelium J Appl Physiol Respir Environ Exerc Physiol. 1984 Jan; 56(1):72-7. . View in PubMed

Type II alveolar epithelial cells in suspension: separation by density and velocity Lung. 1984; 162(5):271-80. . View in PubMed

Recent developments in pulmonary edema Ann Intern Med. 1983 Dec; 99(6):808-22. . View in PubMed

Evidence for active Na+ transport by cultured monolayers of pulmonary alveolar epithelial cells Am J Physiol. 1983 Jul; 245(1):C78-83. . View in PubMed

Water and nonelectrolyte transport across alveolar epithelium Am Rev Respir Dis. 1983 May; 127(5 Pt 2):S16-24. . View in PubMed

Heteropore populations of bullfrog alveolar epithelium J Appl Physiol Respir Environ Exerc Physiol. 1983 Jan; 54(1):140-6. . View in PubMed

Dome formation in primary cultured monolayers of alveolar epithelial cells Am J Physiol. 1982 Jul; 243(1):C96-100. . View in PubMed

Effects of lung inflation on alveolar epithelial solute and water transport properties J Appl Physiol Respir Environ Exerc Physiol. 1982 Jun; 52(6):1498-505. . View in PubMed

Effects of exposure to acid on alveolar epithelial water and solute transport J Appl Physiol Respir Environ Exerc Physiol. 1982 Apr; 52(4):902-9. . View in PubMed

Effects of salicylate on HCO-3/Cl- exchange across the human erythrocyte membrane J Membr Biol. 1982; 65(1-2):139-45. . View in PubMed

Effects of inhibition of RBC HCO3-/Cl- exchange on CO2 excretion and downstream pH disequilibrium in isolated rat lungs J Clin Invest. 1981 Oct; 68(4):853-62. . View in PubMed

Transport of water and solutes across bullfrog alveolar epithelium J Appl Physiol Respir Environ Exerc Physiol. 1981 Jun; 50(6):1263-71. . View in PubMed

Effects of red blood cell HCO3(-)/Cl- exchange kinetics on lung CO2 transfer: theory J Appl Physiol Respir Environ Exerc Physiol. 1981 Feb; 50(2):265-71. . View in PubMed

Exchange of HCO3- for monovalent anions across the human erythrocyte membrane J Membr Biol. 1980; 52(2):173-9. . View in PubMed

HCO3-/Cl- exchange across the human erythrocyte membrane: effects of pH and temperature J Membr Biol. 1979 Oct 05; 50(1):23-41. . View in PubMed

Transport of water and solutes across sheep visceral pleura Am Rev Respir Dis. 1979 Oct; 120(4):883-92. . View in PubMed

Kinetics of bicarbonate/chloride exchange in dogfish erythrocytes Am J Physiol. 1979 Sep; 237(3):R132-8. . View in PubMed

Analysis of PCO2 differences during rebreathing due to slow pH equilibration in blood J Appl Physiol Respir Environ Exerc Physiol. 1978 Nov; 45(5):666-73. . View in PubMed

Influence of pH on elastic deformability of the human erythrocyte membrane Am J Physiol. 1978 Nov; 235(5):C269-78. . View in PubMed

Analysis of the effects of pulsatile capillary blood flow and volume on gas exchange Respir Physiol. 1978 Oct; 35(1):27-42. . View in PubMed

Bicarbonate-chloride exchange in erythrocyte suspensionsStopped-flow pH electrode measurements. Biophys J. 1978 Oct; 24(1):35-47. . View in PubMed

Direct evidence of participation of rat lung carbonic anhydrase in CO2 reactions J Clin Invest. 1978 Sep; 62(3):618-22. . View in PubMed

Analysis of postcapillary pH changes in blood in vivo after gas exchange J Appl Physiol Respir Environ Exerc Physiol. 1978 May; 44(5):770-81. . View in PubMed

Delayed pH equilibration in blood during carbonic anhydrase inhibition Adv Exp Med Biol. 1978; 99:243-54. . View in PubMed

Kinetics of bicarbonate-chloride exchange across the human red blood cell membrane J Gen Physiol. 1976 Dec; 68(6):633-52. . View in PubMed

Pulmonarygas exchange Annu Rev Physiol. 1976; 38:69-93. . View in PubMed

Kinetic analysis of calcium transport across the placenta J Appl Physiol. 1973 Nov; 35(5):682-8. . View in PubMed

Hydroxyl ion movements across the human erythrocyte membraneMeasurement of rapid pH changes in red cell suspensions. J Gen Physiol. 1971 Jun; 57(6):664-83. . View in PubMed