Keck School Faculty

Eric Lin Chang

Eric Lin Chang

Chair and Professor of Radiation Oncology
Radiation Oncology
NOR G358 1441 EASTLAKE AVE Health Sciences Campus Los Angeles

: Listed in Best Doctors in America, 2011-2012

: James D. Cox Mentorship Award, 2011

: Listed in Best Doctors in America, 2009-2010

: Named in Strathmore's Who's Who, 2002-2003

: The American Society for Therapeutic Radiology and Oncology (ASTRO), Travel Grant to attend ESTRO an, 2001

: The American College of Radiation Oncology (ACRO), Howard H. Wong Fellowship in Radiation Oncology, 1997

Vail, Colorado: American Society for Clinical Oncology (ASCO) Award, Methods in Clinical Cancer Research Workshop, 1997

: Howard Hughes Medical Institute Research Fellowship, 1993

: Sigma Xi Research Society,, 1990

Late Effects of Craniospinal Irradiation Using Electron Spinal Fields for Pediatric Patients With Cancer Int J Radiat Oncol Biol Phys. 2022 Jun 15. . View in PubMed

Management of complications from brain metastasis treatment: a narrative review Chin Clin Oncol. 2022 Apr; 11(2):11. . View in PubMed

Dose to neuroanatomical structures surrounding pituitary adenomas and the effect of stereotactic radiosurgery on neuroendocrine function: an international multicenter study J Neurosurg. 2022 Mar 01; 136(3):813-821. . View in PubMed

Automatic segmentation of high-risk clinical target volume for tandem-and-ovoids brachytherapy patients using an asymmetric dual-path convolutional neural network Med Phys. 2022 Mar; 49(3):1712-1722. . View in PubMed

The optimal management of brain metastases from gestational trophoblastic neoplasia Expert Rev Anticancer Ther. 2022 Mar; 22(3):307-315. . View in PubMed

Executive summary of American Radium Society's appropriate use criteria for the postoperative management of lower grade gliomas Radiother Oncol. 2022 05; 170:79-88. . View in PubMed

Thecal Sac Contouring as a Surrogate for the Cauda Equina and Intracanal Spinal Nerve Roots for Spine Stereotactic Body Radiation Therapy (SBRT): Contour Variability and Recommendations for Safe Practice Int J Radiat Oncol Biol Phys. 2022 01 01; 112(1):114-120. . View in PubMed

Automatic differentiation of Grade I and II meningiomas on magnetic resonance image using an asymmetric convolutional neural network Sci Rep. 2022 03 09; 12(1):3806. . View in PubMed

Voxelwise Prediction of Recurrent High-Grade Glioma via Proximity Estimation-Coupled Multidimensional Support Vector Machine Int J Radiat Oncol Biol Phys. 2022 04 01; 112(5):1279-1287. . View in PubMed

Clinical and radiologic outcomes after stereotactic radiosurgery for meningiomas in direct contact with the optic apparatus: an international multicenter study J Neurosurg. 2022 04 01; 136(4):1070-1076. . View in PubMed

Surviving Over a Decade With Glioblastoma: A Clinical Course Characterized by Multiple Recurrences, Numerous Salvage Treatments, and Novel Use of Cesium-131 Tiles Cureus. 2021 Nov; 13(11):e19573. . View in PubMed

Phase 1 study of spinal cord constraint relaxation with single session spine stereotactic radiosurgery in the primary management of patients with inoperable, previously irradiated metastatic epidural spinal cord compression N Am Spine Soc J. 2021 Jun; 6:100066. . View in PubMed

Use of Salvage Surgery or Stereotactic Radiosurgery for Multiply Recurrent Skull Base Chordomas: A Single-Institution Experience and Review of the Literature J Neurol Surg B Skull Base. 2021 Apr; 82(2):161-174. . View in PubMed

Stereotactic radiosurgery for clinoid meningiomas: a multi-institutional study Acta Neurochir (Wien). 2021 10; 163(10):2861-2869. . View in PubMed

Stereotactic Radiosurgery for Differentiated Thyroid Cancer Brain Metastases: An International, Multicenter Study Thyroid. 2021 08; 31(8):1244-1252. . View in PubMed

Sheep, Meet Stupp Int J Radiat Oncol Biol Phys. 2021 04 01; 109(5):1139-1140. . View in PubMed

Automatic detection and segmentation of multiple brain metastases on magnetic resonance image using asymmetric UNet architecture Phys Med Biol. 2021 01 13; 66(1):015003. . View in PubMed

Stereotactic Radiosurgery for Olfactory Groove Meningiomas: An International, Multicenter Study Neurosurgery. 2021 10 13; 89(5):784-791. . View in PubMed

Radiotherapy to the brain: what are the consequences of this age-old treatment? Ann Palliat Med. 2021 Jan; 10(1):936-952.. View in PubMed

Stereotactic Radiosurgery for Perioptic Meningiomas: An International, Multicenter Study Neurosurgery. 2021 03 15; 88(4):828-837. . View in PubMed

Radiation Necrosis from Stereotactic Radiosurgery-How Do We Mitigate? Curr Treat Options Oncol. 2021 06 07; 22(7):57.. View in PubMed

Stereotactic radiosurgery for treatment of radiation-induced meningiomas: a multiinstitutional study J Neurosurg. 2021 Jan 01; 1-9. . View in PubMed

The Judicious Use of Stereotactic Radiosurgery and Hypofractionated Stereotactic Radiotherapy in the Management of Large Brain Metastases Cancers (Basel). 2020 Dec 29; 13(1). . View in PubMed

Neuro-oncology Management During the COVID-19 Pandemic With a Focus on WHO Grade III and IV Gliomas Neuro Oncol. 2020 May 05. . View in PubMed

Low risk of radiation myelopathy with relaxed spinal cord dose constraints in de novo, single fraction spine stereotactic radiosurgery Radiother Oncol. 2020 11; 152:49-55. . View in PubMed

Current approaches to the management of brain metastases Nat Rev Clin Oncol. 2020 05; 17(5):279-299. . View in PubMed

Identifying Disparities in Care in Treating Glioblastoma: A Retrospective Cohort Study of Patients Treated at a Safety-net Versus Private Hospital Setting World Neurosurg. 2020 05; 137:e213-e220. . View in PubMed

International consensus recommendations for target volume delineation specific to sacral metastases and spinal stereotactic body radiation therapy (SBRT) Radiother Oncol. 2020 04; 145:21-29. . View in PubMed

Quantifying vascular invasion in pancreatic cancer-a contrast CT based method for surgical resectability evaluation Phys Med Biol. 2020 06 01; 65(10):105012. . View in PubMed

Effectiveness of Gamma Knife Radiosurgery in the Treatment of Refractory Trigeminal Neuralgia: A Case Series Oper Neurosurg (Hagerstown). 2020 06 01; 18(6):571-576. . View in PubMed

Executive summary from American Radium Society's appropriate use criteria on neurocognition after stereotactic radiosurgery for multiple brain metastases Neuro Oncol. 2020 12 18; 22(12):1728-1741. . View in PubMed

Commentary: Mature Imaging-Based Outcomes Supporting Local Control for Complex Reirradiation Salvage Spine Stereotactic Body Radiotherapy Neurosurgery. 2020 09 15; 87(4):E498-E499. . View in PubMed

Bevacizumab is more effective in nasopharyngeal carcinoma patients with lower maximum radiation dose to the temporal lobe Chin Clin Oncol. 2019 Oct; 8(S1):S20. . View in PubMed

Long-Term Tumor Control Rates Following Gamma Knife Radiosurgery for Acoustic Neuroma World Neurosurg. 2019 Feb; 122:366-371. . View in PubMed

Assembling the brain trust: the multidisciplinary imperative in neuro-oncology Nat Rev Clin Oncol. 2019 08; 16(8):521-522. . View in PubMed

Updates in the management of intradural spinal cord tumors: a radiation oncology focus Neuro Oncol. 2019 06 10; 21(6):707-718. . View in PubMed

Preserve the Facial Nerve Int J Radiat Oncol Biol Phys. 2019 03 15; 103(4):798-799. . View in PubMed

Lens Dose-Response Prediction Modeling and Cataract Incidence in Patients With Retinoblastoma After Lens-Sparing or Whole-Eye Radiation Therapy Int J Radiat Oncol Biol Phys. 2019 04 01; 103(5):1143-1150. . View in PubMed

Strategies to Mitigate Toxicities From Stereotactic Body Radiation Therapy for Spine Metastases Neurosurgery. 2019 12 01; 85(6):729-740. . View in PubMed

Stereotactic body radiotherapy for benign spinal tumors: Meningiomas, schwannomas, and neurofibromas J Radiosurg SBRT. 2019; 6(3):167-177. . View in PubMed

Commentary: Clinical Outcomes of Upfront Stereotactic Radiosurgery Alone for Patient With 5 to 15 Brain Metastases Neurosurgery. 2019 08 01; 85(2):E247-E248. . View in PubMed

Commentary: Long-Term Update of Stereotactic Radiosurgery for Benign Spinal Tumors Neurosurgery. 2019 11 01; 85(5):E840-E841. . View in PubMed

Stereotactic radiosurgery and ipilimumab for patients with melanoma brain metastases: clinical outcomes and toxicity J Neurooncol. 2018 Sep; 139(2):421-429. . View in PubMed

Novel multidisciplinary approaches in the management of metastatic epidural spinal cord compression Future Oncol. 2018 Jul; 14(17):1665-1668. . View in PubMed

The evolution and rise of stereotactic body radiotherapy (SBRT) for spinal metastases Expert Rev Anticancer Ther. 2018 09; 18(9):887-900. . View in PubMed

The growing importance of lesion volume as a prognostic factor in patients with multiple brain metastases treated with stereotactic radiosurgery Cancer Med. 2018 03; 7(3):757-764. . View in PubMed

Development of a Radiation Oncology Resident Continuity Clinic to Improve Clinical Competency and Patient Compliance Int J Radiat Oncol Biol Phys. 2018 03 01; 100(3):551-555. . View in PubMed

Safety-net versus private hospital setting for brain metastasis patients treated with radiosurgery alone: Disparities in follow-up care and outcomes Cancer. 2018 Jan 01; 124(1):167-175. . View in PubMed

Phase 1 Study of Spinal Cord Constraint Relaxation With Single Session Spine Stereotactic Radiosurgery in the Primary Management of Patients With Inoperable, Previously Unirradiated Metastatic Epidural Spinal Cord Compression Int J Radiat Oncol Biol Phys. 2018 12 01; 102(5):1481-1488. . View in PubMed

Population description and clinical response assessment for spinal metastases: part 2 of the SPIne response assessment in Neuro-Oncology (SPINO) group report Neuro Oncol. 2018 08 02; 20(9):1215-1224. . View in PubMed

Combination ipilimumab and radiosurgery for brain metastases: tumor, edema, and adverse radiation effects J Neurosurg. 2018 12 01; 129(6):1397-1406. . View in PubMed

Stereotactic Radiosurgery for Multiple Brain Metastases: Two Cases of Preserved Quality of Life Cureus. 2017 Dec 28; 9(12):e1995. . View in PubMed

Submillimeter alignment of more than three contiguous vertebrae in spinal SRS/SBRT with 6-degree couch J Appl Clin Med Phys. 2017 Sep; 18(5):225-236. . View in PubMed

Spine stereotactic radiosurgery for metastatic sarcoma: patterns of failure and radiation treatment volume considerations J Neurosurg Spine. 2017 Sep; 27(3):303-311. . View in PubMed

An update on radiation therapy for brain metastases Chin Clin Oncol. 2017 Aug; 6(4):35. . View in PubMed

Combined-modality hypofractionated radiotherapy for elderly patients with glioblastoma: setting a new standard Future Sci OA. 2017 Aug; 3(3):FSO210. . View in PubMed

Modern approaches to the management of metastatic epidural spinal cord compression CNS Oncol. 2017 Jul 18. . View in PubMed

Spine Stereotactic Body Radiotherapy: Indications, Outcomes, and Points of Caution Global Spine J. 2017 Apr; 7(2):179-197. . View in PubMed

Consensus guidelines for postoperative stereotactic body radiation therapy for spinal metastases: results of an international survey J Neurosurg Spine. 2017 Mar; 26(3):299-306. . View in PubMed

Preserving Neurocognition in Patients With Brain Metastases JAMA Oncol. 2017 Feb 01; 3(2):269-270. . View in PubMed

Postoperative stereotactic radiosurgery for limited brain metastases: are we ready for prime time? Expert Rev Anticancer Ther. 2017 09; 17(9):775-777.. View in PubMed

Radiosurgery for resected brain metastases-a new standard of care? Lancet Oncol. 2017 08; 18(8):985-987.. View in PubMed

Consensus Contouring Guidelines for Postoperative Stereotactic Body Radiation Therapy for Metastatic Solid Tumor Malignancies to the Spine Int J Radiat Oncol Biol Phys. 2017 01 01; 97(1):64-74. . View in PubMed

In Regard to Dr Vapiwala Int J Radiat Oncol Biol Phys. 2017 05 01; 98(1):215. . View in PubMed

A quantitative analysis of craniopharyngioma cyst expansion during and after radiation therapy and surgical implications Neurosurg Focus. 2016 Dec; 41(6):E15. . View in PubMed

Single-fraction versus multifraction spinal stereotactic radiosurgery for spinal metastases from renal cell carcinoma: secondary analysis of Phase I/II trials J Neurosurg Spine. 2016 May; 24(5):829-36. . View in PubMed

Re-irradiation of Recurrent Pineal Germ Cell Tumors with Radiosurgery: Report of Two Cases and Review of Literature Cureus. 2016 Apr 25; 8(4):e585. . View in PubMed

Treatment of high numbers of brain metastases with Gamma Knife radiosurgery: a review Acta Neurochir (Wien). 2016 Apr; 158(4):625-634. . View in PubMed

The era of stereotactic body radiotherapy for spinal metastases and the multidisciplinary management of complex cases Neurooncol Pract. 2016 Mar; 3(1):48-58. . View in PubMed

Prognostic factors for melanoma brain metastases treated with stereotactic radiosurgery J Neurosurg. 2016 12; 125(Suppl 1):31-39. . View in PubMed

Spine Stereotactic Radiosurgery for Patients with Metastatic Thyroid Cancer: Secondary Analysis of Phase I/II Trials Thyroid. 2016 09; 26(9):1269-75. . View in PubMed

In Regard to Johnson et al Int J Radiat Oncol Biol Phys. 2016 07 01; 95(3):1083-1085. . View in PubMed

Stereotactic radiosurgery alone for limited brain metastases: are we ready for prime time? CNS Oncol. 2016; 5(1):1-4.. View in PubMed

Prospective validation of treatment accuracy using implanted fiducial markers for spinal stereotactic body radiation therapy J Radiosurg SBRT. 2016; 4(1):7-14. . View in PubMed

Point/Counterpoint: Is stereotactic radiosurgery needed following resection of brain metastasis? Neuro Oncol. 2016 Jan; 18(1):12-5.. View in PubMed

Prospective evaluation of target and spinal cord motion and dosimetric changes with respiration in spinal stereotactic body radiation therapy utilizing 4-D CT J Radiosurg SBRT. 2016; 4(3):191-201. . View in PubMed

Stereotactic Body Radiation Therapy for Spinal Metastases in the Postoperative Setting: A Secondary Analysis of Mature Phase 1-2 Trials Int J Radiat Oncol Biol Phys. 2016 08 01; 95(5):1405-1413. . View in PubMed

Response assessment after stereotactic body radiotherapy for spinal metastasis: a report from the SPIne response assessment in Neuro-Oncology (SPINO) group Lancet Oncol. 2015 Dec; 16(16):e595-603. . View in PubMed

The development of stereotactic body radiotherapy in the past decade: a global perspective Future Oncol. 2015 Oct; 11(19):2721-2733. . View in PubMed

Outcomes for Spine Stereotactic Body Radiation Therapy and an Analysis of Predictors of Local Recurrence Int J Radiat Oncol Biol Phys. 2015 Aug 01; 92(5):1016-1026. . View in PubMed

In Reply to Gemici and Yaprak and Lowrey and Marcus Int J Radiat Oncol Biol Phys. 2015 Jul 15; 92(4):948-9. . View in PubMed

ACR Appropriateness Criteria® Metastatic Epidural Spinal Cord Compression and Recurrent Spinal Metastasis J Palliat Med. 2015 Jul; 18(7):573-84. . View in PubMed

Extra-CNS metastasis from glioblastoma: a rare clinical entity Expert Rev Anticancer Ther. 2015 May; 15(5):545-52. . View in PubMed

Phase 3 trials of stereotactic radiosurgery with or without whole-brain radiation therapy for 1 to 4 brain metastases: individual patient data meta-analysis Int J Radiat Oncol Biol Phys. 2015 Mar 15; 91(4):710-7. . View in PubMed

Randomized phase II adjuvant factorial study of dose-dense temozolomide alone and in combination with isotretinoin, celecoxib, and/or thalidomide for glioblastoma Neuro Oncol. 2015 Feb; 17(2):266-73. . View in PubMed

Single versus multiple session stereotactic body radiotherapy for spinal metastasis: the risk-benefit ratio Future Oncol. 2015; 11(17):2405-15. . View in PubMed

Factors affecting survival in 37 consecutive patients undergoing de novo stereotactic radiosurgery for contiguous sites of vertebral body metastasis from renal cell carcinoma J Neurosurg Spine. 2015 Jan; 22(1):52-9. . View in PubMed

Is there any role for stereotactic body radiotherapy in the management of metastatic epidural spinal cord compression? CNS Oncol. 2015; 4(1):1-4.. View in PubMed

Stereotactic radiosurgery to the resection cavity for brain metastases: prognostic factors and outcomes J Radiosurg SBRT. 2015; 3(3):179-186. . View in PubMed

ACR Appropriateness Criteria(®) non-spine bone metastases J Palliat Med. 2015 Jan; 18(1):11-7. . View in PubMed

Prognostic significance of EGFR and KRAS mutations in NSCLC patients with brain metastases treated with radiosurgery† J Radiosurg SBRT. 2015; 3(3):171-178. . View in PubMed

Radiosurgery for metastatic disease at the craniocervical junction World Neurosurg. 2014 Dec; 82(6):1331-6. . View in PubMed

Incidence and predictive factors of pain flare after spine stereotactic body radiation therapy: secondary analysis of phase 1/2 trials Int J Radiat Oncol Biol Phys. 2014 Nov 15; 90(4):870-6. . View in PubMed

Spot scanning proton therapy for malignancies of the base of skull: treatment planning, acute toxicities, and preliminary clinical outcomes Int J Radiat Oncol Biol Phys. 2014 Nov 01; 90(3):540-6. . View in PubMed

Stereotactic radiosurgery for multiple brain metastases Expert Rev Anticancer Ther. 2014 Oct; 14(10):1153-72. . View in PubMed

A single-field integrated boost treatment planning technique for spot scanning proton therapy Radiat Oncol. 2014 Sep 11; 9:202. . View in PubMed

Outcomes after surgery and radiotherapy for spinal myxopapillary ependymoma: update of the MD Anderson Cancer Center experience Neurosurgery. 2014 Sep; 75(3):205-14; discussion 213-4. . View in PubMed

Rare primary central nervous system tumors Rare Tumors. 2014 Jul 30; 6(3):5449. . View in PubMed

Emerging applications of stereotactic body radiotherapy Future Oncol. 2014 May; 10(7):1299-310. . View in PubMed

Resection cavity radiosurgery for intracranial metastases: a review of the literature J Radiosurg SBRT. 2014; 3(2):91-102. . View in PubMed

The impact of tyrosine kinase inhibitors on the multimodality treatment of brain metastases from renal cell carcinoma Am J Clin Oncol. 2013 Dec; 36(6):620-4. . View in PubMed

Intracranial hemangiopericytoma: patterns of failure and the role of radiation therapy Neurosurgery. 2013 Oct; 73(4):624-30; discussion 630-1. . View in PubMed

Best of International Stereotactic Radiosurgery Society Congress 2013: stereotactic body radiation therapyPart I: spinal tumors. Future Oncol. 2013 Sep; 9(9):1299-302. . View in PubMed

What is the most appropriate clinical target volume for glioblastoma? CNS Oncol. 2013 Sep; 2(5):419-25.. View in PubMed

Best of International Stereotactic Radiosurgery Society Congress 2013: stereotactic body radiation therapyPart II: nonspinal tumors. Future Oncol. 2013 Sep; 9(9):1303-6. . View in PubMed

Stereotactic body radiotherapy: a new paradigm in the management of spinal metastases CNS Oncol. 2013 May; 2(3):259-70. . View in PubMed

Predictors of survival in contemporary practice after initial radiosurgery for brain metastases Int J Radiat Oncol Biol Phys. 2013 Mar 01; 85(3):656-61. . View in PubMed

ACR Appropriateness Criteria ® spinal bone metastases J Palliat Med. 2013 Jan; 16(1):9-19. . View in PubMed

Validation of Recursive Partitioning Analysis and Diagnosis-Specific Graded Prognostic Assessment in patients treated initially with radiosurgery alone J Neurosurg. 2012 Dec; 117 Suppl:38-44. . View in PubMed

Generalizable class solutions for treatment planning of spinal stereotactic body radiation therapy Int J Radiat Oncol Biol Phys. 2012 Nov 01; 84(3):847-53. . View in PubMed

Phase 1/2 trial of single-session stereotactic body radiotherapy for previously unirradiated spinal metastases Cancer. 2012 Oct 15; 118(20):5069-77. . View in PubMed

Radiotherapeutic and surgical management for newly diagnosed brain metastasis(es): An American Society for Radiation Oncology evidence-based guideline Pract Radiat Oncol. 2012 Jul-Sep; 2(3):210-225. . View in PubMed

Whole abdominopelvic intensity-modulated radiation therapy for desmoplastic small round cell tumor after surgery Int J Radiat Oncol Biol Phys. 2012 May 01; 83(1):317-26. . View in PubMed

ACR Appropriateness Criteria® non-spine bone metastases J Palliat Med. 2012 May; 15(5):521-6. . View in PubMed

Stereotactic body radiation therapy for management of spinal metastases in patients without spinal cord compression: a phase 1-2 trial Lancet Oncol. 2012 Apr; 13(4):395-402. . View in PubMed

Vertebral compression fracture risk after stereotactic body radiotherapy for spinal metastases J Neurosurg Spine. 2012 Apr; 16(4):379-86. . View in PubMed

Cost-effectiveness analysis of a randomized study comparing radiosurgery with radiosurgery and whole brain radiation therapy in patients with 1 to 3 brain metastases Am J Clin Oncol. 2012 Feb; 35(1):45-50. . View in PubMed

Advances in radiation therapy of brain metastasis Prog Neurol Surg. 2012; 25:96-109. . View in PubMed

Reirradiation human spinal cord tolerance for stereotactic body radiotherapy Int J Radiat Oncol Biol Phys. 2012 Jan 01; 82(1):107-16. . View in PubMed

Use of a deformable atlas to identify cryptic critical structures in the treatment of glioblastoma multiforme PLoS One. 2012; 7(3):e32098. . View in PubMed

Radiation-induced middle ear and mastoid opacification in skull base tumors treated with radiotherapy Int J Radiat Oncol Biol Phys. 2011 Dec 01; 81(5):e819-23. . View in PubMed

Stereotactic body radiotherapy is an effective treatment in reirradiating spinal metastases: current status and practical considerations for safe practice Expert Rev Anticancer Ther. 2011 Dec; 11(12):1923-33. . View in PubMed

Irradiation of spinal metastases: should we continue to include one uninvolved vertebral body above and below in the radiation field? Int J Radiat Oncol Biol Phys. 2011 Dec 01; 81(5):1495-9.. View in PubMed

Outcomes and prognostic factors for patients with brainstem metastases undergoing stereotactic radiosurgery Neurosurgery. 2011 Oct; 69(4):796-806; discussion 806. . View in PubMed

Prospective evaluation of spinal reirradiation by using stereotactic body radiation therapy: The University of Texas MD Anderson Cancer Center experience Cancer. 2011 Aug 01; 117(15):3509-16. . View in PubMed

Induction treatment for diffuse intrinsic pontine glioma, experience of MD. Anderson Cancer Center. Anticancer Res. 2011 Jun; 31(6):2265-9. . View in PubMed

Stereotactic body radiotherapy for spinal metastases: current status, with a focus on its application in the postoperative patient J Neurosurg Spine. 2011 Feb; 14(2):151-66. . View in PubMed

Spine radiosurgery for spinal cord compression: the radiation oncologist's perspective J Radiosurg SBRT. 2011; 1(1):55-61. . View in PubMed

A quality assurance procedure to evaluate cone-beam CT image center congruence with the radiation isocenter of a linear accelerator J Appl Clin Med Phys. 2010 Jul 02; 11(4):3297. . View in PubMed

Management of metastatic spinal cord compression Expert Rev Anticancer Ther. 2010 May; 10(5):697-708. . View in PubMed

Stereotactic body radiation therapy for spinal metastases Discov Med. 2010 Apr; 9(47):289-96. . View in PubMed

Management of spinal metastases from renal cell carcinoma using stereotactic body radiotherapy Int J Radiat Oncol Biol Phys. 2010 Mar 15; 76(4):1185-92. . View in PubMed

Stereotactic body radiation therapy: a novel treatment modality Nat Rev Clin Oncol. 2010 Jan; 7(1):44-54. . View in PubMed

Neurocognition in patients with brain metastases treated with radiosurgery or radiosurgery plus whole-brain irradiation: a randomised controlled trial Lancet Oncol. 2009 Nov; 10(11):1037-44. . View in PubMed

Optimal treatment planning for skull base chordoma: photons, protons, or a combination of both? Int J Radiat Oncol Biol Phys. 2009 Jul 15; 74(4):1033-9.. View in PubMed

CNS germinomas: what is the best treatment strategy? Expert Rev Neurother. 2008 Oct; 8(10):1527-36.. View in PubMed

Dosimetric effect of translational and rotational errors for patients undergoing image-guided stereotactic body radiotherapy for spinal metastases Int J Radiat Oncol Biol Phys. 2008 Jul 15; 71(4):1261-71. . View in PubMed

Stereotactic body radiosurgery for spinal metastases: a critical review Int J Radiat Oncol Biol Phys. 2008 Jul 01; 71(3):652-65. . View in PubMed

Emerging role of proton beam radiation therapy for chordoma and chondrosarcoma of the skull base Curr Oncol Rep. 2008 Jul; 10(4):338-43. . View in PubMed

Optimizing radiotherapy schedules for elderly glioblastoma multiforme patients Expert Rev Anticancer Ther. 2008 May; 8(5):733-41. . View in PubMed

Multimodality treatment of osteosarcoma: radiation in a high-risk cohort Pediatr Blood Cancer. 2008 May; 50(5):976-82. . View in PubMed

Role of stereotactic radiosurgery and fractionated stereotactic radiotherapy in pediatric brain tumors Expert Rev Neurother. 2008 Jan; 8(1):121-32. . View in PubMed

Phase I/II study of stereotactic body radiotherapy for spinal metastasis and its pattern of failure J Neurosurg Spine. 2007 Aug; 7(2):151-60. . View in PubMed

Automatic target localization and verification for on-line image-guided stereotactic body radiotherapy of the spine Technol Cancer Res Treat. 2007 Jun; 6(3):187-96. . View in PubMed

Stereotactic radiosurgical treatment of cerebral metastases arising from breast cancer Am J Clin Oncol. 2007 Jun; 30(3):310-4. . View in PubMed

Evaluation of peritumoral edema in the delineation of radiotherapy clinical target volumes for glioblastoma Int J Radiat Oncol Biol Phys. 2007 May 01; 68(1):144-50. . View in PubMed

Intensity-modulated radiotherapy (IMRT) and conventional three-dimensional conformal radiotherapy for high-grade gliomas: does IMRT increase the integral dose to normal brain? Int J Radiat Oncol Biol Phys. 2007 Mar 15; 67(4):1135-44.. View in PubMed

Portal imaging practice patterns of children's oncology group institutions: Dosimetric assessment and recommendations for minimizing unnecessary exposure Int J Radiat Oncol Biol Phys. 2007 Feb 01; 67(2):594-600. . View in PubMed

A pilot study of neurocognitive function in patients with one to three new brain metastases initially treated with stereotactic radiosurgery alone Neurosurgery. 2007 Feb; 60(2):277-83; discussion 283-4. . View in PubMed

Stereotactic radiosurgery and radiation therapy for spinal tumors Expert Rev Neurother. 2007 Jan; 7(1):85-93. . View in PubMed

Focal and craniospinal irradiation for patients with intracranial germinoma and patterns of failure Cancer. 2006 Nov 01; 107(9):2228-36. . View in PubMed

Spinal myxopapillary ependymoma outcomes in patients treated with surgery and radiotherapy at MD. Anderson Cancer Center. J Neurooncol. 2006 Nov; 80(2):177-83. . View in PubMed

Nonsmall cell lung cancer presenting with synchronous solitary brain metastasis Cancer. 2006 May 01; 106(9):1998-2004. . View in PubMed

Role of stereotactic radiosurgery and fractionated stereotactic radiotherapy in the management of intracranial ependymoma Expert Rev Neurother. 2006 Apr; 6(4):501-7. . View in PubMed

Phase III study of efaproxiral as an adjunct to whole-brain radiation therapy for brain metastases J Clin Oncol. 2006 Jan 01; 24(1):106-14. . View in PubMed

Treatment planning with protons for pediatric retinoblastoma, medulloblastoma, and pelvic sarcoma: how do protons compare with other conformal techniques? Int J Radiat Oncol Biol Phys. 2005 Oct 01; 63(2):362-72.. View in PubMed

Case-control study of stereotactic radiosurgery for recurrent glioblastoma multiforme J Neurosurg. 2005 Aug; 103(2):210-7. . View in PubMed

Stereotactic radiosurgery with and without whole-brain radiotherapy for newly diagnosed brain metastases Expert Rev Neurother. 2005 Jul; 5(4):487-95. . View in PubMed

Development of a sensitive and specific enzyme-linked immunosorbent assay for thymosin beta15, a urinary biomarker of human prostate cancer Clin Biochem. 2005 Jun; 38(6):558-71. . View in PubMed

YKL-40 expression is associated with poorer response to radiation and shorter overall survival in glioblastoma Clin Cancer Res. 2005 May 01; 11(9):3326-34. . View in PubMed

Outcome variation among "radioresistant" brain metastases treated with stereotactic radiosurgery Neurosurgery. 2005 May; 56(5):936-45; discussion 936-45. . View in PubMed

Phase I clinical evaluation of near-simultaneous computed tomographic image-guided stereotactic body radiotherapy for spinal metastases Int J Radiat Oncol Biol Phys. 2004 Aug 01; 59(5):1288-94. . View in PubMed

Stereotactic radiosurgical treatment in 103 patients for 153 cerebral melanoma metastases Int J Radiat Oncol Biol Phys. 2004 Jul 15; 59(4):1097-106. . View in PubMed

An evaluation of radiation exposure from portal films taken during definitive course of pediatric radiotherapy Int J Radiat Oncol Biol Phys. 2004 Jul 15; 59(4):1229-35. . View in PubMed

Intracranial meningeal hemangiopericytoma: the role of radiotherapy: report of 29 cases and review of the literature Cancer. 2004 Apr 01; 100(7):1491-7. . View in PubMed

Radiotherapy after surgery for benign cerebral meningioma Radiother Oncol. 2004 Apr; 71(1):85-90. . View in PubMed

Near simultaneous computed tomography image-guided stereotactic spinal radiotherapy: an emerging paradigm for achieving true stereotaxy Int J Radiat Oncol Biol Phys. 2003 Nov 01; 57(3):605-13. . View in PubMed

The role of tumor size in the radiosurgical management of patients with ambiguous brain metastases Neurosurgery. 2003 Aug; 53(2):272-80; discussion 280-1. . View in PubMed

Hypofractionated radiotherapy for elderly or younger low-performance status glioblastoma patients: outcome and prognostic factors Int J Radiat Oncol Biol Phys. 2003 Jun 01; 56(2):519-28. . View in PubMed

The prognostic value of neurologic function in astrocytic spinal cord glioma Neuro Oncol. 2003 07; 5(3):208-13. . View in PubMed

Verification techniques and dose distribution for computed tomographic planned supine craniospinal radiation therapy Med Dosim. 2003; 28(2):127-31. . View in PubMed

Diagnosis and management of central nervous system metastases from breast cancer Oncologist. 2003; 8(5):398-410. . View in PubMed

Standard and novel radiotherapeutic approaches to neoplastic meningitis Curr Oncol Rep. 2003 Jan; 5(1):24-8. . View in PubMed

Acute toxicity and treatment interruption related to electron and photon craniospinal irradiation in pediatric patients treated at the University of Texas MD. Anderson Cancer Center. Int J Radiat Oncol Biol Phys. 2002 Mar 15; 52(4):1008-16. . View in PubMed

Prior to joining USC Keck School of Medicine as Professor and Chair of Radiation Oncology, Dr. Eric L. Chang was on the faculty as an attending radiation oncologist at The University of Texas M. D. Anderson Cancer Center for over 12 years, rising to an academic rank of Professor. Having established the first Gamma Knife radiosurgery program at M. D. Anderson which treats over 450 patients a year, he served as the Director of the CNS Stereotactic Radiation Program comprising the Gamma Knife program, and the Steretoactic Body Radiation Therapy (SBRT) program for spine which treats over 100 spine patients a year. He is board certified by the American Board of Radiology in radiation oncology and specializes in the radiotherapeutic evaluation and management of patients with tumors of the central nervous system. He attended Harvard Medical School where he received his Doctorate in Medicine.

Dr. Chang's post-graduate training was conducted at the Harvard Joint Center for Radiation Therapy, in Boston, Massachusetts. He has held research leadership roles including having served as member, and Chair of the M. D. Anderson Cancer Center Clinical Research Committee (CRC) Chair. He is the 2011 CNS track leader for the American Society for Clinical Oncology (ASCO) Scientific Program Committee, and member of the ASCO Cancer Education Committee. Dr. Chang is currently the co-leader for the American Society of Radiation Oncology (ASTRO) brain metastasis guidelines development task force and member of the Annual Program Committee of the Educational Council of ASTRO. He is current member of the American College of Radiology Appropriateness Criteria Expert Panel on bone metastases. He has been listed in the Best Doctors Directory. Dr. Chang led a phase III randomized controlled trial on brain metastasis published in the Lancet Oncology 2009 which is starting to change the practice patterns for metastatic brain disease. Dr. Chang has been selected as a plenary speaker for past meetings of ASTRO and the American Association for Neurological Surgeons (AANS). He has authored or co-authored over 100 peer-reviewed papers and abstracts.
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