Keck School Faculty

Eric Lin Chang

Eric Lin Chang

Chair and Professor of Radiation Oncology
Radiation Oncology
NOR G358 1441 EASTLAKE AVE Health Sciences Campus Los Angeles

: Listed in Best Doctors in America, 2011-2012

: James D. Cox Mentorship Award, 2011

: Listed in Best Doctors in America, 2009-2010

: Named in Strathmore's Who's Who, 2002-2003

: The American Society for Therapeutic Radiology and Oncology (ASTRO), Travel Grant to attend ESTRO an, 2001

: The American College of Radiation Oncology (ACRO), Howard H. Wong Fellowship in Radiation Oncology, 1997

Vail, Colorado: American Society for Clinical Oncology (ASCO) Award, Methods in Clinical Cancer Research Workshop, 1997

: Howard Hughes Medical Institute Research Fellowship, 1993

: Sigma Xi Research Society,, 1990

Commentary: Mature Imaging-Based Outcomes Supporting Local Control for Complex Reirradiation Salvage Spine Stereotactic Body Radiotherapy Neurosurgery. 2020 Sep 15; 87(4):E498-E499. . View in PubMed

Executive Summary from American Radium Society's Appropriate Use Criteria on Neurocognition after stereotactic radiosurgery for multiple brain metastases Neuro Oncol. 2020 Aug 11. . View in PubMed

Low risk of radiation myelopathy with relaxed spinal cord dose constraints in de novo, single fraction spine stereotactic radiosurgery Radiother Oncol. 2020 Jul 31; 152:49-55. . View in PubMed

Radiotherapy to the brain: what are the consequences of this age-old treatment? Ann Palliat Med. 2020 Jul 29.. View in PubMed

Effectiveness of Gamma Knife Radiosurgery in the Treatment of Refractory Trigeminal Neuralgia: A Case Series Oper Neurosurg (Hagerstown). 2020 Jun 01; 18(6):571-576. . View in PubMed

Neuro-oncology Management During the COVID-19 Pandemic With a Focus on WHO Grade III and IV Gliomas Neuro Oncol. 2020 May 05. . View in PubMed

International consensus recommendations for target volume delineation specific to sacral metastases and spinal stereotactic body radiation therapy (SBRT) Radiother Oncol. 2020 Apr; 145:21-29. . View in PubMed

Current approaches to the management of brain metastases Nat Rev Clin Oncol. 2020 05; 17(5):279-299. . View in PubMed

Identifying Disparities in Care in Treating Glioblastoma: A Retrospective Cohort Study of Patients Treated at a Safety-net Versus Private Hospital Setting World Neurosurg. 2020 05; 137:e213-e220. . View in PubMed

Quantifying vascular invasion in pancreatic cancer-a contrast CT based method for surgical resectability evaluation Phys Med Biol. 2020 06 01; 65(10):105012. . View in PubMed

Bevacizumab is more effective in nasopharyngeal carcinoma patients with lower maximum radiation dose to the temporal lobe Chin Clin Oncol. 2019 Oct; 8(S1):S20. . View in PubMed

Long-Term Tumor Control Rates Following Gamma Knife Radiosurgery for Acoustic Neuroma World Neurosurg. 2019 Feb; 122:366-371. . View in PubMed

Assembling the brain trust: the multidisciplinary imperative in neuro-oncology Nat Rev Clin Oncol. 2019 08; 16(8):521-522. . View in PubMed

Commentary: Clinical Outcomes of Upfront Stereotactic Radiosurgery Alone for Patient With 5 to 15 Brain Metastases Neurosurgery. 2019 08 01; 85(2):E247-E248. . View in PubMed

Preserve the Facial Nerve Int J Radiat Oncol Biol Phys. 2019 03 15; 103(4):798-799. . View in PubMed

Lens Dose-Response Prediction Modeling and Cataract Incidence in Patients With Retinoblastoma After Lens-Sparing or Whole-Eye Radiation Therapy Int J Radiat Oncol Biol Phys. 2019 04 01; 103(5):1143-1150. . View in PubMed

Commentary: Long-Term Update of Stereotactic Radiosurgery for Benign Spinal Tumors Neurosurgery. 2019 11 01; 85(5):E840-E841. . View in PubMed

Novel multidisciplinary approaches in the management of metastatic epidural spinal cord compression Future Oncol. 2018 Jul; 14(17):1665-1668. . View in PubMed

Development of a Radiation Oncology Resident Continuity Clinic to Improve Clinical Competency and Patient Compliance Int J Radiat Oncol Biol Phys. 2018 03 01; 100(3):551-555. . View in PubMed

Combination ipilimumab and radiosurgery for brain metastases: tumor, edema, and adverse radiation effects J Neurosurg. 2018 12 01; 129(6):1397-1406. . View in PubMed

Phase 1 Study of Spinal Cord Constraint Relaxation With Single Session Spine Stereotactic Radiosurgery in the Primary Management of Patients With Inoperable, Previously Unirradiated Metastatic Epidural Spinal Cord Compression Int J Radiat Oncol Biol Phys. 2018 12 01; 102(5):1481-1488. . View in PubMed

Population description and clinical response assessment for spinal metastases: part 2 of the SPIne response assessment in Neuro-Oncology (SPINO) group report Neuro Oncol. 2018 08 02; 20(9):1215-1224. . View in PubMed

An update on radiation therapy for brain metastases Chin Clin Oncol. 2017 Aug; 6(4):35. . View in PubMed

Combined-modality hypofractionated radiotherapy for elderly patients with glioblastoma: setting a new standard Future Sci OA. 2017 Aug; 3(3):FSO210. . View in PubMed

Modern approaches to the management of metastatic epidural spinal cord compression CNS Oncol. 2017 Jul 18. . View in PubMed

Consensus guidelines for postoperative stereotactic body radiation therapy for spinal metastases: results of an international survey J Neurosurg Spine. 2017 Mar; 26(3):299-306. . View in PubMed

Preserving Neurocognition in Patients With Brain Metastases JAMA Oncol. 2017 Feb 01; 3(2):269-270. . View in PubMed

Postoperative stereotactic radiosurgery for limited brain metastases: are we ready for prime time? Expert Rev Anticancer Ther. 2017 09; 17(9):775-777.. View in PubMed

Radiosurgery for resected brain metastases-a new standard of care? Lancet Oncol. 2017 08; 18(8):985-987.. View in PubMed

In Regard to Dr Vapiwala Int J Radiat Oncol Biol Phys. 2017 05 01; 98(1):215. . View in PubMed

Consensus Contouring Guidelines for Postoperative Stereotactic Body Radiation Therapy for Metastatic Solid Tumor Malignancies to the Spine Int J Radiat Oncol Biol Phys. 2017 01 01; 97(1):64-74. . View in PubMed

A quantitative analysis of craniopharyngioma cyst expansion during and after radiation therapy and surgical implications Neurosurg Focus. 2016 Dec; 41(6):E15. . View in PubMed

Re-irradiation of Recurrent Pineal Germ Cell Tumors with Radiosurgery: Report of Two Cases and Review of Literature Cureus. 2016 Apr 25; 8(4):e585. . View in PubMed

Prognostic factors for melanoma brain metastases treated with stereotactic radiosurgery J Neurosurg. 2016 12; 125(Suppl 1):31-39. . View in PubMed

In Regard to Johnson et al Int J Radiat Oncol Biol Phys. 2016 07 01; 95(3):1083-1085. . View in PubMed

Point/Counterpoint: Is stereotactic radiosurgery needed following resection of brain metastasis? Neuro Oncol. 2016 Jan; 18(1):12-5.. View in PubMed

Prospective evaluation of target and spinal cord motion and dosimetric changes with respiration in spinal stereotactic body radiation therapy utilizing 4-D CT J Radiosurg SBRT. 2016; 4(3):191-201. . View in PubMed

Prospective validation of treatment accuracy using implanted fiducial markers for spinal stereotactic body radiation therapy J Radiosurg SBRT. 2016; 4(1):7-14. . View in PubMed

Outcomes for Spine Stereotactic Body Radiation Therapy and an Analysis of Predictors of Local Recurrence Int J Radiat Oncol Biol Phys. 2015 Aug 01; 92(5):1016-1026. . View in PubMed

In Reply to Gemici and Yaprak and Lowrey and Marcus Int J Radiat Oncol Biol Phys. 2015 Jul 15; 92(4):948-9. . View in PubMed

ACR Appropriateness Criteria® Metastatic Epidural Spinal Cord Compression and Recurrent Spinal Metastasis J Palliat Med. 2015 Jul; 18(7):573-84. . View in PubMed

Extra-CNS metastasis from glioblastoma: a rare clinical entity Expert Rev Anticancer Ther. 2015 May; 15(5):545-52. . View in PubMed

Phase 3 trials of stereotactic radiosurgery with or without whole-brain radiation therapy for 1 to 4 brain metastases: individual patient data meta-analysis Int J Radiat Oncol Biol Phys. 2015 Mar 15; 91(4):710-7. . View in PubMed

Randomized phase II adjuvant factorial study of dose-dense temozolomide alone and in combination with isotretinoin, celecoxib, and/or thalidomide for glioblastoma Neuro Oncol. 2015 Feb; 17(2):266-73. . View in PubMed

Factors affecting survival in 37 consecutive patients undergoing de novo stereotactic radiosurgery for contiguous sites of vertebral body metastasis from renal cell carcinoma J Neurosurg Spine. 2015 Jan; 22(1):52-9. . View in PubMed

Prognostic significance of EGFR and KRAS mutations in NSCLC patients with brain metastases treated with radiosurgery† J Radiosurg SBRT. 2015; 3(3):171-178. . View in PubMed

ACR Appropriateness Criteria(®) non-spine bone metastases J Palliat Med. 2015 Jan; 18(1):11-7. . View in PubMed

Is there any role for stereotactic body radiotherapy in the management of metastatic epidural spinal cord compression? CNS Oncol. 2015; 4(1):1-4.. View in PubMed

Radiosurgery for metastatic disease at the craniocervical junction World Neurosurg. 2014 Dec; 82(6):1331-6. . View in PubMed

Incidence and predictive factors of pain flare after spine stereotactic body radiation therapy: secondary analysis of phase 1/2 trials Int J Radiat Oncol Biol Phys. 2014 Nov 15; 90(4):870-6. . View in PubMed

A single-field integrated boost treatment planning technique for spot scanning proton therapy Radiat Oncol. 2014 Sep 11; 9:202. . View in PubMed

Outcomes after surgery and radiotherapy for spinal myxopapillary ependymoma: update of the MD Anderson Cancer Center experience Neurosurgery. 2014 Sep; 75(3):205-14; discussion 213-4. . View in PubMed

Rare primary central nervous system tumors Rare Tumors. 2014 Jul 30; 6(3):5449. . View in PubMed

Emerging applications of stereotactic body radiotherapy Future Oncol. 2014 May; 10(7):1299-310. . View in PubMed

Intracranial hemangiopericytoma: patterns of failure and the role of radiation therapy Neurosurgery. 2013 Oct; 73(4):624-30; discussion 630-1. . View in PubMed

Best of International Stereotactic Radiosurgery Society Congress 2013: stereotactic body radiation therapyPart II: nonspinal tumors. Future Oncol. 2013 Sep; 9(9):1303-6. . View in PubMed

Best of International Stereotactic Radiosurgery Society Congress 2013: stereotactic body radiation therapyPart I: spinal tumors. Future Oncol. 2013 Sep; 9(9):1299-302. . View in PubMed

Predictors of survival in contemporary practice after initial radiosurgery for brain metastases Int J Radiat Oncol Biol Phys. 2013 Mar 01; 85(3):656-61. . View in PubMed

ACR Appropriateness Criteria ® spinal bone metastases J Palliat Med. 2013 Jan; 16(1):9-19. . View in PubMed

Generalizable class solutions for treatment planning of spinal stereotactic body radiation therapy Int J Radiat Oncol Biol Phys. 2012 Nov 01; 84(3):847-53. . View in PubMed

Phase 1/2 trial of single-session stereotactic body radiotherapy for previously unirradiated spinal metastases Cancer. 2012 Oct 15; 118(20):5069-77. . View in PubMed

Radiotherapeutic and surgical management for newly diagnosed brain metastasis(es): An American Society for Radiation Oncology evidence-based guideline Pract Radiat Oncol. 2012 Jul-Sep; 2(3):210-225. . View in PubMed

ACR Appropriateness Criteria® non-spine bone metastases J Palliat Med. 2012 May; 15(5):521-6. . View in PubMed

Cost-effectiveness analysis of a randomized study comparing radiosurgery with radiosurgery and whole brain radiation therapy in patients with 1 to 3 brain metastases Am J Clin Oncol. 2012 Feb; 35(1):45-50. . View in PubMed

Advances in radiation therapy of brain metastasis Prog Neurol Surg. 2012; 25:96-109. . View in PubMed

Irradiation of spinal metastases: should we continue to include one uninvolved vertebral body above and below in the radiation field? Int J Radiat Oncol Biol Phys. 2011 Dec 01; 81(5):1495-9.. View in PubMed

Radiation-induced middle ear and mastoid opacification in skull base tumors treated with radiotherapy Int J Radiat Oncol Biol Phys. 2011 Dec 01; 81(5):e819-23. . View in PubMed

Outcomes and prognostic factors for patients with brainstem metastases undergoing stereotactic radiosurgery Neurosurgery. 2011 Oct; 69(4):796-806; discussion 806. . View in PubMed

Prospective evaluation of spinal reirradiation by using stereotactic body radiation therapy: The University of Texas MD Anderson Cancer Center experience Cancer. 2011 Aug 01; 117(15):3509-16. . View in PubMed

Induction treatment for diffuse intrinsic pontine glioma, experience of MD. Anderson Cancer Center. Anticancer Res. 2011 Jun; 31(6):2265-9. . View in PubMed

A quality assurance procedure to evaluate cone-beam CT image center congruence with the radiation isocenter of a linear accelerator J Appl Clin Med Phys. 2010 Jul 02; 11(4):3297. . View in PubMed

Management of metastatic spinal cord compression Expert Rev Anticancer Ther. 2010 May; 10(5):697-708. . View in PubMed

Management of spinal metastases from renal cell carcinoma using stereotactic body radiotherapy Int J Radiat Oncol Biol Phys. 2010 Mar 15; 76(4):1185-92. . View in PubMed

Neurocognition in patients with brain metastases treated with radiosurgery or radiosurgery plus whole-brain irradiation: a randomised controlled trial Lancet Oncol. 2009 Nov; 10(11):1037-44. . View in PubMed

Optimal treatment planning for skull base chordoma: photons, protons, or a combination of both? Int J Radiat Oncol Biol Phys. 2009 Jul 15; 74(4):1033-9.. View in PubMed

CNS germinomas: what is the best treatment strategy? Expert Rev Neurother. 2008 Oct; 8(10):1527-36.. View in PubMed

Dosimetric effect of translational and rotational errors for patients undergoing image-guided stereotactic body radiotherapy for spinal metastases Int J Radiat Oncol Biol Phys. 2008 Jul 15; 71(4):1261-71. . View in PubMed

Emerging role of proton beam radiation therapy for chordoma and chondrosarcoma of the skull base Curr Oncol Rep. 2008 Jul; 10(4):338-43. . View in PubMed

Multimodality treatment of osteosarcoma: radiation in a high-risk cohort Pediatr Blood Cancer. 2008 May; 50(5):976-82. . View in PubMed

Optimizing radiotherapy schedules for elderly glioblastoma multiforme patients Expert Rev Anticancer Ther. 2008 May; 8(5):733-41. . View in PubMed

Phase I/II study of stereotactic body radiotherapy for spinal metastasis and its pattern of failure J Neurosurg Spine. 2007 Aug; 7(2):151-60. . View in PubMed

Automatic target localization and verification for on-line image-guided stereotactic body radiotherapy of the spine Technol Cancer Res Treat. 2007 Jun; 6(3):187-96. . View in PubMed

Evaluation of peritumoral edema in the delineation of radiotherapy clinical target volumes for glioblastoma Int J Radiat Oncol Biol Phys. 2007 May 01; 68(1):144-50. . View in PubMed

Intensity-modulated radiotherapy (IMRT) and conventional three-dimensional conformal radiotherapy for high-grade gliomas: does IMRT increase the integral dose to normal brain? Int J Radiat Oncol Biol Phys. 2007 Mar 15; 67(4):1135-44.. View in PubMed

Portal imaging practice patterns of children's oncology group institutions: Dosimetric assessment and recommendations for minimizing unnecessary exposure Int J Radiat Oncol Biol Phys. 2007 Feb 01; 67(2):594-600. . View in PubMed

A pilot study of neurocognitive function in patients with one to three new brain metastases initially treated with stereotactic radiosurgery alone Neurosurgery. 2007 Feb; 60(2):277-83; discussion 283-4. . View in PubMed

Focal and craniospinal irradiation for patients with intracranial germinoma and patterns of failure Cancer. 2006 Nov 01; 107(9):2228-36. . View in PubMed

Nonsmall cell lung cancer presenting with synchronous solitary brain metastasis Cancer. 2006 May 01; 106(9):1998-2004. . View in PubMed

Phase III study of efaproxiral as an adjunct to whole-brain radiation therapy for brain metastases J Clin Oncol. 2006 Jan 01; 24(1):106-14. . View in PubMed

Case-control study of stereotactic radiosurgery for recurrent glioblastoma multiforme J Neurosurg. 2005 Aug; 103(2):210-7. . View in PubMed

Development of a sensitive and specific enzyme-linked immunosorbent assay for thymosin beta15, a urinary biomarker of human prostate cancer Clin Biochem. 2005 Jun; 38(6):558-71. . View in PubMed

Outcome variation among "radioresistant" brain metastases treated with stereotactic radiosurgery Neurosurgery. 2005 May; 56(5):936-45; discussion 936-45. . View in PubMed

Phase I clinical evaluation of near-simultaneous computed tomographic image-guided stereotactic body radiotherapy for spinal metastases Int J Radiat Oncol Biol Phys. 2004 Aug 01; 59(5):1288-94. . View in PubMed

An evaluation of radiation exposure from portal films taken during definitive course of pediatric radiotherapy Int J Radiat Oncol Biol Phys. 2004 Jul 15; 59(4):1229-35. . View in PubMed

Radiotherapy after surgery for benign cerebral meningioma Radiother Oncol. 2004 Apr; 71(1):85-90. . View in PubMed

Intracranial meningeal hemangiopericytoma: the role of radiotherapy: report of 29 cases and review of the literature Cancer. 2004 Apr 01; 100(7):1491-7. . View in PubMed

Near simultaneous computed tomography image-guided stereotactic spinal radiotherapy: an emerging paradigm for achieving true stereotaxy Int J Radiat Oncol Biol Phys. 2003 Nov 01; 57(3):605-13. . View in PubMed

Hypofractionated radiotherapy for elderly or younger low-performance status glioblastoma patients: outcome and prognostic factors Int J Radiat Oncol Biol Phys. 2003 Jun 01; 56(2):519-28. . View in PubMed

Diagnosis and management of central nervous system metastases from breast cancer Oncologist. 2003; 8(5):398-410. . View in PubMed

Acute toxicity and treatment interruption related to electron and photon craniospinal irradiation in pediatric patients treated at the University of Texas MD. Anderson Cancer Center. Int J Radiat Oncol Biol Phys. 2002 Mar 15; 52(4):1008-16. . View in PubMed

Prior to joining USC Keck School of Medicine as Professor and Chair of Radiation Oncology, Dr. Eric L. Chang was on the faculty as an attending radiation oncologist at The University of Texas M. D. Anderson Cancer Center for over 12 years, rising to an academic rank of Professor. Having established the first Gamma Knife radiosurgery program at M. D. Anderson which treats over 450 patients a year, he served as the Director of the CNS Stereotactic Radiation Program comprising the Gamma Knife program, and the Steretoactic Body Radiation Therapy (SBRT) program for spine which treats over 100 spine patients a year. He is board certified by the American Board of Radiology in radiation oncology and specializes in the radiotherapeutic evaluation and management of patients with tumors of the central nervous system. He attended Harvard Medical School where he received his Doctorate in Medicine.

Dr. Chang's post-graduate training was conducted at the Harvard Joint Center for Radiation Therapy, in Boston, Massachusetts. He has held research leadership roles including having served as member, and Chair of the M. D. Anderson Cancer Center Clinical Research Committee (CRC) Chair. He is the 2011 CNS track leader for the American Society for Clinical Oncology (ASCO) Scientific Program Committee, and member of the ASCO Cancer Education Committee. Dr. Chang is currently the co-leader for the American Society of Radiation Oncology (ASTRO) brain metastasis guidelines development task force and member of the Annual Program Committee of the Educational Council of ASTRO. He is current member of the American College of Radiology Appropriateness Criteria Expert Panel on bone metastases. He has been listed in the Best Doctors Directory. Dr. Chang led a phase III randomized controlled trial on brain metastasis published in the Lancet Oncology 2009 which is starting to change the practice patterns for metastatic brain disease. Dr. Chang has been selected as a plenary speaker for past meetings of ASTRO and the American Association for Neurological Surgeons (AANS). He has authored or co-authored over 100 peer-reviewed papers and abstracts.
Powered by SC CTSI
Go to Top