Eric Lin Chang, MD

Chair and Professor of Radiation Oncology

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Overview

Prior to joining USC Keck School of Medicine as Professor and Chair of Radiation Oncology, Dr. Eric L. Chang was on the faculty as an attending radiation oncologist at The University of Texas M. D. Anderson Cancer Center for over 12 years, rising to an academic rank of Professor. Having established the first Gamma Knife radiosurgery program at M. D. Anderson which treats over 450 patients a year, he served as the Director of the CNS Stereotactic Radiation Program comprising the Gamma Knife program, and the Steretoactic Body Radiation Therapy (SBRT) program for spine which treats over 100 spine patients a year. He is board certified by the American Board of Radiology in radiation oncology and specializes in the radiotherapeutic evaluation and management of patients with tumors of the central nervous system. He attended Harvard Medical School where he received his Doctorate in Medicine.

Dr. Chang’s post-graduate training was conducted at the Harvard Joint Center for Radiation Therapy, in Boston, Massachusetts. He has held research leadership roles including having served as member, and Chair of the M. D. Anderson Cancer Center Clinical Research Committee (CRC) Chair. He is the 2011 CNS track leader for the American Society for Clinical Oncology (ASCO) Scientific Program Committee, and member of the ASCO Cancer Education Committee. Dr. Chang is currently the co-leader for the American Society of Radiation Oncology (ASTRO) brain metastasis guidelines development task force and member of the Annual Program Committee of the Educational Council of ASTRO. He is current member of the American College of Radiology Appropriateness Criteria Expert Panel on bone metastases. He has been listed in the Best Doctors Directory. Dr. Chang led a phase III randomized controlled trial on brain metastasis published in the Lancet Oncology 2009 which is starting to change the practice patterns for metastatic brain disease. Dr. Chang has been selected as a plenary speaker for past meetings of ASTRO and the American Association for Neurological Surgeons (AANS). He has authored or co-authored over 100 peer-reviewed papers and abstracts.

Awards

  • Sigma Xi Research Society,, 1990
  • Howard Hughes Medical Institute Research Fellowship, 1993
  • Vail, Colorado: American Society for Clinical Oncology (ASCO) Award, Methods in Clinical Cancer Research Workshop, 1997
  • The American College of Radiation Oncology (ACRO), Howard H. Wong Fellowship in Radiation Oncology, 1997
  • The American Society for Therapeutic Radiology and Oncology (ASTRO), Travel Grant to attend ESTRO an, 2001
  • 2002
     -: Named in Strathmore’s Who’s Who, 2002
     – 2003
  • 2009
     -: Listed in Best Doctors in America, 2009
     – 2010
  • 2011
     -: Listed in Best Doctors in America, 2011
     – 2012
  • James D. Cox Mentorship Award, 2011

Publications

  • Letter to the Editor regarding “Questionable indication for postoperative radiotherapy after surgery for metastases of the major long bones”: A cautionary note on methodology and analysis. J Bone Oncol. 2026 Jun; 58:100757.. View in PubMed
  • Modern Radiosurgery Approaches for Brain Metastases. Cancer J. 2026 Jan-Feb 01; 32(1).. View in PubMed
  • Stereotactic Gamma Knife radiosurgery: Past, present and future. J Radiosurg SBRT. 2026; 10(1-2):33-41.. View in PubMed
  • Special issue on Contemporary and emerging stereotactic radiosurgery and stereotactic body radiation therapy technology. J Radiosurg SBRT. 2026; 10(1-2):1.. View in PubMed
  • Initial experience of spatially fractionated lattice radiation therapy for palliative treatment of pediatric bulky tumors. Front Oncol. 2025; 15:1648847.. View in PubMed
  • Stereotactic core ablative radiation therapy for small hypoxic tumors: impact of dosimetric approaches and consequent optimization strategy in the context of spatially fractionated radiation therapy. Front Oncol. 2025; 15:1568959.. View in PubMed
  • Multiparametric Dynamic Contrast Imaging for Voxelwise Quantitative Assessment of Brain Tumors. Radiol Imaging Cancer. 2025 09; 7(5):e250049.. View in PubMed
  • Long-term Results From a Phase 1 Study of Spinal Cord Constraint Relaxation With Single Session Spine Stereotactic Radiosurgery in the Primary Management of Patients With Inoperable, Previously Unirradiated Spinal Metastases With Epidural Extension. Int J Radiat Oncol Biol Phys. 2026 Apr 01; 124(5):1219-1225.. View in PubMed
  • Predictors of treatment response and overall survival in patients with breast cancer brain metastases treated with stereotactic radiosurgery: a prospective study using the NeuroPoint Alliance SRS Registry. J Neurosurg. 2025 Nov 01; 143(5):1419-1430.. View in PubMed
  • Spot-Scanning Confocal Photon Beams for Hypofractionated Brain Radiosurgery. Technol Cancer Res Treat. 2025 Jan-Dec; 24:15330338251342873.. View in PubMed