Eunjung Lee, PhD

Associate Professor of Research Population and Public Health Sciences

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Overview

My primary research interests are in understanding the environmental and lifestyle factors that influence cancer risk and cancer disparities with focus on understudied Asian American and Latinx populations.

Publications

  • ATM-deficiency-induced microglial activation promotes neurodegeneration in ataxia-telangiectasia Cell Rep. 2023 Dec 28; 43(1):113622. . View in PubMed
  • Impaired neural stress resistance and loss of REST in bipolar disorder Mol Psychiatry. 2023 Nov 08. . View in PubMed
  • Contribution of Somatic Ras/Raf/Mitogen-Activated Protein Kinase Variants in the Hippocampus in Drug-Resistant Mesial Temporal Lobe Epilepsy JAMA Neurol. 2023 06 01; 80(6):578-587. . View in PubMed
  • Characterizing the molecular impact of KMT2D variants on the epigenetic and transcriptional landscapes in Kabuki syndrome Hum Mol Genet. 2023 06 19; 32(13):2251-2261. . View in PubMed
  • Contribution and therapeutic implications of retroelement insertions in ataxia telangiectasia Am J Hum Genet. 2023 11 02; 110(11):1976-1982. . View in PubMed
  • An Approach to the Primary and Secondary Prevention of Gastric Cancer in the United StatesClin Gastroenterol Hepatol. 2022 10; 20(10):2218-2228. e2. . View in PubMed
  • Rates and Patterns of Clonal Oncogenic Mutations in the Normal Human Brain Cancer Discov. 2022 01; 12(1):172-185. . View in PubMed
  • Bariatric surgery in patients with breast and endometrial cancer in California: population-based prevalence and survival Surg Obes Relat Dis. 2022 Jan; 18(1):42-52. . View in PubMed
  • Endoscopy screening in high-risk populations as a strategy to improve early detection of gastric cancer in the United States Journal of Asian Health. 2022; 9:e202201. . View in PubMed
  • Non-steroidal Anti-inflammatory Drug Use and Risk of Age-Related Macular Degeneration in the California Teachers Study Drugs Aging. 2021 09; 38(9):817-828. . View in PubMed
  • Identification of Somatic Mutations From Bulk and Single-Cell Sequencing Data Front Aging. 2021; 2:800380. . View in PubMed
  • Combined Associations of a Polygenic Risk Score and Classical Risk Factors With Breast Cancer Risk J Natl Cancer Inst. 2021 03 01; 113(3):329-337. . View in PubMed
  • Immigration history, lifestyle characteristics, and breast density in the Vietnamese American Women’s Health Study: a cross-sectional analysis Cancer Causes Control. 2020 Feb; 31(2):127-138. . View in PubMed
  • A Summary of the 2020 Gastric Cancer Summit at Stanford University Gastroenterology. 2020 10; 159(4):1221-1226. . View in PubMed
  • Hypertension, antihypertensive medications use and risk of age-related macular degeneration in California Teachers Cohort J Hum Hypertens. 2020 09; 34(8):568-576. . View in PubMed
  • Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes Nat Genet. 2020 01; 52(1):56-73. . View in PubMed
  • Serum Levels of Commonly Detected Persistent Organic Pollutants and Per- and Polyfluoroalkyl Substances (PFASs) and Mammographic Density in Postmenopausal Women Int J Environ Res Public Health. 2020 01 17; 17(2). . View in PubMed
  • Genome-wide association study of germline variants and breast cancer-specific mortality Br J Cancer. 2019 03; 120(6):647-657. . View in PubMed
  • Polygenic Risk Scores for Prediction of Breast Cancer and Breast Cancer Subtypes Am J Hum Genet. 2019 01 03; 104(1):21-34. . View in PubMed
  • Shared heritability and functional enrichment across six solid cancers Nat Commun. 2019 01 25; 10(1):431. . View in PubMed
  • Evaluation of Medicare Claims Data as a Tool to Identify Dementia J Alzheimers Dis. 2019; 67(2):769-778. . View in PubMed
  • Growth factor genes and change in mammographic density after stopping combined hormone therapy in the California Teachers Study BMC Cancer. 2018 Nov 06; 18(1):1072. . View in PubMed
  • Body mass index at age 18 years and recent body mass index in relation to risk of breast cancer overall and ER/PR/HER2-defined subtypes in white women and African-American women: a pooled analysis Breast Cancer Res. 2018 01 22; 20(1):5. . View in PubMed
  • Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer Nat Genet. 2017 Dec; 49(12):1767-1778. . View in PubMed
  • A Randomized Controlled Trial of Green Tea Extract Supplementation and Mammographic Density in Postmenopausal Women at Increased Risk of Breast Cancer Cancer Prev Res (Phila). 2017 Dec; 10(12):710-718. . View in PubMed
  • Stomach Cancer Disparity among Korean Americans by Tumor Characteristics: Comparison with Non-Hispanic Whites, Japanese Americans, South Koreans, and Japanese Cancer Epidemiol Biomarkers Prev. 2017 04; 26(4):587-596. . View in PubMed
  • Reproductive factors and the risk of triple-negative breast cancer in white women and African-American women: a pooled analysis Breast Cancer Res. 2017 01 13; 19(1):6. . View in PubMed
  • Association analysis identifies 65 new breast cancer risk loci Nature. 2017 11 02; 551(7678):92-94. . View in PubMed
  • Body size over the life-course and the risk of endometrial cancer: the California Teachers Study Cancer Causes Control. 2016 Dec; 27(12):1419-1428. . View in PubMed
  • Association of genetic susceptibility variants for type 2 diabetes with breast cancer risk in women of European ancestry Cancer Causes Control. 2016 May; 27(5):679-93. . View in PubMed
  • Breast cancer risk variants at 6q25 display different phenotype associations and regulate ESR1, RMND1 and CCDC170 Nat Genet. 2016 Apr; 48(4):374-86. . View in PubMed
  • Disparities in colorectal cancer incidence among Latino subpopulations in California defined by country of origin Cancer Causes Control. 2016 Feb; 27(2):147-55. . View in PubMed
  • BRCA2 Polymorphic Stop Codon K3326X and the Risk of Breast, Prostate, and Ovarian Cancers J Natl Cancer Inst. 2016 Feb; 108(2). . View in PubMed
  • International Consortium on Mammographic Density: Methodology and population diversity captured across 22 countries Cancer Epidemiol. 2016 Feb; 40:141-51. . View in PubMed
  • Novel polymorphisms in caspase-8 are associated with breast cancer risk in the California Teachers Study BMC Cancer. 2016 Jan 12; 16:14. . View in PubMed
  • Traditional Breast Cancer Risk Factors in Filipina Americans Compared with Chinese and Japanese Americans in Los Angeles County Cancer Epidemiol Biomarkers Prev. 2016 12; 25(12):1572-1586. . View in PubMed
  • Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer Nat Commun. 2016 04 27; 7:11375. . View in PubMed
  • Recreational physical activity and risk of triple negative breast cancer in the California Teachers Study Breast Cancer Res. 2016 06 17; 18(1):62. . View in PubMed
  • Pleiotropic analysis of cancer risk loci on esophageal adenocarcinoma risk Cancer Epidemiol Biomarkers Prev. 2015 Nov; 24(11):1801-3. . View in PubMed
  • Indicators of microbial-rich environments and the development of papillary thyroid cancer in the California Teachers Study Cancer Epidemiol. 2015 Aug; 39(4):548-53. . View in PubMed
  • Risk factors for endometrial cancer in black and white women: a pooled analysis from the Epidemiology of Endometrial Cancer Consortium (E2C2) Cancer Causes Control. 2015 Feb; 26(2):287-296. . View in PubMed
  • Hormone metabolism pathway genes and mammographic density change after quitting estrogen and progestin combined hormone therapy in the California Teachers Study Breast Cancer Res. 2014 Dec 11; 16(6):477. . View in PubMed
  • Genetic variation in mitotic regulatory pathway genes is associated with breast tumor grade Hum Mol Genet. 2014 Nov 15; 23(22):6034-46. . View in PubMed
  • Estimating risks for variants of unknown significance according to their predicted pathogenicity classes with application to BRCA1 Breast Cancer Res Treat. 2014 Feb; 144(1):171-7. . View in PubMed
  • Reproductive factors, exogenous hormones, and pancreatic cancer risk in the CTS Am J Epidemiol. 2013 Nov 01; 178(9):1403-13. . View in PubMed
  • Hormone metabolism genes and mammographic density in Singapore Chinese women Cancer Epidemiol Biomarkers Prev. 2013 May; 22(5):984-6. . View in PubMed
  • Genetic variation in transforming growth factor beta 1 and mammographic density in Singapore Chinese women Cancer Res. 2013 Mar 15; 73(6):1876-82. . View in PubMed
  • Variation in inflammatory cytokine/growth-factor genes and mammographic density in premenopausal women aged 50-55 PLoS One. 2013; 8(6):e65313. . View in PubMed
  • Soy isoflavones and breast cancer Am Soc Clin Oncol Educ Book. 2013; 102-6. . View in PubMed
  • Common breast cancer susceptibility variants in LSP1 and RAD51L1 are associated with mammographic density measures that predict breast cancer risk Cancer Epidemiol Biomarkers Prev. 2012 Jul; 21(7):1156-66. . View in PubMed
  • Variations in sex hormone metabolism genes, postmenopausal hormone therapy and risk of endometrial cancer Int J Cancer. 2012 Apr 01; 130(7):1629-38. . View in PubMed
  • Genetic variation in peroxisome proliferator-activated receptor gamma, soy, and mammographic density in Singapore Chinese women Cancer Epidemiol Biomarkers Prev. 2012 Apr; 21(4):635-44. . View in PubMed
  • Characteristics of triple-negative breast cancer in patients with a BRCA1 mutation: results from a population-based study of young women J Clin Oncol. 2011 Nov 20; 29(33):4373-80. . View in PubMed
  • The association of polymorphisms in hormone metabolism pathway genes, menopausal hormone therapy, and breast cancer risk: a nested case-control study in the California Teachers Study cohort Breast Cancer Res. 2011 Apr 01; 13(2):R37. . View in PubMed
  • GRP78 as potential predictor for breast cancer response to adjuvant taxane therapy Int J Cancer. 2011 Feb 01; 128(3):726-31. . View in PubMed
  • Menopausal hormone therapy and subsequent risk of specific invasive breast cancer subtypes in the California Teachers Study Cancer Epidemiol Biomarkers Prev. 2010 Sep; 19(9):2366-78. . View in PubMed
  • Genetic variation in the progesterone receptor gene and risk of endometrial cancer: a haplotype-based approach Carcinogenesis. 2010 Aug; 31(8):1392-9. . View in PubMed
  • Effect of reproductive factors and oral contraceptives on breast cancer risk in BRCA1/2 mutation carriers and noncarriers: results from a population-based study Cancer Epidemiol Biomarkers Prev. 2008 Nov; 17(11):3170-8. . View in PubMed
  • The role of established breast cancer susceptibility loci in mammographic density in young women Cancer Epidemiol Biomarkers Prev. 2008 Jan; 17(1):258-60. . View in PubMed
  • Evaluation of unclassified variants in the breast cancer susceptibility genes BRCA1 and BRCA2 using five methods: results from a population-based study of young breast cancer patients Breast Cancer Res. 2008; 10(1):R19. . View in PubMed
  • GRP78 as a novel predictor of responsiveness to chemotherapy in breast cancer Cancer Res. 2006 Aug 15; 66(16):7849-53. . View in PubMed
  • Mitogen-activated protein kinase kinase inhibitor PD98059 blocks the trans-activation but not the stabilization or DNA binding ability of hypoxia-inducible factor-1alpha Mol Pharmacol. 2001 May; 59(5):1216-24. . View in PubMed