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Frances Chow, MD

Assistant Professor of Clinical Neurological Surgery and Neurology

Neuro-Oncology Disease Affinity Group Leader, USC Norris Comprehensive Cancer Center

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Email chow@usc.edu
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Awards

  • Society for Immunotherapy of Cancer (SITC): Scholar, Women in Cancer Immunotherapy Network (WIN) Leadership Institute, 2024
  • Society for Neuro-Oncology (SNO): Scholar, Future Leaders Development Program, 2024
  • Keck School of Medicine of USC: Service Excellence Award, 2023-2024
  • Pasadena Magazine: Top Doctor Award, 2022-2024
  • Los Angeles Magazine: Top Doctor Award, 2022-2024
  • Super Doctors: Rising Stars Award, 2020-2024
  • Keck School of Medicine of USC: Outstanding Teaching Award, 2018

Publications

  • Incidence of brain metastasis according to patient race and primary cancer origin: a systematic review J Neurooncol. 2024 Sep; 169(3):457-467. . View in PubMed
  • Targeting MDSC-HTR2B to Improve Immune Checkpoint Inhibitors in Breast to Brain Metastasis bioRxiv. 2024 Jun 25. . View in PubMed
  • Editorial: Developing next-generation therapeutics to defeat mutation-driven cancer Front Immunol. 2024; 15:1487952. . View in PubMed
  • Profiling the molecular and clinical landscape of glioblastoma utilizing the Oncology Research Information Exchange Network brain cancer database Neurooncol Adv. 2024 Jan-Dec; 6(1):vdae046. . View in PubMed
  • Multi-omic profiling reveals discrepant immunogenic properties and a unique tumor microenvironment among melanoma brain metastases NPJ Precis Oncol. 2023 Nov 14; 7(1):120. . View in PubMed
  • Increased time to surgery and worse perioperative outcome in benign brain tumor patients with COVID-19 J Clin Neurosci. 2023 Nov; 117:20-26. . View in PubMed
  • Comparison of preoperative versus postoperative treatment dosimetry plans of single-fraction stereotactic radiosurgery for surgically resected brain metastases Neurosurg Focus. 2023 08; 55(2):E9. . View in PubMed
  • Distinct molecular features and potential therapeutic strategies for spinal cord gliomas American Society of Clinical Oncology. 2023. . View in PubMed
  • Neurofibromatosis–Diagnosis and Treatments Immunotherapy Strategies for NF2 Associated Tumors. 2023. . View in PubMed
  • Breast to Brain Metastasis: From Microenvironment to Plasticity Curr Breast Can Rep. 2023. . View in PubMed
  • Identification of sub-clonal loss of heterozygosity (LOH) in glioblastomas analyzed with spatial transcriptomics Cancer Res. 2023; 7_Supp(83):3124. . View in PubMed
  • A cross-sectional study to test equivalence of low- versus intermediate-flip angle dynamic susceptibility contrast MRI measures of relative cerebral blood volume in patients with high-grade gliomas at 15 Tesla field strength. Front Oncol. 2023; 13:1156843. . View in PubMed
  • Coronavirus disease-19 is associated with decreased treatment access and worsened outcomes in malignant brain tumor patients Surg Neurol Int. 2023; 14:292. . View in PubMed
  • Cancer stem cell assay-guided chemotherapy improves survival of patients with recurrent glioblastoma in a randomized trial Cell Rep Med. 2023 05 16; 4(5):101025. . View in PubMed
  • MR multitasking-based dynamic imaging for cerebrovascular evaluation (MT-DICE): Simultaneous quantification of permeability and leakage-insensitive perfusion by dynamic T1/T2* mapping Magn Reson Med. 2023 Jan; 89(1):161-176. . View in PubMed
  • A Phase 1 and Randomized Phase 2 Clinical Trial of Selinexor and Temozolomide in Recurrent Glioblastoma Among Adults: The Product of a Successful Team Science Approach Journal of Clinical and Translational Science. 2023. . View in PubMed
  • Cancer stem cell assay-guided chemotherapy promotes survival benefit for patients with recurrent high-grade glioma in a randomized clinical trial Cell Rep. 2023. . View in PubMed
  • The Abscopal Effect: Systematic Review in Patients with Brain and Spine Metastases Neurooncol Adv. 2022. . View in PubMed
  • Breast to brain metastasis is exacerbated with chemotherapy through blood-cerebral spinal fluid-barrier and induces alzheimer’s-like pathology Neuro-Oncol. 2022; 24(s7):vii21–vii22. . View in PubMed
  • Clinical features and molecular characterization of leptomeningeal disease in patients with high grade glioma Neuro-Oncol. 2022; 24(s7):vii154–vii155. . View in PubMed
  • Anaplastic Pleomorphic Xanthoastrocytoma with Extracranial Bone Metastasis: A Case Report and Literature Review Neurology. 2022; 18(98):1251. . View in PubMed
  • Interplay between B cell and GABA metabolism (GABAm) and association with immune evasion in breast carcinoma (BC) Journal of Clinical Oncology. 2022; 16(40):1097. . View in PubMed
  • Modulating glioblastoma chemotherapy response: Evaluating long non-coding RNA effects on DNA damage response, glioma stem cell function, and hypoxic processes Neurooncol Adv. 2022 Jan-Dec; 4(1):vdac119. . View in PubMed
  • Two Rare Cases of Glioma in Total Spine with Metastases to Brain Neurology. 2022; 18(98):3885. . View in PubMed
  • Test-retest repeatability of high-resolution whole-brain DCE-MRI in high-grade glioma patients International Society for Magnetic Resonance in Medicine Annual Meeting. 2022. . View in PubMed
  • Utilization of Discarded Surgical Tissue from Ultrasonic Aspirators to Establish Patient-Derived Metastatic Brain Tumor Cells: A Guide from the Operating Room to the Research Laboratory Curr Protoc. 2021 Jun; 1(6):e140. . View in PubMed
  • Comorbid depression in surgical cancer patients associated with non-routine discharge and readmission Surg Oncol. 2021 Jun; 37:101533. . View in PubMed
  • Complementary and Alternative Medicine for the Treatment of Gliomas: Scoping Review of Clinical Studies, Patient Outcomes, and Toxicity Profiles World Neurosurg. 2021 07; 151:e682-e692. . View in PubMed
  • Neoadjuvant PD-1 blockade induces T cell and cDC1 activation but fails to overcome the immunosuppressive tumor associated macrophages in recurrent glioblastoma Nat Commun. 2021 11 26; 12(1):6938. . View in PubMed
  • Unique challenges for glioblastoma immunotherapy-discussions across neuro-oncology and non-neuro-oncology experts in cancer immunologyMeeting Report from the 2019 SNO Immuno-Oncology Think Tank. Neuro Oncol. 2021 03 25; 23(3):356-375. . View in PubMed
  • A phase 1 with dose expansion/phase 2 study of selinexor in combination with standard of care therapy for newly diagnosed or recurrent glioblastoma Neuro-Oncology. 2021; 6(23):vi62-63. . View in PubMed
  • Phase I trial of intranasal NEO100, highly purified perillyl alcohol, in adult patients with recurrent glioblastoma Neurooncol Adv. 2021 Jan-Dec; 3(1):vdab005. . View in PubMed
  • Resolution of tissue signatures of therapy response in patients with recurrent GBM treated with neoadjuvant anti-PD1 Nat Commun. 2021 06 29; 12(1):4031. . View in PubMed
  • Neoadjuvant PD-1 blockade induces T cell and cDC1 activation but fails to overcome the immunosuppressive tumor associated macrophages in recurrent glioblastoma (in press) Nature Commun. 2021. . View in PubMed
  • Neoadjuvant PD-1 antibody blockade remodels the immune microenvironment of metastatic brain tumors Neuro-Oncology. 2020; 2(22):ii212-ii213. . View in PubMed
  • Targeted next-generation sequencing of 565 neuro-oncology patients at UCLA: A single-institution experience Neurooncol Adv. 2020 Jan-Dec; 2(1):vdaa009. . View in PubMed
  • Validation of response to neoadjuvant anti-PD-1 immunotherapy in recurrent glioblastoma Neuro-Oncology. 2020; 21(6):vi4-vi5. . View in PubMed
  • Single-cell RNAseq of tumor infiltrating immune cells from neoadjuvant anti-PD1 treated GBM patients reveals global transcriptional changes and immunosuppressive adaptive responses by myeloid cells Neuro-Oncology. 2020; 2(22):ii108-ii109. . View in PubMed
  • Amyloid Beta Oligomers Target to Extracellular and Intracellular Neuronal Synaptic Proteins in Alzheimer’s Disease Front Neurol. 2019; 10:1140. . View in PubMed
  • Myeloid populations and the effect of neoadjuvant PD-1 inhibition in the glioblastoma microenvironment: a surfaceomic and transcriptomic dissection at the single-cell level Neuro-Oncology. 2019; 21(6):vi248. . View in PubMed
  • Neoantigens arising from alternative splicing events may be targeted by tumor infiltrating lymphocytes in glioblastomas Neuro-Oncology. 2019; 21(6):vi118-vi119. . View in PubMed
  • Neuro-Oncology Myeloid populations and the effect of neoadjuvant PD-1 inhibition in the glioblastoma microenvironment: a surfaceomic and transcriptomic dissection at the single-cell level. 2019; 21(6):vi248. . View in PubMed
  • Patterns of long-term survivorship following bevacizumab treatment for recurrent glioma: a case series CNS Oncol. 2019 06 01; 8(2):CNS35. . View in PubMed
  • Treatment at Safety-Net Hospitals Is Associated with Delays in Coil Embolization in Patients with Subarachnoid Hemorrhage World Neurosurg. 2018 Dec; 120:e434-e439. . View in PubMed
  • The challenge of distinguishing POEMS from chronic inflammatory demyelinating polyneuropathy US Neurology. 2018; 2(14):94-7. . View in PubMed
  • Pathological Role of Peptidyl-Prolyl Isomerase Pin1 in the Disruption of Synaptic Plasticity in Alzheimer’s Disease Neural Plast. 2017; 2017:3270725. . View in PubMed
  • The Potential Role of Insulin on the Shank-Postsynaptic Platform in Neurodegenerative Diseases Involving Cognition Am J Alzheimers Dis Other Demen. 2014 Jun; 29(4):303-10. . View in PubMed
  • Molecular characteristics and pathways of Avastin for the treatment of glioblastoma multiforme Neurosurg Clin N Am. 2012 Jul; 23(3):417-27. . View in PubMed
  • Temozolomide and other potential agents for the treatment of glioblastoma multiforme Neurosurg Clin N Am. 2012 Apr; 23(2):307-22ix. . View in PubMed

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